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KIF18A Gene

protein-coding   GIFtS: 58
GCID: GC11M028042

Kinesin Family Member 18A

  See KIF18A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kinesin Family Member 18A1 2
MS-KIF18A2 3
Kinesin-Like Protein KIF18A2
Marrow Stromal KIF18A3

External Ids:    HGNC: 294411   Entrez Gene: 819302   Ensembl: ENSG000001216217   OMIM: 6112715   UniProtKB: Q8NI773   

Export aliases for KIF18A gene to outside databases

Previous GC identifers: GC11M027998 GC11M027740


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KIF18A Gene:
KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use
hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 (PubMed
15878648)).(supplied by OMIM, Aug 2008)

GeneCards Summary for KIF18A Gene:
KIF18A (kinesin family member 18A) is a protein-coding gene. Diseases associated with KIF18A include asbestosis. GO annotations related to this gene include ubiquitin binding and actin binding. An important paralog of this gene is KIF16B.

UniProtKB/Swiss-Prot: KI18A_HUMAN, Q8NI77
Function: Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the
amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome
movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE
levels at kinetochores during chromosome congression

Gene Wiki entry for KIF18A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIF18A gene promoter:
         LHX3b/Lhx3b   AML1a   p53   SREBP-1c   POU6F1 (c2)   Nkx2-5   SREBP-1b   SREBP-1a   Chx10   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIF18A promoter sequence
   Search Chromatin IP Primers for KIF18A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIF18A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p14.1   Ensembl cytogenetic band:  11p14.1   HGNC cytogenetic band: 11p14.1

KIF18A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF18A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M028042:  view genomic region     (about GC identifiers)

Start:
28,042,163 bp from pter      End:
28,129,855 bp from pter
Size:
87,693 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KI18A_HUMAN, Q8NI77 (See protein sequence)
Recommended Name: Kinesin-like protein KIF18A  
Size: 898 amino acids; 102281 Da
Subunit: Interacts with CENPE and ESR1
1 PDB 3D structure from and Proteopedia for KIF18A:
3LRE (3D)    
Secondary accessions: Q4VPE3 Q86VS5 Q9H0F3

Explore the universe of human proteins at neXtProt for KIF18A: NX_Q8NI77

Explore proteomics data for KIF18A at MOPED

Post-translational modifications: 

  • Glycosylated1
  • Ubiquitinated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KIF18A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_112494.3  
    ENSEMBL proteins: 
     ENSP00000263181  
    Reactome Protein details: Q8NI77

    KIF18A Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KIF: Kinesins

    4 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR001752 Kinesin_motor_dom
     IPR019821 Kinesin_motor_CS
     IPR027640 Kinesin-like_fam

    Graphical View of Domain Structure for InterPro Entry Q8NI77

    ProtoNet protein and cluster: Q8NI77

    1 Blocks protein domain: IPB001752 Kinesin

    UniProtKB/Swiss-Prot: KI18A_HUMAN, Q8NI77
    Similarity: Belongs to the kinesin-like protein family
    Similarity: Contains 1 kinesin-motor domain


    Find genes that share domains with KIF18A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KI18A_HUMAN, Q8NI77
    Function: Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the
    amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome
    movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE
    levels at kinetochores during chromosome congression
    Induction: By estrogen

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity ----
    GO:0003779actin binding IPI18680169
    GO:0005515protein binding IPI17006958
    GO:0005524ATP binding IEA--
    GO:0008017microtubule binding IDA18680169
         
    Find genes that share ontologies with KIF18A           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for KIF18A:
     Cell cycle / mitosis defect  Decreased G3BP1 protein expres 

    Animal Models:
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    miRNA
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    hsa-mir-192-5p (MIRT026687), hsa-mir-215-5p (MIRT024821)

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    1 qRT-PCR Assays for microRNA that regulate KIF18A:
    hsa-miR-493*
    SwitchGear 3'UTR luciferase reporter plasmidKIF18A 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KI18A_HUMAN, Q8NI77: Cell projection, ruffle. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing
    center, centrosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    plasma membrane5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IDA17006958
    GO:0005634nucleus IDA17006958
    GO:0005737cytoplasm IDA--
    GO:0005815microtubule organizing center IEA--
    GO:0005828kinetochore microtubule IDA17346968

