Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KIF21A Gene

protein-coding GIFtS: 57
GCID: GC12M039687

kinesin family member 21A

(Previous names: fibrosis of the extraocular muscles, congenital, 1 )
(Previous symbol: FEOM1)

Explore 16 diseases affiliated with
KIF21A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Kinesin Family Member 21A¹ ²		FLJ20052¹
FEOM1¹ ² ⁵		Fibrosis Of The Extraocular Muscles, Congenital, 1¹
Kinesin-Like Protein KIF2² ³		FEOM3A²
Renal Carcinoma Antigen NY-REN-62² ³		Kinesin-Like Protein KIF21A²
CFEOM1² ⁵		KIF2³
KIAA1708³ ⁵		CFEOM3B⁵

External Ids:	HGNC: 19349¹	Entrez Gene: 55605²	Ensembl: ENSG00000139116⁷	OMIM: 608283⁵	UniProtKB: Q7Z4S6³

Export aliases for KIF21A gene to outside databases

Previous GC identifers: GC12U990160 GC12M039586 GC12M039404 GC12M037973 GC12M036712

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KIF21A:

This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized

by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be

involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of

extraocular muscles-1. Alternate splicing results in multiple transcript variants.(provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: KI21A_HUMAN, Q7Z4S6

Function: Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end

directed motor activity (By similarity)

Gene Wiki entry for KIF21A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KIF21A gene promoter:
HFH-3 C/EBPalpha YY1 FOXI1 S8 POU2F1 HFH-1 POU2F1a TGIF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KIF21A promoter sequence

Search SABiosciences Chromatin IP Primers for KIF21A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF21A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12 Ensembl cytogenetic band: 12q12 HGNC cytogenetic band: 12q12

KIF21A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF21A gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M039687: view genomic region (about GC identifiers)

Start:	39,687,030 bp from pter	End:	39,837,192 bp from pter
Size:	150,163 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KI21A_HUMAN, Q7Z4S6 (See protein sequence)

Recommended Name: Kinesin-like protein KIF21A

Size: 1674 amino acids; 187179 Da

Subcellular location: Cytoplasm, cytoskeleton (Probable)

Sequence caution: Sequence=AAD42883.1; Type=Frameshift; Positions=185, 191, 380, 405; Sequence=AAH41430.1;

Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAP97680.1;

Type=Frameshift; Positions=185, 191; Sequence=BAA90916.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.

Potential poly-A sequence;

Secondary accessions: A8MX28 B0I1R9 Q6UKL9 Q7Z668 Q86WZ5 Q8IVZ8 Q9C0F5 Q9NXU4 Q9Y590

Alternative splicing: 4 isoforms: Q7Z4S6-1 Q7Z4S6-2 Q7Z4S6-3 Q7Z4S6-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KIF21A: NX_Q7Z4S6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q7Z4S6

KIF21A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001166934.1 NP_001166935.1 NP_001166936.1 NP_060111.2

ENSEMBL proteins:

ENSP00000354851 ENSP00000448792 ENSP00000447765 ENSP00000445606 ENSP00000354878

ENSP00000438075 ENSP00000449698 ENSP00000447070 ENSP00000449700 ENSP00000379029

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: KIF21A OriGene Custom Protein Services for KIF21A
	GenScript Custom Purified and Recombinant Proteins Services for KIF21A
	Novus Biologicals KIF21A Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KIF21A

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005874	microtubule	IEA	--
GO:0005875	microtubule associated complex	IEA	--

KIF21A for ontologies About GeneDecksing

KIF21A Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of KIF21A
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for KIF21A
	GenScript Custom Superior Antibodies Services for KIF21A
	Novus Biologicals KIF21A Antibody
	Search for Antibodies for KIF21A at Abcam
	Uscn Antibodies for KIF21A
	Search ThermoFisher Antibodies for KIF21A

Assay Products for KIF21A:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KIF21A
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KIF21A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KIF21A for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR019775 WD40_repeat_CS

