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KIF23 Gene

protein-coding   GIFtS: 65
GCID: GC15P069706

Kinesin Family Member 23

(Previous name: kinesin-like 5 (mitotic kinesin-like protein 1))
(Previous symbol: KNSL5)
  See KIF23-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kinesin Family Member 231 2     MKLP-12
KNSL51 2 3 5     Kinesin-Like Protein KIF232
MKLP12 3 5     Kinesin-Like Protein 53
Kinesin-Like 5 (Mitotic Kinesin-Like Protein 1)1 2     Mitotic Kinesin-Like Protein 13
CHO12     

External Ids:    HGNC: 63921   Entrez Gene: 94932   Ensembl: ENSG000001378077   OMIM: 6050645   UniProtKB: Q022413   

Export aliases for KIF23 gene to outside databases

Previous GC identifers: GC15P062805 GC15P067285 GC15P067422 GC15P067493 GC15P046539


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KIF23 Gene:
The protein encoded by this gene is a member of kinesin-like protein family. This family includes
microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell
division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in
vitro. Alternate splicing of this gene results in multiple transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for KIF23 Gene:
KIF23 (kinesin family member 23) is a protein-coding gene. Diseases associated with KIF23 include congenital dyserythropoietic anemia type 3. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIF20A.

UniProtKB/Swiss-Prot: KIF23_HUMAN, Q02241
Function: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated
signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for
cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle.
Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro

Gene Wiki entry for KIF23 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIF23 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B2   oct-B3   CUTL1   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIF23 promoter sequence
   Search Chromatin IP Primers for KIF23

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIF23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23   Ensembl cytogenetic band:  15q23   HGNC cytogenetic band: 15q23

KIF23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF23 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P069706:  view genomic region     (about GC identifiers)

Start:
69,706,585 bp from pter      End:
69,740,764 bp from pter
Size:
34,180 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KIF23_HUMAN, Q02241 (See protein sequence)
Recommended Name: Kinesin-like protein KIF23  
Size: 960 amino acids; 110059 Da
Subunit: Heterotetramer of two molecules each of RACGAP1 and KIF23. Found in the centralspindlin complex composed
of RACGAP1 and KIF23. Interacts with RACGAP1; the interaction is direct. Interacts with ECT2 and PRC1. Interacts
with ANXA11 during cytokinesis. Interacts with BIRC6/bruce and USP8/UBPY. Interacts with ARF6, forming
heterodimers and heterotetramers
1 PDB 3D structure from and Proteopedia for KIF23:
3VHX (3D)    
Secondary accessions: Q8WVP0
Alternative splicing: 2 isoforms:  Q02241-1   Q02241-2   

Explore the universe of human proteins at neXtProt for KIF23: NX_Q02241

Explore proteomics data for KIF23 at MOPED

Post-translational modifications: 

  • Ubiquitinated. Deubiquitinated by USP8/UBPY1
  • Ubiquitination2 at Lys149, Lys384, Lys503, Lys523, Lys571, Lys577, Lys599, Lys624, Lys643, Lys741
  • Modification sites at PhosphoSitePlus

  • See KIF23 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001268230.1  NP_004847.2  NP_612565.1  

    ENSEMBL proteins: 
     ENSP00000453386   ENSP00000378790   ENSP00000304978   ENSP00000453629   ENSP00000453576  
     ENSP00000453102   ENSP00000452901   ENSP00000260363   ENSP00000442969  
    Reactome Protein details: Q02241

    KIF23 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for KIF23

     
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    antibodies-online peptides for KIF23

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KIF: Kinesins

    4 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR001752 Kinesin_motor_dom
     IPR019821 Kinesin_motor_CS
     IPR027640 Kinesin-like_fam

    Graphical View of Domain Structure for InterPro Entry Q02241

    ProtoNet protein and cluster: Q02241

    1 Blocks protein domain: IPB001752 Kinesin

    UniProtKB/Swiss-Prot: KIF23_HUMAN, Q02241
    Similarity: Belongs to the kinesin-like protein family
    Similarity: Contains 1 kinesin-motor domain


    Find genes that share domains with KIF23           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KIF23_HUMAN, Q02241
    Function: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated
    signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for
    cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle.
    Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity IEA--
    GO:0005515protein binding IPI11782313
    GO:0005524ATP binding IEA--
    GO:0008017microtubule binding IDA11782313
         
    Find genes that share ontologies with KIF23           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for KIF23:
     Cell division defect  Decreased cell number, increas  Increased cell number in G2M,   Upregulation of Wnt/beta-caten 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KIF23

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    miRTarBase miRNAs that target KIF23:
    hsa-mir-106b-5p (MIRT020426), hsa-mir-373-3p (MIRT002495), hsa-mir-192-5p (MIRT026716), hsa-mir-424-5p (MIRT000657), hsa-mir-25-3p (MIRT050321), hsa-mir-215-5p (MIRT024496), hsa-mir-16-5p (MIRT031809)

