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Aliases for KIF25 Gene

Aliases for KIF25 Gene

  • Kinesin Family Member 25 2 3 5
  • Kinesin-Like Protein 3 3 4
  • Kinesin-Like 3 2 3
  • KNSL3 3 4

External Ids for KIF25 Gene

Previous HGNC Symbols for KIF25 Gene

  • KNSL3

Previous GeneCards Identifiers for KIF25 Gene

  • GC06P168140
  • GC06P168176
  • GC06P168177
  • GC06P168237
  • GC06P168161
  • GC06P168418
  • GC06P165847

Summaries for KIF25 Gene

Entrez Gene Summary for KIF25 Gene

  • The protein encoded by this gene is a member of the kinesin-like protein family. Protein family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. However, the particular function of this gene product has not yet been determined. Two alternatively spliced transcript variants which encode products have been described. Other splice variants have been found that lack exon 2 and the initiation codon for translation. [provided by RefSeq, Jul 2008]

GeneCards Summary for KIF25 Gene

KIF25 (Kinesin Family Member 25) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIFC1.

UniProtKB/Swiss-Prot for KIF25 Gene

  • Negative regulator of amino acid starvation-induced autophagy.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF25 Gene

Genomics for KIF25 Gene

Regulatory Elements for KIF25 Gene

Promoters for KIF25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIF25 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIF25 Gene

Chromosome:
6
Start:
167,996,241 bp from pter
End:
168,045,089 bp from pter
Size:
48,849 bases
Orientation:
Plus strand

Genomic View for KIF25 Gene

Genes around KIF25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF25 Gene

Proteins for KIF25 Gene

  • Protein details for KIF25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIL4-KIF25_HUMAN
    Recommended name:
    Kinesin-like protein KIF25
    Protein Accession:
    Q9UIL4
    Secondary Accessions:
    • O94775
    • Q5SZU9

    Protein attributes for KIF25 Gene

    Size:
    384 amino acids
    Molecular mass:
    40686 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIF25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF25 Gene

Proteomics data for KIF25 Gene at MOPED

Post-translational modifications for KIF25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF25 Gene

No data available for DME Specific Peptides for KIF25 Gene

Domains & Families for KIF25 Gene

Gene Families for KIF25 Gene

Protein Domains for KIF25 Gene

Suggested Antigen Peptide Sequences for KIF25 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UIL4

UniProtKB/Swiss-Prot:

KIF25_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF25: view

Function for KIF25 Gene

Molecular function for KIF25 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of amino acid starvation-induced autophagy.

Gene Ontology (GO) - Molecular Function for KIF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF25: view
genes like me logo Genes that share phenotypes with KIF25: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KIF25 Gene

Localization for KIF25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF25 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF25 Gene COMPARTMENTS Subcellular localization image for KIF25 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for KIF25 Gene

Pathways & Interactions for KIF25 Gene

genes like me logo Genes that share pathways with KIF25: view

Interacting Proteins for KIF25 Gene

Gene Ontology (GO) - Biological Process for KIF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS 9925916
genes like me logo Genes that share ontologies with KIF25: view

No data available for SIGNOR curated interactions for KIF25 Gene

Drugs & Compounds for KIF25 Gene

No Compound Related Data Available

Transcripts for KIF25 Gene

mRNA/cDNA for KIF25 Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIF25 Gene

Kinesin family member 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF25 Gene

No ASD Table

Relevant External Links for KIF25 Gene

GeneLoc Exon Structure for
KIF25
ECgene alternative splicing isoforms for
KIF25

Expression for KIF25 Gene

mRNA expression in normal human tissues for KIF25 Gene

mRNA differential expression in normal tissues according to GTEx for KIF25 Gene

This gene is overexpressed in Brain - Cerebellum (x7.5) and Brain - Cerebellar Hemisphere (x4.1).