IPR001752 Kinesin_motor_dom

IPR009053 Prefoldin

IPR001680 WD40_repeat

IPR019821 Kinesin_motor_CS

Graphical View of Domain Structure for InterPro Entry Q7Z4S6

ProtoNet protein and cluster: Q7Z4S6

1 Blocks protein family: IPB001752 Kinesin

UniProtKB/Swiss-Prot: KI21A_HUMAN, Q7Z4S6

Similarity: Belongs to the kinesin-like protein family

Similarity: Contains 1 kinesin-motor domain

Similarity: Contains 7 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KI21A_HUMAN, Q7Z4S6

Function: Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end

directed motor activity (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: KIF21A Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIF21A
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate KIF21A (see all 29):
		hsa-miR-579 hsa-miR-520d-5p hsa-miR-15a hsa-miR-485-3p hsa-miR-503 hsa-miR-1258 hsa-miR-103a hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: KIF21A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIF21A (see all 7) OriGene shRNA RFP: KIF21A OriGene siRNA: KIF21A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF21A

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for KIF21A

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF21A (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF21A (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): KIF21A (NM_017641)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIF21A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF21A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KIF21A
		Search LifeMap BioReagents cell lines for KIF21A

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF21A

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003777	microtubule motor activity	IEA	--
GO:0005515	protein binding	IPI	19020088
GO:0005524	ATP binding	IEA	--

KIF21A for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Reelin Pathway (Cajal-Retzius cells)

Reelin Pathway (Cajal-Retzius cells)

1.00

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KIF21A

Reelin Pathway (Cajal-Retzius cells)

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KIF21A

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/743 Interacting proteins for KIF21A (Q7Z4S6^{1, 2, 3} ENSP00000354851⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 743)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDC5L	Q99459², ENSP00000360532⁴	MINT-7945693 MINT-7947479 STRING: ENSP00000360532
ELAVL1	Q15717², ENSP00000385269⁴	MINT-7945693 MINT-7947479 STRING: ENSP00000385269
SNW1	Q13573², ENSP00000261531⁴	MINT-7945693 MINT-7947479 STRING: ENSP00000261531
ARFGEF1	Q9Y6D6¹, ENSP00000262215⁴	EBI-2691397,EBI-1044254 STRING: ENSP00000262215
ABCF1	Q8NE71²	MINT-7945693 MINT-7947479

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007018	microtubule-based movement	IEA	--

KIF21A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KIF21A
Search CenterWatch for drugs/clinical trials and news about KIF21A / KI21A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KIF21A gene (4 alternative transcripts):

NM_001173463.1 NM_001173464.1 NM_001173465.1 NM_017641.3

Unigene Cluster for KIF21A:

Kinesin family member 21A

Hs.374201 [show with all ESTs]

Unigene Representative Sequence: NM_001173464

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000547733(uc001rlt.3) ENST00000361961(uc001rlu.3 uc001rlv.3 uc001rlw.3 uc001rlx.3 uc001rlz.3 uc010skl.2)

ENST00000551264 ENST00000552961 ENST00000544797 ENST00000361418 ENST00000541463

ENST00000547745 ENST00000547108 ENST00000552475 ENST00000551066 ENST00000546817

ENST00000550429 ENST00000552908 ENST00000395670(uc001rly.3)

miRNA Products:		OriGene 3'-UTR Clone: KIF21A Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIF21A
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate KIF21A (see all 29):
		hsa-miR-579 hsa-miR-520d-5p hsa-miR-15a hsa-miR-485-3p hsa-miR-503 hsa-miR-1258 hsa-miR-103a hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: KIF21A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIF21A (see all 7) OriGene shRNA RFP: KIF21A OriGene siRNA: KIF21A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF21A

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF21A (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF21A (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): KIF21A (NM_017641)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIF21A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF21A

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIF21A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KIF21A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF21A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF21A

Additional cDNA sequence:

AB051495.2 AB290166.1 AF155117.1 AF450487.1 AK000059.1 AM177179.1 AY368076.1 BC032344.1

BC041430.1 BC047572.1 BC136414.1 BX537855.1

8 DOTS entries:

DT.313386 DT.100680848 DT.99956111 DT.100782971 DT.99978500 DT.95262865 DT.97838517 DT.304281

24/141 AceView cDNA sequences (see all 141):

