Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KIF26A Gene

protein-coding   GIFtS: 50
GCID: GC14P104605

Kinesin Family Member 26A

  See KIF26A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Kinesin Family Member 26A1 2
KIAA12363 5
KIF26A Variant Protein2
Kinesin-Like Protein KIF26A2

External Ids:    HGNC: 202261   Entrez Gene: 261532   Ensembl: ENSG000000667357   OMIM: 6132315   UniProtKB: Q9ULI43   

Export aliases for KIF26A gene to outside databases

Previous GC identifers: GC14P098420 GC14P102595 GC14P103674 GC14P084784


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for KIF26A Gene:
KIF26A (kinesin family member 26A) is a protein-coding gene. Diseases associated with KIF26A include megacolon. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIF26B.

UniProtKB/Swiss-Prot: KI26A_HUMAN, Q9ULI4
Function: Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth
signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents
GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based
motility due to the absence of ATPase activity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIF26A gene promoter:
         USF1   Pbx1a   Lmo2   Arnt   Egr-4   Max   CP2   USF-1   Hand1   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KIF26A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIF26A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

KIF26A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF26A gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P104605:  view genomic region     (about GC identifiers)

Start:
104,605,060 bp from pter      End:
104,647,235 bp from pter
Size:
42,176 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KI26A_HUMAN, Q9ULI4 (See protein sequence)
Recommended Name: Kinesin-like protein KIF26A  
Size: 1882 amino acids; 194590 Da
Subunit: Interacts with GRB2 (via SH2 domain) (By similarity)
Caution: In contrast to other kinesin-like proteins, residues required for ATPase activity are missing
Sequence caution: Sequence=AAH09415.1; Type=Erroneous initiation;
Secondary accessions: Q8TAZ7 Q96GK3 Q9UFL3

Explore the universe of human proteins at neXtProt for KIF26A: NX_Q9ULI4

Explore proteomics data for KIF26A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KIF26A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056471.1  
    ENSEMBL proteins: 
     ENSP00000388241   ENSP00000325452  
    Reactome Protein details: Q9ULI4

    KIF26A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for KIF26A
    GenScript Custom Purified and Recombinant Proteins Services for KIF26A
    Novus Biologicals KIF26A Protein
    Novus Biologicals KIF26A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KIF26A

     
    Search eBioscience for Proteins for KIF26A 

    KIF26A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KIF26A
    Novus Biologicals KIF26A Antibodies
    Abcam antibodies for KIF26A
    Cloud-Clone Corp. Antibodies for KIF26A
    Search ThermoFisher Antibodies for KIF26A
    LSBio Antibodies in human, mouse, rat for KIF26A

    KIF26A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KIF26A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KIF26A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KIF26A
    Cloud-Clone Corp. CLIAs for KIF26A
    Search eBioscience for ELISAs for KIF26A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    KIF: Kinesins

    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR001752 Kinesin_motor_dom
     IPR027640 Kinesin-like_fam

    Graphical View of Domain Structure for InterPro Entry Q9ULI4

    ProtoNet protein and cluster: Q9ULI4

    1 Blocks protein domain: IPB001752 Kinesin

    UniProtKB/Swiss-Prot: KI26A_HUMAN, Q9ULI4
    Similarity: Belongs to the kinesin-like protein family. KIF26 subfamily
    Similarity: Contains 1 kinesin-motor domain


    Find genes that share domains with KIF26A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KI26A_HUMAN, Q9ULI4
    Function: Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth
    signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents
    GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based
    motility due to the absence of ATPase activity (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777NOT microtubule motor activity ISS--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0008017microtubule binding ISS--
    GO:0016887NOT ATPase activity ISS--
         
    Find genes that share ontologies with KIF26A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KIF26A:
     Increased HPV18 LCR reporter a 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Kif26a):
     cellular  digestive/alimentary  growth/size/body  homeostasis/metabolism  mortality/aging 
     nervous system  no phenotypic analysis 

    Find genes that share phenotypes with KIF26A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Kif26atm1.1Noh for KIF26A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIF26A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KIF26A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KIF26A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KIF26A

    miRNA
    Products:
        
    miRTarBase miRNAs that target KIF26A:
    hsa-mir-124-3p (MIRT022436)

    Block miRNA regulation of human, mouse, rat KIF26A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KIF26A (see all 26):
    hsa-miR-320a hsa-miR-520d-5p hsa-miR-1271 hsa-miR-29c hsa-miR-29a hsa-let-7a-2* hsa-miR-3921 hsa-miR-511
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KIF26A
    Predesigned siRNA for gene silencing in human, mouse, rat KIF26A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KIF26A

    Clone
    Products:
         
    OriGene clones in human, mouse for KIF26A (see all 6)
    OriGene ORF clones in mouse, rat for KIF26A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KIF26A (NM_015656)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIF26A
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KIF26A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KIF26A
    Browse ESI BIO Cell Lines and PureStem Progenitors for KIF26A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF26A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    KI26A_HUMAN, Q9ULI4: Cytoplasm, cytoskeleton (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    plasma membrane3
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005871kinesin complex IEA--
    GO:0005874microtubule IEA--