    Find genes that share ontologies with KIF18A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KIF18A About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    4Hemostasis
    Hemostasis0.43
    5Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41


    Find genes that share SuperPaths with KIF18A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 Reactome Pathways for KIF18A
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids
    MHC class II antigen presentation
    Kinesins


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIF18A
    Interactions:

        Search GeneGlobe Interaction Network for KIF18A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KIF18A (Q8NI771, 2, 3 ENSP000002631814) via UniProtKB, MINT, STRING, and/or I2D (see all 177)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANAPC4Q9UJX51, 2EBI-355426,EBI-2554854 MINT-8412937 MINT-8412957
    PPP1CAP621362, 3MINT-62197 I2D: score=3 
    NFKBIBQ156533I2D: score=1 
    NEK2P519552MINT-8412937
    BIRC5ENSP000003016334STRING: ENSP00000301633
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006200ATP catabolic process IDA17346968
    GO:0007018microtubule-based movement TAS--
    GO:0007019microtubule depolymerization IDA17346968
    GO:0007080mitotic metaphase plate congression IDA17346968

    Find genes that share ontologies with KIF18A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIF18A (KI18A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KIF18A gene: 
    NM_031217.3  

    Unigene Cluster for KIF18A:

    Kinesin family member 18A
    Hs.301052  [show with all ESTs]
    Unigene Representative Sequence: NM_031217
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263181(uc001msc.2) ENST00000533466 ENST00000531047 ENST00000526288(uc001msd.3)

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate KIF18A:
    hsa-miR-493*
    SwitchGear 3'UTR luciferase reporter plasmidKIF18A 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for KIF18A
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      QuantiTect SYBR Green Assays in human, mouse, rat KIF18A
      QuantiFast Probe-based Assays in human, mouse, rat KIF18A

    Additional mRNA sequence: 

    AB062483.1 AK093850.1 AK312576.1 AL136819.1 AY791349.1 BC026090.1 BC035917.1 BC048347.2 

    6 DOTS entries:

    DT.402985  DT.97813038  DT.100749771  DT.95172254  DT.91761488  DT.95172252 

    Selected AceView cDNA sequences (see all 96):

    AL136819 BM971094 AA765523 AK093850 BM541288 BM972993 AA355936 AI056037 
    AI185060 AI933806 BU161346 AI002195 BP355504 AX748337 BX090090 AI027214 
    BP355503 AA252366 BC048347 BM468071 AL523812 BM466083 AI953706 CR610087 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KIF18A (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
    SP1:                          -                 -     -                                               -                                                         
    SP2:                                            -     -                                                                                                         
    SP3:                                                                                                                                                            
    SP4:                    -     -                                                                                                                                 
    SP5:                    -     -                                                                                                                                 

    ExUns: 18
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for KIF18A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIF18A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCAGCTT
    KIF18A Expression
    About this image


    KIF18A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             XX Germ Cells Ovigerous Cord
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    KIF18A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIF18A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.301052
        Custom PCR Arrays for KIF18A
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF18A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KIF18A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kif18a1 , 5 kinesin family member 18A1, 5 81.6(n)1
    76.98(a)1
      2 (56.55 cM)5
    2284211  NM_139303.11  NP_647464.11 
     1092807385 
    chicken
    (Gallus gallus)
    Aves KIF18A1 kinesin family member 18A 68.94(n)
    65.75(a)
      421607  NM_001199426.1  NP_001186355.1 
    lizard
    (Anolis carolinensis)
    Reptilia KIF18A6
    kinesin family member 18A
    56(a)
    1 ↔ 1
    GL343314.1(667873-723706)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986502 hypothetical protein LOC398650 76.03(n)    BC054210.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc559952 hypothetical protein MGC55995 75(n)   393209  BC047799.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Klp67A6
    Kinesin-like protein at 67A
    32(a)
    1 → many
    3L(9355736-9360051)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIP36
    Kinesin-related motor protein involved in mitotic ...
    29(a)
    1 → many
    VII(84885-87302) YGL216W


