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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KIF23 Gene

protein-coding GIFtS: 60
GCID: GC15P069706

kinesin family member 23

(Previous name: kinesin-like 5 (mitotic kinesin-like protein 1) )
(Previous symbol: KNSL5)

Explore 8 diseases affiliated with
KIF23 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Kinesin Family Member 23¹ ²		Kinesin-Like Protein 5² ³
KNSL5¹ ² ³ ⁵		Mitotic Kinesin-Like Protein 1² ³
MKLP1¹ ² ³ ⁵		CHO1²
MKLP-1¹ ²		Kinesin-Like Protein KIF23²
Kinesin-Like 5 (Mitotic Kinesin-Like Protein 1)¹ ²		Mitotic Kinesin-Like 1²

External Ids:	HGNC: 6392¹	Entrez Gene: 9493²	Ensembl: ENSG00000137807⁷	OMIM: 605064⁵	UniProtKB: Q02241³

Export aliases for KIF23 gene to outside databases

Previous GC identifers: GC15P062805 GC15P067285 GC15P067422 GC15P067493 GC15P046539

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KIF23:

The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent

molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has

been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of

this gene results in two transcript variants encoding two different isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KIF23_HUMAN, Q02241

Function: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling

required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in

Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme

that moves antiparallel microtubules in vitro

Gene Wiki entry for KIF23

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KIF23 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B2 oct-B3 CUTL1 POU2F2 POU2F2C POU2F1 POU2F1a POU2F2B
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KIF23 promoter sequence

Search SABiosciences Chromatin IP Primers for KIF23

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF23

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23 Ensembl cytogenetic band: 15q23 HGNC cytogenetic band: 15q23

KIF23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF23 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P069706: view genomic region (about GC identifiers)

Start:	69,706,585 bp from pter	End:	69,740,764 bp from pter
Size:	34,180 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KIF23_HUMAN, Q02241 (See protein sequence)

Recommended Name: Kinesin-like protein KIF23

Size: 960 amino acids; 110059 Da

Subunit: Heterotetramer of two molecules each of RACGAP1 and KIF23. Found in the centralspindlin complex composed of

RACGAP1 and KIF23. Interacts with RACGAP1; the interaction is direct. Interacts with ECT2 and PRC1. Interacts with

ANXA11 during cytokinesis. Interacts with BIRC6/bruce and USP8/UBPY

Subcellular location: Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the interzone of mitotic spindles

1 PDB 3D structure from and Proteopedia for KIF23:

3VHX (3D)

Secondary accessions: Q8WVP0

Alternative splicing: 2 isoforms: Q02241-1 Q02241-2

Explore the universe of human proteins at neXtProt for KIF23: NX_Q02241

Post-translational modifications:

Ubiquitinated. Deubiquitinated by USP8/UBPY¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q02241

KIF23 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_004847.2 NP_612565.1

ENSEMBL proteins:

ENSP00000453386 ENSP00000378790 ENSP00000304978 ENSP00000453629 ENSP00000453576

ENSP00000453102 ENSP00000452901 ENSP00000260363 ENSP00000442969

Reactome Protein details: Q02241
Human Recombinant Protein Products for KIF23:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KIF23

Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	11782313
GO:0005654	nucleoplasm	TAS	--
GO:0005813	centrosome	IDA	--
GO:0005819	spindle	IDA	15197175
GO:0005829	cytosol	TAS	--

KIF23 for ontologies About GeneDecksing

KIF23 Antibody Products:

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Assay Products for KIF23:

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	Uscn ELISAs and CLIAs for KIF23

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KIF23 for domains About GeneDecksing

2 InterPro domains/families:

IPR001752 Kinesin_motor_dom

IPR019821 Kinesin_motor_CS

Graphical View of Domain Structure for InterPro Entry Q02241

ProtoNet protein and cluster: Q02241

1 Blocks protein family: IPB001752 Kinesin

UniProtKB/Swiss-Prot: KIF23_HUMAN, Q02241

Similarity: Belongs to the kinesin-like protein family

Similarity: Contains 1 kinesin-motor domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: KIF23_HUMAN, Q02241

Function: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling

required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in

Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme

that moves antiparallel microtubules in vitro

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003777	microtubule motor activity	IEA	--
GO:0005515	protein binding	IPI	18329369
GO:0005524	ATP binding	IEA	--
GO:0008017	microtubule binding	IDA	11782313

KIF23 for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for KIF23:

Cell division defect

Decreased cell number, increas

Increased cell number in G2M,

Upregulation of Wnt/beta-caten

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for KIF23

miRNA Products:		miRTarBase miRNAs that target KIF23: hsa-mir-373 (MIRT002495), hsa-mir-424 (MIRT000657)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIF23
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		hsa-miR-520f hsa-miR-522 hsa-miR-106a hsa-miR-15a hsa-miR-503 hsa-miR-485-3p hsa-miR-519a hsa-miR-103a

