KIF24 Gene
protein-coding GIFtS: 48
GCID: GC09M034252
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|
kinesin family member 24(Previous name: chromosome 9 open reading frame 48 )
(Previous symbol: C9orf48)
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Aliases
for KIF24 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kinesin Family Member 241 2 | | FLJ438841 | | C9orf481 2 3 | | Chromosome 9 Open Reading Frame 481 | | BA571F15.41 | | Kinesin-Like Protein KIF242 | | FLJ109331 | | |
Export aliases for KIF24 gene to outside databasesPrevious GC identifers: GC09M034479 GC09M034299 GC09M034300 GC09U900713 GC09M034247 GC09M034208 |
Summaries
for KIF24 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KIF24:
Kinesins, such as KIF24, are microtubule-dependent ATPases that function as molecular motors. They play important rolesin intracellular vesicle transport and cell division (summary by Venturelli et al., 2010 (PubMed 20670673)).(suppliedby OMIM, Feb 2011)
UniProtKB/Swiss-Prot: KIF24_HUMAN, Q5T7B8Function: Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediatingrecruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles.Mediates depolymerization of microtubules of centriolar origin, possibly to suppress abberrant cilia formation
Gene Wiki entry for KIF24
|
Genomic Views
for KIF24 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KIF24 gene promoter:
GR GR-beta MyoD LCR-F1 Egr-4 HNF-1 HFH-1 GR-alpha NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIF24
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF24 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p13.3 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p13.3KIF24 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M034252: view genomic region
(about GC identifiers)
Start:
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34,252,378 bp from pter |
End:
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34,329,198 bp from pter |
Size:
|
76,821 bases |
Orientation:
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minus strand |
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Proteins
for KIF24 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KIF24_HUMAN, Q5T7B8 (See
protein sequence)Recommended Name: Kinesin-like protein KIF24 Size: 1368 amino acids; 151903 Da
Subunit: Interacts with CCP110 and CEP97
Subcellular location: Cytoplasm, cytoskeleton, centrosome, centriole. Note=Primarily localizes to the mothercentriole/basal body and is either absent at daughter centriole
Developmental stage: Increases as cells progress through G1, peaks during S and G2 phases and decreases as cells entermitosis during G2/M (at protein level)
Sequence caution: Sequence=AAI10504.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAC86074.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC86329.1;Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI15917.1; Type=Erroneous gene modelprediction;
Secondary accessions: Q2TB93 Q5T7B5 Q5T7B7 Q6ZU97 Q6ZUZ2 Q86XZ0 Q9NV43Alternative splicing: 4 isoforms: Q5T7B8-1 Q5T7B8-2 Q5T7B8-3 Q5T7B8-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KIF24: NX_Q5T7B8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T7B8
KIF24 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_919289.2
ENSEMBL proteins: ENSP00000414628 ENSP00000384433 ENSP00000368472 ENSP00000368464 ENSP00000340179
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
KIF24 for ontologies About GeneDecksing
KIF24 Antibody Products:
Assay Products for KIF24: |
Protein
Domains /
Families
for KIF24 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KIF24 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5T7B8ProtoNet protein and cluster: Q5T7B8 1 Blocks protein family: IPB001660 Sterile alpha motif SAM
UniProtKB/Swiss-Prot: KIF24_HUMAN, Q5T7B8Similarity: Belongs to the kinesin-like protein familySimilarity: Contains 1 kinesin-motor domainSimilarity: Contains 1 SAM (sterile alpha motif) domain |
Function
for KIF24 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KIF24_HUMAN, Q5T7B8Function: Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediatingrecruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles.Mediates depolymerization of microtubules of centriolar origin, possibly to suppress abberrant cilia formation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF24 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF24
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF24 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
KIF24 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for KIF24:
|
Pathways & Interactions
for KIF24 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIF24
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for KIF24 (Q5T7B81 ENSP000003684644) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007018 | microtubule-based movement |
IEA | -- | | GO:0007019 | microtubule depolymerization |
IDA | -- | | GO:0042384 | cilium assembly |
IMP | -- |
KIF24 for ontologies About GeneDecksing
|
Drugs & Compounds
for KIF24 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KIF24
Search CenterWatch for drugs/clinical trials and news about KIF24
|
Transcripts
