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Aliases for KIF20B Gene

Aliases for KIF20B Gene

  • Kinesin Family Member 20B 2 3 4 5
  • Cancer/Testis Antigen 90 2 3 4
  • M-Phase Phosphoprotein 1 2 3 4
  • Kinesin-Related Motor Interacting With PIN1 3 4
  • MPHOSPH1 3 4
  • KRMP1 3 4
  • CT90 3 4
  • MPP1 3 4
  • Mitotic Kinesin-Related Protein 3
  • Mitotic Kinesin-Like Protein 3
  • Kinesin-Like Protein KIF20B 3
  • EC 6.3.5.5 58
  • EC 2.1.1 58
  • MPP-1 3

External Ids for KIF20B Gene

Previous HGNC Symbols for KIF20B Gene

  • MPHOSPH1

Previous GeneCards Identifiers for KIF20B Gene

  • GC10P091452
  • GC10P085095

Summaries for KIF20B Gene

GeneCards Summary for KIF20B Gene

KIF20B (Kinesin Family Member 20B) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Golgi-to-ER retrograde transport. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF20A.

UniProtKB/Swiss-Prot for KIF20B Gene

  • Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).

Gene Wiki entry for KIF20B Gene

Additional gene information for KIF20B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF20B Gene

Genomics for KIF20B Gene

Regulatory Elements for KIF20B Gene

Enhancers for KIF20B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H089860 1.2 Ensembl ENCODE 41.6 +160.0 159979 2 FEZF1 ZNF2 FOS ZNF202 SP3 JUNB TSHZ1 ZNF518A ZNF610 ZNF658 KIF20B LINC00865 ENSG00000235100 ACTA2-AS1 ENSG00000280560 GC10M089924
GH10H088878 1.9 FANTOM5 Ensembl ENCODE dbSUPER 21.9 -817.4 -817375 10 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 KIF20B RPL11P3 STAMBPL1 FAS ACTA2-AS1 ENSG00000201548 RNLS LIPJ LIPM LIPN
GH10H089641 1.4 Ensembl ENCODE 21.7 -56.9 -56869 5 HDGF FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENSG00000235100 KIF20B LINC00865 ENSG00000240996 PANK1 ENSG00000249962 GC10M089600
GH10H089700 1.1 ENCODE 21.7 +0.5 475 3 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 KIF20B LINC00865 ENSG00000235100 PANK1 GC10P089733
GH10H088892 1.5 Ensembl ENCODE dbSUPER 9.8 -803.3 -803261 12 HDGF PKNOX1 FEZF1 FOS ATF7 RUNX3 JUNB PPARG ZNF592 NFIL3 STAMBPL1 ACTA2-AS1 ANKRD22 FAS LIPM KIF20B ENSG00000201548 RNLS LIPJ IFIT1B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIF20B on UCSC Golden Path with GeneCards custom track

Promoters for KIF20B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000031411 210 2001 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207

Genomic Location for KIF20B Gene

Chromosome:
10
Start:
89,701,590 bp from pter
End:
89,774,943 bp from pter
Size:
73,354 bases
Orientation:
Plus strand

Genomic View for KIF20B Gene

Genes around KIF20B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF20B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF20B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF20B Gene

Proteins for KIF20B Gene

  • Protein details for KIF20B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96Q89-KI20B_HUMAN
    Recommended name:
    Kinesin-like protein KIF20B
    Protein Accession:
    Q96Q89
    Secondary Accessions:
    • A8MXM7
    • O43277
    • Q09471
    • Q2KQ73
    • Q32NE1
    • Q561V3
    • Q58EX8
    • Q5T9M8
    • Q5T9M9
    • Q5T9N0
    • Q5T9N1
    • Q7KZ68
    • Q7Z5E0
    • Q7Z5E1
    • Q7Z6M9
    • Q86X82
    • Q9H3R8
    • Q9H6Q9
    • Q9H755
    • Q9NTC1
    • Q9UFR5

    Protein attributes for KIF20B Gene

    Size:
    1820 amino acids
    Molecular mass:
    210629 Da
    Quaternary structure:
    • Oligomerizes (via kinesin motor domain) (PubMed:11470801). Associates with microtubules (PubMed:12740395). Interacts (via C-terminal globular tail region) with PIN1 (via WW domain) (PubMed:11470801). Interacts with PRC1 (PubMed:17409436). Interacts with SHTN1 (via N-terminus); the interaction is direct and promotes the association of SHTN1 to microtubules in primary neurons.
    SequenceCaution:
    • Sequence=AAH46134.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH58913.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH93089.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI08689.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB15043.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAI12885.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16829.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF20B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF20B Gene