		SwitchGear 3'UTR luciferase reporter plasmid: KIF23 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF23

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

M Phase

M Phase

1.00

Mitotic M-M/G1 phases

0.88

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Kinesins

Kinesins

1.00

Kinesins move along microtubules consuming ATP

0.95

Cell Cycle

Cell Cycle

1.00

Cell Cycle, Mitotic

0.84

MHC class II antigen presentation

MHC class II antigen presentation

1.00

Transport of antigen loaded MHC II molecules to surface

0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for KIF23

Cytoplasmic microtubules

1 BioSystems Pathway for KIF23

Aurora B signaling

5/13 Reactome Pathways for KIF23 (see all 13)

	Hemostasis
	Mitotic Telophase/Cytokinesis
	Cell Cycle
	M Phase
	Adaptive Immune System

KIF23 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KIF23

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/66 Interacting proteins for KIF23 (Q02241^{1, 2, 3} ENSP00000260363⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 66)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARF6	P62330²	MINT-8397642 MINT-8398021 MINT-8397725 MINT-8397742 MINT-8397810 MINT-8397759 MINT-8397988 MINT-8397913 MINT-8397949 MINT-8395820 MINT-8397844 MINT-8397776 MINT-8398039 MINT-8397691 MINT-8397969 MINT-8397669 MINT-8397793 MINT-8397827 MINT-8398059 MINT-8397708 MINT-8398005 MINT-8397899 MINT-8400598
SFN	P31947²^,³	MINT-3975708 I2D: score=2
RACGAP1	Q9H0H5²^,³, ENSP00000309871⁴	MINT-8400617 MINT-6799707 MINT-8397624 MINT-8397862 MINT-6166596 MINT-8397899 I2D: score=1 STRING: ENSP00000309871
YWHAZ	P63104²^,³, ENSP00000309503⁴	MINT-3297678 MINT-8009958 MINT-8397881 MINT-3318708 MINT-8397609 I2D: score=3 STRING: ENSP00000309503
YWHAG	P61981²^,³, ENSP00000306330⁴	MINT-8009965 MINT-50855 I2D: score=4 STRING: ENSP00000306330

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000022	mitotic spindle elongation	TAS	1406973
GO:0000087	M phase of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0000910	cytokinesis	TAS	--
GO:0007018	microtubule-based movement	TAS	--

KIF23 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KIF23
Search CenterWatch for drugs/clinical trials and news about KIF23

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KIF23 gene (2 alternative transcripts):

NM_004856.5 NM_138555.2

Unigene Cluster for KIF23:

Kinesin family member 23

Hs.270845 [show with all ESTs]

Unigene Representative Sequence: NM_138555

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000559279(uc002asc.3) ENST00000395392 ENST00000352331(uc010ukc.2)

ENST00000561089 ENST00000558346(uc010bih.2) ENST00000560042 ENST00000558585

ENST00000559283 ENST00000559456 ENST00000558303 ENST00000560125 ENST00000559944

ENST00000260363(uc002asb.3 uc010bii.3) ENST00000537891

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		8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate KIF23 (see all 30):
		hsa-miR-520f hsa-miR-522 hsa-miR-106a hsa-miR-15a hsa-miR-503 hsa-miR-485-3p hsa-miR-519a hsa-miR-103a

		SwitchGear 3'UTR luciferase reporter plasmid: KIF23 3' UTR sequence

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Additional cDNA sequence:

AK303874.1 AK308322.1 AK308361.1 AK310402.1 BC017705.2 BC051826.1 X67155.2

8 DOTS entries:

DT.413636 DT.92424691 DT.100761107 DT.91701943 DT.92043513 DT.102830631 DT.105577 DT.40295047

24/2388 AceView cDNA sequences (see all 2388):

AI718187 AA340483 BU158139 BQ549169 BI517573 AA386022 BE276471 BM894102

BQ128215 BU149080 BQ582158 AV682312 AA378541 T19402 AA363474 AJ346291

AW327335 BU948242 BU931971 BQ671473 BQ478282 F18361 BU728011 BU783488

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KIF23 (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20	^	21	^
SP1:											-																																		-
SP2:											-
SP3:											-		-
SP4:																																							-		-		-		-
SP5:																																													-

ExUns:	22	^	23
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for KIF23

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KIF23 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTGATTTTT

About this image

KIF23 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

S-shaped Body

Kidney Endothelial Cells

Endothelium

Brain

Brain

Diencephalic Ventricular Zone

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Extraembryonic endoderm-like cells (Generation of extrae...)

