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KIF1C Gene

protein-coding   GIFtS: 55
GCID: GC17P004901

Kinesin Family Member 1C

(Previous name: spastic ataxia 2 (autosomal recessive))
(Previous symbol: SAX2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kinesin Family Member 1C1 2     KIAA07063 5
SAX21 2     SATX22
Spastic Ataxia 2 (Autosomal Recessive)1 2     SPG582
LTXS12 5     Kinesin-Like Protein KIF1C2
SPAX22 5     

External Ids:    HGNC: 63171   Entrez Gene: 107492   Ensembl: ENSG000001292507   OMIM: 6030605   UniProtKB: O438963   

Export aliases for KIF1C gene to outside databases

Previous GC identifers: GC17P005320 GC17P005239 GC17P004846 GC17P005101 GC17P004843 GC17P004844


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KIF1C Gene:
KIF1C (kinesin family member 1C) is a protein-coding gene. Diseases associated with KIF1C include benign glioma, and cutaneous anthrax. GO annotations related to this gene include microtubule binding and motor activity. An important paralog of this gene is KIF18A.

UniProtKB/Swiss-Prot: KIF1C_HUMAN, O43896
Function: Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a
microtubule plus end-directed motility

Gene Wiki entry for KIF1C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIF1C gene promoter:
         E2F-4   E2F-3a   E2F-1   E2F   E2F-2   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIF1C promoter sequence
   Search Chromatin IP Primers for KIF1C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIF1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.2

KIF1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF1C gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P004901:  view genomic region     (about GC identifiers)

Start:
4,901,243 bp from pter      End:
4,931,696 bp from pter
Size:
30,454 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KIF1C_HUMAN, O43896 (See protein sequence)
Recommended Name: Kinesin-like protein KIF1C  
Size: 1103 amino acids; 122947 Da
Subunit: Monomer (Potential)
Sequence caution: Sequence=BAA31681.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for KIF1C:
2G1L (3D)    
Secondary accessions: D3DTL6 O75186 Q5U618

Explore the universe of human proteins at neXtProt for KIF1C: NX_O43896

Explore proteomics data for KIF1C at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KIF1C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006603.2  
    ENSEMBL proteins: 
     ENSP00000320821   ENSP00000458697  

    KIF1C Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for KIF1C

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KIF: Kinesins

    Selected InterPro protein domains (see all 6):
     IPR008984 SMAD_FHA_domain
     IPR027417 P-loop_NTPase
     IPR000253 FHA_dom
     IPR001752 Kinesin_motor_dom
     IPR019821 Kinesin_motor_CS

    Graphical View of Domain Structure for InterPro Entry O43896

    ProtoNet protein and cluster: O43896

    2 Blocks protein domains:
    IPB000253 Forkhead-associated (FHA)
    IPB001752 Kinesin


    UniProtKB/Swiss-Prot: KIF1C_HUMAN, O43896
    Similarity: Belongs to the kinesin-like protein family. Unc-104 subfamily
    Similarity: Contains 1 FHA domain
    Similarity: Contains 1 kinesin-motor domain


    KIF1C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KIF1C_HUMAN, O43896
    Function: Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a
    microtubule plus end-directed motility

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity TAS9685376
    GO:0003777microtubule motor activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0008017microtubule binding IEA--
         
    KIF1C for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for KIF1C:
     Increased G1 DNA content  Low eccentricity cells  Upregulation of Wnt/beta-caten 

         3 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Kif1c):
     immune system  normal  reproductive system 

    KIF1C for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIF1C
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KIF1C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KIF1C

    miRNA
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    miRTarBase miRNAs that target KIF1C:
    hsa-mir-769-3p (MIRT039061), hsa-mir-149-5p (MIRT045685), hsa-mir-484 (MIRT041907), hsa-let-7b-5p (MIRT051959), hsa-mir-26b-5p (MIRT029029), hsa-mir-1260b (MIRT052743), hsa-mir-877-3p (MIRT036900)

    Block miRNA regulation of human, mouse, rat KIF1C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KIF1C (see all 55):
    hsa-miR-15a hsa-miR-200a hsa-miR-503 hsa-miR-3605-3p hsa-miR-578 hsa-miR-766 hsa-miR-877* hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidKIF1C 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KIF1C
    Predesigned siRNA for gene silencing in human, mouse, rat KIF1C

