Aliases for KIF21A Gene
External Ids for KIF21A Gene
Previous HGNC Symbols for KIF21A Gene
Previous GeneCards Identifiers for KIF21A Gene
This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
GeneCards Summary for KIF21A Gene
KIF21A (Kinesin Family Member 21A) is a Protein Coding gene. Diseases associated with KIF21A include fibrosis of extraocular muscles, congenital, 1 and congenital fibrosis of the extraocular muscles. Among its related pathways are Platelet activation, signaling and aggregation and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include binding and microtubule binding. An important paralog of this gene is KIF5C.
UniProtKB/Swiss-Prot for KIF21A Gene
Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity (By similarity).