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Aliases for KIF24 Gene

Aliases for KIF24 Gene

  • Kinesin Family Member 24 2 3 5
  • C9orf48 3 4
  • Chromosome 9 Open Reading Frame 48 2
  • Kinesin-Like Protein KIF24 3
  • BA571F15.4 3

External Ids for KIF24 Gene

Previous HGNC Symbols for KIF24 Gene

  • C9orf48

Previous GeneCards Identifiers for KIF24 Gene

  • GC09M034479
  • GC09M034299
  • GC09M034300
  • GC09U900713
  • GC09M034247
  • GC09M034208

Summaries for KIF24 Gene

Entrez Gene Summary for KIF24 Gene

  • This gene encodes a member of the kinesin superfamily of microtubule-based motor proteins which are involved in the intracellular transport of membranous organelles, protein complexes, and mRNAs. They also play critical roles in mitosis, morphogenesis, and signal transduction. The encoded protein contains an N-terminal sterile alpha motif (SAM) domain and an ATP-binding kinesin motor domain. It binds centriolar coiled coil protein 110 and centrosomal protein 97 and localizes to the mother centriole to regulate ciliogenesis by controlling microtubule polymerization. [provided by RefSeq, Mar 2017]

GeneCards Summary for KIF24 Gene

KIF24 (Kinesin Family Member 24) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF2A.

UniProtKB/Swiss-Prot for KIF24 Gene

  • Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419).

Gene Wiki entry for KIF24 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF24 Gene

Genomics for KIF24 Gene

Regulatory Elements for KIF24 Gene

Enhancers for KIF24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G034373 1.3 ENCODE dbSUPER 8.6 -15.8 -15820 4.2 HDGF PKNOX1 FOXA2 CREB3L1 AGO1 ARID4B SIN3A DMAP1 YY1 SLC30A9 NUDT2 KIF24 UBAP1 KIAA1161
GH09G034378 1.3 ENCODE dbSUPER 8.6 -20.3 -20276 2.5 HDGF ATF1 PKNOX1 MLX ARID4B DMAP1 ZNF2 ZNF48 YY1 SLC30A9 NUDT2 KIF24 KIAA1161 ENSG00000207032 GC09M034390
GH09G034248 1.1 Ensembl ENCODE 10.1 +107.2 107160 7.8 RB1 NFIB ARID4B RAD21 RFX5 SCRT2 ZNF143 FOS DEK ZNF654 NUDT2 UBAP1 KIF24 ENSG00000260947 GC09M034257 PIR51676 PIR47801
GH09G034327 1.1 ENCODE 9.8 +30.9 30923 3.4 HDGF FOXA2 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 NUDT2 ENSG00000228352 UNC13B PIGO KIF24 FANCG UBAP1 SERPINH1P1
GH09G034351 1.1 ENCODE dbSUPER 8.5 +7.3 7277 1.6 SOX13 FOXA2 SAP130 ZMYM3 MAX CEBPG ZNF384 RAD21 NCOR1 HNF4G NUDT2 KIF24 UBAP1 GC09P034356
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIF24 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIF24 Gene

Chromosome:
9
Start:
34,252,380 bp from pter
End:
34,359,914 bp from pter
Size:
107,535 bases
Orientation:
Minus strand

Genomic View for KIF24 Gene

Genes around KIF24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF24 Gene

Proteins for KIF24 Gene

  • Protein details for KIF24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T7B8-KIF24_HUMAN
    Recommended name:
    Kinesin-like protein KIF24
    Protein Accession:
    Q5T7B8
    Secondary Accessions:
    • Q2TB93
    • Q5T7B5
    • Q5T7B7
    • Q6ZU97
    • Q6ZUZ2
    • Q86XZ0
    • Q9NV43

    Protein attributes for KIF24 Gene

    Size:
    1368 amino acids
    Molecular mass:
    151903 Da
    Quaternary structure:
    • Interacts with CCP110, CEP97, TALPID3.
    SequenceCaution:
    • Sequence=AAI10504.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86074.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86329.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI15917.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF24 Gene

Post-translational modifications for KIF24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF24 Gene

No data available for DME Specific Peptides for KIF24 Gene

Domains & Families for KIF24 Gene

Gene Families for KIF24 Gene

Suggested Antigen Peptide Sequences for KIF24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T7B8

UniProtKB/Swiss-Prot:

KIF24_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF24: view

Function for KIF24 Gene

Molecular function for KIF24 Gene

UniProtKB/Swiss-Prot Function:
Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419).

