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Aliases for KIF23 Gene

Aliases for KIF23 Gene

  • Kinesin Family Member 23 2 3
  • KNSL5 3 4 6
  • MKLP1 3 4 6
  • Kinesin-Like 5 (Mitotic Kinesin-Like Protein 1) 2 3
  • Mitotic Kinesin-Like Protein 1 4
  • Kinesin-Like Protein KIF23 3
  • Kinesin-Like Protein 5 4
  • MKLP-1 3
  • CHO1 3

External Ids for KIF23 Gene

Previous Symbols for KIF23 Gene

  • KNSL5

Summaries for KIF23 Gene

Entrez Gene Summary for KIF23 Gene

  • The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for KIF23 Gene

KIF23 (Kinesin Family Member 23) is a Protein Coding gene. Diseases associated with KIF23 include dyserythropoietic anemia, congenital, type iii. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cell Cycle, Mitotic. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIF20B.

UniProtKB/Swiss-Prot for KIF23 Gene

  • Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.

Gene Wiki entry for KIF23 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF23 Gene

Genomics for KIF23 Gene

Genomic Location for KIF23 Gene

Start:
69,414,246 bp from pter
End:
69,448,427 bp from pter
Size:
34,182 bases
Orientation:
Plus strand

Genomic View for KIF23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF23 Gene

Regulatory Elements for KIF23 Gene

Proteins for KIF23 Gene

  • Protein details for KIF23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02241-KIF23_HUMAN
    Recommended name:
    Kinesin-like protein KIF23
    Protein Accession:
    Q02241
    Secondary Accessions:
    • B4E1K0
    • Q8WVP0

    Protein attributes for KIF23 Gene

    Size:
    960 amino acids
    Molecular mass:
    110059 Da
    Quaternary structure:
    • Heterotetramer of two molecules each of RACGAP1 and KIF23. Found in the centralspindlin complex composed of RACGAP1 and KIF23. Interacts with RACGAP1; the interaction is direct. Interacts with ECT2 and PRC1. Interacts with ANXA11 during cytokinesis. Interacts with BIRC6/bruce and USP8/UBPY. Interacts with ARF6, forming heterodimers and heterotetramers.

    Three dimensional structures from OCA and Proteopedia for KIF23 Gene

    Alternative splice isoforms for KIF23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF23 Gene

Proteomics data for KIF23 Gene at MOPED

Post-translational modifications for KIF23 Gene

  • Ubiquitinated. Deubiquitinated by USP8/UBPY.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys149, Lys384, Lys503, Lys523, Lys571, Lys577, Lys599, Lys624, Lys643, and Lys741

Other Protein References for KIF23 Gene

No data available for DME Specific Peptides for KIF23 Gene

Domains for KIF23 Gene

Gene Families for KIF23 Gene

HGNC:
  • KIF :Kinesins

Protein Domains for KIF23 Gene

Suggested Antigen Peptide Sequences for KIF23 Gene

Graphical View of Domain Structure for InterPro Entry

Q02241

UniProtKB/Swiss-Prot:

KIF23_HUMAN
Domain:
  • Contains 1 kinesin motor domain.:
    • Q02241
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.:
    • Q02241
genes like me logo Genes that share domains with KIF23: view

Function for KIF23 Gene

Molecular function for KIF23 Gene

UniProtKB/Swiss-Prot Function: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.

Gene Ontology (GO) - Molecular Function for KIF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IBA --
GO:0005515 protein binding IPI 11782313
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IDA 11782313
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF23: view
genes like me logo Genes that share phenotypes with KIF23: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIF23 Gene

Localization for KIF23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF23 Gene

Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF23 Gene COMPARTMENTS Subcellular localization image for KIF23 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
extracellular 2

Gene Ontology (GO) - Cellular Components for KIF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11782313
GO:0005654 nucleoplasm TAS --
GO:0005813 centrosome IDA 20186884
GO:0005819 spindle IDA 15197175
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KIF23: view

Pathways for KIF23 Gene

genes like me logo Genes that share pathways with KIF23: view

Pathways by source for KIF23 Gene

1 Qiagen pathway for KIF23 Gene
1 BioSystems pathway for KIF23 Gene
1 KEGG pathway for KIF23 Gene

Gene Ontology (GO) - Biological Process for KIF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000022 mitotic spindle elongation TAS 1406973
GO:0000278 mitotic cell cycle TAS --
GO:0000281 mitotic cytokinesis IMP 15843429
GO:0000910 cytokinesis IMP 16236794
GO:0006200 obsolete ATP catabolic process --
genes like me logo Genes that share ontologies with KIF23: view