AI520660 BX106399 BQ717428 BM724689 BM312834 AI857856 AW129306 BU069138

BI916829 AA845381 AY368076 AA496082 BQ723198 AL526004 N39407 BU151008

BQ882439 BC041430 BQ889705 AI815500 AA573847 BM662588 BU785011 BQ423380

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for KIF21A (see all 16) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17	^
SP1:							-												-																		-
SP2:
SP3:
SP4:
SP5:

ExUns:	18	^	19a	·	19b	^	20	^	21a	·	21b	^	22a	·	22b	^	23a	·	23b	^	24	^	25	^	26a	·	26b	^	27	^	28	^	29a	·	29b	^	30a	·	30b	^	31	^	32a	·	32b	^	33	^	34a	·	34b	·
SP1:
SP2:
SP3:
SP4:																					-
SP5:

ExUns:	34c	^	35	^	36	^	37	^	38
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for KIF21A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KIF21A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGCTATGAA

About this image
See KIF21A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIF21A

SOURCE GeneReport for Unigene cluster: Hs.374201

SABiosciences Custom PCR Arrays for KIF21A

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIF21A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KIF21A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF21A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF21A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF21A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KIF21A gene from 6/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KIF21A¹	kinesin family member 21A	80.84(n) 86.66(a)		417692 XM_415936.3 XP_415936.3
lizard (Anolis carolinensis)	Reptilia	KIF21A⁶ --	--	90(a) 85(a)	1 ↔ 1 possible ortholog	5(98734913-98763363) 5(98775181-98827158)
African clawed frog (Xenopus laevis)	Amphibia	Xl.10601²	Xenopus laevis transcribed sequence with moderate similarity to protein pirT00066 (H.sapiens) T00066 hypothetical protein KIAA0449 - human (fragment) less	76.89(n)		CF342339.1
zebrafish (Danio rerio)	Actinopterygii	kif21a¹	kinesin family member 21A	66.36(n) 72.99(a)		566481 XM_001920223.3 XP_001920258.3
fruit fly (Drosophila melanogaster)	Insecta	Klp31E⁶	Klp31E	42(a)	1 → many	2L(10414017-10418991)
worm (Caenorhabditis elegans)	Secernentea	klp-12¹	Protein KLP-12	48.6(n) 39.83(a)		178057 NM_001129324.1 NP_001122796.1

ENSEMBL Gene Tree for KIF21A (if available)
TreeFam Gene Tree for KIF21A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KIF21A gene

KIF5C² KIF11² KIF3B² KIF21B² KIF9² KIF17² KIF4B² KIF27²

KIF3A² KIF4A² KIF5B² KIF6² KIF15² CENPE² KIF5A² KIF7²

KIF3C²

18/31 SIMAP similar genes for KIF21A using alignment to 11 protein entries: KI21A_HUMAN (see all proteins) (see all similar genes):

DKFZp779C159 KIF21B KIF2C KIF7 KIF27 KIF17

KIF23 KLP6 KIF18A KIF1B KIF1Bbeta KIF13A

KIF5B CENPE KIF22 KIF3A KIF1A KIF5C

KIF21A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112735607^1,2		--	36712627(+)	`GGTCAC/TCACTG`	4	--	ds500¹		1	CSA	2
rs74088336^1,2	C,	--	36713675(+)	`ATACCC/TGACAA`	4	--	ut3¹		1	WA	2
rs77242017^1,2		--	36713704(+)	`AACATT/CTTCAA`	4	--	ut3¹		2	CSA WA	120
rs111409014^1,2		--	36714051(+)	`GTACAG/CGACAA`	4	--	ut3¹		1	CSA	2
rs77726062^1,2		--	36714573(+)	`AGGCAG/ATCTGG`	4	--	int¹		1	WA	118
rs77155219^1,2		--	36714605(+)	`CACTGG/AGTCTG`	4	--	int¹		1	EA	120
rs111596114^1,2		--	36715129(+)	`TGCACC/TTCAGA`	4	--	int¹		1	CSA	2
rs12227757^1,2	C,F,H	--	36715218(+)	`GCTTTC/TTAGAT`	4	--	int¹		7	NS EA NA	808
rs112057449^1,2	C,	--	36715618(+)	`GCCTCG/CATCTC`	4	--	int¹		1	WA	2
rs12367902^1,2	C,F,H	--	36716090(+)	`aaaaaC/Aaaaaa`	4	--	int¹		3	NS NA CSA	174

