Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KIF24 Gene

Aliases for KIF24 Gene

  • Kinesin Family Member 24 2 3 5
  • C9orf48 3 4
  • Chromosome 9 Open Reading Frame 48 2
  • Kinesin-Like Protein KIF24 3
  • BA571F15.4 3

External Ids for KIF24 Gene

Previous HGNC Symbols for KIF24 Gene

  • C9orf48

Previous GeneCards Identifiers for KIF24 Gene

  • GC09M034479
  • GC09M034299
  • GC09M034300
  • GC09U900713
  • GC09M034247
  • GC09M034208

Summaries for KIF24 Gene

Entrez Gene Summary for KIF24 Gene

  • This gene encodes a member of the kinesin superfamily of microtubule-based motor proteins which are involved in the intracellular transport of membranous organelles, protein complexes, and mRNAs. They also play critical roles in mitosis, morphogenesis, and signal transduction. The encoded protein contains an N-terminal sterile alpha motif (SAM) domain and an ATP-binding kinesin motor domain. It binds centriolar coiled coil protein 110 and centrosomal protein 97 and localizes to the mother centriole to regulate ciliogenesis by controlling microtubule polymerization. [provided by RefSeq, Mar 2017]

GeneCards Summary for KIF24 Gene

KIF24 (Kinesin Family Member 24) is a Protein Coding gene. Diseases associated with KIF24 include Basal Cell Nevus Syndrome. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF2A.

UniProtKB/Swiss-Prot for KIF24 Gene

  • Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419).

Gene Wiki entry for KIF24 Gene

Additional gene information for KIF24 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF24 Gene

Genomics for KIF24 Gene

GeneHancer (GH) Regulatory Elements for KIF24 Gene

Promoters and enhancers for KIF24 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I034327 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 559.8 +30.9 30875 3.5 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 NUDT2 KIF24 UBAP2 ENSG00000228352 NOL6 PIGO FAM205A C9orf131 UNC13B VCP
GH09I034373 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 8.6 -15.8 -15819 4.2 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF143 MYORG NUDT2 KIF24 UBAP1
GH09I034378 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 8.6 -20.3 -20276 2.5 HDGF PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 NUDT2 KIF24 MYORG GC09M034390 ENSG00000207032 C9orf24
GH09I034046 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 6.1 +311.2 311178 3.9 PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 UBAP2 RN7SKP114 SMU1 ENSG00000228352 NFX1 NOL6 B4GALT1 UBE2R2 PRSS3 ENSG00000260947
GH09I034248 Enhancer 1 Ensembl ENCODE 10.2 +107.2 107160 7.8 RB1 NFIB ARID4B RAD21 RFX5 ZNF213 SCRT2 ZNF143 FOS RUNX3 PIR43892 PIR51676 PIR47801 GC09M034257 NUDT2 UBAP1 KIF24 ENSG00000260947 PIR43535
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KIF24 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KIF24 gene promoter:

Genomic Locations for KIF24 Gene

Genomic Locations for KIF24 Gene
chr9:34,252,380-34,359,914
(GRCh38/hg38)
Size:
107,535 bases
Orientation:
Minus strand
chr9:34,252,378-34,329,198
(GRCh37/hg19)

Genomic View for KIF24 Gene

Genes around KIF24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF24 Gene

Proteins for KIF24 Gene

  • Protein details for KIF24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T7B8-KIF24_HUMAN
    Recommended name:
    Kinesin-like protein KIF24
    Protein Accession:
    Q5T7B8
    Secondary Accessions:
    • Q2TB93
    • Q5T7B5
    • Q5T7B7
    • Q6ZU97
    • Q6ZUZ2
    • Q86XZ0
    • Q9NV43

    Protein attributes for KIF24 Gene

    Size:
    1368 amino acids
    Molecular mass:
    151903 Da
    Quaternary structure:
    • Interacts with CCP110, CEP97, TALPID3.
    SequenceCaution:
    • Sequence=AAI10504.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86074.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86329.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI15917.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF24 Gene

Post-translational modifications for KIF24 Gene

No Post-translational modifications

Other Protein References for KIF24 Gene

No data available for DME Specific Peptides for KIF24 Gene

Domains & Families for KIF24 Gene

Gene Families for KIF24 Gene

Suggested Antigen Peptide Sequences for KIF24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T7B8

UniProtKB/Swiss-Prot:

KIF24_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF24: view

Function for KIF24 Gene

Molecular function for KIF24 Gene

UniProtKB/Swiss-Prot Function:
Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419).

