Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KIF21B Gene

Aliases for KIF21B Gene

  • Kinesin Family Member 21B 2 3 5
  • KIAA0449 4

External Ids for KIF21B Gene

Previous GeneCards Identifiers for KIF21B Gene

  • GC01M198226
  • GC01M198231
  • GC01M197674
  • GC01M199205
  • GC01M172186

Summaries for KIF21B Gene

Entrez Gene Summary for KIF21B Gene

  • This gene encodes a member of the kinesin superfamily. Kinesins are ATP-dependent microtubule-based motor proteins that are involved in the intracellular transport of membranous organelles. Single nucleotide polymorphisms in this gene are associated with inflammatory bowel disease and multiple sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for KIF21B Gene

KIF21B (Kinesin Family Member 21B) is a Protein Coding gene. Diseases associated with KIF21B include Tukel Syndrome. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Golgi-to-ER retrograde transport. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF21A.

UniProtKB/Swiss-Prot for KIF21B Gene

  • Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface.

Additional gene information for KIF21B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF21B Gene

Genomics for KIF21B Gene

Regulatory Elements for KIF21B Gene

Enhancers for KIF21B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H200970 0.9 ENCODE 11.5 +53.5 53513 0.1 HDGF PKNOX1 TBL1XR1 RB1 BMI1 BATF RAD21 ZNF143 ZNF207 ATF7 ENSG00000234132 KIF21B ENSG00000229191 INAVA PIR41355 GC01P200949
GH01H201094 0.9 ENCODE dbSUPER 10.6 -74.0 -74021 6.5 PKNOX1 ZNF175 CEBPB CEBPG ZIC2 FOSL1 ZFHX2 ZNF589 IKZF1 ATF7 ENSG00000234132 RNU6-704P ENSG00000229191 KIF21B IGFN1 ENSG00000229821 GPR25 LAD1 PKP1 GC01M201077
GH01H200972 0.7 ENCODE 11.6 +51.6 51553 0.2 CTCF ZNF654 MAZ NFIB ZNF740 ELF1 REST RAD21 CC2D1A PATZ1 ENSG00000234132 KIF21B ENSG00000229191 CACNA1S ASCL5 PIR41355
GH01H200887 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.6 +135.4 135389 1.9 HDGF PKNOX1 TBL1XR1 ARID4B BMI1 BATF ZNF143 ZNF207 ATF7 ETV6 DDX59 ENSG00000234132 MROH3P KIF21B INAVA GPR25
GH01H200880 1.4 FANTOM5 ENCODE dbSUPER 1.4 +143.3 143268 0.2 PKNOX1 TBL1XR1 BACH1 BMI1 EBF1 BATF RELA POLR2A EED ATF7 KIF21B GPR25 INAVA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIF21B on UCSC Golden Path with GeneCards custom track

Promoters for KIF21B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000018023 200 1001 TBP RB1 GLIS2 CREM IKZF2 EGR2 NFYC SMARCB1 SP1 NFIC

Genomic Locations for KIF21B Gene

Genomic Locations for KIF21B Gene
chr1:200,969,386-201,023,700
(GRCh38/hg38)
Size:
54,315 bases
Orientation:
Minus strand
chr1:200,938,520-200,992,828
(GRCh37/hg19)

Genomic View for KIF21B Gene

Genes around KIF21B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF21B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF21B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF21B Gene

Proteins for KIF21B Gene

  • Protein details for KIF21B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75037-KI21B_HUMAN
    Recommended name:
    Kinesin-like protein KIF21B
    Protein Accession:
    O75037
    Secondary Accessions:
    • B2RP62
    • B7ZMI0
    • Q5T4J3

    Protein attributes for KIF21B Gene

    Size:
    1637 amino acids
    Molecular mass:
    182662 Da
    Quaternary structure:
    • Interacts with TRIM3; the interaction positively affects motility of KIF21B. Interacts with GABARAP and GABA(A) receptor subunits: GABRG2, GABRA1 and GABRA2. May interact with GABA(A) receptor subunits: GABRB2 and GABRB3.
    SequenceCaution:
    • Sequence=BAA32294.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF21B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF21B Gene

Post-translational modifications for KIF21B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIF21B Gene

Domains & Families for KIF21B Gene

Gene Families for KIF21B Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KIF21B Gene

Graphical View of Domain Structure for InterPro Entry

O75037

UniProtKB/Swiss-Prot:

KI21B_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF21B: view

Function for KIF21B Gene

Molecular function for KIF21B Gene

UniProtKB/Swiss-Prot Function:
Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface.

