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Aliases for KIF17 Gene

Aliases for KIF17 Gene

  • Kinesin Family Member 17 2 3 5
  • KIF3-Related Motor Protein 2 3 4
  • KIF17 Variant Protein 2 3
  • KIF3X 3 4
  • Kinesin-Like Protein KIF17 2
  • KIAA1405 4
  • KIF17B 3
  • KLP-2 3
  • OSM-3 3

External Ids for KIF17 Gene

Previous GeneCards Identifiers for KIF17 Gene

  • GC01M020560
  • GC01M020026
  • GC01M020136
  • GC01M020459
  • GC01M020735
  • GC01M020863
  • GC01M020990
  • GC01M019236

Summaries for KIF17 Gene

GeneCards Summary for KIF17 Gene

KIF17 (Kinesin Family Member 17) is a Protein Coding gene. Diseases associated with KIF17 include sulfhemoglobinemia. Among its related pathways are Organelle biogenesis and maintenance and Intraflagellar transport. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF14.

UniProtKB/Swiss-Prot for KIF17 Gene

  • Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules.

Gene Wiki entry for KIF17 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF17 Gene

Genomics for KIF17 Gene

Regulatory Elements for KIF17 Gene

Enhancers for KIF17 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KIF17 on UCSC Golden Path with GeneCards custom track

Promoters for KIF17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIF17 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIF17 Gene

Chromosome:
1
Start:
20,661,643 bp from pter
End:
20,718,017 bp from pter
Size:
56,375 bases
Orientation:
Minus strand

Genomic View for KIF17 Gene

Genes around KIF17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF17 Gene

Proteins for KIF17 Gene

  • Protein details for KIF17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2E2-KIF17_HUMAN
    Recommended name:
    Kinesin-like protein KIF17
    Protein Accession:
    Q9P2E2
    Secondary Accessions:
    • A2A3Q7
    • A2A3Q8
    • O95077
    • Q53YS6
    • Q5VWA9
    • Q6GSA8
    • Q8N411

    Protein attributes for KIF17 Gene

    Size:
    1029 amino acids
    Molecular mass:
    115068 Da
    Quaternary structure:
    • Interacts with LIN-10 PDZ domain. Interacts with PIWIL1 (By similarity). Interacts with TBATA (By similarity).
    SequenceCaution:
    • Sequence=AAD01428.1; Type=Frameshift; Positions=970, 990; Evidence={ECO:0000305}; Sequence=AAD01428.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAH36871.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA92643.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=CAH73471.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23390.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF17 Gene

Proteomics data for KIF17 Gene at MOPED

Post-translational modifications for KIF17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF17 Gene

No data available for DME Specific Peptides for KIF17 Gene

Domains & Families for KIF17 Gene

Gene Families for KIF17 Gene

Protein Domains for KIF17 Gene

Suggested Antigen Peptide Sequences for KIF17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2E2

UniProtKB/Swiss-Prot:

KIF17_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF17: view

Function for KIF17 Gene

Molecular function for KIF17 Gene

UniProtKB/Swiss-Prot Function:
Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules.
genes like me logo Genes that share phenotypes with KIF17: view

Animal Models for KIF17 Gene

MGI Knock Outs for KIF17:

Animal Model Products

miRNA for KIF17 Gene

miRTarBase miRNAs that target KIF17

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF17 Gene

Localization for KIF17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF17 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF17 Gene COMPARTMENTS Subcellular localization image for KIF17 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 3
plasma membrane 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KIF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005874 microtubule IEA --
GO:0015630 microtubule cytoskeleton IEA --
GO:0032391 photoreceptor connecting cilium IEA --
genes like me logo Genes that share ontologies with KIF17: view

Pathways & Interactions for KIF17 Gene

genes like me logo Genes that share pathways with KIF17: view

Pathways by source for KIF17 Gene

1 GeneGo (Thomson Reuters) pathway for KIF17 Gene

Gene Ontology (GO) - Biological Process for KIF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0007017 microtubule-based process IEA --
GO:0015031 protein transport IEA --
GO:0022008 neurogenesis IBA --
GO:0030030 cell projection organization IBA --
genes like me logo Genes that share ontologies with KIF17: view