Gene Ontology (GO) - Molecular Function for KIF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IDA 21620453
GO:0005515 protein binding IPI 21620453
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF24: view
genes like me logo Genes that share phenotypes with KIF24: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF24 Gene

Localization for KIF24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF24 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF24 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for KIF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005814 centriole IEA,IDA 21620453
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex IBA --
genes like me logo Genes that share ontologies with KIF24: view

Pathways & Interactions for KIF24 Gene

genes like me logo Genes that share pathways with KIF24: view

Pathways by source for KIF24 Gene

Gene Ontology (GO) - Biological Process for KIF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IBA --
GO:0007019 microtubule depolymerization IDA 21620453
GO:0030030 cell projection organization IEA --
GO:0060271 cilium assembly IMP 21620453
GO:0097711 ciliary basal body docking TAS --
genes like me logo Genes that share ontologies with KIF24: view

No data available for SIGNOR curated interactions for KIF24 Gene

Transcripts for KIF24 Gene

Unigene Clusters for KIF24 Gene

Kinesin family member 24:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF24 Gene

No ASD Table

Relevant External Links for KIF24 Gene

GeneLoc Exon Structure for
KIF24
ECgene alternative splicing isoforms for
KIF24

Expression for KIF24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF24 Gene

mRNA differential expression in normal tissues according to GTEx for KIF24 Gene

This gene is overexpressed in Testis (x12.2).

Protein differential expression in normal tissues from HIPED for KIF24 Gene

This gene is overexpressed in Plasma (28.2), Heart (13.5), Rectum (9.0), and Salivary gland (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KIF24 Gene



NURSA nuclear receptor signaling pathways regulating expression of KIF24 Gene:

KIF24

SOURCE GeneReport for Unigene cluster for KIF24 Gene:

Hs.710246

Evidence on tissue expression from TISSUES for KIF24 Gene

  • Nervous system(4.1)
  • Intestine(4)
genes like me logo Genes that share expression patterns with KIF24: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF24 Gene

Orthologs for KIF24 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF24 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia KIF24 34 35
  • 85.95 (n)
cow
(Bos Taurus)
Mammalia KIF24 34 35
  • 84.47 (n)
mouse
(Mus musculus)
Mammalia Kif24 34 16 35
  • 79.62 (n)
rat
(Rattus norvegicus)
Mammalia Kif24 34
  • 79.18 (n)
oppossum
(Monodelphis domestica)
Mammalia KIF24 35
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF24 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF24 34 35
  • 59.58 (n)
lizard
(Anolis carolinensis)
Reptilia KIF24 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif24 34
  • 57.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta Klp59C 35
  • 31 (a)
ManyToMany
Klp59D 35
  • 30 (a)
ManyToMany
Klp10A 35
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea klp-7 35
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
OneToMany
Species where no ortholog for KIF24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for KIF24 Gene

ENSEMBL:
Gene Tree for KIF24 (if available)
TreeFam:
Gene Tree for KIF24 (if available)

Paralogs for KIF24 Gene

Paralogs for KIF24 Gene

(7) SIMAP similar genes for KIF24 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KIF24: view

Variants for KIF24 Gene

Sequence variations from dbSNP and Humsavar for KIF24 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000015497 -- 34,326,798(+) AGTAG(A/G)AAGTC intron-variant
rs1000029224 -- 34,287,586(+) ATACA(A/C)GAATG intron-variant
rs1000100338 -- 34,278,461(+) GTAAA(A/C)TTCTA intron-variant
rs1000120988 -- 34,285,584(+) TCTGG(A/C/T)AAACA intron-variant
rs1000156318 -- 34,327,218(+) TTGAG(A/G)ATCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF24 Gene

Variant ID Type Subtype PubMed ID
esv2659715 CNV deletion 23128226
esv3414152 CNV insertion 20981092
esv3620335 CNV gain 21293372
esv3620354 CNV loss 21293372
nsv1030732 CNV gain 25217958
nsv1125318 OTHER inversion 24896259
nsv472035 CNV novel sequence insertion 20440878
nsv831542 CNV gain 17160897

Variation tolerance for KIF24 Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.45; 90.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF24 Gene

Human Gene Mutation Database (HGMD)
KIF24
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF24 Gene

Disorders for KIF24 Gene

Relevant External Links for KIF24

Genetic Association Database (GAD)
KIF24
Human Genome Epidemiology (HuGE) Navigator
KIF24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF24

No disorders were found for KIF24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF24 Gene

Publications for KIF24 Gene

  1. Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle. (PMID: 26290419) Kim S. … Dynlacht B.D. (Nat. Commun. 2015) 3 4 64
  2. The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. (PMID: 24421332) Kobayashi T. … Dynlacht B.D. (J. Cell Biol. 2014) 3 4 64
  3. Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis. (PMID: 21620453) Kobayashi T. … Dynlacht B.D. (Cell 2011) 3 4 64
  4. Is KIF24 a genetic risk factor for Frontotemporal Lobar Degeneration? (PMID: 20670673) Venturelli E. … Galimberti D. (Neurosci. Lett. 2010) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for KIF24 Gene

Sources for KIF24 Gene

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