Phenotypes From GWAS Catalog for KIF21B Gene

Gene Ontology (GO) - Molecular Function for KIF21B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IBA --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF21B: view
genes like me logo Genes that share phenotypes with KIF21B: view

Animal Models for KIF21B Gene

MGI Knock Outs for KIF21B:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF21B Gene

Localization for KIF21B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF21B Gene

Cytoplasm, cytoskeleton. Cell projection, dendrite. Cell projection, growth cone. Cell projection, axon. Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF21B gene
Compartment Confidence
cytoskeleton 4
cytosol 3

Gene Ontology (GO) - Cellular Components for KIF21B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with KIF21B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KIF21B Gene

Pathways & Interactions for KIF21B Gene

genes like me logo Genes that share pathways with KIF21B: view

Gene Ontology (GO) - Biological Process for KIF21B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IBA --
genes like me logo Genes that share ontologies with KIF21B: view

No data available for SIGNOR curated interactions for KIF21B Gene

Drugs & Compounds for KIF21B Gene

No Compound Related Data Available

Transcripts for KIF21B Gene

mRNA/cDNA for KIF21B Gene

Unigene Clusters for KIF21B Gene

Kinesin family member 21B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF21B Gene

No ASD Table

Relevant External Links for KIF21B Gene

GeneLoc Exon Structure for
KIF21B
ECgene alternative splicing isoforms for
KIF21B

Expression for KIF21B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF21B Gene

mRNA differential expression in normal tissues according to GTEx for KIF21B Gene

This gene is overexpressed in Whole Blood (x8.1), Brain - Cortex (x4.6), and Brain - Amygdala (x4.2).

Protein differential expression in normal tissues from HIPED for KIF21B Gene

This gene is overexpressed in Pancreatic juice (37.5), Fetal Brain (8.5), and Brain (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIF21B Gene



NURSA nuclear receptor signaling pathways regulating expression of KIF21B Gene:

KIF21B

SOURCE GeneReport for Unigene cluster for KIF21B Gene:

Hs.169182

Evidence on tissue expression from TISSUES for KIF21B Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with KIF21B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF21B Gene

Orthologs for KIF21B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIF21B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF21B 33 34
  • 98.06 (n)
dog
(Canis familiaris)
Mammalia KIF21B 33 34
  • 91.41 (n)
oppossum
(Monodelphis domestica)
Mammalia KIF21B 34
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF21B 34
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif21b 33
  • 88.64 (n)
mouse
(Mus musculus)
Mammalia Kif21b 33 16 34
  • 88.58 (n)
cow
(Bos Taurus)
Mammalia KIF21B 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF21B 33 34
  • 83 (n)
lizard
(Anolis carolinensis)
Reptilia KIF21B 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif21b 33
  • 64.81 (n)
zebrafish
(Danio rerio)
Actinopterygii KIF21B 34
  • 74 (a)
OneToOne
kif21b 33
  • 73.69 (n)
fruit fly
(Drosophila melanogaster)
Insecta Klp31E 34
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea klp-12 34
  • 36 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.22630 33
corn
(Zea mays)
Liliopsida Zm.11718 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2958 34
  • 43 (a)
OneToMany
Species where no ortholog for KIF21B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF21B Gene

ENSEMBL:
Gene Tree for KIF21B (if available)
TreeFam:
Gene Tree for KIF21B (if available)

Paralogs for KIF21B Gene

Paralogs for KIF21B Gene

(8) SIMAP similar genes for KIF21B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIF21B: view

Variants for KIF21B Gene

Sequence variations from dbSNP and Humsavar for KIF21B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs750865418 Uncertain significance 200,996,249(+) CCTCT(C/G/T)GTAGC reference, missense
rs796052152 Uncertain significance 200,987,009(-) CTACC(C/T)GGGGC reference, missense
rs1000097253 -- 200,983,668(+) CCAAG(C/G)CCTCC intron-variant
rs1000147975 -- 200,983,378(+) CCCAC(A/G)CATGG intron-variant
rs1000153475 -- 200,986,660(+) GCCCA(C/T)TTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF21B Gene

Variant ID Type Subtype PubMed ID
nsv472323 CNV novel sequence insertion 20440878
nsv1142787 CNV deletion 24896259
nsv1075401 CNV duplication 25765185
nsv1069197 CNV deletion 25765185
esv989611 CNV deletion 20482838
esv3588567 CNV loss 21293372
esv3364403 CNV duplication 20981092
esv33174 CNV loss 17666407
esv2721395 CNV deletion 23290073
esv2678555 CNV deletion 23128226
dgv267e59 CNV duplication 20981092

Variation tolerance for KIF21B Gene

Residual Variation Intolerance Score: 0.711% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.26; 62.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF21B Gene

Human Gene Mutation Database (HGMD)
KIF21B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF21B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF21B Gene

Disorders for KIF21B Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF21B Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
tukel syndrome
  • congenital fibrosis of the extraocular muscles
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for KIF21B

Genetic Association Database (GAD)
KIF21B
Human Genome Epidemiology (HuGE) Navigator
KIF21B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF21B
genes like me logo Genes that share disorders with KIF21B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF21B Gene

Publications for KIF21B Gene

  1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 60
  2. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. (PMID: 21743469) Evans DM … Wellcome Trust Case Control Consortium 2 (WTCCC2) (Nature genetics 2011) 3 45 60
  3. Replication of KIF21B as a susceptibility locus for multiple sclerosis. (PMID: 20587413) Goris A … Dubois B (Journal of medical genetics 2010) 3 45 60
  4. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. (PMID: 19915572) UK IBD Genetics Consortium … Strachan DP (Nature genetics 2009) 3 45 60
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60

Products for KIF21B Gene

Sources for KIF21B Gene

Content
Loading form....