KIF18B Gene
protein-coding GIFtS: 43
GCID: GC17M043003
|
|
kinesin family member 18B
| |
Aliases
for KIF18B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kinesin Family Member 18B1 2 | | Kinesin-Like Protein KIF18B2 |
Export aliases for KIF18B gene to outside databasesPrevious GC identifers: GC17M040359 GC17M038768 |
Summaries
for KIF18B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: KI18B_HUMAN, Q86Y91Function: In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells.Its major role may be to transport KIF2C and/or MAPRE1 along microtubules
|
Genomic Views
for KIF18B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KIF18B gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 POU6F1 (c2) POU2F2 POU2F2C POU2F1 POU2F1a POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIF18B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF18B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.31 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.31KIF18B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M043003: view genomic region
(about GC identifiers)
Start:
|
43,002,077 bp from pter |
End:
|
43,025,082 bp from pter |
Size:
|
23,006 bases |
Orientation:
|
minus strand |
|
Proteins
for KIF18B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KI18B_HUMAN, Q86Y91 (See
protein sequence)Recommended Name: Kinesin-like protein KIF18B Size: 864 amino acids; 94223 Da
Subunit: Interacts with MAPRE1; this interaction is required for efficient accumulation at microtubule plus ends.Interacts with KIF2C at microtubule tips; this interaction increases the affinity of both partners for microtubuleplus ends and is required for robust microtubule depolymerization. KIF2C phosphorylation by AURKA or AURKB stronglyreduces KIF18B-binding
Subcellular location: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Present predominantly in the nucleus and to alesser extent in the cytoplasm of interphase cells. During mitosis, found to be closely associated with astralmicrotubule plus ends emanating from the spindle pole during prometaphase and metaphase
Developmental stage: Regulated in a cell cycle-dependent manner. Not expressed in the G1 phase. In G2, sequestered inthe nucleus. Maximal levels seen at late G2/M phase and early prometaphase. Degraded at the metaphase-anaphasetransition (at protein level)
Sequence caution: Sequence=AAI36591.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAI44272.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6NJI2 B7ZM49 B9EGM8 D5L6I1Alternative splicing: 4 isoforms: Q86Y91-1 Q86Y91-2 Q86Y91-3 Q86Y91-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KIF18B: NX_Q86Y91
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86Y91
KIF18B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001251503.1 NP_001252506.1
ENSEMBL proteins: ENSP00000465377 ENSP00000465992 ENSP00000465501 ENSP00000341466 ENSP00000412798
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
KIF18B for ontologies About GeneDecksing
KIF18B Antibody Products:
Assay Products for KIF18B: |
Protein
Domains /
Families
for KIF18B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KIF18B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86Y91ProtoNet protein and cluster: Q86Y91 UniProtKB/Swiss-Prot: KI18B_HUMAN, Q86Y91Similarity: Belongs to the kinesin-like protein familySimilarity: Contains 1 kinesin-motor domain |
Function
for KIF18B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KI18B_HUMAN, Q86Y91Function: In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells.Its major role may be to transport KIF2C and/or MAPRE1 along microtubules
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF18B
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF18B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003777 | microtubule motor activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
KIF18B for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KIF18B:
|
Pathways & Interactions
for KIF18B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIF18B
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for KIF18B (ENSP000003414664) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
KIF18B for ontologies About GeneDecksing
|
Drugs & Compounds
for KIF18B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KIF18B
Search CenterWatch for drugs/clinical trials and news about KIF18B / KI18B
|
Transcripts
for KIF18B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KIF18B gene (3 alternative transcripts): NM_001080443.1 NM_001264573.1 NM_001265577.1 Unigene Cluster for KIF18B: Kinesin family member 18B Hs.135094 [show with all ESTs]Unigene Representative Sequence: NM_0012645736 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000587309 ENST00000593135 ENST00000590129 ENST00000585687 ENST00000339151(uc010wji.2)
