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Aliases for KIF21B Gene

Aliases for KIF21B Gene

  • Kinesin Family Member 21B 2 3
  • KIAA0449 4 6

External Ids for KIF21B Gene

Previous GeneCards Identifiers for KIF21B Gene

  • GC01M198226
  • GC01M198231
  • GC01M197674
  • GC01M199205
  • GC01M172186

Summaries for KIF21B Gene

Entrez Gene Summary for KIF21B Gene

  • This gene encodes a member of the kinesin superfamily. Kinesins are ATP-dependent microtubule-based motor proteins that are involved in the intracellular transport of membranous organelles. Single nucleotide polymorphisms in this gene are associated with inflammatory bowel disease and multiple sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for KIF21B Gene

KIF21B (Kinesin Family Member 21B) is a Protein Coding gene. Diseases associated with KIF21B include inflammatory bowel disease. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIF5C.

UniProtKB/Swiss-Prot for KIF21B Gene

  • Microtubule-binding motor protein probably involved in neuronal dendritic transport. In vitro, has a plus-end directed motor activity (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF21B Gene

Genomics for KIF21B Gene

Regulatory Elements for KIF21B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIF21B Gene

Start:
200,969,386 bp from pter
End:
201,023,700 bp from pter
Size:
54,315 bases
Orientation:
Minus strand

Genomic View for KIF21B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF21B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF21B Gene

Proteins for KIF21B Gene

  • Protein details for KIF21B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75037-KI21B_HUMAN
    Recommended name:
    Kinesin-like protein KIF21B
    Protein Accession:
    O75037
    Secondary Accessions:
    • B2RP62
    • B7ZMI0
    • Q5T4J3

    Protein attributes for KIF21B Gene

    Size:
    1637 amino acids
    Molecular mass:
    182662 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA32294.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF21B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF21B Gene

Proteomics data for KIF21B Gene at MOPED

Post-translational modifications for KIF21B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF21B Gene

No data available for DME Specific Peptides for KIF21B Gene

Domains for KIF21B Gene

Gene Families for KIF21B Gene

HGNC:
  • KIF :Kinesins
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for KIF21B Gene

Graphical View of Domain Structure for InterPro Entry

O75037

UniProtKB/Swiss-Prot:

KI21B_HUMAN :
  • O75037
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with KIF21B: view

Function for KIF21B Gene

Molecular function for KIF21B Gene

UniProtKB/Swiss-Prot Function: Microtubule-binding motor protein probably involved in neuronal dendritic transport. In vitro, has a plus-end directed motor activity (By similarity).

Gene Ontology (GO) - Molecular Function for KIF21B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IBA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF21B: view

Phenotypes for KIF21B Gene

genes like me logo Genes that share phenotypes with KIF21B: view

Animal Model Products

CRISPR Products

miRNA for KIF21B Gene

miRTarBase miRNAs that target KIF21B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF21B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIF21B Gene

Localization for KIF21B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF21B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF21B Gene COMPARTMENTS Subcellular localization image for KIF21B gene
Compartment Confidence
cytoskeleton 3
cytosol 3

Gene Ontology (GO) - Cellular Components for KIF21B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KIF21B: view

Pathways for KIF21B Gene

SuperPathways for KIF21B Gene

No Data Available

Interacting Proteins for KIF21B Gene

Gene Ontology (GO) - Biological Process for KIF21B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0007018 microtubule-based movement IBA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with KIF21B: view

No data available for Pathways by source for KIF21B Gene

Transcripts for KIF21B Gene

Unigene Clusters for KIF21B Gene

Kinesin family member 21B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF21B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF21B Gene

No ASD Table

Relevant External Links for KIF21B Gene

GeneLoc Exon Structure for
KIF21B
ECgene alternative splicing isoforms for
KIF21B

Expression for KIF21B Gene

mRNA expression in normal human tissues for KIF21B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF21B Gene

This gene is overexpressed in Whole Blood (8.1), Brain - Cortex (4.6), and Brain - Amygdala (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KIF21B Gene

SOURCE GeneReport for Unigene cluster for KIF21B Gene Hs.169182

genes like me logo Genes that share expressions with KIF21B: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KIF21B Gene

Orthologs for KIF21B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIF21B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF21B 35
  • 98.06 (n)
  • 97.56 (a)
KIF21B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIF21B 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF21B 35
  • 91.41 (n)
  • 97.65 (a)
KIF21B 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif21b 35
  • 88.58 (n)
  • 95.86 (a)
Kif21b 16
Kif21b 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF21B 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF21B 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif21b 35
  • 88.64 (n)
  • 96.63 (a)
chicken
(Gallus gallus)
Aves KIF21B 35
  • 83 (n)
  • 89.86 (a)
KIF21B 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF21B 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif21b 35
  • 64.81 (n)
  • 70.91 (a)
zebrafish
(Danio rerio)
Actinopterygii kif21b 35
  • 73.69 (n)
  • 77.69 (a)
KIF21B 36
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Klp31E 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea klp-12 36
  • 36 (a)
OneToMany
corn
(Zea mays)
Liliopsida Zm.11718 35
rice
(Oryza sativa)
Liliopsida Os.22630 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2958 36
  • 43 (a)
OneToMany
Species with no ortholog for KIF21B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF21B Gene

ENSEMBL:
Gene Tree for KIF21B (if available)
TreeFam:
Gene Tree for KIF21B (if available)

Paralogs for KIF21B Gene

Selected SIMAP similar genes for KIF21B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIF21B: view

Variants for KIF21B Gene

Sequence variations from dbSNP and Humsavar for KIF21B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs190921 -- 200,982,801(+) AGGGC(C/T)TGCGA intron-variant
rs296557 -- 200,984,435(+) AGGCA(A/G)TTTGG intron-variant
rs296558 -- 200,983,687(+) ATCAG(A/G)CTGGG intron-variant
rs296559 -- 200,983,358(+) GGAGA(C/T)GTGGG intron-variant
rs296560 -- 200,980,241(+) ATGAA(A/T)GAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF21B Gene

Variant ID Type Subtype PubMed ID
esv33174 CNV Loss 17666407
esv989611 CNV Deletion 20482838
esv2721395 CNV Deletion 23290073
esv2678555 CNV Deletion 23128226

Relevant External Links for KIF21B Gene

HapMap Linkage Disequilibrium report
KIF21B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF21B Gene

Disorders for KIF21B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for KIF21B Gene including...

Search for KIF21B Gene in MalaCards »

Relevant External Links for KIF21B

Genetic Association Database (GAD)
KIF21B
Human Genome Epidemiology (HuGE) Navigator
KIF21B
genes like me logo Genes that share disorders with KIF21B: view

No data available for UniProtKB/Swiss-Prot for KIF21B Gene

Publications for KIF21B Gene

  1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. (PMID: 19915572) . … Strachan D.P. (Nat. Genet. 2009) 3 48
  4. Replication of KIF21B as a susceptibility locus for multiple sclerosis. (PMID: 20587413) Goris A. … Dubois B. (J. Med. Genet. 2010) 3 48
  5. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. (PMID: 21743469) Evans D.M. … . (Nat. Genet. 2011) 3 48

Products for KIF21B Gene

Sources for KIF21B Gene

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