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Aliases for KIF22 Gene

Aliases for KIF22 Gene

  • Kinesin Family Member 22 2 3
  • KNSL4 3 4 6
  • KID 3 4 6
  • Kinesin-Like Protein 4 3 4
  • SEMDJL2 3 6
  • OBP 3 6
  • Origin Of Plasmid DNA Replication-Binding Protein 3
  • Kinesin-Like DNA-Binding Protein Pseudogene 3
  • Kinesin-Like DNA-Binding Protein 4
  • Kinesin-Like Protein KIF22 3
  • OriP Binding Protein 3
  • Kinesin-Like 4 2
  • A-328A3.2 3
  • OBP-1 3
  • OBP-2 3

External Ids for KIF22 Gene

Previous HGNC Symbols for KIF22 Gene

  • KNSL4

Previous GeneCards Identifiers for KIF22 Gene

  • GC16P030125
  • GC16P029800
  • GC16P029839
  • GC16P029709
  • GC16P027462

Summaries for KIF22 Gene

Entrez Gene Summary for KIF22 Gene

  • The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for KIF22 Gene

KIF22 (Kinesin Family Member 22) is a Protein Coding gene. Diseases associated with KIF22 include spondyloepimetaphyseal dysplasia with joint laxity, type 2 and spondyloepimetaphyseal dysplasia with multiple dislocations. Among its related pathways are Class I MHC mediated antigen processing and presentation and Hemostasis. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIF14.

UniProtKB/Swiss-Prot for KIF22 Gene

  • Kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA

Gene Wiki entry for KIF22 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF22 Gene

Genomics for KIF22 Gene

Regulatory Elements for KIF22 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIF22 Gene

29,790,062 bp from pter
29,805,385 bp from pter
15,324 bases
Plus strand

Genomic View for KIF22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF22 Gene

Proteins for KIF22 Gene

  • Protein details for KIF22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kinesin-like protein KIF22
    Protein Accession:
    Secondary Accessions:
    • B2R5M0
    • B7Z265
    • O60845
    • O94814
    • Q53F58
    • Q9BT46

    Protein attributes for KIF22 Gene

    665 amino acids
    Molecular mass:
    73262 Da
    Quaternary structure:
    • Interacts with FAM83D.
    • Sequence=AAC08709.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW80007.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIF22 Gene

    Alternative splice isoforms for KIF22 Gene


neXtProt entry for KIF22 Gene

Proteomics data for KIF22 Gene at MOPED

Post-translational modifications for KIF22 Gene

  • Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
  • Ubiquitination at Lys133, Lys213, Lys253, Lys269, Lys465, Lys591, and Lys643
  • Modification sites at PhosphoSitePlus

Other Protein References for KIF22 Gene

Antibody Products

No data available for DME Specific Peptides for KIF22 Gene

Domains for KIF22 Gene

Gene Families for KIF22 Gene

  • KIF :Kinesins

Suggested Antigen Peptide Sequences for KIF22 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q14807
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF22: view

Function for KIF22 Gene

Molecular function for KIF22 Gene

UniProtKB/Swiss-Prot Function:
Kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA

Gene Ontology (GO) - Molecular Function for KIF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003777 microtubule motor activity IBA --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF22: view
genes like me logo Genes that share phenotypes with KIF22: view

Animal Models for KIF22 Gene

MGI Knock Outs for KIF22:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF22

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KIF22 Gene

Localization for KIF22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF22 Gene

Nucleus. Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for KIF22 Gene COMPARTMENTS Subcellular localization image for KIF22 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 4
mitochondrion 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for KIF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore TAS 8599929
GO:0000785 chromatin IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with KIF22: view

Pathways for KIF22 Gene

genes like me logo Genes that share pathways with KIF22: view

Gene Ontology (GO) - Biological Process for KIF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006281 DNA repair IEA --
GO:0007018 microtubule-based movement TAS --
GO:0007062 sister chromatid cohesion IMP 15843429
GO:0007067 mitotic nuclear division TAS 8599929
genes like me logo Genes that share ontologies with KIF22: view

Compounds for KIF22 Gene

(2) ApexBio Compounds for KIF22 Gene

Compound Action Cas Number
GSK-923295 "CENP-E inhibitor,small-molecule" [1088965-37-0]
MPI-0479605 "Mps1 inhibitor,selective and ATP competitive" [1246529-32-7]

(1) Novoseek inferred chemical compound relationships for KIF22 Gene

Compound -log(P) Hits PubMed IDs
atp 0 3
genes like me logo Genes that share compounds with KIF22: view

Transcripts for KIF22 Gene

Unigene Clusters for KIF22 Gene

Kinesin family member 22:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF22

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF22 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - - - - -
SP2: -
SP4: - -
SP5: -

Relevant External Links for KIF22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIF22 Gene

mRNA expression in normal human tissues for KIF22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for KIF22 Gene

This gene is overexpressed in Cardia (28.4), Prostate (11.8), Lymph node (8.1), and Oral epithelium (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF22 Gene

