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Aliases for KIF26A Gene

Aliases for KIF26A Gene

  • Kinesin Family Member 26A 2 3 5
  • KIAA1236 4

External Ids for KIF26A Gene

Previous GeneCards Identifiers for KIF26A Gene

  • GC14P098420
  • GC14P102595
  • GC14P103674
  • GC14P104605
  • GC14P084784

Summaries for KIF26A Gene

GeneCards Summary for KIF26A Gene

KIF26A (Kinesin Family Member 26A) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Immune System. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF26B.

UniProtKB/Swiss-Prot for KIF26A Gene

  • Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF26A Gene

Genomics for KIF26A Gene

Regulatory Elements for KIF26A Gene

Promoters for KIF26A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIF26A on UCSC Golden Path with GeneCards custom track

Genomic Location for KIF26A Gene

Chromosome:
14
Start:
104,138,723 bp from pter
End:
104,180,898 bp from pter
Size:
42,176 bases
Orientation:
Plus strand

Genomic View for KIF26A Gene

Genes around KIF26A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF26A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF26A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF26A Gene

Proteins for KIF26A Gene

  • Protein details for KIF26A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULI4-KI26A_HUMAN
    Recommended name:
    Kinesin-like protein KIF26A
    Protein Accession:
    Q9ULI4
    Secondary Accessions:
    • Q8TAZ7
    • Q96GK3
    • Q9UFL3

    Protein attributes for KIF26A Gene

    Size:
    1882 amino acids
    Molecular mass:
    194590 Da
    Quaternary structure:
    • Interacts with GRB2 (via SH2 domain).
    SequenceCaution:
    • Sequence=AAH09415.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KIF26A Gene

Proteomics data for KIF26A Gene at MOPED

Post-translational modifications for KIF26A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF26A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIF26A Gene

Domains & Families for KIF26A Gene

Gene Families for KIF26A Gene

Protein Domains for KIF26A Gene

Suggested Antigen Peptide Sequences for KIF26A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULI4

UniProtKB/Swiss-Prot:

KI26A_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily.
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily.
genes like me logo Genes that share domains with KIF26A: view

Function for KIF26A Gene

Molecular function for KIF26A Gene

UniProtKB/Swiss-Prot Function:
Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity).

Gene Ontology (GO) - Molecular Function for KIF26A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 NOT microtubule motor activity IEA,ISS --
GO:0016887 NOT ATPase activity ISS --
genes like me logo Genes that share ontologies with KIF26A: view
genes like me logo Genes that share phenotypes with KIF26A: view

Animal Models for KIF26A Gene

MGI Knock Outs for KIF26A:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF26A Gene

Localization for KIF26A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF26A Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF26A Gene COMPARTMENTS Subcellular localization image for KIF26A gene
Compartment Confidence
cytosol 5
plasma membrane 4
cytoskeleton 3
nucleus 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for KIF26A Gene

Pathways & Interactions for KIF26A Gene

genes like me logo Genes that share pathways with KIF26A: view

Gene Ontology (GO) - Biological Process for KIF26A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IEA,TAS --
GO:0007596 blood coagulation TAS --
GO:0008152 metabolic process IEA --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
GO:0030705 cytoskeleton-dependent intracellular transport IBA --
genes like me logo Genes that share ontologies with KIF26A: view

No data available for SIGNOR curated interactions for KIF26A Gene

Drugs & Compounds for KIF26A Gene

No Compound Related Data Available

Transcripts for KIF26A Gene

mRNA/cDNA for KIF26A Gene

Unigene Clusters for KIF26A Gene

Kinesin family member 26A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF26A Gene

No ASD Table

Relevant External Links for KIF26A Gene

GeneLoc Exon Structure for
KIF26A
ECgene alternative splicing isoforms for
KIF26A

Expression for KIF26A Gene

mRNA expression in normal human tissues for KIF26A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIF26A Gene

