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Aliases for KIF18A Gene

Aliases for KIF18A Gene

  • Kinesin Family Member 18A 2 3
  • MS-KIF18A 3 4
  • Protein Phosphatase 1, Regulatory Subunit 99 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 99 2
  • Marrow Stromal KIF18A 4
  • PPP1R99 3

External Ids for KIF18A Gene

Previous GeneCards Identifiers for KIF18A Gene

  • GC11M027998
  • GC11M027740

Summaries for KIF18A Gene

Entrez Gene Summary for KIF18A Gene

  • KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM, Aug 2008]

GeneCards Summary for KIF18A Gene

KIF18A (Kinesin Family Member 18A) is a Protein Coding gene. Diseases associated with KIF18A include asbestosis. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include actin binding and microtubule motor activity. An important paralog of this gene is KIF14.

UniProtKB/Swiss-Prot for KIF18A Gene

  • Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression.

Gene Wiki entry for KIF18A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF18A Gene

Genomics for KIF18A Gene

Regulatory Elements for KIF18A Gene

Genomic Location for KIF18A Gene

Chromosome:
11
Start:
28,020,616 bp from pter
End:
28,108,308 bp from pter
Size:
87,693 bases
Orientation:
Minus strand

Genomic View for KIF18A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF18A Gene

Proteins for KIF18A Gene

  • Protein details for KIF18A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI77-KI18A_HUMAN
    Recommended name:
    Kinesin-like protein KIF18A
    Protein Accession:
    Q8NI77
    Secondary Accessions:
    • Q4VPE3
    • Q86VS5
    • Q9H0F3

    Protein attributes for KIF18A Gene

    Size:
    898 amino acids
    Molecular mass:
    102281 Da
    Quaternary structure:
    • Interacts with CENPE and ESR1.

    Three dimensional structures from OCA and Proteopedia for KIF18A Gene

neXtProt entry for KIF18A Gene

Proteomics data for KIF18A Gene at MOPED

Post-translational modifications for KIF18A Gene

Other Protein References for KIF18A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KIF18A Gene

Domains & Families for KIF18A Gene

Protein Domains for KIF18A Gene

Suggested Antigen Peptide Sequences for KIF18A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NI77

UniProtKB/Swiss-Prot:

KI18A_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF18A: view

Function for KIF18A Gene

Molecular function for KIF18A Gene

UniProtKB/Swiss-Prot Function:
Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression.
UniProtKB/Swiss-Prot Induction:
By estrogen.

Gene Ontology (GO) - Molecular Function for KIF18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity --
GO:0003779 actin binding IPI 18680169
GO:0005515 protein binding IPI 17006958
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IDA 18680169
genes like me logo Genes that share ontologies with KIF18A: view
genes like me logo Genes that share phenotypes with KIF18A: view

Animal Model Products

miRNA for KIF18A Gene

miRTarBase miRNAs that target KIF18A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF18A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF18A Gene

Localization for KIF18A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF18A Gene

Cell projection, ruffle. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF18A Gene COMPARTMENTS Subcellular localization image for KIF18A gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 5
cytosol 4

Gene Ontology (GO) - Cellular Components for KIF18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0001726 ruffle IDA 17006958
GO:0005634 nucleus IDA 17006958
GO:0005737 cytoplasm IDA 17006958
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with KIF18A: view

Pathways & Interactions for KIF18A Gene

genes like me logo Genes that share pathways with KIF18A: view

Pathways by source for KIF18A Gene

Gene Ontology (GO) - Biological Process for KIF18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IBA --
GO:0000278 mitotic cell cycle TAS --
GO:0007018 microtubule-based movement TAS --
GO:0007019 microtubule depolymerization IDA 17346968
GO:0007080 mitotic metaphase plate congression IDA 17346968
genes like me logo Genes that share ontologies with KIF18A: view

No data available for SIGNOR curated interactions for KIF18A Gene

Drugs & Compounds for KIF18A Gene

No Compound Related Data Available

Transcripts for KIF18A Gene

Unigene Clusters for KIF18A Gene

Kinesin family member 18A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF18A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF18A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - - -
SP2: - -
SP3:
SP4: - -
SP5: - -
SP6: -

ExUns: 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for KIF18A Gene

GeneLoc Exon Structure for
KIF18A
ECgene alternative splicing isoforms for
KIF18A

Expression for KIF18A Gene

mRNA expression in normal human tissues for KIF18A Gene

mRNA differential expression in normal tissues according to GTEx for KIF18A Gene

This gene is overexpressed in Testis (x11.6).

