KIF21B Gene
protein-coding GIFtS: 50
GCID: GC01M200938
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kinesin family member 21B
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Aliases
for KIF21B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kinesin Family Member 21B1 2 | | KIAA04491 3 5 | | DKFZP434J2121 | | Kinesin-Like Protein KIF21B2 |
Export aliases for KIF21B gene to outside databasesPrevious GC identifers: GC01M198226 GC01M198231 GC01M197674 GC01M199205 GC01M172186 |
Summaries
for KIF21B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KIF21B:
This gene encodes a member of the kinesin superfamily. Kinesins are ATP-dependent microtubule-based motor proteins thatare involved in the intracellular transport of membranous organelles. Single nucleotide polymorphisms in this gene areassociated with inflammatory bowel disease and multiple sclerosis. Alternatively spliced transcript variants encodingmultiple isoforms have been observed for this gene. (provided by RefSeq, Nov 2011)
UniProtKB/Swiss-Prot: KI21B_HUMAN, O75037Function: Microtubule-binding motor protein probably involved in neuronal dendritic transport. In vitro, has a plus-enddirected motor activity (By similarity)
|
Genomic Views
for KIF21B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KIF21B gene promoter:
RFX1 NF-YA NF-YC CBF-C NF-YB CBF-B CBF-A CP1A CP1C NF-Y
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIF21B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF21B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1KIF21B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M200938: view genomic region
(about GC identifiers)
Start:
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200,938,520 bp from pter |
End:
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200,992,828 bp from pter |
Size:
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54,309 bases |
Orientation:
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minus strand |
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Proteins
for KIF21B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KI21B_HUMAN, O75037 (See
protein sequence)Recommended Name: Kinesin-like protein KIF21B Size: 1637 amino acids; 182662 Da
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
Sequence caution: Sequence=BAA32294.2; Type=Erroneous initiation;
Secondary accessions: B2RP62 B7ZMI0 Q5T4J3Alternative splicing: 4 isoforms: O75037-1 O75037-2 O75037-3 O75037-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KIF21B: NX_O75037
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75037
KIF21B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001239029.1 NP_001239031.1 NP_001239032.1 NP_060066.2
ENSEMBL proteins: ENSP00000435557 ENSP00000328494 ENSP00000353724 ENSP00000433808 ENSP00000411831
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
KIF21B for ontologies About GeneDecksing
KIF21B Antibody Products:
Assay Products for KIF21B: |
Protein
Domains /
Families
for KIF21B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KIF21B for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry O75037ProtoNet protein and cluster: O75037 UniProtKB/Swiss-Prot: KI21B_HUMAN, O75037Similarity: Belongs to the kinesin-like protein familySimilarity: Contains 1 kinesin-motor domainSimilarity: Contains 7 WD repeats |
Function
for KIF21B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KI21B_HUMAN, O75037Function: Microtubule-binding motor protein probably involved in neuronal dendritic transport. In vitro, has a plus-enddirected motor activity (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF21B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF21B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF21B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003777 | microtubule motor activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
KIF21B for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for KIF21B:
|
Pathways & Interactions
for KIF21B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIF21B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/8 Interacting proteins for KIF21B (O750372, 3 ENSP000003284944) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007018 | microtubule-based movement |
IEA | -- |
KIF21B for ontologies About GeneDecksing
|
Drugs & Compounds
for KIF21B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KIF21B
Search CenterWatch for drugs/clinical trials and news about KIF21B / KI21B
|
Transcripts
for KIF21B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KIF21B gene (4 alternative transcripts): NM_001252100.1 NM_001252102.1 NM_001252103.1 NM_017596.3 Unigene Cluster for KIF21B: Kinesin family member 21B Hs.169182 [show with all ESTs]Unigene Representative Sequence: NM_0012521006 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000477146 ENST00000332129(uc001gvs.2 uc009wzl.2 uc001gvr.2 uc010ppn.2)
ENST00000360529 ENST00000461742 ENST00000422435 ENST00000534043(uc001gvt.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF21B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF21B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KIF21B (NM_017596) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIF21B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF21B |
