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Aliases for KIF24 Gene

Aliases for KIF24 Gene

  • Kinesin Family Member 24 2 3
  • C9orf48 3 4
  • Chromosome 9 Open Reading Frame 48 2
  • Kinesin-Like Protein KIF24 3
  • BA571F15.4 3

External Ids for KIF24 Gene

Previous Symbols for KIF24 Gene

  • C9orf48

Summaries for KIF24 Gene

Entrez Gene Summary for KIF24 Gene

  • Kinesins, such as KIF24, are microtubule-dependent ATPases that function as molecular motors. They play important roles in intracellular vesicle transport and cell division (summary by Venturelli et al., 2010 [PubMed 20670673]).[supplied by OMIM, Feb 2011]

GeneCards Summary for KIF24 Gene

KIF24 (Kinesin Family Member 24) is a Protein Coding gene. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIF2B.

UniProtKB/Swiss-Prot for KIF24 Gene

  • Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation.

Gene Wiki entry for KIF24 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF24 Gene

Genomics for KIF24 Gene

Genomic Location for KIF24 Gene

Start:
34,252,380 bp from pter
End:
34,329,200 bp from pter
Size:
76,821 bases
Orientation:
Minus strand

Genomic View for KIF24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF24 Gene

Regulatory Elements for KIF24 Gene

Proteins for KIF24 Gene

  • Protein details for KIF24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T7B8-KIF24_HUMAN
    Recommended name:
    Kinesin-like protein KIF24
    Protein Accession:
    Q5T7B8
    Secondary Accessions:
    • Q2TB93
    • Q5T7B5
    • Q5T7B7
    • Q6ZU97
    • Q6ZUZ2
    • Q86XZ0
    • Q9NV43

    Protein attributes for KIF24 Gene

    Size:
    1368 amino acids
    Molecular mass:
    151903 Da
    Quaternary structure:
    • Interacts with CCP110 and CEP97.
    SequenceCaution:
    • Sequence=AAI10504.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86074.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86329.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI15917.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF24 Gene

Proteomics data for KIF24 Gene at MOPED

Post-translational modifications for KIF24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIF24 Gene

Domains for KIF24 Gene

Gene Families for KIF24 Gene

HGNC:
  • SAMD :Sterile alpha motif (SAM) domain containing
  • KIF :Kinesins

UniProtKB/Swiss-Prot:

KIF24_HUMAN
Domain:
  • Contains 1 kinesin motor domain.:
    • Q5T7B8
  • Contains 1 SAM (sterile alpha motif) domain.:
    • Q5T7B8
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.:
    • Q5T7B8
genes like me logo Genes that share domains with KIF24: view

Function for KIF24 Gene

Molecular function for KIF24 Gene

UniProtKB/Swiss-Prot Function: Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation.

Gene Ontology (GO) - Molecular Function for KIF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IDA 21620453
GO:0005515 protein binding IPI 21620453
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF24: view
genes like me logo Genes that share phenotypes with KIF24: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIF24 Gene

Localization for KIF24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF24 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF24 Gene COMPARTMENTS Subcellular localization image for KIF24 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for KIF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005814 centriole IDA 21620453
GO:0005829 cytosol TAS --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
GO:0043234 protein complex IDA 24421332
genes like me logo Genes that share ontologies with KIF24: view

Pathways for KIF24 Gene

SuperPathways for KIF24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006996 organelle organization TAS --
GO:0007018 microtubule-based movement IBA --
GO:0007019 microtubule depolymerization IDA 21620453
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with KIF24: view

No data available for Pathways by source for KIF24 Gene

Transcripts for KIF24 Gene

Unigene Clusters for KIF24 Gene

Kinesin family member 24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF24 Gene

No ASD Table

Relevant External Links for KIF24 Gene

GeneLoc Exon Structure for
KIF24
ECgene alternative splicing isoforms for
KIF24

Expression for KIF24 Gene

mRNA expression in normal human tissues for KIF24 Gene

mRNA differential expression in normal tissues according to GTEx for KIF24 Gene

This gene is overexpressed in Testis (12.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KIF24 Gene

SOURCE GeneReport for Unigene cluster for KIF24 Gene Hs.710246

genes like me logo Genes that share expressions with KIF24: view

Orthologs for KIF24 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF24 36
  • 99.56 (n)
  • 99.42 (a)
KIF24 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIF24 36
  • 84.47 (n)
  • 77.78 (a)
KIF24 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF24 36
  • 85.95 (n)
  • 79 (a)
KIF24 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif24 36
  • 79.62 (n)
  • 73.13 (a)
Kif24 16
Kif24 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF24 37
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF24 37
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif24 36
  • 79.18 (n)
  • 73.23 (a)
chicken
(Gallus gallus)
Aves KIF24 36
  • 59.58 (n)
  • 53.56 (a)
KIF24 37
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF24 37
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif24 36
  • 57.49 (n)
  • 50.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta Klp10A 37
  • 27 (a)
ManyToMany
Klp59C 37
  • 31 (a)
ManyToMany
Klp59D 37
  • 30 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea klp-7 37
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 31 (a)
OneToMany
Species with no ortholog for KIF24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for KIF24 Gene

ENSEMBL:
Gene Tree for KIF24 (if available)
TreeFam:
Gene Tree for KIF24 (if available)

Paralogs for KIF24 Gene

Paralogs for KIF24 Gene

Selected SIMAP similar genes for KIF24 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KIF24: view

Variants for KIF24 Gene

Sequence variations from dbSNP and Humsavar for KIF24 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs950546 -- 34,310,085(-) TAGTG(C/T)TTCGA intron-variant
rs950547 -- 34,309,969(-) AAAAA(A/G)GTACT intron-variant
rs950548 -- 34,309,994(-) TTCTT(G/T)TAATC intron-variant
rs1105655 -- 34,298,145(+) ATGAA(C/T)AGAGT intron-variant
rs1337591 -- 34,288,423(+) GATGA(A/G)GCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF24 Gene

Variant ID Type Subtype PubMed ID
nsv893034 CNV Loss 21882294
dgv8166n71 CNV Loss 21882294
nsv893037 CNV Gain 21882294
esv2659715 CNV Deletion 23128226
nsv831542 CNV Gain 17160897
esv267813 CNV Insertion 20981092

Relevant External Links for KIF24 Gene

HapMap Linkage Disequilibrium report
KIF24
Human Gene Mutation Database (HGMD)
KIF24

Disorders for KIF24 Gene

(1) University of Copenhagen DISEASES for KIF24 Gene

Relevant External Links for KIF24

Genetic Association Database (GAD)
KIF24
Human Genome Epidemiology (HuGE) Navigator
KIF24
genes like me logo Genes that share disorders with KIF24: view

No data available for UniProtKB/Swiss-Prot for KIF24 Gene

Publications for KIF24 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Is KIF24 a genetic risk factor for Frontotemporal Lobar Degeneration? (PMID: 20670673) Venturelli E. … Galimberti D. (Neurosci. Lett. 2010) 3 49

Products for KIF24 Gene

Sources for KIF24 Gene

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