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Aliases for KIF23 Gene

Aliases for KIF23 Gene

  • Kinesin Family Member 23 2 3 5
  • Kinesin-Like 5 (Mitotic Kinesin-Like Protein 1) 2 3
  • KNSL5 3 4
  • MKLP1 3 4
  • Mitotic Kinesin-Like Protein 1 4
  • Kinesin-Like Protein KIF23 3
  • Kinesin-Like Protein 5 4
  • MKLP-1 3
  • CHO1 3

External Ids for KIF23 Gene

Previous HGNC Symbols for KIF23 Gene

  • KNSL5

Previous GeneCards Identifiers for KIF23 Gene

  • GC15P062805
  • GC15P067285
  • GC15P067422
  • GC15P067493
  • GC15P069706
  • GC15P046539

Summaries for KIF23 Gene

Entrez Gene Summary for KIF23 Gene

  • The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]

CIViC summary for KIF23 Gene

GeneCards Summary for KIF23 Gene

KIF23 (Kinesin Family Member 23) is a Protein Coding gene. Diseases associated with KIF23 include Dyserythropoietic Anemia, Congenital, Type Iii and Congenital Dyserythropoietic Anemia. Among its related pathways are Innate Immune System and Aurora B signaling. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF20B.

UniProtKB/Swiss-Prot for KIF23 Gene

  • Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.

Gene Wiki entry for KIF23 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF23 Gene

Genomics for KIF23 Gene

Regulatory Elements for KIF23 Gene

Enhancers for KIF23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G069412 1.1 ENCODE 0.7 +0.4 406 4.1 PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 ZNF766 PAQR5 LOC145694 KIF23
GH15G069410 0.8 ENCODE 0.7 -3.8 -3760 0.1 GTF2F1 HDGF CTCF PKNOX1 JUN MAX SIN3A BRCA1 RAD21 ZKSCAN1 ENSG00000207395 KIF23
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIF23 on UCSC Golden Path with GeneCards custom track

Promoters for KIF23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000078626 454 1801 PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF766 FOS

Genomic Location for KIF23 Gene

Chromosome:
15
Start:
69,414,246 bp from pter
End:
69,448,427 bp from pter
Size:
34,182 bases
Orientation:
Plus strand

Genomic View for KIF23 Gene

Genes around KIF23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF23 Gene

Proteins for KIF23 Gene

  • Protein details for KIF23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02241-KIF23_HUMAN
    Recommended name:
    Kinesin-like protein KIF23
    Protein Accession:
    Q02241
    Secondary Accessions:
    • B4E1K0
    • Q8WVP0

    Protein attributes for KIF23 Gene

    Size:
    960 amino acids
    Molecular mass:
    110059 Da
    Quaternary structure:
    • Heterotetramer of two molecules each of RACGAP1 and KIF23. Found in the centralspindlin complex composed of RACGAP1 and KIF23. Interacts with RACGAP1; the interaction is direct. Interacts with ECT2 and PRC1. Interacts with ANXA11 during cytokinesis. Interacts with BIRC6/bruce and USP8/UBPY. Interacts with ARF6, forming heterodimers and heterotetramers.

    Three dimensional structures from OCA and Proteopedia for KIF23 Gene

    Alternative splice isoforms for KIF23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF23 Gene

Post-translational modifications for KIF23 Gene

  • Ubiquitinated. Deubiquitinated by USP8/UBPY.
  • Ubiquitination at isoforms=2149, posLast=384384, isoforms=2, 3503, posLast=523523, isoforms=2, 3571, posLast=577577, posLast=599599, isoforms=2, 3624, and posLast=643643
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KIF23 Gene

Domains & Families for KIF23 Gene

Gene Families for KIF23 Gene

Suggested Antigen Peptide Sequences for KIF23 Gene

Graphical View of Domain Structure for InterPro Entry

Q02241

UniProtKB/Swiss-Prot:

KIF23_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF23: view

Function for KIF23 Gene

Molecular function for KIF23 Gene

UniProtKB/Swiss-Prot Function:
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.

Gene Ontology (GO) - Molecular Function for KIF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003774 motor activity IEA --
GO:0003777 microtubule motor activity TAS,IBA --
GO:0005515 protein binding IPI 11782313
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with KIF23: view
genes like me logo Genes that share phenotypes with KIF23: view

Animal Model Products

CRISPR Products

miRNA for KIF23 Gene

miRTarBase miRNAs that target KIF23

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KIF23

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF23 Gene

Localization for KIF23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF23 Gene

Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF23 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 2

Gene Ontology (GO) - Cellular Components for KIF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005623 cell IEA --
GO:0005634 nucleus IDA,IEA 11782313
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with KIF23: view

Pathways & Interactions for KIF23 Gene

genes like me logo Genes that share pathways with KIF23: view

Pathways by source for KIF23 Gene

Gene Ontology (GO) - Biological Process for KIF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000022 mitotic spindle elongation TAS 1406973
GO:0000281 mitotic cytokinesis IMP 15843429
GO:0000910 cytokinesis IMP 16236794
GO:0000915 actomyosin contractile ring assembly IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
genes like me logo Genes that share ontologies with KIF23: view

