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KIF18B Gene

protein-coding   GIFtS: 46
GCID: GC17M043003

Kinesin Family Member 18B

  Search for KIF18B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kinesin Family Member 18B1 2
Kinesin-Like Protein KIF18B2

External Ids:    HGNC: 271021   Entrez Gene: 1469092   Ensembl: ENSG000001861857   OMIM: 6145705   UniProtKB: Q86Y913   

Export aliases for KIF18B gene to outside databases

Previous GC identifers: GC17M040359 GC17M038768


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KIF18B Gene:
KIF18B (kinesin family member 18B) is a protein-coding gene. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIF18A.

UniProtKB/Swiss-Prot: KI18B_HUMAN, Q86Y91
Function: In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic
cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIF18B gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   POU6F1 (c2)   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KIF18B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIF18B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

KIF18B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF18B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M043003:  view genomic region     (about GC identifiers)

Start:
43,002,077 bp from pter      End:
43,025,082 bp from pter
Size:
23,006 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KI18B_HUMAN, Q86Y91 (See protein sequence)
Recommended Name: Kinesin-like protein KIF18B  
Size: 864 amino acids; 94223 Da
Subunit: Interacts with MAPRE1; this interaction is required for efficient accumulation at microtubule plus ends.
Interacts with KIF2C at microtubule tips; this interaction increases the affinity of both partners for
microtubule plus ends and is required for robust microtubule depolymerization. KIF2C phosphorylation by AURKA or
AURKB strongly reduces KIF18B-binding
Developmental stage: Regulated in a cell cycle-dependent manner. Not expressed in the G1 phase. In G2, sequestered
in the nucleus. Maximal levels seen at late G2/M phase and early prometaphase. Degraded at the metaphase-anaphase
transition (at protein level)
Sequence caution: Sequence=AAI36591.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI44272.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6NJI2 B7ZM49 B9EGM8 D5L6I1
Alternative splicing: 4 isoforms:  Q86Y91-1   Q86Y91-2   Q86Y91-3   Q86Y91-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KIF18B: NX_Q86Y91

Explore proteomics data for KIF18B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys352
  • Modification sites at PhosphoSitePlus

  • See KIF18B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001251503.1  NP_001252506.1  

    ENSEMBL proteins: 
     ENSP00000465377   ENSP00000465992   ENSP00000465501   ENSP00000341466   ENSP00000412798  

    KIF18B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KIF: Kinesins

    4 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR001752 Kinesin_motor_dom
     IPR019821 Kinesin_motor_CS
     IPR027640 Kinesin-like_fam

    Graphical View of Domain Structure for InterPro Entry Q86Y91

    ProtoNet protein and cluster: Q86Y91

    UniProtKB/Swiss-Prot: KI18B_HUMAN, Q86Y91
    Similarity: Belongs to the kinesin-like protein family
    Similarity: Contains 1 kinesin-motor domain


    KIF18B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KI18B_HUMAN, Q86Y91
    Function: In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic
    cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IDA--
    GO:0003777microtubule motor activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0008017microtubule binding IEA--
         
    KIF18B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KIF18B:
     Increased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIF18B
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    hsa-mir-92a-3p (MIRT049401), hsa-mir-196a-5p (MIRT048234)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KI18B_HUMAN, Q86Y91: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Present predominantly in the nucleus and
    to a lesser extent in the cytoplasm of interphase cells. During mitosis, found to be closely associated with
    astral microtubule plus ends emanating from the spindle pole during prometaphase and metaphase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    plasma membrane4
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000235astral microtubule IDA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005871kinesin complex IEA--

    KIF18B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIF18B
    Interactions:

        Search GeneGlobe Interaction Network for KIF18B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KIF18B (ENSP000003414664) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CKAP5ENSP000003465664STRING: ENSP00000346566
    MAD2L1ENSP000002965094STRING: ENSP00000296509
    PAFAH1B1ENSP000003803784STRING: ENSP00000380378
    SUMO2ENSP000004059654STRING: ENSP00000405965
    MAPRE1ENSP000003647214STRING: ENSP00000364721
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    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle IDA--
    GO:0007018microtubule-based movement IEA--
    GO:0007019microtubule depolymerization IDA--
    GO:0007067mitosis IEA--
    GO:0008152metabolic process IDA--

    KIF18B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIF18B (KI18B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KIF18B gene (3 alternative transcripts): 
    NM_001080443.1  NM_001264573.1  NM_001265577.1  

    Unigene Cluster for KIF18B:

    Kinesin family member 18B
    Hs.135094  [show with all ESTs]
    Unigene Representative Sequence: NM_001264573
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587309 ENST00000593135 ENST00000590129 ENST00000585687 ENST00000339151(uc010wji.2)
    ENST00000438933(uc002iht.3 uc010wjh.2)
    miRNA
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    Additional mRNA sequence: 

    BC044933.1 BC048263.1 BC067365.1 BC136590.1 BC144271.1 GU808359.1 

    4 DOTS entries:

    DT.75193632  DT.40226930  DT.100683655  DT.91874757 

    Selected AceView cDNA sequences (see all 43):

