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Aliases for KIF18B Gene

Aliases for KIF18B Gene

  • Kinesin Family Member 18B 2 3

External Ids for KIF18B Gene

Previous GeneCards Identifiers for KIF18B Gene

  • GC17M040359
  • GC17M043003
  • GC17M038768

Summaries for KIF18B Gene

GeneCards Summary for KIF18B Gene

KIF18B (Kinesin Family Member 18B) is a Protein Coding gene. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIF14.

UniProtKB/Swiss-Prot for KIF18B Gene

  • In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF18B Gene

Genomics for KIF18B Gene

Regulatory Elements for KIF18B Gene

Genomic Location for KIF18B Gene

Start:
44,924,709 bp from pter
End:
44,947,711 bp from pter
Size:
23,003 bases
Orientation:
Minus strand

Genomic View for KIF18B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF18B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF18B Gene

Proteins for KIF18B Gene

  • Protein details for KIF18B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y91-KI18B_HUMAN
    Recommended name:
    Kinesin-like protein KIF18B
    Protein Accession:
    Q86Y91
    Secondary Accessions:
    • A6NJI2
    • B7ZM49
    • B9EGM8
    • D5L6I1

    Protein attributes for KIF18B Gene

    Size:
    864 amino acids
    Molecular mass:
    94223 Da
    Quaternary structure:
    • Interacts with MAPRE1; this interaction is required for efficient accumulation at microtubule plus ends. Interacts with KIF2C at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. KIF2C phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.
    SequenceCaution:
    • Sequence=AAI36591.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI44272.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF18B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF18B Gene

Proteomics data for KIF18B Gene at MOPED

Post-translational modifications for KIF18B Gene

  • Ubiquitination at Lys352
  • Modification sites at PhosphoSitePlus

Other Protein References for KIF18B Gene

No data available for DME Specific Peptides for KIF18B Gene

Domains for KIF18B Gene

Gene Families for KIF18B Gene

HGNC:
  • KIF :Kinesins

Protein Domains for KIF18B Gene

Suggested Antigen Peptide Sequences for KIF18B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86Y91

UniProtKB/Swiss-Prot:

KI18B_HUMAN :
  • Q86Y91
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF18B: view

Function for KIF18B Gene

Molecular function for KIF18B Gene

UniProtKB/Swiss-Prot Function: In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.

Gene Ontology (GO) - Molecular Function for KIF18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IDA 21820309
GO:0003777 microtubule motor activity --
GO:0005515 protein binding IPI 21820309
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with KIF18B: view

Phenotypes for KIF18B Gene

genes like me logo Genes that share phenotypes with KIF18B: view

miRNA for KIF18B Gene

miRTarBase miRNAs that target KIF18B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIF18B Gene

Localization for KIF18B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF18B Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Present predominantly in the nucleus and to a lesser extent in the cytoplasm of interphase cells. During mitosis, found to be closely associated with astral microtubule plus ends emanating from the spindle pole during prometaphase and metaphase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF18B Gene COMPARTMENTS Subcellular localization image for KIF18B gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 4
cytosol 3

Gene Ontology (GO) - Cellular Components for KIF18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000235 astral microtubule IDA 21820309
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with KIF18B: view

Pathways for KIF18B Gene

SuperPathways for KIF18B Gene

No Data Available

Interacting Proteins for KIF18B Gene

Gene Ontology (GO) - Biological Process for KIF18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IBA --
GO:0000278 mitotic cell cycle IDA 20600703
GO:0006200 obsolete ATP catabolic process --
GO:0007018 microtubule-based movement IBA --
GO:0007019 microtubule depolymerization IDA 21820309
genes like me logo Genes that share ontologies with KIF18B: view

No data available for Pathways by source for KIF18B Gene

Transcripts for KIF18B Gene

Unigene Clusters for KIF18B Gene

Kinesin family member 18B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF18B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2:
SP3:
SP4:
SP5: -