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: KIF1C (NM_006612)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIF1C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF1C

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF1C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KIF1C_HUMAN, O43896: Cytoplasm, cytoskeleton (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    endoplasmic reticulum4
    golgi apparatus4
    cytosol3
    nucleus2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS9685376
    GO:0005794Golgi apparatus IEA--
    GO:0005871kinesin complex IEA--
    GO:0005874microtubule IEA--

    KIF1C for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KIF1C About    
    See pathways by source

    SuperPathContained pathways About
    1Reelin Pathway (Cajal-Retzius cells)
    Reelin Pathway (Cajal-Retzius cells)

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KIF1C
        Reelin Pathway (Cajal-Retzius cells)


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIF1C
    Interactions:

        GeneGlobe Interaction Network for KIF1C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KIF1C (O438961, 2, 3 ENSP000003208214) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-8005401 I2D: score=3 STRING: ENSP00000306330
    CSNK2A2P197843, ENSP000002625064I2D: score=2 STRING: ENSP00000262506
    YWHAEP622583, ENSP000002643354I2D: score=2 STRING: ENSP00000264335
    YWHAZP631043, ENSP000003095034I2D: score=2 STRING: ENSP00000309503
    PTPN21Q168253, ENSP000003302764I2D: score=2 STRING: ENSP00000330276
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006890retrograde vesicle-mediated transport, Golgi to ER IEA--
    GO:0007018microtubule-based movement IEA--
    GO:0008152metabolic process TAS9685376

    KIF1C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIF1C



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KIF1C gene: 
    NM_006612.5  

    Unigene Cluster for KIF1C:

    Kinesin family member 1C
    Hs.435120  [show with all ESTs]
    Unigene Representative Sequence: NM_006612
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000320785(uc002gan.2) ENST00000574165 ENST00000572959 ENST00000573815

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KIF1C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KIF1C (see all 55):
    hsa-miR-15a hsa-miR-200a hsa-miR-503 hsa-miR-3605-3p hsa-miR-578 hsa-miR-766 hsa-miR-877* hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidKIF1C 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KIF1C
    Predesigned siRNA for gene silencing in human, mouse, rat KIF1C
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KIF1C (NM_006612)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF1C
    Primer
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    OriGene qPCR primer pairs and template standards for KIF1C
    OriGene qSTAR qPCR primer pairs in human, mouse for KIF1C
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KIF1C
      QuantiTect SYBR Green Assays in human, mouse, rat KIF1C
      QuantiFast Probe-based Assays in human, mouse, rat KIF1C

    Additional mRNA sequence: 

    AB014606.2 AK307401.1 BC025365.2 BC034993.1 BC040307.1 U91329.1 

    13 DOTS entries:

    DT.455260  DT.40273471  DT.87016676  DT.92324691  DT.100788250  DT.121003584  DT.121003608  DT.91910230 
    DT.92030880  DT.91728152  DT.91769850  DT.91791138  DT.97804963 

    Selected AceView cDNA sequences (see all 409):

    AW149038 AI419468 BM694897 AI471102 CA502837 AI073641 CO248265 BF725589 
    BU845151 BG152620 BC040307 BM549508 CD671092 BC025365 BU507647 BE252943 
    BQ950815 BU429070 BQ772393 BG109313 AA159770 BM458656 BU542108 BQ934648 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIF1C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGATGTGGG
    KIF1C Expression
    About this image


    KIF1C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)
             Meninges
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
     
     Lung (Respiratory System)
     
     Esophagus (Gastrointestinal Tract)
    KIF1C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIF1C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435120

    UniProtKB/Swiss-Prot: KIF1C_HUMAN, O43896
    Tissue specificity: Expressed in all tissues examined, with most abundant expression in heart and skeletal muscle

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KIF1C gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kif1c1 , 5 kinesin family member 1C1, 5 87.79(n)1
    93.27(a)1
      11 (43.21 cM)5
    165621  NM_153103.21  NP_694743.21 
     707005485 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    38(a)
    many ↔ many
    3(33173349-33182377)
    lizard
    (Anolis carolinensis)
    Reptilia KIF1C6
    kinesin family member 1C
    80(a)
    1 ↔ 1
    GL344025.1(33022-89798)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.24072 Xenopus laevis transcribed sequence with moderate similarity more 78.45(n)    BJ040171.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kif1b2 kinesin family member 1B 78.24(n)   369190  AY029411.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nod3 meiotic chromosome segregation kinesin
    motor
    30(a)   1 10C9   --
    worm
    (Caenorhabditis elegans)
    Secernentea klp-63   -- 38(a)   III(5102738-5108133)   --