SOURCE GeneReport for Unigene cluster for KIF22 Gene Hs.612151

mRNA Expression by UniProt/SwissProt for KIF22 Gene

Tissue specificity: Expressed in bone, cartilage, joint capsule, ligament, skin, and primary cultured chondrocytes.
genes like me logo Genes that share expressions with KIF22: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for KIF22 Gene

Orthologs for KIF22 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF22 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KIF22 35
  • 89.37 (n)
  • 93.47 (a)
KIF22 36
  • 92 (a)
(Canis familiaris)
Mammalia KIF22 35
  • 88.96 (n)
  • 91.83 (a)
KIF22 36
  • 91 (a)
(Mus musculus)
Mammalia Kif22 35
  • 82.04 (n)
  • 82.19 (a)
Kif22 16
Kif22 36
  • 82 (a)
(Pan troglodytes)
Mammalia KIF22 35
  • 99.4 (n)
  • 99.25 (a)
KIF22 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Kif22 35
  • 82.8 (n)
  • 84.29 (a)
(Monodelphis domestica)
Mammalia KIF22 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia KIF22 36
  • 71 (a)
(Anolis carolinensis)
Reptilia KIF22 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kif22 35
  • 59.84 (n)
  • 57.9 (a)
MGC75575 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.512 35
(Danio rerio)
Actinopterygii kif22 35
  • 58.53 (n)
  • 56.86 (a)
kif22 36
  • 53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIP3 36
  • 20 (a)
Species with no ortholog for KIF22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIF22 Gene

Gene Tree for KIF22 (if available)
Gene Tree for KIF22 (if available)

Paralogs for KIF22 Gene

genes like me logo Genes that share paralogs with KIF22: view

Variants for KIF22 Gene

Sequence variations from dbSNP and Humsavar for KIF22 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs235628 -- 29,795,383(+) CTTTG(C/T)AGGGG intron-variant
rs235629 -- 29,797,387(+) GTTGG(C/G)GGAAC intron-variant
rs235646 -- 29,791,094(+) CTTTT(C/T)CTTTG intron-variant, utr-variant-5-prime
rs235647 -- 29,793,557(+) TGACC(G/T)GCCTA intron-variant
rs235648 -- 29,799,998(+) GAGAT(C/T)GGGAG reference, synonymous-codon, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF22 Gene

Variant ID Type Subtype PubMed ID
dgv34n68 CNV Loss 17160897
nsv833186 CNV Loss 17160897
dgv2667n71 CNV Loss 21882294

Relevant External Links for KIF22 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF22 Gene

Disorders for KIF22 Gene

(1) OMIM Diseases for KIF22 Gene (603213)


  • Spondyloepimetaphyseal dysplasia with joint laxity, 2 (SEMDJL2) [MIM:603546]: A bone disease characterized by short stature, distinctive midface retrusion, progressive knee malalignment (genu valgum and/or varum), generalized ligamentous laxity, and mild spinal deformity. Intellectual development is not impaired. Radiographic characteristics include significantly retarded epiphyseal ossification that evolves into epiphyseal dysplasia and precocious osteoarthritis, metaphyseal irregularities and vertical striations, constricted femoral neck, slender metacarpals and metatarsals, and mild thoracolumbar kyphosis or scoliosis with normal or mild platyspondyly. The most distinctive features for differential diagnosis of SEMDJL2 are the slender metacarpals and phalanges and the progressive degeneration of carpal bones; however, these 2 features are evident only in older children and young adults. The soft consistency of cartilage in the airways leads to laryngotracheomalacia with proneness to respiratory obstruction and inspiratory stridor in infancy and childhood. {ECO:0000269 PubMed:22152677, ECO:0000269 PubMed:22152678}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for KIF22 Gene

(3) Novoseek inferred disease relationships for KIF22 Gene

Disease -log(P) Hits PubMed IDs
herpes simplex 50.7 5
breast cancer 13.2 8
metastasis 0 4
genes like me logo Genes that share disorders with KIF22: view

No data available for Genatlas and External Links for KIF22 Gene

Publications for KIF22 Gene

  1. Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle. (PMID: 8599929) Tokai N. … Yamamoto T. (EMBO J. 1996) 2 3 4 23
  2. Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2. (PMID: 9790757) Song J. … Yokoyama K.K. (Genomics 1998) 3 4 23
  3. SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. (PMID: 11146551) Germani A. … Calvo F. (Oncogene 2000) 3 4 23
  4. Distinct expression patterns of the E3 ligase SIAH-1 and its partner Kid/KIF22 in normal tissues and in the breast tumoral processes. (PMID: 20144232) Bruzzoni-Giovanelli H. … MarA-n M. (J. Exp. Clin. Cancer Res. 2010) 3 23
  5. All kinesin superfamily protein, KIF, genes in mouse and human. (PMID: 11416179) Miki H. … Hirokawa N. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3

Products for KIF22 Gene

Sources for KIF22 Gene

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