See KIF23 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIF23

SOURCE GeneReport for Unigene cluster: Hs.270845

SABiosciences Custom PCR Arrays for KIF23

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF23

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KIF23 gene from 6/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KIF23¹	kinesin family member 23	75.57(n) 83.17(a)		415567 NM_001030554.1 NP_001025725.1
lizard (Anolis carolinensis)	Reptilia	KIF23⁶	--	73(a)	1 ↔ 1	4(85616123-85635039)
African clawed frog (Xenopus laevis)	Amphibia	Xl.11537²	Xenopus laevis, Similar to kinesin family member 23, more	78.51(n)		BC046735.1
zebrafish (Danio rerio)	Actinopterygii	kif23²	kinesin family member 23	75.4(n)		30627 AF139990.1
fruit fly (Drosophila melanogaster)	Insecta	pav¹	pavarotti	49.28(n) 44.32(a)		38515 NM_057677.3 NP_477025.1
worm (Caenorhabditis elegans)	Secernentea	zen-4¹	Protein ZEN-4	46.42(n) 37.81(a)		177374 NM_001028140.3 NP_001023311.1

ENSEMBL Gene Tree for KIF23 (if available)
TreeFam Gene Tree for KIF23 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KIF23 gene

KIF20A² KIF20B²

16 SIMAP similar genes for KIF23 using alignment to 6 protein entries: KIF23_HUMAN (see all proteins):

KIF20A KIF20B KIF21A CENPE KIF13B KIF13A

KIF18B KIF5B-ALK KIF1A KIF3A KLP6 KIF5C

KIFC3 KIF6 KIF27 KIF5A

KIF23 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for KIF23
PGOHUM00000241589

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1394417^1,2	C,H	--	46538042(-)	`CATTTC/GTGAAG`	1	--	int¹		4		NS EA	410
rs1394416^1,2	C	--	46538210(-)	`ACAGAG/TAGGCC`	1	--	int¹		2		NA	4
rs117032745^1,2	C,F	--	46539181(+)	`NNNNAT/CGTACA`	1	--	int¹		1		NA	120
rs77853593^1,2	F	--	46539457(+)	`CAAGAT/GCTCCC`	1	--	nc-transcript-variant		1		EA	120
rs76176579^1,2		--	46540379(+)	`TAAGCT/CAATAT`	1	--	us2k¹		2		CSA WA	120
rs74826317^1,2	C,F	--	46540410(+)	`TGGGTA/GANNNN`	1	--	us2k¹		1		NA	120
rs74752720^1,2		--	46540689(+)	`TAAATC/GTATAT`	1	--	us2k¹		0	--	--	--	--
rs190288324^1,2		--	69704734(+)	`CTCTCA/CTACAG`	3	--	us2k¹ int¹		0	--	--	--	--
rs183484913^1,2		--	69704765(+)	`GGACAA/C/GCTTTT`	3	--	int¹ us2k¹		0	--	--	--	--
rs139430251^1,2		--	69704849(+)	`GAAATA/GTTTCC`	3	--	int¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KIF23 (69706585 - 69740764 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KIF23
1 CNV: 3966

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KIF23 for disorders           About GeneDecksing

OMIM gene information: 605064    OMIM disorders: --

8 diseases for KIF23:    About MalaCards

papillary thyroid carcinoma thyroid carcinoma fibrosarcoma thyroiditis

pancreatic cancer breast cancer pancreatitis carcinoma

Human Genome Epidemiology (HuGE) Navigator: KIF23 (1 document)

Export disorders for KIF23 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KIF23 gene, integrated from 9 sources (see all 70):
(articles sorted by number of sources associating them with KIF23)

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A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles. (PubMed id 1406973)^{1, 2, 3} Nislow C.... McIntosh J.R. (1992)
Final stages of cytokinesis and midbody ring formation are controlled by BRUCE. (PubMed id 18329369)^{1, 2} Pohl C. and Jentsch S. (2008)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Dissecting the role of Rho-mediated signaling in contractile ring formation. (PubMed id 16236794)^{1, 2} Kamijo K....Miki T. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
An ECT2-centralspindlin complex regulates the localization and function of RhoA. (PubMed id 16103226)^{1, 2} Yuce O....Glotzer M. (2005)
Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. (PubMed id 15297875)^{1, 2} Kurasawa Y.... Todokoro K. (2004)
Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis. (PubMed id 15197175)^{1, 2} Tomas A.... Moss S.E. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity. (PubMed id 11782313)^{1, 2} Mishima M....Glotzer M. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9493	HGNC: 6392	AceView: RPLP1andKIF23	Ensembl:ENSG00000137807	euGenes: HUgn9493
ECgene: KIF23	H-InvDB: KIF23

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KIF23	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for KIF23	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for KIF23 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KIF23 gene:
Search GeneIP for patents involving KIF23

GeneCards and IP:
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kinesin family member 23

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kinesin family member 23

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