KIF26A Gene
protein-coding GIFtS : 50
GCID: GC14 P104605
kinesin family member 26A
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Aliasesfor KIF26A gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Kinesin Family Member 26A 1 2 KIAA12361 3 5 DKFZP434N1781 KIF26A Variant Protein2 Kinesin-Like Protein KIF26A2
Export aliases for KIF26A gene to outside databases Previous GC identifers: GC14P098420 GC14P102595 GC14P103674 GC14P084784
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Summariesfor KIF26A gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: KI26A_HUMAN, Q9ULI4 Function : Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growthsignaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity)
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Genomic Viewsfor KIF26A gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000014.8 NC_018925.1 NT_026437.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the KIF26A gene promoter: USF1 Pbx1a Lmo2 Arnt Egr-4 Max CP2 USF-1 Hand1 c-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for KIF26A Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat KIF26A
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 14q32.33 Ensembl cytogenetic band: 14q32.33 HGNC cytogenetic band: 14q32.33 KIF26A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14P104605: view genomic region
(about GC identifiers )
Start:
104,605,060 bp from pter
End:
104,647,235 bp from pter
Size:
42,176 bases
Orientation:
plus strand
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Proteinsfor KIF26A gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: KI26A_HUMAN, Q9ULI4 (See
protein sequence )Recommended Name: Kinesin-like protein KIF26A Size : 1882 amino acids; 194590 Da
Subunit : Interacts with GRB2 (via SH2 domain) (By similarity)
Subcellular location : Cytoplasm, cytoskeleton (Probable)
Caution : In contrast to other kinesin-like proteins, residues required for ATPase activity are missing
Sequence caution : Sequence=AAH09415.1; Type=Erroneous initiation;
Secondary accessions : Q8TAZ7 Q96GK3 Q9UFL3Explore the universe of human proteins at neXtProt for KIF26A: NX_Q9ULI4 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9ULI4 KIF26A Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_056471.1 ENSEMBL proteins: ENSP00000388241 ENSP00000325452 Reactome Protein details: Q9ULI4 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
KIF26A for ontologies About GeneDecksing KIF26A Antibody Products: Assay Products for KIF26A:
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Protein
Domains / Familiesfor KIF26A gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
KIF26A for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q9ULI4 ProtoNet protein and cluster: Q9ULI4
1 Blocks protein family : IPB001752 Kinesin UniProtKB/Swiss-Prot: KI26A_HUMAN, Q9ULI4 Similarity : Belongs to the kinesin-like protein family. KIF26 subfamilySimilarity : Contains 1 kinesin-motor domain
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Functionfor KIF26A gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: KI26A_HUMAN, Q9ULI4 Function : Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growthsignaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KIF26A (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KIF26A (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KIF26A (NM_015656 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIF26A Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KIF26A
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF26A
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view) : About this table
KIF26A for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for KIF26A :Animal Models: Mouse knock-out Kif26a tm1.1Noh for KIF26A 7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Kif26a) :
KIF26A for phenotypes About GeneDecksing
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Pathways & Interactionsfor KIF26A gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Immune System 2 Kinesins 3 MHC class II antigen presentation 4 Factors involved in megakaryocyte development and platelet production 5 Platelet activation, signaling and aggregation
Pathway sources See GeneCards unified pathways Show all pathways 5/8
Reactome Pathways for KIF26A (see all 8 )
KIF26A for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIF26A STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/44 Interacting proteins for KIF26A (Q9ULI4 3 ENSP00000388241 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 44 )About this table Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0001560 regulation of cell growth by extracellular stimulus
ISS -- GO:0007018 microtubule-based movement
TAS -- GO:0007596 blood coagulation
TAS -- GO:0009968 negative regulation of signal transduction
ISS -- GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
TAS --
KIF26A for ontologies About GeneDecksing
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Drugs & Compoundsfor KIF26A gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for KIF26A Search CenterWatch for drugs/clinical trials and news about KIF26A / KI26A
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Transcriptsfor KIF26A gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for KIF26A gene: NM_015656.1 Unigene Cluster for KIF26A:
Kinesin family member 26A Hs.134970 [show with all ESTs ] Unigene Representative Sequence: NM_015656 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000423312 ENST00000315264 (uc001yos.4 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KIF26A (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KIF26A (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KIF26A (NM_015656 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIF26A Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KIF26A
Additional cDNA sequence: AB033062.2 AB290161.1 AK026406.1 AL117589.1 BC009415.1 BC025353.1
2 DOTS entries : DT.40310256 DT.97839528
24/46 AceView cDNA sequences (see all 46 ):
AI094289 AB033062 BX280272 CA397394 BM821339 AI866870 BC025353 AK026406 BM559278 BE545089 BQ942959 BM826443 BV168643 AW674509 BG473075 BI770102 BM850896 BG912662 BU538460 BM789579 BC009415 BV168640 AW675120 BV168641 GeneLoc Exon Structure
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Expression for KIF26A gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section KIF26A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATGGTCACCT
About this image KIF26A expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See KIF26A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for KIF26A SOURCE GeneReport for Unigene cluster: Hs.134970 SABiosciences Custom PCR Arrays for KIF26A Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for KIF26ABrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat KIF26A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KIF26A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KIF26A In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF26A
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Orthologsfor KIF26A gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for KIF26A gene from 7/19 species (see all 19 ) About this table
ENSEMBL Gene Tree for KIF26A (if available)TreeFam Gene Tree for KIF26A (if available)
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Paralogsfor KIF26A gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for KIF26A gene KIF26B 2 1 SIMAP similar gene for KIF26A using alignment to 2 protein entries: KI26A_HUMAN (see all proteins ):KIF26B
KIF26A for paralogs About GeneDecksing
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Genomic Variantsfor KIF26A gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 14 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for KIF26A (104605060 - 104647235 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 4 variations for KIF26A 2 CNVs : 49289 29960 2 Indels : 102029 61416
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor KIF26A gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
KIF26A for disorders About GeneDecksing
OMIM gene information: 613231
OMIM disorders : --2 diseases for KIF26A : About MalaCards megacolon neuronitis 1 disease from the University of Copenhagen DISEASES database for KIF26A :Megacolon Export disorders for KIF26A gene to outside databases
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Publicationsfor KIF26A gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for KIF26A gene integrated from 9 sources : (articles sorted by number of sources associating them with KIF26A) Utopia : connect your pdf to the dynamic world of online information
Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462) 1 , 2 , 3 Nagase T.... Ohara O. (1999) All kinesin superfamily protein, KIF, genes in mouse and human. (PubMed id 11416179) 1 , 3 Miki H....Hirokawa N. (2001) A human MAP kinase interactome. (PubMed id 20936779) 1 Bandyopadhyay S....Ideker T. (2010) KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development. (PubMed id 19914172) 1 Zhou R.... Hirokawa N. (2009) Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PubMed id 17620599) 1 Xiao K....Lefkowitz R.J. (2007) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121) 2 Heilig R.... Weissenbach J. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954) 2 Nakajima D.... Nagase T. (2002)
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External Searches for KIF26A gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing KIF26A gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing KIF26A gene
(According to HUGE )
About This Section
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Specialized Databases showing KIF26A gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for KIF26A Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for KIF26A gene: Search GeneIP for patents involving KIF26A GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor KIF26A gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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Aliases for KIF26A
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Disorders / Diseases for KIF26A
Domains / Families for KIF26A
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Expression for KIF26A
Function for KIF26A
Genomic Views for KIF26A
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