    BM470271 BX283983 BE550578 BC044933 AA354103 BC067365 BI870026 AA227033 
    AA292789 BF001474 BC048263 BU945457 BX464747 BE295857 BX405609 AA394268 
    BQ070852 BG420786 BG388330 AA315393 BE869895 CD657231 BE747980 BV201643 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KIF18B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                                                                
    SP2:                                                                                                
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                            -                                                   


    ECgene alternative splicing isoforms for KIF18B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIF18B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGCAGCCG
    KIF18B Expression
    About this image

    KIF18B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIF18B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.135094

    UniProtKB/Swiss-Prot: KI18B_HUMAN, Q86Y91
    Tissue specificity: Shows a prominent expression in the amygdala

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KIF18B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kif18b1 kinesin family member 18B 79.43(n)
    74.72(a)
      70218  NM_197959.2  NP_932063.2 
    chicken
    (Gallus gallus)
    Aves KIF18B1 kinesin family member 18B 63.68(n)
    59.95(a)
      419968  NM_001030928.1  NP_001026099.1 
    lizard
    (Anolis carolinensis)
    Reptilia KIF18B6
    kinesin family member 18B
    47(a)
    1 ↔ 1
    6(64477615-64509405)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004909531 kinesin-like protein KIF18B-like 57.34(n)
    51.94(a)
      100490953  XM_002939237.2  XP_002939283.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-26i13.86
    si:dkey-26i13.8
    21(a)
    many ↔ many
    1(10892349-10914253) ENSDARG00000062606
    fruit fly
    (Drosophila melanogaster)
    Insecta Klp67A6
    Kinesin-like protein at 67A
    31(a)
    1 → many
    3L(9355736-9360051)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIP3(YGL216W)4 Kinesin-related motor protein involved in mitotic spindle more   --   7(84885-87302) 852655  NP_011299.1 


    ENSEMBL Gene Tree for KIF18B (if available)
    TreeFam Gene Tree for KIF18B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIF18B gene
    KIF18A2  KIF16B2  KIF1C2  STARD92  KIF1B2  KIF192  KIF142  KIF222  
    KIF13B2  KIF13A2  KIF1A2  
    14 SIMAP similar genes for KIF18B using alignment to 3 protein entries:     KI18B_HUMAN (see all proteins):
    KIF18A    KIF6    KIF5B    KIF5C    KIF2C    KIF5A
    KIF27    KIF13B    KIF23    KIF9    KIF3A    KIF1A
    KIF21A    KIF19

    KIF18B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KIF18B
    PGOHUM00000248872


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIF18B (see all 572)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1391071671,2
    --43001646(+) ATGGGA/GAGAAC 2 -- int10--------
    rs728288171,2
    C--43001776(+) GGAGCC/GTCACC 2 -- int11Minor allele frequency- G:0.01NA 120
    rs1884126051,2
    --43002050(+) ATCCTA/GTCTAG 2 -- int10--------
    rs1997391531,2
    --43002225(+) TTACA-/CTTT  
            
    ATTTT
    2 -- ut310--------
    rs38378381,2
    C--43002226(-) TAAAA-/TAAA  
            
    GTGTA
    2 -- ut311Minor allele frequency- TAAA:0.50CSA 2
    rs1160177761,2
    C--43002511(+) CTGCAC/TAGAGG 2 -- ut310--------
    rs72142581,2
    C,F,A,H--43002672(+) TAGCCG/AGGCGT 2 -- ut314Minor allele frequency- A:0.40NA 10
    rs1418420461,2
    C--43002687(+) GTGGGC/TGCCTG 2 -- ut310--------
    rs1113055691,2
    C,F--43002704(+) CAGCTG/ACTTGG 2 -- ut312Minor allele frequency- A:0.50NA WA 4
    rs1931943801,2
    --43002747(+) GAGGCA/GGAGCT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for KIF18B (43002077 - 43025082 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KIF18B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833457CNV Loss17160897
    nsv527788CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIF18B
    DNA2.0 Custom Variant and Variant Library Synthesis for KIF18B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614570    OMIM disorders: --


    KIF18B for disorders           About GeneDecksing


    Export disorders for KIF18B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIF18B gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with KIF18B)
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    1. A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. (PubMed id 21820309)1, 2 Tanenbaum M.E....Medema R.H. (Curr. Biol. 2011)
    2. Cell cycle-regulated expression and subcellular localization of a kinesin-8 member human KIF18B. (PubMed id 20600703)1, 2 Lee Y.M.... Kim W. (Gene 2010)
    3. Analysis of the kinesin superfamily: insights into structure and function. (PubMed id 16084724)1, 3 Miki H....Hirokawa N. (Trends Cell Biol. 2005)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Kif18B interacts with EB1 and controls astral microtubule length during mitosis. (PubMed id 21737685)1 Stout J.R....Walczak C.E. (Mol. Biol. Cell 2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    7. Purification and identification of endogenous polySUMO conjugates. (PubMed id 21252943)1 Bruderer R....Hay R.T. (EMBO Rep. 2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    9. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (J. Proteome Res. 2008)
    10. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 146909 HGNC: 27102 AceView: LOC146909 Ensembl:ENSG00000186185 euGenes: HUgn146909
    ECgene: KIF18B H-InvDB: KIF18B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIF18B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIF18B gene:
    Search GeneIP for patents involving KIF18B

    GeneCards and IP:
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