Selected DME Specific Peptides for KIF20B Gene

Q96Q89:
  • RSHSAKL
  • AEDRERF

Post-translational modifications for KIF20B Gene

  • Phosphorylated during mitosis by CDK1 (PubMed:11470801, PubMed:12740395).
  • Ubiquitination at isoforms=2, 3, 4117, posLast=767767, isoforms=2, 3, 4983, isoforms=2, 3, 41202, and isoforms=2, 3, 4, 51345
  • Modification sites at PhosphoSitePlus

Other Protein References for KIF20B Gene

Domains & Families for KIF20B Gene

Gene Families for KIF20B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KIF20B Gene

Suggested Antigen Peptide Sequences for KIF20B Gene

Graphical View of Domain Structure for InterPro Entry

Q96Q89

UniProtKB/Swiss-Prot:

KI20B_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF20B: view

Function for KIF20B Gene

Molecular function for KIF20B Gene

UniProtKB/Swiss-Prot Function:
Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).

Enzyme Numbers (IUBMB) for KIF20B Gene

Phenotypes From GWAS Catalog for KIF20B Gene

Gene Ontology (GO) - Molecular Function for KIF20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003777 microtubule motor activity IEA --
GO:0005515 protein binding IPI 17409436
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IDA,IEA 12740395
genes like me logo Genes that share ontologies with KIF20B: view
genes like me logo Genes that share phenotypes with KIF20B: view

Animal Model Products

CRISPR Products

miRNA for KIF20B Gene

miRTarBase miRNAs that target KIF20B

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KIF20B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF20B Gene

Localization for KIF20B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF20B Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Midbody. Cell projection, axon. Cell projection, growth cone. Note=Localizes mainly in the nucleus during interphase although it is also detected in the cytoplasm without clear association with microtubules (PubMed:12740395). Localized to the central spindle during cytokinetic furrowing and with the midbody during abscission (PubMed:12740395, PubMed:17409436). A 2-3 fold expression increase is seen as cells progress from G1 to G2/M phase (PubMed:12740395). During prophase and metaphase it is found throughout the cytoplasm and at anaphase accumulates at the midplan of the cell and forms a distinct band extending across the spindle midzone (PubMed:12740395). At anaphase it is concentrated in the midbody (PubMed:12740395). Colocalized partially along microtubules in primary neurons. Colocalized with SHTN1 along microtubules to the tip of the growing cone in primary hippocampal neurons. Localized in midbodies between dividing radial progenitors in the ventricular zone (By similarity). Colocalized with PRC1 in the nucleus of bladder carcinoma cells at the interphase. Colocalized with PRC1 in bladder carcinoma cells at prophase, metaphase, early anaphase, at the midzone in late anaphase and at the contractile ring in telophase (PubMed:17409436). {ECO:0000250 UniProtKB:Q80WE4, ECO:0000269 PubMed:12740395, ECO:0000269 PubMed:17409436}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF20B gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Midbody (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KIF20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IDA,IEA 12740395
GO:0005654 nucleoplasm IEA,IDA 11470801
GO:0005730 nucleolus IEA,IDA 11470801
GO:0005737 cytoplasm IDA,IEA 8885239
genes like me logo Genes that share ontologies with KIF20B: view

Pathways & Interactions for KIF20B Gene

genes like me logo Genes that share pathways with KIF20B: view

Gene Ontology (GO) - Biological Process for KIF20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure IEA --
GO:0007018 microtubule-based movement IBA,IEA --
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest NAS 11470801
GO:0007088 regulation of mitotic nuclear division NAS,IEA 11470801
genes like me logo Genes that share ontologies with KIF20B: view

No data available for SIGNOR curated interactions for KIF20B Gene

Drugs & Compounds for KIF20B Gene

No Compound Related Data Available

Transcripts for KIF20B Gene

Unigene Clusters for KIF20B Gene

Kinesin family member 20B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KIF20B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KIF20B Gene

No ASD Table

Relevant External Links for KIF20B Gene

GeneLoc Exon Structure for
KIF20B
ECgene alternative splicing isoforms for
KIF20B

