Aliases for KIF21A Gene
External Ids for KIF21A Gene
Previous HGNC Symbols for KIF21A Gene
Previous GeneCards Identifiers for KIF21A Gene
This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
GeneCards Summary for KIF21A Gene
KIF21A (Kinesin Family Member 21A) is a Protein Coding gene. Diseases associated with KIF21A include Fibrosis Of Extraocular Muscles, Congenital, 1 and Congenital Fibrosis Of The Extraocular Muscles. Among its related pathways are Golgi-to-ER retrograde transport and Platelet activation, signaling and aggregation. GO annotations related to this gene include binding and microtubule binding. An important paralog of this gene is KIF5C.
UniProtKB/Swiss-Prot for KIF21A Gene
Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity (By similarity).