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Aliases for KIF24 Gene

Aliases for KIF24 Gene

  • Kinesin Family Member 24 2 3 5
  • C9orf48 3 4
  • Chromosome 9 Open Reading Frame 48 2
  • BA571F15.4 3

External Ids for KIF24 Gene

Previous HGNC Symbols for KIF24 Gene

  • C9orf48

Previous GeneCards Identifiers for KIF24 Gene

  • GC09M034479
  • GC09M034299
  • GC09M034300
  • GC09U900713
  • GC09M034247
  • GC09M034208

Summaries for KIF24 Gene

Entrez Gene Summary for KIF24 Gene

  • Kinesins, such as KIF24, are microtubule-dependent ATPases that function as molecular motors. They play important roles in intracellular vesicle transport and cell division (summary by Venturelli et al., 2010 [PubMed 20670673]).[supplied by OMIM, Feb 2011]

GeneCards Summary for KIF24 Gene

KIF24 (Kinesin Family Member 24) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF2B.

UniProtKB/Swiss-Prot for KIF24 Gene

  • Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation.

Gene Wiki entry for KIF24 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF24 Gene

Genomics for KIF24 Gene

Regulatory Elements for KIF24 Gene

Genomic Location for KIF24 Gene

Chromosome:
9
Start:
34,252,380 bp from pter
End:
34,359,914 bp from pter
Size:
107,535 bases
Orientation:
Minus strand

Genomic View for KIF24 Gene

Genes around KIF24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF24 Gene

Proteins for KIF24 Gene

  • Protein details for KIF24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T7B8-KIF24_HUMAN
    Recommended name:
    Kinesin-like protein KIF24
    Protein Accession:
    Q5T7B8
    Secondary Accessions:
    • Q2TB93
    • Q5T7B5
    • Q5T7B7
    • Q6ZU97
    • Q6ZUZ2
    • Q86XZ0
    • Q9NV43

    Protein attributes for KIF24 Gene

    Size:
    1368 amino acids
    Molecular mass:
    151903 Da
    Quaternary structure:
    • Interacts with CCP110 and CEP97.
    SequenceCaution:
    • Sequence=AAI10504.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86074.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86329.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI15917.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF24 Gene

Proteomics data for KIF24 Gene at MOPED

Post-translational modifications for KIF24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIF24 Gene

Domains & Families for KIF24 Gene

Suggested Antigen Peptide Sequences for KIF24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T7B8

UniProtKB/Swiss-Prot:

KIF24_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Domain:
  • Contains 1 kinesin motor domain.
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF24: view

Function for KIF24 Gene

Molecular function for KIF24 Gene

UniProtKB/Swiss-Prot Function:
Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation.

Gene Ontology (GO) - Molecular Function for KIF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 21620453
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF24: view
genes like me logo Genes that share phenotypes with KIF24: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF24 Gene

Localization for KIF24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF24 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF24 Gene COMPARTMENTS Subcellular localization image for KIF24 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for KIF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005814 centriole IDA 21620453
genes like me logo Genes that share ontologies with KIF24: view

Pathways & Interactions for KIF24 Gene

genes like me logo Genes that share pathways with KIF24: view

Gene Ontology (GO) - Biological Process for KIF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IEA,IBA --
genes like me logo Genes that share ontologies with KIF24: view

No data available for SIGNOR curated interactions for KIF24 Gene

Drugs & Compounds for KIF24 Gene

No Compound Related Data Available

Transcripts for KIF24 Gene

Unigene Clusters for KIF24 Gene

Kinesin family member 24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF24 Gene

No ASD Table

Relevant External Links for KIF24 Gene

GeneLoc Exon Structure for
KIF24
ECgene alternative splicing isoforms for
KIF24

Expression for KIF24 Gene

mRNA expression in normal human tissues for KIF24 Gene

mRNA differential expression in normal tissues according to GTEx for KIF24 Gene

This gene is overexpressed in Testis (x12.2).

Protein differential expression in normal tissues from HIPED for KIF24 Gene

This gene is overexpressed in Plasma (28.2), Heart (13.5), Rectum (9.0), and Salivary gland (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIF24 Gene



SOURCE GeneReport for Unigene cluster for KIF24 Gene Hs.710246

genes like me logo Genes that share expression patterns with KIF24: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KIF24 Gene

Orthologs for KIF24 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF24 36
  • 99 (a)
OneToOne
KIF24 35
  • 99.56 (n)
  • 99.42 (a)
cow
(Bos Taurus)
Mammalia KIF24 36
  • 77 (a)
OneToOne
KIF24 35
  • 84.47 (n)
  • 77.78 (a)
dog
(Canis familiaris)
Mammalia KIF24 35
  • 85.95 (n)
  • 79 (a)
KIF24 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif24 16
Kif24 35
  • 79.62 (n)
  • 73.13 (a)
Kif24 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF24 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF24 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif24 35
  • 79.18 (n)
  • 73.23 (a)
chicken
(Gallus gallus)
Aves KIF24 35
  • 59.58 (n)
  • 53.56 (a)
KIF24 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF24 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif24 35
  • 57.49 (n)
  • 50.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta Klp10A 36
  • 27 (a)
ManyToMany
Klp59C 36
  • 31 (a)
ManyToMany
Klp59D 36
  • 30 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea klp-7 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for KIF24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for KIF24 Gene

ENSEMBL:
Gene Tree for KIF24 (if available)
TreeFam:
Gene Tree for KIF24 (if available)

Paralogs for KIF24 Gene

Paralogs for KIF24 Gene

(7) SIMAP similar genes for KIF24 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KIF24: view

Variants for KIF24 Gene

Sequence variations from dbSNP and Humsavar for KIF24 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs16935508 - 34,311,197(+) TTGCG(C/G)TCGTT reference, missense
rs10972048 - 34,310,929(+) TAGCA(C/T)GTGTT reference, missense
rs17350674 - 34,306,412(+) CAGTC(A/C)AAGGA upstream-variant-2KB, reference, missense
rs34101674 - 34,256,377(-) GGCTA(A/C/T)GCACA reference, missense
rs41274845 - 34,311,022(+) ATTTC(C/T)GTCTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KIF24 Gene

Variant ID Type Subtype PubMed ID
nsv893034 CNV Loss 21882294
dgv8166n71 CNV Loss 21882294
nsv893037 CNV Gain 21882294
esv2659715 CNV Deletion 23128226
nsv831542 CNV Gain 17160897
esv267813 CNV Insertion 20981092

Variation tolerance for KIF24 Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.45; 90.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF24 Gene

HapMap Linkage Disequilibrium report
KIF24
Human Gene Mutation Database (HGMD)
KIF24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF24 Gene

Disorders for KIF24 Gene

Relevant External Links for KIF24

Genetic Association Database (GAD)
KIF24
Human Genome Epidemiology (HuGE) Navigator
KIF24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF24

No disorders were found for KIF24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF24 Gene

Publications for KIF24 Gene

  1. Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis. (PMID: 21620453) Kobayashi T. … Dynlacht B.D. (Cell 2011) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. (PMID: 24421332) Kobayashi T. … Dynlacht B.D. (J. Cell Biol. 2014) 3
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for KIF24 Gene

Sources for KIF24 Gene

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