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Aliases for KIF20B Gene

Aliases for KIF20B Gene

  • Kinesin Family Member 20B 2 3 4 5
  • Cancer/Testis Antigen 90 2 3 4
  • M-Phase Phosphoprotein 1 2 3 4
  • Kinesin-Related Motor Interacting With PIN1 3 4
  • MPHOSPH1 3 4
  • KRMP1 3 4
  • CT90 3 4
  • MPP1 3 4
  • Mitotic Kinesin-Related Protein 3
  • Mitotic Kinesin-Like Protein 3
  • EC 6.3.5.5 63
  • EC 2.1.1 63
  • MPP-1 3

External Ids for KIF20B Gene

Previous HGNC Symbols for KIF20B Gene

  • MPHOSPH1

Previous GeneCards Identifiers for KIF20B Gene

  • GC10P091452
  • GC10P085095

Summaries for KIF20B Gene

GeneCards Summary for KIF20B Gene

KIF20B (Kinesin Family Member 20B) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF23.

UniProtKB/Swiss-Prot for KIF20B Gene

  • Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).

Gene Wiki entry for KIF20B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF20B Gene

Genomics for KIF20B Gene

Regulatory Elements for KIF20B Gene

Promoters for KIF20B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIF20B on UCSC Golden Path with GeneCards custom track

Genomic Location for KIF20B Gene

Chromosome:
10
Start:
89,701,590 bp from pter
End:
89,774,943 bp from pter
Size:
73,354 bases
Orientation:
Plus strand

Genomic View for KIF20B Gene

Genes around KIF20B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF20B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF20B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF20B Gene

Proteins for KIF20B Gene

  • Protein details for KIF20B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96Q89-KI20B_HUMAN
    Recommended name:
    Kinesin-like protein KIF20B
    Protein Accession:
    Q96Q89
    Secondary Accessions:
    • A8MXM7
    • O43277
    • Q09471
    • Q2KQ73
    • Q32NE1
    • Q561V3
    • Q58EX8
    • Q5T9M8
    • Q5T9M9
    • Q5T9N0
    • Q5T9N1
    • Q7KZ68
    • Q7Z5E0
    • Q7Z5E1
    • Q7Z6M9
    • Q86X82
    • Q9H3R8
    • Q9H6Q9
    • Q9H755
    • Q9NTC1
    • Q9UFR5

    Protein attributes for KIF20B Gene

    Size:
    1820 amino acids
    Molecular mass:
    210629 Da
    Quaternary structure:
    • Oligomerizes (via kinesin motor domain) (PubMed:11470801). Associates with microtubules (PubMed:12740395). Interacts (via C-terminal globular tail region) with PIN1 (via WW domain) (PubMed:11470801). Interacts with PRC1 (PubMed:17409436). Interacts with SHTN1 (via N-terminus); the interaction is direct and promotes the association of SHTN1 to microtubules in primary neurons.
    SequenceCaution:
    • Sequence=AAH46134.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH58913.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH93089.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI08689.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB15043.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAI12885.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16829.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF20B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF20B Gene

Proteomics data for KIF20B Gene at MOPED

Selected DME Specific Peptides for KIF20B Gene

Post-translational modifications for KIF20B Gene

  • Phosphorylated during mitosis by CDK1 (PubMed:11470801, PubMed:12740395).
  • Ubiquitination at Lys 117, Lys 767, Lys 983, Lys 1202, and Lys 1345
  • Modification sites at PhosphoSitePlus

Other Protein References for KIF20B Gene

Domains & Families for KIF20B Gene

Gene Families for KIF20B Gene

Protein Domains for KIF20B Gene

Suggested Antigen Peptide Sequences for KIF20B Gene

Graphical View of Domain Structure for InterPro Entry

Q96Q89

UniProtKB/Swiss-Prot:

KI20B_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF20B: view

Function for KIF20B Gene

Molecular function for KIF20B Gene

UniProtKB/Swiss-Prot Function:
Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).

Enzyme Numbers (IUBMB) for KIF20B Gene

genes like me logo Genes that share phenotypes with KIF20B: view

Animal Model Products

CRISPR Products

miRNA for KIF20B Gene

miRTarBase miRNAs that target KIF20B

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF20B Gene

Localization for KIF20B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF20B Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Midbody. Cell projection, axon. Cell projection, growth cone. Note=Localizes mainly in the nucleus during interphase although it is also detected in the cytoplasm without clear association with microtubules (PubMed:12740395). Localized to the central spindle during cytokinetic furrowing and with the midbody during abscission (PubMed:12740395, PubMed:17409436). A 2-3 fold expression increase is seen as cells progress from G1 to G2/M phase (PubMed:12740395). During prophase and metaphase it is found throughout the cytoplasm and at anaphase accumulates at the midplan of the cell and forms a distinct band extending across the spindle midzone (PubMed:12740395). At anaphase it is concentrated in the midbody (PubMed:12740395). Colocalized partially along microtubules in primary neurons. Colocalized with SHTN1 along microtubules to the tip of the growing cone in primary hippocampal neurons. Localized in midbodies between dividing radial progenitors in the ventricular zone (By similarity). Colocalized with PRC1 in the nucleus of bladder carcinoma cells at the interphase. Colocalized with PRC1 in bladder carcinoma cells at prophase, metaphase, early anaphase, at the midzone in late anaphase and at the contractile ring in telophase (PubMed:17409436). {ECO:0000250 UniProtKB:Q80WE4, ECO:0000269 PubMed:12740395, ECO:0000269 PubMed:17409436}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF20B Gene COMPARTMENTS Subcellular localization image for KIF20B gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KIF20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12740395
GO:0005730 nucleolus IDA 11470801
GO:0005737 cytoplasm IDA 8885239
GO:0070938 contractile ring IDA 17409436
genes like me logo Genes that share ontologies with KIF20B: view