for KIF24 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KIF24 gene: NM_194313.2 Unigene Cluster for KIF24: Kinesin family member 24 Hs.710246 [show with all ESTs]Unigene Representative Sequence: NM_1943135 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000443226 ENST00000402558 ENST00000379174 ENST00000379166(uc010mkb.3 uc003zua.4)
ENST00000345050
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF24 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF24
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KIF24 (NM_194313) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIF24 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF24 |
Additional cDNA sequence: AK001795.1 AK125180.1 AK125872.1 AK310014.1 BC048311.1 BC110502.1 BC110503.1 9 DOTS entries: DT.97774851 DT.99954471 DT.85105562 DT.92068094 DT.75154722 DT.91732828 DT.100811475 DT.95243963 DT.99987216 24/55 AceView cDNA sequences (see all 55): BC048311 AI302300 BU154473 AK125180 AI201177 BM980679 AW377400 BQ216169 AA610300 CD677102 BE742733 AW503083 AW591325 AA283108 BM468549 AK125872 AA688165 AW752955 BF195447 AA806785 AI868766 AA283022 BF513823 BG116154
GeneLoc Exon Structure
|
Expression
for KIF24 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIF24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCCCCCAC
About this image
See KIF24 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIF24
SOURCE GeneReport for Unigene cluster: Hs.710246
SABiosciences Custom PCR Arrays for KIF24
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIF24
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIF24 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF24 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF24 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF24 |
Orthologs
for KIF24 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KIF24 gene from 4/16 species (see all 16) About this table
ENSEMBL Gene Tree for KIF24 (if available)
TreeFam Gene Tree for KIF24 (if available) |
Paralogs
for KIF24 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KIF24 gene
- KIF2A2 KIF2B2 KIF2C2
7 SIMAP similar genes for KIF24 using alignment to 2 protein entries: KIF24_HUMAN (see all proteins):KIF2C KIF2B KIF3A KIF5B KIF5C KIF6
KIF5A
KIF24 for paralogs About GeneDecksing
|
Genomic Variants
for KIF24 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KIF24 (34252378 - 34329198 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KIF24: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIF24 |
|
Disorders
/ Diseases
for KIF24 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KIF24 for disorders About GeneDecksing
OMIM gene information: 613747
OMIM disorders: --
2  diseases for KIF24: About MalaCardsaphasia malaria
1 disease from the University of Copenhagen DISEASES database for KIF24:Aphasia Human Genome Epidemiology (HuGE) Navigator: KIF24 (1 document)
Export disorders for KIF24 gene to outside databases
|
Publications
for KIF24 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIF24 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with KIF24) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Centriolar kinesin Kif24 interacts with CP110 to remo del microtubules and regulate ciliogenesis. (PubMed id 21620453)1, 2 Kobayashi T....Dynlacht B.D. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Is KIF24 a genetic risk factor for Frontotemporal Lob ar Degeneration? (PubMed id 20670673)1 Venturelli E....Galimberti D. (2010)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- Distinct class of putative 'non-conserved' promoters in humans: comparative studies of alternative promoters of human and mouse genes. (PubMed id 17567985)1 Tsuritani K....Suzuki Y. (2007)
|
External Searches for KIF24 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KIF24 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KIF24 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KIF24 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KIF24 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KIF24 gene:
Search GeneIP for patents involving KIF24
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIF24 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KIF24 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIF24 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIF24 | | | OriGene Protein Over-expression Lysate for KIF24 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KIF24 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF24 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF24 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIF24 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIF24 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF24 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF24 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF24 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF24 |
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| | | | Search Tocris compounds for KIF24 |
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 | | | KIF24 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF24 |
|  |  |  | | | | ThermoFisher Antibody for KIF24 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF24 |
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