    Find genes that share ontologies with KIF26A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for KIF26A About    
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    3MHC class II antigen presentation
    MHC class II antigen presentation
    4Kinesins
    Kinesins
    5Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production


    Find genes that share SuperPaths with KIF26A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for KIF26A
        MHC class II antigen presentation
    Kinesins


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIF26A
    Interactions:

        Search GeneGlobe Interaction Network for KIF26A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KIF26A (Q9ULI43 ENSP000003882414) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK10P537793, ENSP000003521574I2D: score=3 STRING: ENSP00000352157
    GRB2P629933, ENSP000003390074I2D: score=2 STRING: ENSP00000339007
    MAP3K10Q027793I2D: score=2 
    MAP3K7O433183I2D: score=2 
    ARRB1P494073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001560regulation of cell growth by extracellular stimulus ISS--
    GO:0007018microtubule-based movement TAS--
    GO:0007596blood coagulation TAS--
    GO:0009968negative regulation of signal transduction ISS--
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    Find genes that share ontologies with KIF26A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIF26A (KI26A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KIF26A gene: 
    NM_015656.1  

    Unigene Cluster for KIF26A:

    Kinesin family member 26A
    Hs.134970  [show with all ESTs]
    Unigene Representative Sequence: NM_015656
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000423312 ENST00000315264(uc001yos.4)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KIF26A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KIF26A (see all 26):
    hsa-miR-320a hsa-miR-520d-5p hsa-miR-1271 hsa-miR-29c hsa-miR-29a hsa-let-7a-2* hsa-miR-3921 hsa-miR-511
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KIF26A
    Predesigned siRNA for gene silencing in human, mouse, rat KIF26A
    Clone
    Products:
         
    OriGene clones in human, mouse for KIF26A (see all 6)
    OriGene ORF clones in mouse, rat for KIF26A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KIF26A (NM_015656)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIF26A
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KIF26A
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KIF26A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KIF26A
      QuantiTect SYBR Green Assays in human, mouse, rat KIF26A
      QuantiFast Probe-based Assays in human, mouse, rat KIF26A

    Additional mRNA sequence: 

    AB033062.2 AB290161.1 AK026406.1 AL117589.1 BC009415.1 BC025353.1 

    2 DOTS entries:

    DT.40310256  DT.97839528 

    Selected AceView cDNA sequences (see all 46):

    AI094289 AB033062 CA397394 BX280272 BM826443 BV168641 BI770102 BE545089 
    AL117589 BG473075 BV168640 BI850688 BM559278 BQ942959 BV168643 BU681620 
    BM850896 AI866870 AW674509 BM821339 BG912662 BM789579 AW675120 BV168642 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KIF26A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGTCACCT
    KIF26A Expression
    About this image


    KIF26A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
             Thalamus
             Septum   
     
     Heart (Cardiovascular System)
             Outflow Tract
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
    KIF26A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIF26A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.134970
        Custom PCR Arrays for KIF26A
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KIF26A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KIF26A
    QuantiTect SYBR Green Assays in human, mouse, rat KIF26A
    QuantiFast Probe-based Assays in human, mouse, rat KIF26A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF26A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KIF26A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kif26a1 , 5 kinesin family member 26A1, 5 79.02(n)1
    78.95(a)1
      12 (61.14 cM)5
    6683031  NM_001097621.11  NP_001091090.11 
     1121462085 
    chicken
    (Gallus gallus)
    Aves KIF26A6
    kinesin family member 26A
    50(a)
    1 ↔ 1
    5(50610382-50708576)
    lizard
    (Anolis carolinensis)
    Reptilia KIF26A6
    kinesin family member 26A
    49(a)
    1 ↔ 1
    1(5369370-5554696)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF547636.12   -- 77.33(n)    CF547636.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kif26ab6
    kif26aa6
    kinesin family member 26Aa
    45(a)
    43(a)
    many → 1
    many → 1
    17(45982869-46156982) ENSDARG00000015016
    20(27458417-27582222) ENSDARG00000042368
    fruit fly
    (Drosophila melanogaster)
    Insecta CG145356
    --
    26(a)
    1 → many
    2L(7844905-7855255)
    worm
    (Caenorhabditis elegans)
    Secernentea vab-86
    Protein VAB-8, isoform a
    20(a)
    1 → many
    V(12213327-12225920) WBGene00006874
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMY16
    Protein that interacts with Myo2p, proposed to be ...
    21(a)
    1 → many
    XI(286603-288573) YKL079W


    ENSEMBL Gene Tree for KIF26A (if available)
    TreeFam Gene Tree for KIF26A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KIF26A gene
    KIF26B2  
    1 SIMAP similar gene for KIF26A using alignment to 2 protein entries:     KI26A_HUMAN (see all proteins):
    KIF26B