No data available for SIGNOR curated interactions for KIF17 Gene

Drugs & Compounds for KIF17 Gene

No Compound Related Data Available

Transcripts for KIF17 Gene

Unigene Clusters for KIF17 Gene

Kinesin family member 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF17 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - -
SP6:

Relevant External Links for KIF17 Gene

GeneLoc Exon Structure for
KIF17
ECgene alternative splicing isoforms for
KIF17

Expression for KIF17 Gene

mRNA expression in normal human tissues for KIF17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF17 Gene

This gene is overexpressed in Testis (x9.8), Spleen (x4.3), and Brain - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for KIF17 Gene

This gene is overexpressed in Stomach (33.3), Cervix (18.1), and Heart (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIF17 Gene



SOURCE GeneReport for Unigene cluster for KIF17 Gene Hs.130411

genes like me logo Genes that share expression patterns with KIF17: view

Protein tissue co-expression partners for KIF17 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KIF17 Gene

Orthologs for KIF17 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIF17 35
  • 83.78 (n)
  • 80.2 (a)
KIF17 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF17 35
  • 86 (n)
  • 82.34 (a)
KIF17 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif17 35
  • 82 (n)
  • 80.9 (a)
Kif17 16
Kif17 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIF17 35
  • 99.07 (n)
  • 98.93 (a)
KIF17 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif17 35
  • 81.22 (n)
  • 81.15 (a)
oppossum
(Monodelphis domestica)
Mammalia KIF17 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF17 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF17 36
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15538 35
zebrafish
(Danio rerio)
Actinopterygii kif17 35
  • 66.13 (n)
  • 65.64 (a)
kif17 36
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003323 35
  • 56.98 (n)
  • 48.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta Kif3C 35
  • 50.65 (n)
  • 50.28 (a)
Kif3C 36
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea osm-3 35
  • 57.55 (n)
  • 56.8 (a)
osm-3 36
  • 53 (a)
OneToOne
Species with no ortholog for KIF17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KIF17 Gene

ENSEMBL:
Gene Tree for KIF17 (if available)
TreeFam:
Gene Tree for KIF17 (if available)

Paralogs for KIF17 Gene

(10) SIMAP similar genes for KIF17 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KIF17: view

Variants for KIF17 Gene

Sequence variations from dbSNP and Humsavar for KIF17 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs522496 - 20,698,408(+) CTCCA(C/T)GTCAT nc-transcript-variant, reference, missense
rs631357 - 20,666,326(-) GAGGA(C/G)GACCG nc-transcript-variant, reference, missense
rs2296225 - 20,704,549(+) ATTGA(C/T)GCGCG nc-transcript-variant, reference, missense
rs558760 - 20,685,017(+) ATCTA(C/T)CTCCT intron-variant, nc-transcript-variant, reference, missense
rs13375609 - 20,684,837(+) CACAA(C/T)GGGCA intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KIF17 Gene

Variant ID Type Subtype PubMed ID
nsv834369 CNV Loss 17160897
nsv870827 CNV Gain 21882294
nsv522796 CNV Loss 19592680
nsv520013 CNV Loss 19592680
esv2667782 CNV Deletion 23128226
nsv870993 CNV Loss 21882294
dgv188n71 CNV Loss 21882294

Variation tolerance for KIF17 Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.52; 82.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF17 Gene

HapMap Linkage Disequilibrium report
KIF17
Human Gene Mutation Database (HGMD)
KIF17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF17 Gene

Disorders for KIF17 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF17 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sulfhemoglobinemia
  • sulfemoglobinemia
- elite association - COSMIC cancer census association via MalaCards
Search KIF17 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KIF17

Genetic Association Database (GAD)
KIF17
Human Genome Epidemiology (HuGE) Navigator
KIF17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF17
genes like me logo Genes that share disorders with KIF17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF17 Gene

Publications for KIF17 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. (PMID: 10846156) Setou M. … Hirokawa N. (Science 2000) 2 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease. (PMID: 25017104) Kottyan L.C. … Rothenberg M.E. (Nat. Genet. 2014) 3
  5. HIV-1 subtypes B and C Tat differentially impact synaptic plasticity expression and implicates HIV-associated neurocognitive disorders. (PMID: 25613138) Samikkannu T. … Nair M.P. (Curr. HIV Res. 2014) 3

Products for KIF17 Gene

Sources for KIF17 Gene

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