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Aliases for KIF23 Gene

Aliases for KIF23 Gene

  • Kinesin Family Member 23 2 3 5
  • Kinesin-Like 5 (Mitotic Kinesin-Like Protein 1) 2 3
  • KNSL5 3 4
  • MKLP1 3 4
  • Mitotic Kinesin-Like Protein 1 4
  • Kinesin-Like Protein 5 4
  • MKLP-1 3
  • CHO1 3

External Ids for KIF23 Gene

Previous HGNC Symbols for KIF23 Gene

  • KNSL5

Previous GeneCards Identifiers for KIF23 Gene

  • GC15P062805
  • GC15P067285
  • GC15P067422
  • GC15P067493
  • GC15P069706
  • GC15P046539

Summaries for KIF23 Gene

Entrez Gene Summary for KIF23 Gene

  • The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for KIF23 Gene

KIF23 (Kinesin Family Member 23) is a Protein Coding gene. Diseases associated with KIF23 include dyserythropoietic anemia, congenital, type iii and congenital dyserythropoietic anemia. Among its related pathways are Platelet activation, signaling and aggregation and Immune System. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF20B.

UniProtKB/Swiss-Prot for KIF23 Gene

  • Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.

Gene Wiki entry for KIF23 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF23 Gene

Genomics for KIF23 Gene

Regulatory Elements for KIF23 Gene

Promoters for KIF23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIF23 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIF23 Gene

Chromosome:
15
Start:
69,414,246 bp from pter
End:
69,448,427 bp from pter
Size:
34,182 bases
Orientation:
Plus strand

Genomic View for KIF23 Gene

Genes around KIF23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF23 Gene

Proteins for KIF23 Gene

  • Protein details for KIF23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02241-KIF23_HUMAN
    Recommended name:
    Kinesin-like protein KIF23
    Protein Accession:
    Q02241
    Secondary Accessions:
    • B4E1K0
    • Q8WVP0

    Protein attributes for KIF23 Gene

    Size:
    960 amino acids
    Molecular mass:
    110059 Da
    Quaternary structure:
    • Heterotetramer of two molecules each of RACGAP1 and KIF23. Found in the centralspindlin complex composed of RACGAP1 and KIF23. Interacts with RACGAP1; the interaction is direct. Interacts with ECT2 and PRC1. Interacts with ANXA11 during cytokinesis. Interacts with BIRC6/bruce and USP8/UBPY. Interacts with ARF6, forming heterodimers and heterotetramers.

    Three dimensional structures from OCA and Proteopedia for KIF23 Gene

    Alternative splice isoforms for KIF23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF23 Gene

Proteomics data for KIF23 Gene at MOPED

Post-translational modifications for KIF23 Gene

  • Ubiquitinated. Deubiquitinated by USP8/UBPY.
  • Ubiquitination at Lys 149, Lys 384, Lys 503, Lys 523, Lys 571, Lys 577, Lys 599, Lys 624, and Lys 643
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for KIF23 Gene

Domains & Families for KIF23 Gene

Gene Families for KIF23 Gene

Suggested Antigen Peptide Sequences for KIF23 Gene

Graphical View of Domain Structure for InterPro Entry

Q02241

UniProtKB/Swiss-Prot:

KIF23_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF23: view

Function for KIF23 Gene

Molecular function for KIF23 Gene

UniProtKB/Swiss-Prot Function:
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.

Gene Ontology (GO) - Molecular Function for KIF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11782313
genes like me logo Genes that share ontologies with KIF23: view
genes like me logo Genes that share phenotypes with KIF23: view

Human Phenotype Ontology for KIF23 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for KIF23 Gene

miRTarBase miRNAs that target KIF23

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF23 Gene

Localization for KIF23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF23 Gene

Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF23 Gene COMPARTMENTS Subcellular localization image for KIF23 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
extracellular 2

Gene Ontology (GO) - Cellular Components for KIF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11782313
GO:0005819 spindle IDA 15197175
GO:0005925 focal adhesion IDA 21423176
GO:0030496 midbody IDA 11782313
GO:0097149 centralspindlin complex IDA 11782313
genes like me logo Genes that share ontologies with KIF23: view

Pathways & Interactions for KIF23 Gene

genes like me logo Genes that share pathways with KIF23: view

Pathways by source for KIF23 Gene

1 BioSystems pathway for KIF23 Gene
15 Reactome pathways for KIF23 Gene
1 KEGG pathway for KIF23 Gene
1 Qiagen pathway for KIF23 Gene

Gene Ontology (GO) - Biological Process for KIF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000915 actomyosin contractile ring assembly IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0008152 metabolic process IEA --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
GO:0032467 positive regulation of cytokinesis IMP 16103226
genes like me logo Genes that share ontologies with KIF23: view

No data available for SIGNOR curated interactions for KIF23 Gene

Drugs & Compounds for KIF23 Gene

No Compound Related Data Available

Transcripts for KIF23 Gene

Unigene Clusters for KIF23 Gene

Kinesin family member 23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF23 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - -
SP2: -
SP3: - -
SP4: - - - -
SP5: -
SP6:

ExUns: 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for KIF23 Gene

GeneLoc Exon Structure for
KIF23
ECgene alternative splicing isoforms for
KIF23

Expression for KIF23 Gene

mRNA expression in normal human tissues for KIF23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIF23 Gene

This gene is overexpressed in Testis (32.0), Lung (18.5), and Ovary (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF23 Gene



SOURCE GeneReport for Unigene cluster for KIF23 Gene Hs.270845

genes like me logo Genes that share expression patterns with KIF23: view

Protein tissue co-expression partners for KIF23 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIF23 Gene

Orthologs for KIF23 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF23 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIF23 35
  • 92.15 (n)
  • 94.32 (a)
KIF23 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF23 35
  • 89.54 (n)
  • 92.02 (a)
KIF23 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif23 35
  • 86.94 (n)
  • 89.6 (a)
Kif23 16
Kif23 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIF23 35
  • 99.76 (n)
  • 99.48 (a)
KIF23 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif23 35
  • 87.8 (n)
  • 89.59 (a)
oppossum
(Monodelphis domestica)
Mammalia KIF23 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF23 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF23 35
  • 76.53 (n)
  • 82.46 (a)
KIF23 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF23 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif23 35
  • 72.84 (n)
  • 77.37 (a)
Str.2307 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.11537 35
zebrafish
(Danio rerio)
Actinopterygii kif23 35
  • 68.26 (n)
  • 74.15 (a)
kif23 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007706 35
  • 50.86 (n)
  • 47.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta pav 35
  • 49.76 (n)
  • 44.83 (a)
pav 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea zen-4 35
  • 48.28 (n)
  • 42.24 (a)
zen-4 36
  • 36 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3303 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9064 36
  • 43 (a)
OneToOne
Species with no ortholog for KIF23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF23 Gene

ENSEMBL:
Gene Tree for KIF23 (if available)
TreeFam:
Gene Tree for KIF23 (if available)

Paralogs for KIF23 Gene

Paralogs for KIF23 Gene

Pseudogenes.org Pseudogenes for KIF23 Gene

genes like me logo Genes that share paralogs with KIF23: view

Variants for KIF23 Gene

Sequence variations from dbSNP and Humsavar for KIF23 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs17310879 - 69,436,710(+) ATGAG(C/T)TTAAC reference, missense
rs13613 -- 69,448,011(+) ATAGT(A/G)TATGT utr-variant-3-prime
rs937724 -- 69,440,397(-) GGTTC(A/G)GTAAC reference, synonymous-codon
rs3825858 -- 69,436,610(+) TTGCC(A/G)TCATG reference, synonymous-codon
rs3834542 -- 69,417,315(+) AATGA(-/ATGA)GAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF23 Gene

Variant ID Type Subtype PubMed ID
dgv753e1 CNV Complex 17122850
nsv520964 CNV Gain 19592680
nsv1585 CNV Insertion 18451855

Variation tolerance for KIF23 Gene

Residual Variation Intolerance Score: 27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.17; 61.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF23 Gene

HapMap Linkage Disequilibrium report
KIF23
Human Gene Mutation Database (HGMD)
KIF23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF23 Gene

Disorders for KIF23 Gene

MalaCards: The human disease database

(3) MalaCards diseases for KIF23 Gene - From: GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
dyserythropoietic anemia, congenital, type iii
  • congenital dyserythropoietic anemia, type iii
congenital dyserythropoietic anemia
  • congenital dyshaematopoietic anaemia
neonatal anemia
  • anemia neonatal
- elite association - COSMIC cancer census association via MalaCards
Search KIF23 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KIF23

Genetic Association Database (GAD)
KIF23
Human Genome Epidemiology (HuGE) Navigator
KIF23
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF23
genes like me logo Genes that share disorders with KIF23: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF23 Gene

Publications for KIF23 Gene

  1. A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles. (PMID: 1406973) Nislow C. … McIntosh J.R. (Nature 1992) 2 3 4 67
  2. CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase. (PMID: 19015243) Seguin L. … Bertoglio J. (Mol. Cell. Biol. 2009) 3 23
  3. The nuclear localization signal of mitotic kinesin-like protein Mklp-1: effect on Mklp-1 function during cytokinesis. (PMID: 17198681) Liu X. … Erikson R.L. (Biochem. Biophys. Res. Commun. 2007) 3 23
  4. Recruitment of MKLP1 to the spindle midzone/midbody by INCENP is essential for midbody formation and completion of cytokinesis in human cells. (PMID: 15796717) Zhu C. … Jiang W. (Biochem. J. 2005) 3 23
  5. Nuclear localization of C-terminal domains of the kinesin-like protein MKLP-1. (PMID: 10403813) Deavours B.E. … Walker R.A. (Biochem. Biophys. Res. Commun. 1999) 3 23

Products for KIF23 Gene

Sources for KIF23 Gene

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