Additional cDNA sequence: AB007918.2 AL137395.1 AM177180.1 BC031927.1 BC052964.1 BC078676.1 BC137281.1 BC144557.1 6 DOTS entries: DT.85105249 DT.95129471 DT.40115568 DT.100822040 DT.95167364 DT.102828181 24/121 AceView cDNA sequences (see all 121): BM697589 AB007918 T33465 BF934208 CR596112 BX645784 T33421 BU735773 AA911750 BU169353 BX418067 AJ705143 BM451715 BM825198 BC078676 CK299723 BG820466 AW468259 BM850865 BM929801 BM728300 AI832692 BC052964 CR608417
GeneLoc Exon Structure
|
Expression
for KIF21B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIF21B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTACATTT
About this image
See KIF21B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIF21B
SOURCE GeneReport for Unigene cluster: Hs.169182
SABiosciences Custom PCR Arrays for KIF21B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIF21B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIF21B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF21B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF21B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF21B |
Orthologs
for KIF21B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KIF21B gene from 6/24 species (see all 24) About this table
ENSEMBL Gene Tree for KIF21B (if available)
TreeFam Gene Tree for KIF21B (if available) |
Paralogs
for KIF21B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KIF21B gene
- KIF5C2 KIF21A2 KIF112 KIF3B2 KIF92 KIF172 KIF4B2 KIF272
- KIF3A2 KIF4A2 KIF5B2 KIF62 KIF152 CENPE2 KIF5A2 KIF72
- KIF3C2
8 SIMAP similar genes for KIF21B using alignment to 3 protein entries: KI21B_HUMAN (see all proteins):KIF21A DKFZp779C159 KIF5B KIF3A KIF5C KIF6
KIF5A KIF4A
KIF21B for paralogs About GeneDecksing
|
Genomic Variants
for KIF21B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KIF21B (200938520 - 200992828 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KIF21B
1 CNV: 6805 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIF21B |
|
Disorders
/ Diseases
for KIF21B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KIF21B for disorders About GeneDecksing
OMIM gene information: 608322
OMIM disorders: --
4  diseases for KIF21B: About MalaCardsmultiple sclerosis inflammatory bowel disease ulcerative colitis neuronitis
Human Genome Epidemiology (HuGE) Navigator: KIF21B (5 documents)
Export disorders for KIF21B gene to outside databases
|
Publications
for KIF21B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIF21B gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with KIF21B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2, 3 Seki N.... Ohara O. (1997)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Interaction between ERAP1 and HLA-B27 in ankylosing sp ondylitis implicates peptide handling in the mechanism for HLA-B27 in disease su sceptibility. (PubMed id 21743469)1 Evans D.M.... . (2011)
- Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)1 ....Compston A. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PubMed id 21102463)1 Franke A....Parkes M. (2010)
- Replication of KIF21B as a susceptibility locus for m ultiple sclerosis. (PubMed id 20587413)1 Goris A....Dubois B. (2010)
- Comprehensive follow-up of the first genome-wide asso ciation study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibi lity loci. (PubMed id 20007504)1 (2010)
- Genome-wide association study of ulcerative colitis i dentifies three new susceptibility loci, including the HNF4A region. (PubMed id 19915572)1 .... D.P. (2009)
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External Searches for KIF21B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KIF21B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KIF21B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KIF21B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KIF21B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KIF21B gene:
Search GeneIP for patents involving KIF21B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIF21B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KIF21B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIF21B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIF21B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KIF21B | | OriGene 3'-UTR Clone for KIF21B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF21B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF21B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIF21B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIF21B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF21B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF21B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF21B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF21B |
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 | | | KIF21B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF21B |
|  |  |  | | | | Search ThermoFisher Antibodies for KIF21B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF21B |
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