Relevant External Links for KIF18B Gene

GeneLoc Exon Structure for
KIF18B
ECgene alternative splicing isoforms for
KIF18B

Expression for KIF18B Gene

mRNA expression in normal human tissues for KIF18B Gene

mRNA differential expression in normal tissues according to GTEx for KIF18B Gene

This gene is overexpressed in Esophagus - Mucosa (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for KIF18B Gene

SOURCE GeneReport for Unigene cluster for KIF18B Gene Hs.135094

mRNA Expression by UniProt/SwissProt for KIF18B Gene

Q86Y91-KI18B_HUMAN
Tissue specificity: Shows a prominent expression in the amygdala.
genes like me logo Genes that share expressions with KIF18B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KIF18B Gene

Orthologs for KIF18B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF18B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF18B 35
  • 99.3 (n)
  • 98.83 (a)
KIF18B 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIF18B 35
  • 84.82 (n)
  • 80.19 (a)
KIF18B 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF18B 35
  • 84.24 (n)
  • 79.01 (a)
KIF18B 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif18b 35
  • 79.43 (n)
  • 74.72 (a)
Kif18b 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF18B 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF18B 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif18b 35
  • 79.39 (n)
  • 75.37 (a)
chicken
(Gallus gallus)
Aves KIF18B 35
  • 63.68 (n)
  • 59.95 (a)
KIF18B 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF18B 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490953 35
  • 57.34 (n)
  • 51.94 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-26i13.8 36
  • 21 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Klp67A 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIP3 36
  • 27 (a)
OneToMany
Species with no ortholog for KIF18B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIF18B Gene

ENSEMBL:
Gene Tree for KIF18B (if available)
TreeFam:
Gene Tree for KIF18B (if available)

Paralogs for KIF18B Gene

Paralogs for KIF18B Gene

Selected SIMAP similar genes for KIF18B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for KIF18B Gene

genes like me logo Genes that share paralogs with KIF18B: view

Variants for KIF18B Gene

Sequence variations from dbSNP and Humsavar for KIF18B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs726612 -- 44,944,594(-) tattg(A/G)gtcta intron-variant
rs729864 -- 44,928,885(-) GGGCA(C/G)AGGCC missense, reference
rs736866 -- 44,932,429(+) ACACA(A/C)CCCTA intron-variant
rs744281 -- 44,932,518(-) ACTGA(C/T)TGTCA intron-variant
rs1059248 -- 44,924,786(-) GCCTT(C/T)TGATC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KIF18B Gene

Variant ID Type Subtype PubMed ID
nsv833457 CNV Loss 17160897
nsv527788 CNV Loss 19592680

Relevant External Links for KIF18B Gene

HapMap Linkage Disequilibrium report
KIF18B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF18B Gene

Disorders for KIF18B Gene

No disorders were found for KIF18B Gene.

No data available for UniProtKB/Swiss-Prot for KIF18B Gene

Publications for KIF18B Gene

  1. A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. (PMID: 21820309) Tanenbaum M.E. … Medema R.H. (Curr. Biol. 2011) 3 4
  2. Analysis of the kinesin superfamily: insights into structure and function. (PMID: 16084724) Miki H. … Hirokawa N. (Trends Cell Biol. 2005) 2 3
  3. Cell cycle-regulated expression and subcellular localization of a kinesin-8 member human KIF18B. (PMID: 20600703) Lee Y.M. … Kim W. (Gene 2010) 3 4
  4. Purification and identification of endogenous polySUMO conjugates. (PMID: 21252943) Bruderer R. … Hay R.T. (EMBO Rep. 2011) 3
  5. Kif18B interacts with EB1 and controls astral microtubule length during mitosis. (PMID: 21737685) Stout J.R. … Walczak C.E. (Mol. Biol. Cell 2011) 3

Products for KIF18B Gene

Sources for KIF18B Gene

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