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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIF1C Gene

protein-coding   GIFtS: 54
GCID: GC17P004901

kinesin family member 1C

 Explore 3 diseases affiliated with
KIF1C via our new
 Human Malady Compendium 
Biological research products
for KIF1C
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Kinesin Family Member 1C1 2
LTXS12
Kinesin-Like Protein KIF1C2
KIAA07063

External Ids:    HGNC: 63171   Entrez Gene: 107492   Ensembl: ENSG000001292507   OMIM: 6030605   UniProtKB: O438963   

Export aliases for KIF1C gene to outside databases

Previous GC identifers: GC17P005320 GC17P005239 GC17P004846 GC17P005101 GC17P004843 GC17P004844


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: KIF1C_HUMAN, O43896
Function: Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule
plus end-directed motility

Gene Wiki entry for KIF1C


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIF1C gene promoter:
         E2F-4   E2F-3a   E2F-1   E2F   E2F-2   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIF1C promoter sequence
   Search SABiosciences Chromatin IP Primers for KIF1C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.2

KIF1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF1C gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P004901:  view genomic region     (about GC identifiers)

Start:
4,901,243 bp from pter      End:
4,931,696 bp from pter
Size:
30,454 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KIF1C_HUMAN, O43896 (See protein sequence)
Recommended Name: Kinesin-like protein KIF1C  
Size: 1103 amino acids; 122947 Da
Subunit: Monomer (Potential)
Subcellular location: Cytoplasm, cytoskeleton (Probable)
Sequence caution: Sequence=BAA31681.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for KIF1C:
2G1L (3D)    
Secondary accessions: D3DTL6 O75186 Q5U618

Explore the universe of human proteins at neXtProt for KIF1C: NX_O43896

Post-translational modifications:

  • Phosphorylated on tyrosine residues1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43896

  • KIF1C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006603.2  
    ENSEMBL proteins: 
     ENSP00000320821   ENSP00000458697  

    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KIF1C

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS9685376
    GO:0005794Golgi apparatus IEA--
    GO:0005874microtubule IEA--
    GO:0005875microtubule associated complex IEA--


    KIF1C for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    KIF1C for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR008984 SMAD_FHA_domain
     IPR001752 Kinesin_motor_dom
     IPR000253 FHA_dom
     IPR019821 Kinesin_motor_CS

    Graphical View of Domain Structure for InterPro Entry O43896

    ProtoNet protein and cluster: O43896

    2 Blocks protein families:
    IPB000253 Forkhead-associated (FHA)
    IPB001752 Kinesin


    UniProtKB/Swiss-Prot: KIF1C_HUMAN, O43896
    Similarity: Belongs to the kinesin-like protein family. Unc-104 subfamily
    Similarity: Contains 1 FHA domain
    Similarity: Contains 1 kinesin-motor domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: KIF1C_HUMAN, O43896
    Function: Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule
    plus end-directed motility

    miRNA
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    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate KIF1C (see all 55):
    hsa-miR-15a hsa-miR-200a hsa-miR-503 hsa-miR-3605-3p hsa-miR-578 hsa-miR-766 hsa-miR-877* hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidKIF1C 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIF1C (see all 7)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF1C

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity TAS9685376
    GO:0003777microtubule motor activity IEA--
    GO:0005524ATP binding IEA--


    KIF1C for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for KIF1C:
     Increased G1 DNA content  Low eccentricity cells  Upregulation of Wnt/beta-caten 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Kif1c):
     immune system  normal 

    KIF1C for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Reelin Pathway (Cajal-Retzius cells)
    Reelin Pathway (Cajal-Retzius cells)1.00

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KIF1C
        Reelin Pathway (Cajal-Retzius cells)


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KIF1C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/13 Interacting proteins for KIF1C (O438962, 3 ENSP000003208214) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-8005401 I2D: score=3 STRING: ENSP00000306330
    CSNK2A2P197843, ENSP000002625064I2D: score=2 STRING: ENSP00000262506
    YWHAEP622583, ENSP000002643354I2D: score=2 STRING: ENSP00000264335
    YWHAZP631043, ENSP000003095034I2D: score=2 STRING: ENSP00000309503
    PTPN21Q168253, ENSP000003302764I2D: score=2 STRING: ENSP00000330276
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006890retrograde vesicle-mediated transport, Golgi to ER IEA--
    GO:0007018microtubule-based movement IEA--


    KIF1C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIF1C
    Search CenterWatch for drugs/clinical trials and news about KIF1C 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIF1C gene: 
    NM_006612.5  

    Unigene Cluster for KIF1C:

    Kinesin family member 1C
    Hs.435120  [show with all ESTs]
    Unigene Representative Sequence: NM_006612
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000320785(uc002gan.2) ENST00000574165 ENST00000572959 ENST00000573815