    Block miRNA regulation of human, mouse, rat KIF23 using miScript Target Protectors
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    hsa-miR-520f hsa-miR-522 hsa-miR-106a hsa-miR-15a hsa-miR-503 hsa-miR-485-3p hsa-miR-519a hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidKIF23 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KIF23_HUMAN, Q02241: Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to the interzone of
    mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005813centrosome IDA--
    GO:0005819spindle IDA15197175

    Find genes that share ontologies with KIF23           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KIF23 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    2Hemostasis
    Hemostasis0.43
    3Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    4Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    5Mitotic Telophase/Cytokinesis
    Mitotic Telophase/Cytokinesis


    Find genes that share SuperPaths with KIF23           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KIF23
        Mitotic Roles of Polo Like Kinases

    1 BioSystems Pathway for KIF23
        Aurora B signaling

    3 Reactome Pathways for KIF23
        Mitotic Telophase/Cytokinesis
    MHC class II antigen presentation
    Kinesins


    1 Kegg Pathway  (Kegg details for KIF23):
        MicroRNAs in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIF23
    Interactions:

        GeneGlobe Interaction Network for KIF23

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KIF23 (Q022411, 2, 3 ENSP000002603634) via UniProtKB, MINT, STRING, and/or I2D (see all 100)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARF6P623301, 2EBI-306852,EBI-638181 MINT-8397642 MINT-8398021 MINT-8397725 MINT-8397742 MINT-8397810 MINT-8397759 MINT-8397988 MINT-8397913 MINT-8397949 MINT-8395820 MINT-8397844 MINT-8397776 MINT-8398039 MINT-8397691 MINT-8397793 MINT-8397969 MINT-8397669 MINT-8397827 MINT-8398059 MINT-8397708 MINT-8398005 MINT-8397899 MINT-8400598
    Arf6P623311, 2EBI-306852,EBI-988682 MINT-8395840 MINT-8395860 MINT-8395795 MINT-8396005 MINT-8396027 MINT-8395740 MINT-8395779 MINT-8396047 MINT-8395709 MINT-8395756
    SFNP319472, 3MINT-3975708 I2D: score=2 
    RACGAP1Q9H0H51, 2, 3, ENSP000003098714EBI-306852,EBI-717233 MINT-8400617 MINT-6799707 MINT-8397624 MINT-8397862 MINT-6166596 MINT-8397899 I2D: score=1 STRING: ENSP00000309871
    YWHAZP631041, 2, 3, ENSP000003095034EBI-306852,EBI-347088 MINT-3297678 MINT-8009958 MINT-8397881 MINT-3318708 MINT-8397609 I2D: score=3 STRING: ENSP00000309503
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000022mitotic spindle elongation TAS1406973
    GO:0000278mitotic cell cycle TAS--
    GO:0000910cytokinesis IMP16236794
    GO:0007018microtubule-based movement TAS--
    GO:0007596blood coagulation TAS--

    Find genes that share ontologies with KIF23           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIF23



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KIF23 gene (3 alternative transcripts): 
    NM_001281301.1  NM_004856.6  NM_138555.3  

    Unigene Cluster for KIF23:

    Kinesin family member 23
    Hs.270845  [show with all ESTs]
    Unigene Representative Sequence: NM_138555
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559279(uc002asc.3) ENST00000395392 ENST00000352331(uc010ukc.2)
    ENST00000561089 ENST00000558346(uc010bih.2) ENST00000560042 ENST00000558585
    ENST00000559283 ENST00000559456 ENST00000558303 ENST00000560125 ENST00000559944
    ENST00000260363(uc002asb.3 uc010bii.3) ENST00000537891
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    hsa-miR-520f hsa-miR-522 hsa-miR-106a hsa-miR-15a hsa-miR-503 hsa-miR-485-3p hsa-miR-519a hsa-miR-103a
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    Additional mRNA sequence: 

    AK303874.1 AK308322.1 AK308361.1 AK310402.1 BC017705.2 BC051826.1 X67155.2 

    8 DOTS entries:

    DT.413636  DT.92424691  DT.100761107  DT.91701943  DT.92043513  DT.102830631  DT.105577  DT.40295047 

    Selected AceView cDNA sequences (see all 2388):

    CR616118 CD105966 AA339828 BU785321 BG340868 R92555 BE251829 AI718573 
    BX334622 BF036856 NM_004856 BU948119 BG575367 BM908554 BM423672 AJ712973 
    AI310507 BQ069059 BQ478307 BU074335 BG112764 BQ675449 AA372535 CB152465 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KIF23 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                                -                                                                                                     -                     
    SP2:                                -                                                                                                                           
    SP3:                                -     -                                                                                                                     
    SP4:                                                                                                                    -     -     -     -                     
    SP5:                                                                                                                                      -                     

    ExUns: 22 ^ 23
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for KIF23

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIF23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGATTTTT
    KIF23 Expression
    About this image


