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Aliases for KIF18B Gene

Aliases for KIF18B Gene

  • Kinesin Family Member 18B 2 3 5

External Ids for KIF18B Gene

Previous GeneCards Identifiers for KIF18B Gene

  • GC17M040359
  • GC17M043003
  • GC17M038768

Summaries for KIF18B Gene

GeneCards Summary for KIF18B Gene

KIF18B (Kinesin Family Member 18B) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Golgi-to-ER retrograde transport. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF18A.

UniProtKB/Swiss-Prot for KIF18B Gene

  • In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.

Additional gene information for KIF18B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF18B Gene

Genomics for KIF18B Gene

GeneHancer (GH) Regulatory Elements for KIF18B Gene

Promoters and enhancers for KIF18B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I044946 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.3 292 2.3 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF766 ENSG00000267334 KIF18B EFTUD2 TMUB2 ASB16-AS1 MAP3K14 ENSG00000224505 GPATCH8 GJC1 UBTF
GH17I044977 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.2 -32.1 -32054 5.2 PKNOX1 FOXA2 MLX SIN3A YBX1 BRCA1 ETS1 YY1 ZNF207 ATF7 UBTF LINC02210 GJC1 NMT1 EFTUD2 MAP3K14-AS1 LRRC37A4P ASB16-AS1 ENSG00000266918 KIF18B
GH17I045020 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.3 -73.7 -73679 2.5 ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF207 ZNF143 ATF7 PAF1 DCAKD NMT1 C1QL1 GFAP CCDC103 EFTUD2 FAM187A KIF18B HEXIM2 ENSG00000224505
GH17I045029 Enhancer 1.1 ENCODE dbSUPER 11.7 -83.4 -83415 3.1 PKNOX1 ATF1 FOXA2 ARNT ZNF48 TCF12 GATA2 ATF7 ZNF263 RXRA DCAKD NMT1 KIF18B GFAP C1QL1 HEXIM2 ENSG00000224505 EFTUD2 FAM187A CCDC103
GH17I045006 Enhancer 0.9 FANTOM5 dbSUPER 12.3 -59.4 -59410 0.3 CTCF MAZ ZIC2 RAD21 ZFP69B ZFHX2 ZNF692 GLIS1 ZNF341 PATZ1 KIF18B C1QL1 FAM187A EFTUD2 CCDC103 GFAP NMT1 DCAKD GC17M045006 GC17M044982
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KIF18B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KIF18B gene promoter:

Genomic Locations for KIF18B Gene

Genomic Locations for KIF18B Gene
chr17:44,924,709-44,947,745
(GRCh38/hg38)
Size:
23,037 bases
Orientation:
Minus strand
chr17:43,002,077-43,025,082
(GRCh37/hg19)

Genomic View for KIF18B Gene

Genes around KIF18B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF18B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF18B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF18B Gene

Proteins for KIF18B Gene

  • Protein details for KIF18B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y91-KI18B_HUMAN
    Recommended name:
    Kinesin-like protein KIF18B
    Protein Accession:
    Q86Y91
    Secondary Accessions:
    • A6NJI2
    • B7ZM49
    • B9EGM8
    • D5L6I1

    Protein attributes for KIF18B Gene

    Size:
    864 amino acids
    Molecular mass:
    94223 Da
    Quaternary structure:
    • Interacts with MAPRE1; this interaction is required for efficient accumulation at microtubule plus ends. Interacts with KIF2C at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. KIF2C phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.
    SequenceCaution:
    • Sequence=AAI36591.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI44272.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF18B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF18B Gene

Post-translational modifications for KIF18B Gene

  • Ubiquitination at isoforms=2, 3, 4352

No data available for DME Specific Peptides for KIF18B Gene

Domains & Families for KIF18B Gene

Gene Families for KIF18B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KIF18B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86Y91

UniProtKB/Swiss-Prot:

KI18B_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF18B: view

Function for KIF18B Gene

Molecular function for KIF18B Gene

UniProtKB/Swiss-Prot Function:
In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.