    Find genes that share paralogs with KIF26A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for KIF26A (see all 1347)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1147101311,2
    F--104603191(+) AGGGAT/CTCTCG 1 -- us2k11Minor allele frequency- C:0.15WA 118
    rs348390451,2
    C,F--104603271(+) GAGGTA/GACTCC 1 -- us2k15Minor allele frequency- G:0.47NA EA 246
    rs740871491,2
    C,F--104603532(+) GTCCTC/GAGTAC 1 -- us2k12Minor allele frequency- G:0.16WA 120
    rs1911573021,2
    --104603556(+) TGGGCA/TGACGC 1 -- us2k10--------
    rs740871511,2
    C,F--104603586(+) TGCGAA/TGAGAC 1 -- us2k12Minor allele frequency- T:0.16WA 120
    rs71563951,2
    C,F,H--104603873(+) GTATGC/TGCCGG 1 -- us2k124Minor allele frequency- T:0.19NS EA NA WA CSA 2352
    rs1840323111,2
    --104603886(+) GCCGCG/TTGTCC 1 -- us2k10--------
    rs1406094281,2
    C--104604098(+) GCCGCC/GGATGC 1 -- us2k10--------
    rs125883931,2
    C,F,H--104604135(+) ACAGAA/GCAACT 1 -- us2k14Minor allele frequency- G:0.44NA EA 244
    rs114295161,2
    C--104604157(+) GGGGG-/GCGGCC 1 -- us2k1 tfbs30--------

    HapMap Linkage Disequilibrium report for KIF26A (104605060 - 104647235 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KIF26A (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749190CNV Deletion23290073
    esv2670922CNV Deletion23128226
    esv2490382CNV Insertion19546169
    nsv509553CNV Insertion20534489
    esv1239775CNV Insertion17803354
    nsv902351CNV Loss21882294
    esv6361CNV Loss19470904
    nsv902336CNV Loss21882294
    dgv2002n71CNV Loss21882294
    dgv2000n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing KIF26A
    DNA2.0 Custom Variant and Variant Library Synthesis for KIF26A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 613231    OMIM disorders: --

    1 disease for KIF26A:    
    About MalaCards
    megacolon

    1 disease from the University of Copenhagen DISEASES database for KIF26A:
    Megacolon

    Find genes that share disorders with KIF26A           About GenesLikeMe

    Genetic Association Database (GAD): KIF26A

    Export disorders for KIF26A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KIF26A gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with KIF26A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    2. All kinesin superfamily protein, KIF, genes in mouse and human. (PubMed id 11416179)1, 3 Miki H....Hirokawa N. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)
    5. KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development. (PubMed id 19914172)1 Zhou R.... Hirokawa N. (Cell 2009)
    6. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PubMed id 17620599)1 Xiao K....Lefkowitz R.J. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (Nature 2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 26153 HGNC: 20226 AceView: KIF26A Ensembl:ENSG00000066735 euGenes: HUgn26153
    ECgene: KIF26A H-InvDB: KIF26A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1236

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KIF26A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KIF26A gene:
    Search GeneIP for patents involving KIF26A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KIF26A  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KIF26A  
     OriGene qSTAR qPCR primer pairs in human, mouse for KIF26A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KIF26A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KIF26A   OriGene Custom Protein Services for KIF26A  

     
     
     Block miRNA regulation of human, mouse, rat KIF26A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KIF26A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIF26A Predesigned siRNA for gene silencing in human, mouse, rat KIF26A
     QuantiFast Probe-based Assays in human, mouse, rat KIF26A QuantiTect SYBR Green Assays in human, mouse, rat KIF26A
     Custom PCR Arrays for KIF26A Search Chromatin IP Primers for KIF26A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KIF26A  Search GeneGlobe Interaction Network for KIF26A
     Regulatory tfbs in KIF26A promoter
     GenScript Custom Purified and Recombinant Proteins Services for KIF26A GenScript cDNA clones with any tag delivered in your preferred vector for KIF26A
     GenScript Custom Assay Services for KIF26A GenScript Custom overexpressing Cell Line Services for KIF26A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for KIF26A (KI26A)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KIF26A antibodies
     KIF26A proteins
     KIF26A lysates
     Antibodies for KIF26A
     See all of Abcam's Antibodies, Kits and Proteins for KIF26A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for KIF26A
     Antibodies for KIF26A
     ELISAs for KIF26A
     CLIAs for KIF26A



     Browse ESI BIO Cell Lines and PureStem Progenitors for KIF26A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF26A
     Browse SwitchGear 3'UTR luciferase reporter plasmids for KIF26A
     Browse SwitchGear Promoter luciferase reporter plasmids for KIF26A
     Search ThermoFisher Antibodies for KIF26A
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KIF26A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIF26A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KIF26A
     LSBio Antibodies in human, mouse, rat for KIF26A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for KIF26A
      Search eBioscience for proteins for KIF26A
      Search eBioscience for elisas for KIF26A
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KIF26A gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4