    KIF23 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Mesencephalic Ventricular Zone
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Bone (Muscoskeletal System)
    KIF23 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIF23 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.270845
        Custom PCR Arrays for KIF23
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KIF23 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kif231 , 5 kinesin family member 231, 5 86.94(n)1
    89.6(a)1
      9 (33.50 cM)5
    718191  NM_024245.41  NP_077207.31 
     619172805 
    chicken
    (Gallus gallus)
    Aves KIF231 kinesin family member 23 76.53(n)
    82.46(a)
      415567  NM_001030554.1  NP_001025725.1 
    lizard
    (Anolis carolinensis)
    Reptilia KIF236
    kinesin family member 23
    73(a)
    1 ↔ 1
    4(85611860-85635567)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.115372 Xenopus laevis, Similar to kinesin family member 23, more 78.51(n)    BC046735.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kif232 kinesin family member 23 75.4(n)   30627  AF139990.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pav1 pavarotti 49.76(n)
    44.83(a)
      38515  NM_057677.4  NP_477025.1 
    worm
    (Caenorhabditis elegans)
    Secernentea zen-41 zen-4 48.28(n)
    42.24(a)
      177374  NM_001028138.1  NP_001023309.1 


    ENSEMBL Gene Tree for KIF23 (if available)
    TreeFam Gene Tree for KIF23 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIF23 gene
    KIF20A2  KIF20B2  
    Selected SIMAP similar genes for KIF23 using alignment to 6 protein entries:     KIF23_HUMAN (see all proteins) (see all similar genes):
    KIF20A    KIF20B    CENPE    KIF13B    KIF13A    KIF18B
    A20    KIF5B-ALK    R11    R12    KIF1A    KIF3A
    KIF28P    KIF5C    KIFC3    KIF6    KIF27    KIF5A

    Find genes that share paralogs with KIF23           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for KIF23
    PGOHUM00000241589


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIF23 (see all 673)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37598241,2
    C,F--69709491(+) ATTTTT/GATTAA 2 -- int11Minor allele frequency- G:0.05EA 120
    rs1174404551,2
    C,F--69709541(+) ATCTAA/GTACAT 2 -- int11Minor allele frequency- G:0.03NA 120
    rs1503430491,2
    --69709610(+) GAGCTC/GTTAAA 2 -- int10--------
    rs1406484341,2
    C--69709635(+) TTTGT-/TGAA  
            
    TGAAT
    2 -- int10--------
    rs38345421,2
    C--69709638(+) AATGA-/ATGA  
            
    GAAGC
    2 -- int10--------
    rs1828721111,2
    C--69709685(+) AAGGTC/TGAACT 2 -- int10--------
    rs37598251,2
    C,F,A,H--69709686(+) AGGTCA/GAACTT 2 -- int130Minor allele frequency- G:0.13NS EA NA WA CSA EU 4072
    rs1494376511,2
    F--69709724(+) CAGGTA/GTACTG 4 V syn11Minor allele frequency- G:0.00NA 4548
    rs2016096501,2
    --69709737(+) GGGTGC/TGCCCA 4 R C mis10--------
    rs1485119301,2
    C,F--69709740(+) TGCGCC/ACACTG 4 /T /P mis12Minor allele frequency- A:0.00NA EU 5873

    HapMap Linkage Disequilibrium report for KIF23 (69706585 - 69740764 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KIF23:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1585CNV Insertion18451855
    nsv520964CNV Gain19592680
    dgv753e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): KIF23
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIF23
    DNA2.0 Custom Variant and Variant Library Synthesis for KIF23

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605064    OMIM disorders: --

    1 disease for KIF23:    
    About MalaCards
    congenital dyserythropoietic anemia type 3


    Find genes that share disorders with KIF23           About GenesLikeMe

    Genetic Association Database (GAD): KIF23
    Human Genome Epidemiology (HuGE) Navigator: KIF23 (1 document)

    Export disorders for KIF23 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIF23 gene, integrated from 10 sources (see all 79):
    (articles sorted by number of sources associating them with KIF23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles. (PubMed id 1406973)1, 2, 3 Nislow C.... McIntosh J.R. (Nature 1992)
    2. Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis. (PubMed id 22522702)1, 2 Makyio H....Nakayama K. (EMBO J. 2012)
    3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    4. Final stages of cytokinesis and midbody ring formation are controlled by BRUCE. (PubMed id 18329369)1, 2 Pohl C. and Jentsch S. (Cell 2008)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    6. Dissecting the role of Rho-mediated signaling in contractile ring formation. (PubMed id 16236794)1, 2 Kamijo K....Miki T. (Mol. Biol. Cell 2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. An ECT2-centralspindlin complex regulates the localization and function of RhoA. (PubMed id 16103226)1, 2 Yuce O.... Glotzer M. (J. Cell Biol. 2005)
    9. Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. (PubMed id 15297875)1, 2 Kurasawa Y.... Todokoro K. (EMBO J. 2004)
    10. Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis. (PubMed id 15197175)1, 2 Tomas A.... Moss S.E. (J. Cell Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9493 HGNC: 6392 AceView: RPLP1andKIF23 Ensembl:ENSG00000137807 euGenes: HUgn9493
    ECgene: KIF23 Kegg: 9493 H-InvDB: KIF23

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KIF23 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KIF23 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KIF23 gene:
    Search GeneIP for patents involving KIF23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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