SOURCE GeneReport for Unigene cluster for KIF25 Gene Hs.150013

genes like me logo Genes that share expression patterns with KIF25: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KIF25 Gene

Orthologs for KIF25 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF25 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIF25 35
  • 68.84 (n)
  • 64.39 (a)
KIF25 36
  • 37 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF25 35
  • 67.64 (n)
  • 63.05 (a)
KIF25 36
  • 37 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIF25 35
  • 97.74 (n)
  • 94.35 (a)
chicken
(Gallus gallus)
Aves KIF25 35
  • 61.23 (n)
  • 57.73 (a)
KIF25 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF25 36
  • 34 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-195e3.4 35
  • 57.39 (n)
  • 53.98 (a)
KIF25 36
  • 31 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ncd 36
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea klp-15 36
  • 17 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAR3 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToOne
Species with no ortholog for KIF25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KIF25 Gene

ENSEMBL:
Gene Tree for KIF25 (if available)
TreeFam:
Gene Tree for KIF25 (if available)

Paralogs for KIF25 Gene

Paralogs for KIF25 Gene

(1) SIMAP similar genes for KIF25 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIF25: view

Variants for KIF25 Gene

Sequence variations from dbSNP and Humsavar for KIF25 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs12197062 - 168,042,007(+) AGCAA(A/C)CAGAG intron-variant, reference, missense
rs2073634 - 168,042,085(+) ACCCC(A/G)CAGGG intron-variant, reference, missense
rs4708626 - 168,029,668(+) TGACA(A/T)GGACC reference, missense
rs34049091 - 168,030,801(-) GACCG(C/T)GCTCT reference, missense
rs170460 -- 168,023,116(+) TGCCT(C/G)CTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF25 Gene

Variant ID Type Subtype PubMed ID
esv2422263 CNV Duplication 17116639
dgv27e196 CNV Duplication 17116639
dgv217e55 CNV Gain 17911159
dgv2034e1 CNV Complex 17122850
esv2422479 CNV Duplication 17116639
nsv830865 CNV Gain 17160897
dgv218e55 CNV Gain 17911159
nsv515568 CNV Gain+Loss 19592680
esv32818 CNV Gain 17666407
dgv791n27 CNV Gain 19166990
dgv2035e1 CNV Complex 17122850
nsv8004 CNV Gain 18304495
esv23528 CNV Gain+Loss 19812545
nsv442020 CNV CNV 18776908
dgv61n64 CNV Gain 17921354
nsv509173 CNV Insertion 20534489
nsv886961 CNV Loss 21882294
nsv886962 CNV Loss 21882294
nsv886972 CNV Loss 21882294
dgv7041n71 CNV Loss 21882294
dgv7042n71 CNV Loss 21882294
nsv823930 CNV Gain 20364138
esv2733270 CNV Deletion 23290073
esv2733271 CNV Deletion 23290073
esv2446593 CNV Insertion 19546169
nsv830866 CNV Gain 17160897
dgv7043n71 CNV Loss 21882294
esv2733272 CNV Deletion 23290073

Variation tolerance for KIF25 Gene

Residual Variation Intolerance Score: 94.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF25 Gene

HapMap Linkage Disequilibrium report
KIF25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF25 Gene

Disorders for KIF25 Gene

Relevant External Links for KIF25

Genetic Association Database (GAD)
KIF25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF25

No disorders were found for KIF25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF25 Gene

Publications for KIF25 Gene

  1. Identification, genomic organization, and alternative splicing of KNSL3, a novel human gene encoding a kinesin-like protein. (PMID: 9925916) Okamoto S. … Nakamura Y. (Cytogenet. Cell Genet. 1998) 3 4 23 67
  2. Assignment1 of CSRP1 encoding the LIM domain protein CRP1, to human chromosome 1q32 by fluorescence in situ hybridization. (PMID: 9925910) Erdel M. … Weiskirchen R. (Cytogenet. Cell Genet. 1998) 2 3
  3. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. (PMID: 23319000) Luykx J.J. … Ophoff R.A. (Mol. Psychiatry 2013) 3
  4. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PMID: 22354037) McKnight N.C. … Tooze S.A. (EMBO J. 2012) 3
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3

Products for KIF25 Gene

Sources for KIF25 Gene

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