KIF25 Gene
protein-coding GIFtS: 45
GCID: GC06P168418
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|
kinesin family member 25(Previous name: kinesin-like 3 )
(Previous symbol: KNSL3)
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Aliases
for KIF25 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kinesin Family Member 251 2 | | KNSL31 2 3 5 | | Kinesin-Like 31 2 | | Kinesin-Like Protein 32 3 | | Kinesin-Like Protein KIF252 |
Export aliases for KIF25 gene to outside databasesPrevious GC identifers: GC06P168140 GC06P168176 GC06P168177 GC06P168237 GC06P168161 GC06P165847 |
Summaries
for KIF25 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KIF25:
The protein encoded by this gene is a member of the kinesin-like protein family. Protein family members aremicrotubule-dependent molecular motors that transport organelles within cells and move chromosomes during celldivision. However, the particular function of this gene product has not yet been determined. Two alternatively splicedtranscript variants which encode products have been described. Other splice variants have been found that lack exon 2and the initiation codon for translation. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: KIF25_HUMAN, Q9UIL4Function: Negative regulator of amino acid starvation-induced autophagy
|
Genomic Views
for KIF25 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for KIF25
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIF25
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF25 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27KIF25 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P168418: view genomic region
(about GC identifiers)
Start:
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168,396,921 bp from pter |
End:
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168,445,769 bp from pter |
Size:
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48,849 bases |
Orientation:
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plus strand |
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Proteins
for KIF25 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KIF25_HUMAN, Q9UIL4 (See
protein sequence)Recommended Name: Kinesin-like protein KIF25 Size: 384 amino acids; 40686 Da
Subcellular location: Cytoplasm, cytoskeleton (Probable)
Secondary accessions: O94775 Q5SZU9Alternative splicing: 2 isoforms: Q9UIL4-1 Q9UIL4-2 Explore the universe of human proteins at neXtProt for KIF25: NX_Q9UIL4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UIL4
KIF25 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_005346.3 NP_085118.2
ENSEMBL proteins: ENSP00000388878 ENSP00000346401 ENSP00000252688 ENSP00000427464
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
KIF25 for ontologies About GeneDecksing
KIF25 Antibody Products:
Assay Products for KIF25: |
Protein
Domains /
Families
for KIF25 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KIF25 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UIL4ProtoNet protein and cluster: Q9UIL4 UniProtKB/Swiss-Prot: KIF25_HUMAN, Q9UIL4Similarity: Belongs to the kinesin-like protein familySimilarity: Contains 1 kinesin-motor domain |
Function
for KIF25 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KIF25_HUMAN, Q9UIL4Function: Negative regulator of amino acid starvation-induced autophagy
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF25 (see all 2)
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Synthesis Service for KIF25 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF25 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF25 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003777 | microtubule motor activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
KIF25 for ontologies About GeneDecksing
|
Pathways & Interactions
for KIF25 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIF25
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/22 Interacting proteins for KIF25 (Q9UIL43 ENSP000003464014) via UniProtKB, MINT, STRING, and/or I2D (see all 22)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
KIF25 for ontologies About GeneDecksing
|
Drugs & Compounds
for KIF25 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KIF25
Search CenterWatch for drugs/clinical trials and news about KIF25
|
Transcripts
for KIF25 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KIF25 gene (2 alternative transcripts): NM_005355.3 NM_030615.2 Unigene Cluster for KIF25: Kinesin family member 25 Hs.150013 [show with all ESTs]Unigene Representative Sequence: AK2894886 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000515361 ENST00000443060(uc010kkt.1) ENST00000354419(uc003qwk.1 uc003qwl.1)
ENST00000351261 ENST00000504593 ENST00000496008
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF25 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF25 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): KIF25 (NM_030615) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIF25 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF25 |
Additional cDNA sequence: AB012722.2 AK289488.1 5 DOTS entries: DT.92072033 DT.121396396 DT.95174531 DT.121396402 DT.70102980 8 AceView cDNA sequences: NM_005355 BX110428 AB012722 NM_030615 AI291787 AW629125 AW243854 BF943522
GeneLoc Exon Structure
|
Expression
for KIF25 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIF25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGGAGCAGGT
About this image
See KIF25 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIF25
SOURCE GeneReport for Unigene cluster: Hs.150013
SABiosciences Custom PCR Arrays for KIF25
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIF25
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat KIF25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF25 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF25 |
Orthologs
for KIF25 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KIF25 gene from 5/12 species (see all 12) About this table
ENSEMBL Gene Tree for KIF25 (if available)
TreeFam Gene Tree for KIF25 (if available) |
Paralogs
for KIF25 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KIF25 gene
- KIFC22 KIFC12 KIFC32
2 SIMAP similar genes for KIF25 using alignment to 2 protein entries: KIF25_HUMAN (see all proteins):KIF27 KIF7
KIF25 for paralogs About GeneDecksing
|
Genomic Variants
for KIF25 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KIF25 (168396921 - 168445769 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 24 variations for KIF25
15/24 CNVs (see all 24): 31312 5231 34566 8540 5229 51850 51849 5234 53975 5235 8541 2667 34495 5233 7547 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIF25 |
|
Disorders
/ Diseases
for KIF25 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 KIF25 for disorders About MalaCards
KIF25 for disorders About GeneDecksing
OMIM gene information: 603815
OMIM disorders: --
Export disorders for KIF25 gene to outside databases
|
Publications
for KIF25 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIF25 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KIF25) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification, genomic organization, and alternative splicing of KNSL3, a novel human gene encoding a kinesin-like protein. (PubMed id 9925916)1, 2, 9 Okamoto S.... Nakamura Y. (1998)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Assignment1 of CSRP1 encoding the LIM domain protein CRP1, to human chromosome 1q32 by fluorescence in situ hybridization. (PubMed id 9925910)1, 3 Erdel M. and Weiskirchen R. (1998)
- Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PubMed id 22354037)2 McKnight N.C.... Tooze S.A. (2012)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- All kinesin superfamily protein, KIF, genes in mouse and human. (PubMed id 11416179)1 Miki H....Hirokawa N. (2001)
- The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line. (PubMed id 12975346)9 Goshima G. and Vale R.D. (2003)
- Heterotrimeric kinesin II is the microtubule motor protein responsible for pigment dispersion in Xenopus melanophores. (PubMed id 9852150)9 Tuma M.C....Gelfand V. (1998)
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External Searches for KIF25 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KIF25 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KIF25 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KIF25 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KIF25 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KIF25 gene:
Search GeneIP for patents involving KIF25
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIF25 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for KIF25 | | OriGene Custom Protein Services for KIF25 | | | OriGene Custom Immunoassay Development | | |
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 | | | KIF25 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF25 |
|  |  |  | | | | Search ThermoFisher Antibodies for KIF25 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF25 |
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