    ENSEMBL Gene Tree for KIF18A (if available)
    TreeFam Gene Tree for KIF18A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIF18A gene
    KIF16B2  KIF1C2  STARD92  KIF1B2  KIF192  KIF142  KIF222  KIF13B2  
    KIF1A2  KIF13A2  KIF18B2  
    8 SIMAP similar genes for KIF18A using alignment to 2 protein entries:     KI18A_HUMAN (see all proteins):
    KIF18B    KIF6    KIF19    KIF5C    KIF21A    KIF5B
    KIF3A    KIF5A

    Find genes that share paralogs with KIF18A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIF18A (see all 1305)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs344095391,2
    C--27763785(+) AAAAC-/AAAAAC
            
    CAAAT
    1 -- int11Minor allele frequency- AAAAAC:0.00NA 2
    rs57906811,2
    C--27804918(+) ATATA-/TAATCAA 1 -- int11Minor allele frequency- TA:0.00NA 2
    rs1892912591,2
    --28041752(+) CCACGC/TATCAG 1 -- ds50010--------
    rs110301851,2
    C,F,A--28041904(+) TCTAGC/TTGCAA 1 -- ds50017Minor allele frequency- T:0.32NA WA CSA EA 250
    rs122736311,2
    C,F,A--28042135(+) GTATGA/TAAGGG 1 -- ds500113Minor allele frequency- T:0.43NA WA CSA EA 504
    rs1819933461,2
    --28042370(+) TAATTC/TTACCA 1 -- ut310--------
    rs1399723261,2
    C,F--28042799(+) TGCTTG/AGATTT 2 /P /L mis11Minor allele frequency- A:0.01NA 2924
    rs1432583121,2
    C--28042804(+) GGATTG/TATTTT 2 I syn10--------
    rs1998515541,2
    C--28042852(+) AGATGC/TATAAA 1 -- int10--------
    rs79396301,2
    C,F--28042916(+) GACCAT/CAGAAA 1 -- int13Minor allele frequency- C:0.16WA CSA 122

    HapMap Linkage Disequilibrium report for KIF18A (28042163 - 28129855 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for KIF18A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744299CNV Deletion23290073
    nsv897150CNV Loss21882294
    nsv832096CNV Loss17160897
    esv9041CNV Gain19470904
    nsv897149CNV Gain21882294

    Human Gene Mutation Database (HGMD): KIF18A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIF18A
    DNA2.0 Custom Variant and Variant Library Synthesis for KIF18A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611271    OMIM disorders: --

    1 disease for KIF18A:    
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    asbestosis


    Find genes that share disorders with KIF18A           About GenesLikeMe

    Genetic Association Database (GAD): KIF18A

    Export disorders for KIF18A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIF18A gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with KIF18A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Defects in chromosome congression and mitotic progression in KIF18A- deficient cells are partly mediated through impaired functions of CENP-E. (PubMed id 19625775)1, 2 Huang Y.... Dai W. (Cell Cycle 2009)
    3. The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment. (PubMed id 18267093)1, 2 Stumpff J.... Wordeman L. (Dev. Cell 2008)
    4. New insights on cellular distribution, microtubule interactions and post-translational modifications of MS-KIF18A. (PubMed id 18680169)1, 2 Zusev M. and Benayahu D. (J. Cell. Physiol. 2008)
    5. The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression. (PubMed id 17346968)1, 2 Mayr M.I....Mayer T.U. (Curr. Biol. 2007)
    6. MS-KIF18A, a kinesin, is associated with estrogen receptor. (PubMed id 17006958)1, 2 Luboshits G. and Benayahu D. (J. Cell. Biochem. 2007)
    7. MS-KIF18A, new kinesin; structure and cellular expression. (PubMed id 15878648)1, 2 Luboshits G. and Benayahu D. (Gene 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex. (PubMed id 23288039)1 Sedgwick G.G....Nilsson J. (EMBO J. 2013)
    10. Kinesin-8 is a low-force motor protein with a weakly bound slip state. (PubMed id 23746518)1 Jannasch A....SchAoffer E. (Biophys. J. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81930 HGNC: 29441 AceView: KIF18A Ensembl:ENSG00000121621 euGenes: HUgn81930
    ECgene: KIF18A H-InvDB: KIF18A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIF18A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIF18A gene:
    Search GeneIP for patents involving KIF18A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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