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Aliases for KIF20B Gene

Aliases for KIF20B Gene

  • Kinesin Family Member 20B 2 3
  • Cancer/Testis Antigen 90 2 3 4
  • M-Phase Phosphoprotein 1 2 3 4
  • MPHOSPH1 3 4 6
  • MPP1 3 4 6
  • Kinesin-Related Motor Interacting With PIN1 3 4
  • KRMP1 3 4
  • CT90 3 4
  • Mitotic Kinesin-Like Protein 3
  • Kinesin-Like Protein KIF20B 3
  • EC 6.3.5.5 63
  • EC 2.1.1 63
  • MPP-1 3

External Ids for KIF20B Gene

Previous HGNC Symbols for KIF20B Gene

  • MPHOSPH1

Previous GeneCards Identifiers for KIF20B Gene

  • GC10P091452
  • GC10P085095

Summaries for KIF20B Gene

GeneCards Summary for KIF20B Gene

KIF20B (Kinesin Family Member 20B) is a Protein Coding gene. Among its related pathways are Gastric cancer network 1. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIF20A.

UniProtKB/Swiss-Prot for KIF20B Gene

  • Plus-end-directed motor enzyme that is required for completion of cytokinesis.

Gene Wiki entry for KIF20B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF20B Gene

Genomics for KIF20B Gene

Regulatory Elements for KIF20B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIF20B Gene

Start:
89,701,590 bp from pter
End:
89,774,943 bp from pter
Size:
73,354 bases
Orientation:
Plus strand

Genomic View for KIF20B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF20B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF20B Gene

Proteins for KIF20B Gene

  • Protein details for KIF20B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96Q89-KI20B_HUMAN
    Recommended name:
    Kinesin-like protein KIF20B
    Protein Accession:
    Q96Q89
    Secondary Accessions:
    • A8MXM7
    • O43277
    • Q09471
    • Q2KQ73
    • Q32NE1
    • Q561V3
    • Q58EX8
    • Q5T9M8
    • Q5T9M9
    • Q5T9N0
    • Q5T9N1
    • Q7KZ68
    • Q7Z5E0
    • Q7Z5E1
    • Q7Z6M9
    • Q86X82
    • Q9H3R8
    • Q9H6Q9
    • Q9H755
    • Q9NTC1
    • Q9UFR5

    Protein attributes for KIF20B Gene

    Size:
    1820 amino acids
    Molecular mass:
    210629 Da
    Quaternary structure:
    • Interacts with PIN1.
    SequenceCaution:
    • Sequence=AAH46134.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH58913.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH93089.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI08689.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB15043.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAI12885.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16829.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF20B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF20B Gene

Proteomics data for KIF20B Gene at MOPED

Selected DME Specific Peptides for KIF20B Gene

Post-translational modifications for KIF20B Gene

  • Ubiquitination at Lys117, Lys767, Lys983, Lys1202, and Lys1345
  • Modification sites at PhosphoSitePlus

Other Protein References for KIF20B Gene

Domains for KIF20B Gene

Protein Domains for KIF20B Gene

Suggested Antigen Peptide Sequences for KIF20B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96Q89

UniProtKB/Swiss-Prot:

KI20B_HUMAN :
  • Q96Q89
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF20B: view

No data available for Gene Families for KIF20B Gene

Function for KIF20B Gene

Molecular function for KIF20B Gene

UniProtKB/Swiss-Prot Function: Plus-end-directed motor enzyme that is required for completion of cytokinesis.

Enzyme Numbers (IUBMB) for KIF20B Gene

Gene Ontology (GO) - Molecular Function for KIF20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IEA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IDA 11470801
genes like me logo Genes that share ontologies with KIF20B: view

Animal Model Products

CRISPR Products

miRNA for KIF20B Gene

miRTarBase miRNAs that target KIF20B

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIF20B Gene

Localization for KIF20B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF20B Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Localizes mainly in the nucleus during interphase although it is also detected in the cytoplasm without clear association with microtubules. A 2-3 fold expression increase is seen as cells progress from G1 to G2/M phase. During prophase and metaphase it is found throughout the cytoplasm and at anaphase accumulates at the midplan of the cell and forms a distinct band extending across the spindle midzone. At anaphase it is concentrated in the mid-body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF20B Gene COMPARTMENTS Subcellular localization image for KIF20B gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KIF20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA 11470801
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 11470801
genes like me logo Genes that share ontologies with KIF20B: view

Pathways for KIF20B Gene

SuperPathways for KIF20B Gene

Superpath Contained pathways
1 Gastric cancer network 1
genes like me logo Genes that share pathways with KIF20B: view

