Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KIF25 Gene

Aliases for KIF25 Gene

  • Kinesin Family Member 25 2 3 5
  • Kinesin-Like Protein 3 3 4
  • Kinesin-Like 3 2 3
  • KNSL3 3 4
  • Kinesin-Like Protein KIF25 3

External Ids for KIF25 Gene

Previous HGNC Symbols for KIF25 Gene

  • KNSL3

Previous GeneCards Identifiers for KIF25 Gene

  • GC06P168140
  • GC06P168176
  • GC06P168177
  • GC06P168237
  • GC06P168161
  • GC06P168418
  • GC06P165847

Summaries for KIF25 Gene

Entrez Gene Summary for KIF25 Gene

  • The protein encoded by this gene is a member of the kinesin-like protein family. Protein family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. However, the particular function of this gene product has not yet been determined. Two alternatively spliced transcript variants which encode products have been described. Other splice variants have been found that lack exon 2 and the initiation codon for translation. [provided by RefSeq, Jul 2008]

GeneCards Summary for KIF25 Gene

KIF25 (Kinesin Family Member 25) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Vesicle-mediated transport. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIFC3.

UniProtKB/Swiss-Prot for KIF25 Gene

  • Negative regulator of amino acid starvation-induced autophagy.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF25 Gene

Genomics for KIF25 Gene

Regulatory Elements for KIF25 Gene

Enhancers for KIF25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G168030 0.9 Ensembl ENCODE 18.5 +35.9 35927 3.0 CTCF MAZ TEAD4 ZNF398 ZBTB40 TEAD3 FOSL1 SMARCA4 GATA2 SMC3 KIF25-AS1 KIF25 FRMD1 LOC105378135
GH06G167931 1.2 Ensembl ENCODE 10.8 -63.0 -62954 3.4 HNRNPUL1 FOXA2 ATF1 MLX ARID4B DMAP1 MIER2 KAT8 PBX2 HNF4A KIF25 KIF25-AS1 AFDN HGC6.3 PIR39756
GH06G167963 0.9 ENCODE 11.5 -31.5 -31522 3.2 HNRNPUL1 FOXA2 MLX ARID4B ZNF48 YY1 SLC30A9 GLIS2 PPARG KAT8 KIF25-AS1 KIF25 FRMD1 AFDN HGC6.3 PIR39756
GH06G168024 1 ENCODE 7.4 +28.1 28095 0.2 PKNOX1 FOXA2 ARNT FEZF1 TSHZ1 PPARG ZNF518A ZNF610 HNF4A WT1 FRMD1 KIF25 LOC105378135 KIF25-AS1
GH06G168007 1.4 FANTOM5 Ensembl ENCODE 4.8 +11.6 11636 1.7 HDAC1 FEZF1 RFX5 GATA2 ZNF366 FOS CEBPB ZNF843 ZFP69B PRDM6 KIF25-AS1 FRMD1 KIF25 LOC105378135
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIF25 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIF25 Gene

Chromosome:
6
Start:
167,996,241 bp from pter
End:
168,045,089 bp from pter
Size:
48,849 bases
Orientation:
Plus strand

Genomic View for KIF25 Gene

Genes around KIF25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF25 Gene

Proteins for KIF25 Gene

  • Protein details for KIF25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIL4-KIF25_HUMAN
    Recommended name:
    Kinesin-like protein KIF25
    Protein Accession:
    Q9UIL4
    Secondary Accessions:
    • O94775
    • Q5SZU9

    Protein attributes for KIF25 Gene

    Size:
    384 amino acids
    Molecular mass:
    40686 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIF25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF25 Gene

Post-translational modifications for KIF25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF25 Gene

Antibody Products

  • Abcam antibodies for KIF25

No data available for DME Specific Peptides for KIF25 Gene

Domains & Families for KIF25 Gene

Gene Families for KIF25 Gene

Protein Domains for KIF25 Gene

Suggested Antigen Peptide Sequences for KIF25 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UIL4

UniProtKB/Swiss-Prot:

KIF25_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF25: view

Function for KIF25 Gene

Molecular function for KIF25 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of amino acid starvation-induced autophagy.

Gene Ontology (GO) - Molecular Function for KIF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003777 microtubule motor activity IBA --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed ISS --
genes like me logo Genes that share ontologies with KIF25: view
genes like me logo Genes that share phenotypes with KIF25: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KIF25 Gene

Localization for KIF25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF25 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF25 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for KIF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome ISS --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex TAS 9925916
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KIF25: view

Pathways & Interactions for KIF25 Gene

genes like me logo Genes that share pathways with KIF25: view

Gene Ontology (GO) - Biological Process for KIF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation TAS 9925916
GO:0006996 organelle organization TAS 9925916
GO:0007018 microtubule-based movement IBA --
GO:0010507 negative regulation of autophagy IMP 22354037
GO:0046603 negative regulation of mitotic centrosome separation IDA 28263957
genes like me logo Genes that share ontologies with KIF25: view