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    hsa-miR-15a hsa-miR-200a hsa-miR-503 hsa-miR-3605-3p hsa-miR-578 hsa-miR-766 hsa-miR-877* hsa-miR-141
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF1C
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    Additional cDNA sequence: 

    AB014606.2 AK307401.1 BC025365.2 BC034993.1 BC040307.1 U91329.1 

    13 DOTS entries:

    DT.455260  DT.40273471  DT.87016676  DT.92324691  DT.100788250  DT.121003584  DT.121003608  DT.91910230 
    DT.92030880  DT.91728152  DT.91769850  DT.91791138  DT.97804963 

    24/409 AceView cDNA sequences (see all 409):

    BM694897 BQ219024 AA984463 BQ934648 AA159770 BQ945872 BU191741 BQ677314 
    AI073641 BU507647 BQ220007 BE856793 BM458656 AW149038 BM468892 BM742811 
    AI680169 BM467294 AI380919 BF725589 BM016517 BM709031 CA502837 BQ228448 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIF1C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGATGTGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    KIF1C expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainMeningesBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KIF1C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIF1C

    SOURCE GeneReport for Unigene cluster: Hs.435120

    UniProtKB/Swiss-Prot: KIF1C_HUMAN, O43896
    Tissue specificity: Expressed in all tissues examined, with most abundant expression in heart and skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF1C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KIF1C gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia KIF1C6
    --
    82(a)
    1 ↔ 1
    GL344025.1(60356-86673)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.24072 Xenopus laevis transcribed sequence with moderate similarity more 78.45(n)    BJ040171.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kif1b2 kinesin family member 1B 78.24(n)   369190  AY029411.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nod3 meiotic chromosome segregation kinesin motor 30(a)   1 10C9   --
    worm
    (Caenorhabditis elegans)
    Secernentea klp-63   -- 38(a)   III(5102738-5108133)   --


    ENSEMBL Gene Tree for KIF1C (if available)
    TreeFam Gene Tree for KIF1C (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIF1C gene
    KIF18A2  KIF16B2  KIF1B2  KIF192  KIF142  KIF222  KIF13B2  KIF1A2  
    KIF13A2  KIF122  KIF18B2  
    10 SIMAP similar genes for KIF1C using alignment to 3 protein entries:     KIF1C_HUMAN (see all proteins):
    KIF1A    KIF1Bbeta    KIF1B    KIF13B    KIF13A    KIF14
    CENPE    KIF16B    KIF3A    KIF27

    KIF1C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/692 NCBI SNPs in KIF1C are shown (see all 692    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1471482311,2
    --4899281(+) TCAACC/TGGTGA 5 -- int1 us2k10--------
    rs1885226031,2
    --4899410(+) CACACC/TGGCTC 5 -- us2k1 int10--------
    rs1385323181,2
    --4899436(+) GCAATC/TTGGGA 5 -- int1 us2k10--------
    rs1928752641,2
    --4899439(+) ATTTGA/GGAGGC 5 -- int1 us2k10--------
    rs1133471271,2
    --4899445(+) GAGGCG/AGAAGT 5 -- int1 us2k13Minor allele frequency- A:0.10CSA WA EA 240
    rs1420284171,2
    --4899458(+) GTGGAC/TTGCTC 5 -- us2k1 int10--------
    rs795167621,2
    --4899506(+) GAAACC/TCCCTC 5 -- us2k1 int11Minor allele frequency- T:0.01WA 118
    rs1506655271,2
    --4899611(+) AGGCTA/GCAGTG 5 -- int1 us2k10--------
    rs1114126321,2
    C--4899612(+) GGCTGC/TAGTGA 5 -- int1 us2k10--------
    rs1848701011,2
    --4899621(+) GAGGTA/GAGATC 5 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for KIF1C (4901243 - 4931696 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KIF1C: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIF1C
    DNA2.0 Custom Variant and Variant Library Synthesis for KIF1C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KIF1C for disorders           About GeneDecksing

    OMIM gene information: 603060    OMIM disorders: --

    3 diseases for KIF1C:    About MalaCards
    cutaneous anthrax    malaria    neuronitis

    3 diseases from the University of Copenhagen DISEASES database for KIF1C:
    Cutaneous anthrax     Asperger syndrome     Benign glioma

    Export disorders for KIF1C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIF1C gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with KIF1C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum. (PubMed id 9685376)1, 2, 3 Dorner C....Lammers R. (1998)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (1998)
    6. Directional persistence of migrating cells requires Ki f1C-mediated stabilization of trailing adhesions. (PubMed id 23237952)1 Theisen U....Straube A. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10749 HGNC: 6317 AceView: KIF1C Ensembl:ENSG00000129250 euGenes: HUgn10749
    ECgene: KIF1C H-InvDB: KIF1C

    (According to HUGE)
    About This Section
    HUGE: KIAA0706

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIF1C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIF1C gene:
    Search GeneIP for patents involving KIF1C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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