Expression for KIF20B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF20B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIF20B Gene

This gene is overexpressed in Heart (54.1) and Fetal heart (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIF20B Gene



Protein tissue co-expression partners for KIF20B Gene

NURSA nuclear receptor signaling pathways regulating expression of KIF20B Gene:

KIF20B

SOURCE GeneReport for Unigene cluster for KIF20B Gene:

Hs.240

mRNA Expression by UniProt/SwissProt for KIF20B Gene:

Q96Q89-KI20B_HUMAN
Tissue specificity: Brain, ovary, kidney and testis (at protein level) (PubMed:12740395). Overexpressed in bladder cancer cells (at protein level) (PubMed:17409436). Expressed in testis. Overexpressed in bladder cancer cells (PubMed:17409436).

Evidence on tissue expression from TISSUES for KIF20B Gene

  • Intestine(4.6)
  • Blood(4.4)
  • Lung(4.1)
  • Pancreas(3.6)
  • Liver(2.5)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with KIF20B: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF20B Gene

Orthologs for KIF20B Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF20B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF20B 33 34
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia KIF20B 33 34
  • 88.44 (n)
cow
(Bos Taurus)
Mammalia KIF20B 33
  • 88.36 (n)
-- 34
  • 82 (a)
OneToMany
-- 34
  • 79 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Kif20b 33 16 34
  • 81 (n)
rat
(Rattus norvegicus)
Mammalia Kif20b 33
  • 79.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KIF20B 34
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF20B 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF20B 34
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF20B 34
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif20b 33
  • 57.15 (n)
Str.17882 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3319 33
zebrafish
(Danio rerio)
Actinopterygii kif20bb 33
  • 55.18 (n)
KIF20B (1 of 2) 34
  • 35 (a)
OneToMany
kif20ba 34
  • 35 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sub 34
  • 28 (a)
OneToMany
Species where no ortholog for KIF20B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIF20B Gene

ENSEMBL:
Gene Tree for KIF20B (if available)
TreeFam:
Gene Tree for KIF20B (if available)

Paralogs for KIF20B Gene

Paralogs for KIF20B Gene

(5) SIMAP similar genes for KIF20B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIF20B: view

Variants for KIF20B Gene

Sequence variations from dbSNP and Humsavar for KIF20B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000002788 -- 89,716,704(+) AAACA(C/T)GTTTA intron-variant
rs1000040218 -- 89,763,825(+) AACTA(G/T)TATTA intron-variant
rs1000118225 -- 89,717,023(+) AGTCA(A/G)TTGGG intron-variant
rs1000128835 -- 89,745,250(+) CTGGG(C/G)ACAGT intron-variant
rs1000165345 -- 89,728,841(+) CAGCT(A/G)GGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF20B Gene

Variant ID Type Subtype PubMed ID
esv2100770 CNV deletion 18987734
esv2739384 CNV deletion 23290073
esv2739395 CNV deletion 23290073
nsv1036581 CNV gain 25217958
nsv1054572 CNV loss 25217958
nsv1119414 CNV insertion 24896259
nsv507568 OTHER sequence alteration 20534489
nsv825506 CNV loss 20364138

Variation tolerance for KIF20B Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 22.46; 99.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF20B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF20B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF20B Gene

Disorders for KIF20B Gene

Relevant External Links for KIF20B

Genetic Association Database (GAD)
KIF20B
Human Genome Epidemiology (HuGE) Navigator
KIF20B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF20B

No disorders were found for KIF20B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF20B Gene

Publications for KIF20B Gene

  1. Oncogenic role of MPHOSPH1, a cancer-testis antigen specific to human bladder cancer. (PMID: 17409436) Kanehira M … Nakamura Y (Cancer research 2007) 3 4 22 60
  2. M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis. (PMID: 12740395) Abaza A … Pirollet F (The Journal of biological chemistry 2003) 3 4 22 60
  3. Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1. (PMID: 11470801) Kamimoto T … Hagiwara M (The Journal of biological chemistry 2001) 2 3 4 60
  4. Autoantibodies from patients with idiopathic ataxia bind to M-phase phosphoprotein-1 (MPP1). (PMID: 10695267) Fritzler MJ … Chan EK (Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2000) 3 4 22 60
  5. Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope. (PMID: 8290587) Westendorf JM … Gerace L (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 4 60

Products for KIF20B Gene

Sources for KIF20B Gene

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