Transcripts for KIF23 Gene

Unigene Clusters for KIF23 Gene

Kinesin family member 23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF23 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - -
SP2: -
SP3: - -
SP4: - - - -
SP5: -
SP6:

ExUns: 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for KIF23 Gene

GeneLoc Exon Structure for
KIF23
ECgene alternative splicing isoforms for
KIF23

Expression for KIF23 Gene

mRNA expression in normal human tissues for KIF23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF23 Gene

SOURCE GeneReport for Unigene cluster for KIF23 Gene Hs.270845

genes like me logo Genes that share expressions with KIF23: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIF23 Gene

Orthologs for KIF23 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF23 35
  • 99.76 (n)
  • 99.48 (a)
KIF23 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIF23 35
  • 92.15 (n)
  • 94.32 (a)
KIF23 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF23 35
  • 89.54 (n)
  • 92.02 (a)
KIF23 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif23 35
  • 86.94 (n)
  • 89.6 (a)
Kif23 16
Kif23 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF23 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF23 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif23 35
  • 87.8 (n)
  • 89.59 (a)
chicken
(Gallus gallus)
Aves KIF23 35
  • 76.53 (n)
  • 82.46 (a)
KIF23 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF23 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11537 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kif23 35
  • 72.84 (n)
  • 77.37 (a)
Str.2307 35
zebrafish
(Danio rerio)
Actinopterygii kif23 35
  • 68.26 (n)
  • 74.15 (a)
kif23 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007706 35
  • 50.86 (n)
  • 47.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta pav 35
  • 49.76 (n)
  • 44.83 (a)
pav 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea zen-4 35
  • 48.28 (n)
  • 42.24 (a)
zen-4 36
  • 36 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3303 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9064 36
  • 43 (a)
OneToOne
Species with no ortholog for KIF23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF23 Gene

ENSEMBL:
Gene Tree for KIF23 (if available)
TreeFam:
Gene Tree for KIF23 (if available)

Paralogs for KIF23 Gene

Paralogs for KIF23 Gene

Pseudogenes.org Pseudogenes for KIF23 Gene

genes like me logo Genes that share paralogs with KIF23: view

Variants for KIF23 Gene

Sequence variations from dbSNP and Humsavar for KIF23 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs13613 -- 69,448,011(+) ATAGT(A/G)TATGT utr-variant-3-prime
rs937724 -- 69,440,397(-) GGTTC(A/G)GTAAC reference, synonymous-codon
rs1394416 -- 69,412,912(-) acaga(G/T)aggcc upstream-variant-2KB
rs1394417 -- 69,412,744(-) cattt(C/G)tgaag upstream-variant-2KB
rs3759824 -- 69,417,152(+) ATTTT(G/T)ATTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF23 Gene

Variant ID Type Subtype PubMed ID
dgv753e1 CNV Complex 17122850
nsv520964 CNV Gain 19592680
nsv1585 CNV Insertion 18451855

Relevant External Links for KIF23 Gene

HapMap Linkage Disequilibrium report
KIF23
Human Gene Mutation Database (HGMD)
KIF23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF23 Gene

Disorders for KIF23 Gene

Relevant External Links for KIF23

Genetic Association Database (GAD)
KIF23
Human Genome Epidemiology (HuGE) Navigator
KIF23
genes like me logo Genes that share disorders with KIF23: view

No data available for UniProtKB/Swiss-Prot for KIF23 Gene

Publications for KIF23 Gene

  1. A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles. (PMID: 1406973) Nislow C. … McIntosh J.R. (Nature 1992) 2 3 4
  2. Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis. (PMID: 15197175) Tomas A. … Moss S.E. (J. Cell Biol. 2004) 3 4
  3. Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. (PMID: 15297875) Kurasawa Y. … Todokoro K. (EMBO J. 2004) 3 4
  4. Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity. (PMID: 11782313) Mishima M. … Glotzer M. (Dev. Cell 2002) 3 4
  5. Nuclear localization of C-terminal domains of the kinesin-like protein MKLP-1. (PMID: 10403813) Deavours B.E. … Walker R.A. (Biochem. Biophys. Res. Commun. 1999) 3 23

Products for KIF23 Gene

Sources for KIF23 Gene

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