No data available for SIGNOR curated interactions for KIF23 Gene

Drugs & Compounds for KIF23 Gene

No Compound Related Data Available

Transcripts for KIF23 Gene

Unigene Clusters for KIF23 Gene

Kinesin family member 23:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KIF23

Alternative Splicing Database (ASD) splice patterns (SP) for KIF23 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - -
SP2: -
SP3: - -
SP4: - - - -
SP5: -
SP6:

ExUns: 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for KIF23 Gene

GeneLoc Exon Structure for
KIF23
ECgene alternative splicing isoforms for
KIF23

Expression for KIF23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIF23 Gene

This gene is overexpressed in Testis (32.0), Lung (18.5), and Ovary (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIF23 Gene



Protein tissue co-expression partners for KIF23 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIF23 Gene:

KIF23

SOURCE GeneReport for Unigene cluster for KIF23 Gene:

Hs.270845

Evidence on tissue expression from TISSUES for KIF23 Gene

  • Blood(2.6)
  • Spleen(2.4)
  • Nervous system(2.3)
  • Eye(2.2)
  • Heart(2.2)
  • Kidney(2.2)
  • Lung(2.2)
  • Thyroid gland(2.2)
  • Adrenal gland(2.1)
  • Bone marrow(2.1)
  • Liver(2.1)
  • Lymph node(2.1)
  • Muscle(2.1)
  • Intestine(2)
  • Skin(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF23 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • integumentary
  • nervous
  • urinary
Organs:
Head and neck:
  • eye
  • head
  • mouth
Abdomen:
  • kidney
General:
  • blood
  • red blood cell
  • skin
genes like me logo Genes that share expression patterns with KIF23: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIF23 Gene

Orthologs for KIF23 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF23 34 35
  • 99.76 (n)
cow
(Bos Taurus)
Mammalia KIF23 34 35
  • 92.15 (n)
dog
(Canis familiaris)
Mammalia KIF23 34 35
  • 89.54 (n)
oppossum
(Monodelphis domestica)
Mammalia KIF23 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif23 34
  • 87.8 (n)
mouse
(Mus musculus)
Mammalia Kif23 34 16 35
  • 86.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KIF23 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF23 34 35
  • 76.53 (n)
lizard
(Anolis carolinensis)
Reptilia KIF23 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif23 34
  • 72.84 (n)
Str.2307 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.11537 34
zebrafish
(Danio rerio)
Actinopterygii kif23 34 35
  • 68.26 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007706 34
  • 50.86 (n)
fruit fly
(Drosophila melanogaster)
Insecta pav 34 35
  • 49.76 (n)
worm
(Caenorhabditis elegans)
Secernentea zen-4 34 35
  • 48.28 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9064 35
  • 43 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3303 34
Species where no ortholog for KIF23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF23 Gene

ENSEMBL:
Gene Tree for KIF23 (if available)
TreeFam:
Gene Tree for KIF23 (if available)

Paralogs for KIF23 Gene

Variants for KIF23 Gene

Sequence variations from dbSNP and Humsavar for KIF23 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000013192 -- 69,444,534(+) AAGAC(A/T)TGCAG intron-variant
rs1000072330 -- 69,436,980(+) AAACT(C/G)CTGAC intron-variant
rs1000218024 -- 69,430,067(+) CAGAA(C/T)TGGGT intron-variant
rs1000284116 -- 69,430,466(+) AGATC(A/C)GTAGA intron-variant
rs1000437287 -- 69,424,277(+) CGTTT(A/G)TTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF23 Gene

Variant ID Type Subtype PubMed ID
esv2760037 CNV loss 17122850
nsv1585 CNV insertion 18451855
nsv520964 CNV gain 19592680

Variation tolerance for KIF23 Gene

Residual Variation Intolerance Score: 27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.17; 61.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF23 Gene

Human Gene Mutation Database (HGMD)
KIF23
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF23 Gene

Disorders for KIF23 Gene

MalaCards: The human disease database

(3) MalaCards diseases for KIF23 Gene - From: GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
dyserythropoietic anemia, congenital, type iii
  • anemia, congenital dyserythropoietic, type iii
congenital dyserythropoietic anemia
  • congenital dyshaematopoietic anaemia
neonatal anemia
  • anemia neonatal
- elite association - COSMIC cancer census association via MalaCards
Search KIF23 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KIF23

Genetic Association Database (GAD)
KIF23
Human Genome Epidemiology (HuGE) Navigator
KIF23
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF23
genes like me logo Genes that share disorders with KIF23: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF23 Gene

Publications for KIF23 Gene

  1. A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles. (PMID: 1406973) Nislow C. … McIntosh J.R. (Nature 1992) 2 3 4 64
  2. Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis. (PMID: 22522702) Makyio H. … Nakayama K. (EMBO J. 2012) 3 4 64
  3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64
  4. Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. (PMID: 19468300) Wolfe B.A. … Glotzer M. (PLoS Biol. 2009) 3 4 64
  5. CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase. (PMID: 19015243) Seguin L. … Bertoglio J. (Mol. Cell. Biol. 2009) 3 22 64

Products for KIF23 Gene

  • Addgene plasmids for KIF23

Sources for KIF23 Gene

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