Phenotypes From GWAS Catalog for KIF18B Gene

Gene Ontology (GO) - Molecular Function for KIF18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003774 motor activity IDA 21820309
GO:0003777 microtubule motor activity IBA --
GO:0005515 protein binding IPI 21820309
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with KIF18B: view
genes like me logo Genes that share phenotypes with KIF18B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF18B Gene

Localization for KIF18B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF18B Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Present predominantly in the nucleus and to a lesser extent in the cytoplasm of interphase cells. During mitosis, found to be closely associated with astral microtubule plus ends emanating from the spindle pole during prometaphase and metaphase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF18B gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Microtubule ends (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KIF18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000235 astral microtubule IDA 21820309
GO:0005634 nucleus IEA,IDA 20600703
GO:0005737 cytoplasm IEA,IDA 20600703
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with KIF18B: view

Pathways & Interactions for KIF18B Gene

genes like me logo Genes that share pathways with KIF18B: view

Interacting Proteins for KIF18B Gene

Gene Ontology (GO) - Biological Process for KIF18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IBA --
GO:0000278 mitotic cell cycle IDA 20600703
GO:0007018 microtubule-based movement IBA --
GO:0007019 microtubule depolymerization IDA 21820309
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with KIF18B: view

No data available for SIGNOR curated interactions for KIF18B Gene

Drugs & Compounds for KIF18B Gene

No Compound Related Data Available

Transcripts for KIF18B Gene

mRNA/cDNA for KIF18B Gene

(10) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIF18B Gene

Kinesin family member 18B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF18B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2:
SP3:
SP4:
SP5: -

Relevant External Links for KIF18B Gene

GeneLoc Exon Structure for
KIF18B
ECgene alternative splicing isoforms for
KIF18B

Expression for KIF18B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF18B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF18B Gene

This gene is overexpressed in Esophagus - Mucosa (x5.0).

Protein differential expression in normal tissues from HIPED for KIF18B Gene

This gene is overexpressed in Heart (63.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIF18B Gene



Protein tissue co-expression partners for KIF18B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KIF18B Gene:

KIF18B

SOURCE GeneReport for Unigene cluster for KIF18B Gene:

Hs.135094

mRNA Expression by UniProt/SwissProt for KIF18B Gene:

Q86Y91-KI18B_HUMAN
Tissue specificity: Shows a prominent expression in the amygdala.

Evidence on tissue expression from TISSUES for KIF18B Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with KIF18B: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF18B Gene

Orthologs for KIF18B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF18B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF18B 33 34
  • 99.3 (n)
cow
(Bos Taurus)
Mammalia KIF18B 33 34
  • 84.82 (n)
dog
(Canis familiaris)
Mammalia KIF18B 33 34
  • 84.24 (n)
mouse
(Mus musculus)
Mammalia Kif18b 33 16 34
  • 79.43 (n)
rat
(Rattus norvegicus)
Mammalia Kif18b 33
  • 79.39 (n)
oppossum
(Monodelphis domestica)
Mammalia KIF18B 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF18B 34
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF18B 33 34
  • 63.68 (n)
lizard
(Anolis carolinensis)
Reptilia KIF18B 34
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490953 33
  • 57.34 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-26i13.8 34
  • 21 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Klp67A 34
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIP3 34
  • 27 (a)
OneToMany
Species where no ortholog for KIF18B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIF18B Gene

ENSEMBL:
Gene Tree for KIF18B (if available)
TreeFam:
Gene Tree for KIF18B (if available)

Paralogs for KIF18B Gene

Paralogs for KIF18B Gene

(14) SIMAP similar genes for KIF18B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for KIF18B Gene

genes like me logo Genes that share paralogs with KIF18B: view

Variants for KIF18B Gene

Sequence variations from dbSNP and Humsavar for KIF18B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000234259 -- 44,927,946(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000553774 -- 44,940,836(-) G/A/C intron_variant
rs1000589145 -- 44,947,536(-) A/C 5_prime_UTR_variant, intron_variant
rs1000686049 -- 44,941,401(-) C/T intron_variant
rs1000959686 -- 44,947,207(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KIF18B Gene

Variant ID Type Subtype PubMed ID
esv29905 CNV loss 19812545
esv3640656 CNV loss 21293372
nsv1146669 OTHER inversion 26484159
nsv527788 CNV loss 19592680
nsv833457 CNV loss 17160897

Variation tolerance for KIF18B Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIF18B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF18B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF18B Gene

Disorders for KIF18B Gene

Additional Disease Information for KIF18B

No disorders were found for KIF18B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF18B Gene

Publications for KIF18B Gene

  1. A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. (PMID: 21820309) Tanenbaum ME … Medema RH (Current biology : CB 2011) 3 4 58
  2. Cell cycle-regulated expression and subcellular localization of a kinesin-8 member human KIF18B. (PMID: 20600703) Lee YM … Kim W (Gene 2010) 3 4 58
  3. Analysis of the kinesin superfamily: insights into structure and function. (PMID: 16084724) Miki H … Hirokawa N (Trends in cell biology 2005) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58

Products for KIF18B Gene

Sources for KIF18B Gene

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