    ENSEMBL Gene Tree for KIF1C (if available)
    TreeFam Gene Tree for KIF1C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIF1C gene
    KIF18A2  KIF16B2  STARD92  KIF1B2  KIF192  KIF142  KIF222  KIF13B2  
    KIF1A2  KIF13A2  KIF18B2  
    Selected SIMAP similar genes for KIF1C using alignment to 3 protein entries:     KIF1C_HUMAN (see all proteins) (see all similar genes):
    KIF1A    KIF1Bbeta    KIF1B    KIF13B    KIF13A    KIF14
    A20    CENPE    KIF16B    KIF3A    R11    R12
    KIF27    KIF5B-ALK_K17    KIF5B-RET(NM_020630)_K15    KIF5B-RET(NM_020630)_K16    KIF5B-RET(NM_020630)_K22    KIF5B-RET(NM_020630)_K23

    KIF1C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIF1C (see all 835)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1422225091,2
    --4902952(+) AGTACA/GTTTGC 1 -- int10--------
    rs2382371,2
    C,F,A,H--4902958(-) TCACTT/CGCAAA 1 -- int137Minor allele frequency- C:0.28MN NS EA NA WA CSA 3651
    rs1831179571,2
    --4903020(+) CCACTC/TTAGAG 1 -- int10--------
    rs752843041,2
    C,F--4903395(+) GGTCCT/CTGAGA 1 -- int11Minor allele frequency- C:0.12WA 118
    rs1511852841,2
    --4903431(+) GAAGAA/GACTGG 1 -- int10--------
    rs1879589651,2
    C--4903509(+) CTGTCC/TTCCAG 1 -- int10--------
    rs1403169251,2
    C--4903512(+) TCCTCC/GAGCTG 1 -- int10--------
    rs1483617941,2
    C,F--4903559(+) TCGGTG/AAAAGT 2 /V syn11Minor allele frequency- A:0.00NA 3636
    rs747662841,2
    C--4903560(+) CGGTGA/GAAGTG 2 K E mis10--------
    rs1996327601,2
    --4903593(+) ACGCCC/TGTGAG 2 R C mis10--------

    HapMap Linkage Disequilibrium report for KIF1C (4901243 - 4931696 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KIF1C:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv907620CNV Loss21882294
    nsv907622CNV Loss21882294
    nsv833350CNV Loss17160897
    nsv907619CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIF1C
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603060   
    OMIM disorders: 611302  
    5 diseases for KIF1C:    
    About MalaCards
    benign glioma    cutaneous anthrax    asperger syndrome    meningitis
    obesity

    3 diseases from the University of Copenhagen DISEASES database for KIF1C:
    Cutaneous anthrax     Asperger syndrome     Benign glioma

    KIF1C for disorders           About GeneDecksing


    Export disorders for KIF1C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIF1C gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with KIF1C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum. (PubMed id 9685376)1, 2, 3 Dorner C....Lammers R. (J. Biol. Chem. 1998)
    2. Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. (PubMed id 24482476)1, 3 Novarino G....Gleeson J.G. (Science 2014)
    3. KIF1C mutations in two families with hereditary spastic paraparesis and cerebellar dysfunction. (PubMed id 24319291)1, 3 Dor T....Edvardson S. (J. Med. Genet. 2014)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (DNA Res. 1998)
    8. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    9. Directional persistence of migrating cells requires Kif1C-mediated stabilization of trailing adhesions. (PubMed id 23237952)1 Theisen U....Straube A. (Dev. Cell 2012)
    10. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10749 HGNC: 6317 AceView: KIF1C Ensembl:ENSG00000129250 euGenes: HUgn10749
    ECgene: KIF1C H-InvDB: KIF1C

    (According to HUGE)
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    HUGE: KIAA0706

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIF1C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIF1C gene:
    Search GeneIP for patents involving KIF1C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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