Pathways & Interactions for KIF20B Gene

genes like me logo Genes that share pathways with KIF20B: view

Gene Ontology (GO) - Biological Process for KIF20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure IEA --
GO:0007088 regulation of mitotic nuclear division IEA,NAS 11470801
GO:0051301 cell division IEA --
GO:2000114 regulation of establishment of cell polarity IEA,ISS --
GO:2001222 regulation of neuron migration IEA --
genes like me logo Genes that share ontologies with KIF20B: view

No data available for SIGNOR curated interactions for KIF20B Gene

Drugs & Compounds for KIF20B Gene

No Compound Related Data Available

Transcripts for KIF20B Gene

Unigene Clusters for KIF20B Gene

Kinesin family member 20B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF20B Gene

No ASD Table

Relevant External Links for KIF20B Gene

GeneLoc Exon Structure for
KIF20B
ECgene alternative splicing isoforms for
KIF20B

Expression for KIF20B Gene

mRNA expression in normal human tissues for KIF20B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIF20B Gene

This gene is overexpressed in Heart (54.1) and Fetal heart (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF20B Gene



SOURCE GeneReport for Unigene cluster for KIF20B Gene Hs.240

mRNA Expression by UniProt/SwissProt for KIF20B Gene

Q96Q89-KI20B_HUMAN
Tissue specificity: Brain, ovary, kidney and testis (at protein level) (PubMed:12740395). Overexpressed in bladder cancer cells (at protein level) (PubMed:17409436). Expressed in testis. Overexpressed in bladder cancer cells (PubMed:17409436).
genes like me logo Genes that share expression patterns with KIF20B: view

Protein tissue co-expression partners for KIF20B Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KIF20B Gene

Orthologs for KIF20B Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF20B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIF20B 35
  • 88.36 (n)
  • 82.12 (a)
-- 36
  • 79 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia KIF20B 35
  • 88.44 (n)
  • 82.95 (a)
KIF20B 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif20b 35
  • 81 (n)
  • 74.28 (a)
Kif20b 16
Kif20b 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIF20B 35
  • 99.51 (n)
  • 99.1 (a)
KIF20B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif20b 35
  • 79.91 (n)
  • 73.23 (a)
oppossum
(Monodelphis domestica)
Mammalia KIF20B 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF20B 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF20B 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF20B 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif20b 35
  • 57.15 (n)
  • 48.27 (a)
Str.17882 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3319 35
zebrafish
(Danio rerio)
Actinopterygii kif20bb 35
  • 55.18 (n)
  • 49.22 (a)
KIF20B (1 of 2) 36
  • 35 (a)
OneToMany
kif20ba 36
  • 35 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sub 36
  • 28 (a)
OneToMany
Species with no ortholog for KIF20B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIF20B Gene

ENSEMBL:
Gene Tree for KIF20B (if available)
TreeFam:
Gene Tree for KIF20B (if available)

Paralogs for KIF20B Gene

Paralogs for KIF20B Gene

(5) SIMAP similar genes for KIF20B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIF20B: view

Variants for KIF20B Gene

Sequence variations from dbSNP and Humsavar for KIF20B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1129777 - 89,709,168(+) TAAGG(C/G)AAACA reference, missense
rs17484219 - 89,719,454(+) CAAGA(G/T)AAATT reference, missense
rs12572012 - 89,727,892(+) ATCTA(A/T)TAAGG reference, missense
rs3758388 - 89,729,222(+) GTCTC(A/T)TATGG reference, missense
rs1062465 - 89,737,874(+) AGGGA(A/T)CTGTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KIF20B Gene

Variant ID Type Subtype PubMed ID
nsv507568 CNV Insertion 20534489
nsv825506 CNV Loss 20364138
esv2100770 CNV Deletion 18987734
esv2739384 CNV Deletion 23290073
esv2739395 CNV Deletion 23290073

Variation tolerance for KIF20B Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 22.46; 99.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF20B Gene

HapMap Linkage Disequilibrium report
KIF20B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF20B Gene

Disorders for KIF20B Gene

Relevant External Links for KIF20B

Genetic Association Database (GAD)
KIF20B
Human Genome Epidemiology (HuGE) Navigator
KIF20B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF20B

No disorders were found for KIF20B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF20B Gene

Publications for KIF20B Gene

  1. Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1. (PMID: 11470801) Kamimoto T. … Hagiwara M. (J. Biol. Chem. 2001) 2 3 4 67
  2. Oncogenic role of MPHOSPH1, a cancer-testis antigen specific to human bladder cancer. (PMID: 17409436) Kanehira M. … Nakamura Y. (Cancer Res. 2007) 3 23
  3. M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis. (PMID: 12740395) Abaza A. … Pirollet F. (J. Biol. Chem. 2003) 3 23
  4. Autoantibodies from patients with idiopathic ataxia bind to M-phase phosphoprotein-1 (MPP1). (PMID: 10695267) Fritzler M.J. … Chan E.K. (J. Invest. Med. 2000) 3 23
  5. Identification of novel M phase phosphoproteins by expression cloning. (PMID: 8885239) Matsumoto-Taniura N. … Westendorf J.M. (Mol. Biol. Cell 1996) 2 3

Products for KIF20B Gene

Sources for KIF20B Gene

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