No data available for SIGNOR curated interactions for KIF25 Gene

Drugs & Compounds for KIF25 Gene

No Compound Related Data Available

Transcripts for KIF25 Gene

mRNA/cDNA for KIF25 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIF25 Gene

Kinesin family member 25:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF25 Gene

No ASD Table

Relevant External Links for KIF25 Gene

GeneLoc Exon Structure for
KIF25
ECgene alternative splicing isoforms for
KIF25

Expression for KIF25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF25 Gene

mRNA differential expression in normal tissues according to GTEx for KIF25 Gene

This gene is overexpressed in Brain - Cerebellum (x7.5) and Brain - Cerebellar Hemisphere (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of KIF25 Gene:

KIF25

SOURCE GeneReport for Unigene cluster for KIF25 Gene:

Hs.150013

Evidence on tissue expression from TISSUES for KIF25 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with KIF25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF25 Gene

Orthologs for KIF25 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF25 34
  • 97.74 (n)
cow
(Bos Taurus)
Mammalia KIF25 34 35
  • 68.84 (n)
dog
(Canis familiaris)
Mammalia KIF25 34 35
  • 67.64 (n)
chicken
(Gallus gallus)
Aves KIF25 34 35
  • 61.23 (n)
lizard
(Anolis carolinensis)
Reptilia KIF25 35
  • 34 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-195e3.4 34
  • 57.39 (n)
KIF25 35
  • 31 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ncd 35
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea klp-15 35
  • 17 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAR3 35
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
OneToOne
Species where no ortholog for KIF25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KIF25 Gene

ENSEMBL:
Gene Tree for KIF25 (if available)
TreeFam:
Gene Tree for KIF25 (if available)

Paralogs for KIF25 Gene

Paralogs for KIF25 Gene

(1) SIMAP similar genes for KIF25 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIF25: view

Variants for KIF25 Gene

Sequence variations from dbSNP and Humsavar for KIF25 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000026375 -- 168,040,419(+) AAATT(A/G)GCTGA intron-variant
rs1000075927 -- 168,045,228(+) CACTC(G/T)CTGTC nc-transcript-variant, downstream-variant-500B
rs1000160743 -- 168,035,252(+) GTGTT(C/T)CCAGT intron-variant
rs1000233341 -- 168,030,192(+) ATGAG(A/G)TTTCC intron-variant
rs1000359225 -- 168,035,706(+) TTTGC(C/T)GTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF25 Gene

Variant ID Type Subtype PubMed ID
dgv11062n54 CNV gain 21841781
dgv11063n54 CNV gain 21841781
dgv11064n54 CNV gain 21841781
dgv1853e212 CNV gain 25503493
dgv217e55 CNV gain 17911159
dgv218e55 CNV gain 17911159
dgv27e196 CNV duplication 17116639
dgv6199n100 CNV gain 25217958
dgv61n64 CNV gain 17921354
dgv791n27 CNV gain 19166990
esv23528 CNV gain+loss 19812545
esv2422263 CNV duplication 17116639
esv2422479 CNV duplication 17116639
esv2446593 CNV insertion 19546169
esv2733270 CNV deletion 23290073
esv2733271 CNV deletion 23290073
esv2733272 CNV deletion 23290073
esv2759493 CNV gain 17122850
esv2761051 CNV gain 21179565
esv2763949 CNV gain 21179565
esv32818 CNV gain 17666407
esv3611678 CNV gain 21293372
esv3611679 CNV gain 21293372
esv3611681 CNV loss 21293372
esv3611682 CNV loss 21293372
nsv1030168 CNV gain 25217958
nsv1031275 CNV gain 25217958
nsv442020 CNV gain 18776908
nsv509173 CNV insertion 20534489
nsv515568 CNV gain+loss 19592680
nsv605445 CNV gain 21841781
nsv8004 CNV gain 18304495
nsv823930 CNV gain 20364138
nsv830865 CNV gain 17160897
nsv830866 CNV gain 17160897

Variation tolerance for KIF25 Gene

Residual Variation Intolerance Score: 94.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF25 Gene

Disorders for KIF25 Gene

Relevant External Links for KIF25

Genetic Association Database (GAD)
KIF25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF25

No disorders were found for KIF25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF25 Gene

Publications for KIF25 Gene

  1. Identification, genomic organization, and alternative splicing of KNSL3, a novel human gene encoding a kinesin-like protein. (PMID: 9925916) Okamoto S. … Nakamura Y. (Cytogenet. Cell Genet. 1998) 3 4 22 64
  2. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PMID: 22354037) McKnight N.C. … Tooze S.A. (EMBO J. 2012) 3 4 64
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  4. Assignment1 of CSRP1 encoding the LIM domain protein CRP1, to human chromosome 1q32 by fluorescence in situ hybridization. (PMID: 9925910) Erdel M. … Weiskirchen R. (Cytogenet. Cell Genet. 1998) 2 3 64
  5. The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindleA orientation. (PMID: 28263957) Decarreau J. … Wordeman L. (Nat. Cell Biol. 2017) 3 64

Products for KIF25 Gene

Sources for KIF25 Gene

Content
Loading form....