This gene is overexpressed in Pancreas (57.4) and Bone marrow mesenchymal stem cell (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIF26A Gene



SOURCE GeneReport for Unigene cluster for KIF26A Gene Hs.134970

genes like me logo Genes that share expression patterns with KIF26A: view

Protein tissue co-expression partners for KIF26A Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIF26A Gene

Orthologs for KIF26A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF26A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIF26A 35
  • 83.67 (n)
  • 83.43 (a)
KIF26A 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF26A 35
  • 83.37 (n)
  • 80.85 (a)
KIF26A 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif26a 35
  • 79.02 (n)
  • 78.95 (a)
Kif26a 16
Kif26a 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIF26A 35
  • 98.1 (n)
  • 97.7 (a)
KIF26A 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif26a 35
  • 78.21 (n)
  • 77.83 (a)
oppossum
(Monodelphis domestica)
Mammalia KIF26A 36
  • 25 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF26A 36
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF26A 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF26A 36
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii kif26aa 36
  • 43 (a)
OneToMany
kif26ab 36
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14535 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vab-8 36
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMY1 36
  • 21 (a)
OneToMany
Species with no ortholog for KIF26A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KIF26A Gene

ENSEMBL:
Gene Tree for KIF26A (if available)
TreeFam:
Gene Tree for KIF26A (if available)

Paralogs for KIF26A Gene

Paralogs for KIF26A Gene

(1) SIMAP similar genes for KIF26A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIF26A: view

Variants for KIF26A Gene

Sequence variations from dbSNP and Humsavar for KIF26A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1107254 -- 104,180,391(-) GCCCT(C/T)GGGAC utr-variant-3-prime
rs871266 -- 104,180,974(+) GGTGA(C/G)GGGCA downstream-variant-500B
rs1004216 -- 104,171,342(+) GCCTG(C/T)GAGGG intron-variant
rs1004880 -- 104,172,698(-) GCAGG(A/G)CCCAT intron-variant
rs884996 -- 104,180,887(+) TGCAT(C/T)GATGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KIF26A Gene

Variant ID Type Subtype PubMed ID
nsv902319 CNV Gain 21882294
dgv1998n71 CNV Loss 21882294
dgv1999n71 CNV Loss 21882294
nsv470674 CNV Loss 18288195
dgv2000n71 CNV Loss 21882294
dgv2001n71 CNV Loss 21882294
nsv902336 CNV Loss 21882294
nsv902339 CNV Gain 21882294
nsv519605 CNV Loss 19592680
nsv902350 CNV Loss 21882294
nsv902351 CNV Loss 21882294
nsv827072 CNV Gain 20364138
nsv509553 CNV Insertion 20534489
nsv902352 CNV Loss 21882294
dgv2002n71 CNV Loss 21882294
nsv832884 CNV Loss 17160897
esv2490382 CNV Insertion 19546169
esv1239775 CNV Insertion 17803354
esv2670922 CNV Deletion 23128226
esv6361 CNV Loss 19470904
esv2749190 CNV Deletion 23290073
nsv902355 CNV Loss 21882294

Variation tolerance for KIF26A Gene

Gene Damage Index Score: 5.54; 72.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF26A Gene

HapMap Linkage Disequilibrium report
KIF26A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF26A Gene

Disorders for KIF26A Gene

Relevant External Links for KIF26A

Genetic Association Database (GAD)
KIF26A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF26A

No disorders were found for KIF26A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF26A Gene

Publications for KIF26A Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. All kinesin superfamily protein, KIF, genes in mouse and human. (PMID: 11416179) Miki H. … Hirokawa N. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3
  3. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3
  4. KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development. (PMID: 19914172) Zhou R. … Hirokawa N. (Cell 2009) 3
  5. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PMID: 17620599) Xiao K. … Lefkowitz R.J. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3

Products for KIF26A Gene

Sources for KIF26A Gene

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