Phenotypes From GWAS Catalog for KIF24 Gene

Gene Ontology (GO) - Molecular Function for KIF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IDA 21620453
GO:0005515 protein binding IPI 21620453
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF24: view
genes like me logo Genes that share phenotypes with KIF24: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF24 Gene

Localization for KIF24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF24 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF24 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for KIF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005814 centriole IEA,IDA 21620453
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex IBA --
genes like me logo Genes that share ontologies with KIF24: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KIF24 Gene

Pathways & Interactions for KIF24 Gene

genes like me logo Genes that share pathways with KIF24: view

Pathways by source for KIF24 Gene

Gene Ontology (GO) - Biological Process for KIF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IBA --
GO:0007019 microtubule depolymerization IDA 21620453
GO:0030030 cell projection organization IEA --
GO:0060271 cilium assembly IMP 21620453
GO:0097711 ciliary basal body-plasma membrane docking TAS --
genes like me logo Genes that share ontologies with KIF24: view

No data available for SIGNOR curated interactions for KIF24 Gene

Drugs & Compounds for KIF24 Gene

No Compound Related Data Available

Transcripts for KIF24 Gene

Unigene Clusters for KIF24 Gene

Kinesin family member 24:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF24 Gene

No ASD Table

Relevant External Links for KIF24 Gene

GeneLoc Exon Structure for
KIF24
ECgene alternative splicing isoforms for
KIF24

Expression for KIF24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF24 Gene

mRNA differential expression in normal tissues according to GTEx for KIF24 Gene

This gene is overexpressed in Testis (x12.2).

Protein differential expression in normal tissues from HIPED for KIF24 Gene

This gene is overexpressed in Plasma (28.2), Heart (13.5), Rectum (9.0), and Salivary gland (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KIF24 Gene



NURSA nuclear receptor signaling pathways regulating expression of KIF24 Gene:

KIF24

SOURCE GeneReport for Unigene cluster for KIF24 Gene:

Hs.710246

Evidence on tissue expression from TISSUES for KIF24 Gene

  • Nervous system(4.1)
  • Intestine(4)
genes like me logo Genes that share expression patterns with KIF24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF24 Gene

Orthologs for KIF24 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF24 33 34
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia KIF24 33 34
  • 85.95 (n)
cow
(Bos Taurus)
Mammalia KIF24 33 34
  • 84.47 (n)
mouse
(Mus musculus)
Mammalia Kif24 33 16 34
  • 79.62 (n)
rat
(Rattus norvegicus)
Mammalia Kif24 33
  • 79.18 (n)
oppossum
(Monodelphis domestica)
Mammalia KIF24 34
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF24 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF24 33 34
  • 59.58 (n)
lizard
(Anolis carolinensis)
Reptilia KIF24 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif24 33
  • 57.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta Klp59C 34
  • 31 (a)
ManyToMany
Klp59D 34
  • 30 (a)
ManyToMany
Klp10A 34
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea klp-7 34
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
OneToMany
Species where no ortholog for KIF24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for KIF24 Gene

ENSEMBL:
Gene Tree for KIF24 (if available)
TreeFam:
Gene Tree for KIF24 (if available)

Paralogs for KIF24 Gene

Paralogs for KIF24 Gene

(7) SIMAP similar genes for KIF24 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KIF24: view

Variants for KIF24 Gene

Sequence variations from dbSNP and Humsavar for KIF24 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000015497 -- 34,326,798(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000029224 -- 34,287,586(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000100338 -- 34,278,461(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000120988 -- 34,285,584(-) C/A/T genic_upstream_transcript_variant, intron_variant
rs1000156318 -- 34,327,218(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KIF24 Gene

Variant ID Type Subtype PubMed ID
esv2659715 CNV deletion 23128226
esv3414152 CNV insertion 20981092
esv3620335 CNV gain 21293372
esv3620354 CNV loss 21293372
nsv1030732 CNV gain 25217958
nsv1125318 OTHER inversion 24896259
nsv472035 CNV novel sequence insertion 20440878
nsv831542 CNV gain 17160897

Variation tolerance for KIF24 Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.45; 90.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF24 Gene

Human Gene Mutation Database (HGMD)
KIF24
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF24 Gene

Disorders for KIF24 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF24 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
basal cell nevus syndrome
  • bcns
- elite association - COSMIC cancer census association via MalaCards
Search KIF24 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KIF24

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KIF24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF24 Gene

Publications for KIF24 Gene

  1. Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle. (PMID: 26290419) Kim S … Dynlacht BD (Nature communications 2015) 3 4 58
  2. The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. (PMID: 24421332) Kobayashi T … Dynlacht BD (The Journal of cell biology 2014) 3 4 58
  3. Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis. (PMID: 21620453) Kobayashi T … Dynlacht BD (Cell 2011) 3 4 58
  4. Is KIF24 a genetic risk factor for Frontotemporal Lobar Degeneration? (PMID: 20670673) Venturelli E … Galimberti D (Neuroscience letters 2010) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for KIF24 Gene

Sources for KIF24 Gene

Content
Loading form....