ENST00000438933(uc002iht.3 uc010wjh.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF18B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF18B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Synthesis Service for KIF18B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF18B |
Additional cDNA sequence: BC044933.1 BC048263.1 BC067365.1 BC136590.1 BC144271.1 GU808359.1 4 DOTS entries: DT.75193632 DT.40226930 DT.100683655 DT.91874757 24/43 AceView cDNA sequences (see all 43): BM470271 AA354103 BX283983 BC067365 BC044933 BE550578 BE295857 BG420786 AA394268 BG388330 BF001474 BQ070852 AA315393 CD657231 BC048263 AA292789 BX405609 AA227033 BX464747 BI870026 BE869895 BU945457 BV201643 BE747980
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for KIF18B About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KIF18B
|
Expression
for KIF18B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIF18B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCGCAGCCG
About this image
See KIF18B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIF18B
SOURCE GeneReport for Unigene cluster: Hs.135094
UniProtKB/Swiss-Prot: KI18B_HUMAN, Q86Y91Tissue specificity: Shows a prominent expression in the amygdala
SABiosciences Custom PCR Arrays for KIF18B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIF18B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIF18B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF18B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF18B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF18B |
Orthologs
for KIF18B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KIF18B gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
KI18B_CHICK6 |
Kinesin-like protein KIF18B |
55(a) |
1 ↔ 1 |
27(1272001-1279349) |
lizard
(Anolis carolinensis) |
Reptilia |
KIF18B6-- |
-- |
47(a)2(a) |
1 ↔ 1possible ortholog |
6(64478663-64505607) 5(98775181-98827158) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Klp67A6 |
Kinesin-like protein at 67A |
27(a) |
1 → many |
3L(9355736-9360051) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G185506 |
ATP binding microtubule motor family protein |
25(a) |
1 → many |
1(6381503-6384340) |
rice
(Oryza sativa) |
Liliopsida |
-- |
kinesin motor domain containing protein, putative,... |
22(a) |
1 → many |
1(23849821-23853440) |
ENSEMBL Gene Tree for KIF18B (if available)
TreeFam Gene Tree for KIF18B (if available) |
Paralogs
for KIF18B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KIF18B gene
- KIF18A2 KIF1C2 KIF16B2 KIF1B2 KIF192 KIF142 KIF222 KIF13B2
- KIF13A2 KIF1A2 KIF122
14 SIMAP similar genes for KIF18B using alignment to 3 protein entries: KI18B_HUMAN (see all proteins):KIF18A KIF6 KIF5B KIF5C KIF2C KIF5A
KIF27 KIF13B KIF23 KIF9 KIF3A KIF1A
KIF21A KIF19
KIF18B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for KIF18B
PGOHUM00000248872
|
Genomic Variants
for KIF18B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KIF18B (43002077 - 43025082 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KIF18B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIF18B |
|
Disorders
/ Diseases
for KIF18B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KIF18B for disorders About GeneDecksing
OMIM gene information: 614570
OMIM disorders: --
1  disease for KIF18B: About MalaCardsmalaria
Export disorders for KIF18B gene to outside databases
|
Publications
for KIF18B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIF18B gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with KIF18B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A complex of Kif18b and MCAK promotes microtubule dep olymerization and is negatively regulated by Aurora kinases. (PubMed id 21820309)1, 2 Tanenbaum M.E....Medema R.H. (2011)
- Cell cycle-regulated expression and subcellular localization of a kinesin-8 member human KIF18B. (PubMed id 20600703)1, 2 Lee Y.M.... Kim W. (2010)
- Analysis of the kinesin superfamily: insights into structure and function. (PubMed id 16084724)1, 3 Miki H....Hirokawa N. (2005)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Kif18B interacts with EB1 and controls astral microtu bule length during mitosis. (PubMed id 21737685)1 Stout J.R....Walczak C.E. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Purification and identification of endogenous polySUMO conjugates. (PubMed id 21252943)1 Bruderer R....Hay R.T. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
|
External Searches for KIF18B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KIF18B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KIF18B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KIF18B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KIF18B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KIF18B gene:
Search GeneIP for patents involving KIF18B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIF18B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | KIF18B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF18B |
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