Pathways by source for KIF20B Gene

1 BioSystems pathway for KIF20B Gene

Gene Ontology (GO) - Biological Process for KIF20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure IEA --
GO:0006200 obsolete ATP catabolic process --
GO:0007018 microtubule-based movement IEA --
GO:0007050 cell cycle arrest NAS 11470801
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with KIF20B: view

Transcripts for KIF20B Gene

Unigene Clusters for KIF20B Gene

Kinesin family member 20B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF20B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KIF20B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF20B Gene

No ASD Table

Relevant External Links for KIF20B Gene

GeneLoc Exon Structure for
KIF20B
ECgene alternative splicing isoforms for
KIF20B

Expression for KIF20B Gene

mRNA expression in normal human tissues for KIF20B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF20B Gene

SOURCE GeneReport for Unigene cluster for KIF20B Gene Hs.240

mRNA Expression by UniProt/SwissProt for KIF20B Gene

Q96Q89-KI20B_HUMAN
Tissue specificity: Brain, ovary, kidney and testis.
genes like me logo Genes that share expressions with KIF20B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KIF20B Gene

Orthologs for KIF20B Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF20B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF20B 35
  • 99.51 (n)
  • 99.1 (a)
KIF20B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
KIF20B 35
  • 88.36 (n)
  • 82.12 (a)
dog
(Canis familiaris)
Mammalia KIF20B 35
  • 88.44 (n)
  • 82.95 (a)
KIF20B 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif20b 35
  • 81 (n)
  • 74.28 (a)
Kif20b 16
Kif20b 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF20B 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF20B 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif20b 35
  • 79.91 (n)
  • 73.23 (a)
chicken
(Gallus gallus)
Aves KIF20B 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF20B 36
  • 43 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3319 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kif20b 35
  • 57.15 (n)
  • 48.27 (a)
Str.17882 35
zebrafish
(Danio rerio)
Actinopterygii KIF20B (1 of 2) 36
  • 35 (a)
OneToMany
kif20ba 36
  • 35 (a)
OneToMany
kif20bb 35
  • 55.18 (n)
  • 49.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta sub 36
  • 28 (a)
OneToMany
Species with no ortholog for KIF20B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIF20B Gene

ENSEMBL:
Gene Tree for KIF20B (if available)
TreeFam:
Gene Tree for KIF20B (if available)

Paralogs for KIF20B Gene

Paralogs for KIF20B Gene

Selected SIMAP similar genes for KIF20B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIF20B: view

Variants for KIF20B Gene

Sequence variations from dbSNP and Humsavar for KIF20B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs10982 -- 89,774,770(+) tagta(A/G)atcat utr-variant-3-prime
rs12948 -- 89,774,767(+) agata(G/T)tagat utr-variant-3-prime
rs14551 -- 89,774,832(+) gcaac(A/C)gtcag utr-variant-3-prime
rs962524 -- 89,769,101(-) GATCA(A/G)TTACT intron-variant
rs980520 -- 89,719,328(-) ATGAA(A/C)ACTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF20B Gene

Variant ID Type Subtype PubMed ID
nsv507568 CNV Insertion 20534489
nsv825506 CNV Loss 20364138
esv2100770 CNV Deletion 18987734
esv2739384 CNV Deletion 23290073
esv2739395 CNV Deletion 23290073

Relevant External Links for KIF20B Gene

HapMap Linkage Disequilibrium report
KIF20B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF20B Gene

Disorders for KIF20B Gene

Relevant External Links for KIF20B

Genetic Association Database (GAD)
KIF20B
Human Genome Epidemiology (HuGE) Navigator
KIF20B
genes like me logo Genes that share disorders with KIF20B: view

No data available for UniProtKB/Swiss-Prot for KIF20B Gene

Publications for KIF20B Gene

  1. M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis. (PMID: 12740395) Abaza A. … Pirollet F. (J. Biol. Chem. 2003) 3 4 23
  2. Autoantibodies from patients with idiopathic ataxia bind to M-phase phosphoprotein-1 (MPP1). (PMID: 10695267) Fritzler M.J. … Chan E.K. (J. Invest. Med. 2000) 3 4 23
  3. Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope. (PMID: 8290587) Westendorf J.M. … Gerace L. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4
  4. Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1. (PMID: 11470801) Kamimoto T. … Hagiwara M. (J. Biol. Chem. 2001) 2 3 4
  5. Identification of novel M phase phosphoproteins by expression cloning. (PMID: 8885239) Matsumoto-Taniura N. … Westendorf J.M. (Mol. Biol. Cell 1996) 2 3

Products for KIF20B Gene

Sources for KIF20B Gene

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