HapMap Linkage Disequilibrium report for KIF21A (39687030 - 39837192 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for KIF21A
1 CNV: 101484
1 Indel: 60084
Human Gene Mutation Database (HGMD): KIF21A

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIF21A

DNA2.0 Custom Variant and Variant Library Synthesis for KIF21A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KIF21A for disorders           About GeneDecksing

OMIM gene information: 608283
OMIM disorders: 135700
UniProtKB/Swiss-Prot: KI21A_HUMAN, Q7Z4S6

Defects in KIF21A are a cause of congenital fibrosis of extraocular muscles type 1 (CFEOM1) [MIM:135700].

CFEOM encompasses several different inherited strabismus syndromes characterized by congenital restrictive

ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. CFEOM is

characterized clinically by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. CFEOM1

individuals show an absence of the superior division of the oculomotor nerve (cranial nerve III) and corresponding

oculomotor subnuclei

16 diseases for KIF21A: About MalaCards

fibrosis of extraocular muscles fibrosis of extraocular muscles, congenital, 1 congenital fibrosis of the extraocular muscles fibrosis

fibrosis of extraocular muscles, congenital, 3 renal carcinoma carcinoma enophthalmos

amblyopia hyperopia astigmatism strabismus

renal cell carcinoma ptosis schizophrenia neuronitis

5 diseases from the University of Copenhagen DISEASES database for KIF21A:

Ophthalmoplegia Hyperopia Enophthalmos Amblyopia

Histidinemia

2 Novoseek disease relationships for KIF21A gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cfeom	98.2	18	11882252 (5), 16157808 (4), 15621876 (2), 19551685 (2) (see all 6)
cfeom2	94.5	3	11882252 (2)

GeneTests: KIF21A

Congenital Fibrosis of the Extraocular Muscles

Genetic Association Database (GAD): KIF21A
Human Genome Epidemiology (HuGE) Navigator: KIF21A (1 document)

Export disorders for KIF21A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KIF21A gene, integrated from 9 sources (see all 53):
(articles sorted by number of sources associating them with KIF21A)

Utopia: connect your pdf to the dynamic
world of online information

A novel KIF21A mutation in a patient with congenital fibrosis of the extraocular muscles and Marcus Gunn jaw-winking phenomenon. (PubMed id 16157808)^{1, 2, 9} Yamada K.... Engle E.C. (2005)
Mutation analysis of KIF21A in congenital fibrosis of the extraocular muscles (CFEOM) patients. (PubMed id 15621876)^{1, 4, 9} Tiab L....Schorderet D. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1). (PubMed id 14595441)^{1, 2} Yamada K.... Engle E.C. (2003)
Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)^{1, 2} Nagase T.... Ohara O. (2000)
Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)^{1, 2} Scanlan M.J....Old L.J. (1999)
Novel dendritic kinesin sorting identified by different process targeting of two related kinesins: KIF21A and KIF21B. (PubMed id 10225949)^{1, 3} Marszalek J.R....Goldstein L.S. (1999)
Recurrent mutation of the KIF21A gene in Japanese patients with congenital fibrosis of the extraocular muscles. (PubMed id 16365788)^{1, 9} Shimizu S....Maruo T. (2005)
A major mutation of KIF21A associated with congenital fibrosis of the extraocular muscles type 1 (CFEOM1) enhances translocation of Kank1 to the membrane. (PubMed id 19559006)^{1, 9} Kakinuma N. and Kiyama R. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55605	HGNC: 19349	AceView: KIF21A	Ensembl:ENSG00000139116	euGenes: HUgn55605
ECgene: KIF21A	H-InvDB: KIF21A

(According to HUGE)
About This Section

HUGE: KIAA1708

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KIF21A	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/KIF21A