Protein differential expression in normal tissues from HIPED for KIF18A Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (26.2), Monocytes (20.0), Fetal heart (11.3), and Lung (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF18A Gene



SOURCE GeneReport for Unigene cluster for KIF18A Gene Hs.301052

genes like me logo Genes that share expression patterns with KIF18A: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KIF18A Gene

Orthologs for KIF18A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF18A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIF18A 35
  • 88.43 (n)
  • 86 (a)
KIF18A 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF18A 35
  • 89.3 (n)
  • 86.06 (a)
KIF18A 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif18a 35
  • 81.6 (n)
  • 76.98 (a)
Kif18a 16
Kif18a 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIF18A 35
  • 99.63 (n)
  • 99.33 (a)
KIF18A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif18a 35
  • 80.35 (n)
  • 74.49 (a)
oppossum
(Monodelphis domestica)
Mammalia KIF18A 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF18A 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF18A 35
  • 68.94 (n)
  • 65.75 (a)
KIF18A 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF18A 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif18a 35
  • 63.72 (n)
  • 61.58 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398650 35
zebrafish
(Danio rerio)
Actinopterygii kif18a 35
  • 56.07 (n)
  • 52.08 (a)
zgc55995 35
kif18a 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Klp67A 36
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIP3 36
  • 29 (a)
OneToMany
Species with no ortholog for KIF18A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIF18A Gene

ENSEMBL:
Gene Tree for KIF18A (if available)
TreeFam:
Gene Tree for KIF18A (if available)

Paralogs for KIF18A Gene

Paralogs for KIF18A Gene

(8) SIMAP similar genes for KIF18A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIF18A: view

Variants for KIF18A Gene

Sequence variations from dbSNP and Humsavar for KIF18A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs716366 -- 28,099,989(-) cactt(A/G)ccacc intron-variant
rs997555 -- 28,084,511(-) GGTTA(C/G)AAGGG intron-variant
rs1384903 -- 28,102,812(+) TCTGC(A/T)GGAAT intron-variant
rs1384905 -- 28,100,956(-) GGTAT(G/T)ATTAT intron-variant
rs1384906 -- 28,093,477(-) TCAGA(A/T)ACCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF18A Gene

Variant ID Type Subtype PubMed ID
nsv897149 CNV Gain 21882294
nsv832096 CNV Loss 17160897
esv2744299 CNV Deletion 23290073
esv9041 CNV Gain 19470904
nsv897150 CNV Loss 21882294

Variation tolerance for KIF18A Gene

Residual Variation Intolerance Score: 29.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF18A Gene

HapMap Linkage Disequilibrium report
KIF18A
Human Gene Mutation Database (HGMD)
KIF18A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF18A Gene

Disorders for KIF18A Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF18A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
asbestosis
  • asbestosis nos
- elite association

Relevant External Links for KIF18A

Genetic Association Database (GAD)
KIF18A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF18A
genes like me logo Genes that share disorders with KIF18A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF18A Gene

Publications for KIF18A Gene

  1. A unique gene having homology with the kinesin family member 18A encodes a tumour-associated antigen recognised by cytotoxic T lymphocytes from HLA-A2+ colon cancer patients. (PMID: 15939267) Shichijo S. … Itoh K. (Eur. J. Cancer 2005) 23 67
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. The human mitotic kinesin KIF18A binds protein phosphatase 1 (PP1) through a highly conserved docking motif. (PMID: 25281536) De Wever V. … Moorhead G.B. (Biochem. Biophys. Res. Commun. 2014) 67
  5. High KIF18A expression correlates with unfavorable prognosis in primary hepatocellular carcinoma. (PMID: 25431949) Liao W. … Wang C. (Oncotarget 2014) 67

Products for KIF18A Gene

Sources for KIF18A Gene

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