Intellectual Property for KIF21A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KIF21A gene:
Search GeneIP for patents involving KIF21A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Small Molecules at EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of KIF21A
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for KIF21A
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIF21A		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIF21A
	OriGene Protein Over-expression Lysate for KIF21A		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for KIF21A		OriGene 3'-UTR Clone for KIF21A
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF21A		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF21A
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for KIF21A		OriGene Custom Protein Services for KIF21A
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIF21A
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIF21A
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF21A
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF21A
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF21A
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF21A

	GenScript Custom Purified and Recombinant Proteins Services for KIF21A		GenScript cDNA clones with any tag delivered in your preferred vector for KIF21A
	GenScript Custom Assay Services for KIF21A		GenScript Custom Superior Antibodies Services for KIF21A
	GenScript Custom overexpressing Cell Line Services for KIF21A		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in KIF21A promoter
	Search Chromatin IP Primers for KIF21A
	RT² qPCR Primer Assay in human, mouse, rat KIF21A
	Search GNC Networks for KIF21A
	SABiosciences PCR Arrays including human, mouse, rat KIF21A

Search Tocris compounds for KIF21A

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	KIF21A antibodies
	KIF21A lysates

	Search for Antibodies for KIF21A at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for KIF21A
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

KIF21A Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for KIF21A

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF21A

	SwitchGear 3'UTR luciferase reporter plasmids for KIF21A
	SwitchGear Promoter luciferase reporter plasmids for KIF21A

Search ThermoFisher Antibodies for KIF21A

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF21A

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes KIF21A gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

KIF21A Gene

kinesin family member 21A

Aliases
for KIF21A gene

Summaries
for KIF21A gene

Genomic Views
for KIF21A gene

Proteins
for KIF21A gene

Protein Domains /
Families
for KIF21A gene

Function
for KIF21A gene

Pathways & Interactions
for KIF21A gene

Drugs & Compounds
for KIF21A gene

Transcripts
for KIF21A gene

Expression
for KIF21A gene

Orthologs
for KIF21A gene

Paralogs
for KIF21A gene

Genomic Variants
for KIF21A gene

Disorders / Diseases
for KIF21A gene

Publications
for KIF21A gene

External Searches for KIF21A gene

Genome Databases showing KIF21A gene

Other Databases showing KIF21A gene

Specialized Databases showing KIF21A gene

Intellectual Property
for KIF21A gene

Products
for KIF21A gene

View Random Gene

Advanced Search

Export list of displayed genes

KIF21A Gene

kinesin family member 21A

Aliasesfor KIF21A gene

Summariesfor KIF21A gene

Genomic Viewsfor KIF21A gene

Proteinsfor KIF21A gene

Protein Domains /Familiesfor KIF21A gene

Functionfor KIF21A gene

Pathways & Interactionsfor KIF21A gene

Drugs & Compoundsfor KIF21A gene

Transcriptsfor KIF21A gene

Expression for KIF21A gene

Orthologsfor KIF21A gene

Paralogsfor KIF21A gene

Genomic Variantsfor KIF21A gene

Disorders / Diseasesfor KIF21A gene

Publicationsfor KIF21A gene

External Searches for KIF21A gene

Genome Databases showing KIF21A gene

Other Databases showing KIF21A gene

Specialized Databases showing KIF21A gene

Intellectual Propertyfor KIF21A gene

Productsfor KIF21A gene

View Random Gene

Aliases
for KIF21A gene

Summaries
for KIF21A gene

Genomic Views
for KIF21A gene

Proteins
for KIF21A gene

Protein Domains /
Families
for KIF21A gene

Function
for KIF21A gene

Pathways & Interactions
for KIF21A gene

Drugs & Compounds
for KIF21A gene

Transcripts
for KIF21A gene

Expression
for KIF21A gene

Orthologs
for KIF21A gene

Paralogs
for KIF21A gene

Genomic Variants
for KIF21A gene

Disorders / Diseases
for KIF21A gene

Publications
for KIF21A gene

Intellectual Property
for KIF21A gene

Products
for KIF21A gene