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Aliases for KIF17 Gene

Aliases for KIF17 Gene

  • Kinesin Family Member 17 2 3 5
  • KIF3-Related Motor Protein 2 3 4
  • Kinesin-Like Protein KIF17 2 3
  • KIF17 Variant Protein 2 3
  • KIF3X 3 4
  • KIAA1405 4
  • KIF17B 3
  • KLP-2 3
  • OSM-3 3

External Ids for KIF17 Gene

Previous GeneCards Identifiers for KIF17 Gene

  • GC01M020560
  • GC01M020026
  • GC01M020136
  • GC01M020459
  • GC01M020735
  • GC01M020863
  • GC01M020990
  • GC01M019236

Summaries for KIF17 Gene

GeneCards Summary for KIF17 Gene

KIF17 (Kinesin Family Member 17) is a Protein Coding gene. Diseases associated with KIF17 include Sulfhemoglobinemia. Among its related pathways are Organelle biogenesis and maintenance and Transcription_CREM signaling in testis. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF3B.

UniProtKB/Swiss-Prot for KIF17 Gene

  • Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules.

Gene Wiki entry for KIF17 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF17 Gene

Genomics for KIF17 Gene

Regulatory Elements for KIF17 Gene

Enhancers for KIF17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G020717 0.9 ENCODE 13.7 +0.1 57 1.1 HDAC1 ATF1 RB1 ZNF76 SIN3A BMI1 ZEB1 GLIS2 SCRT2 CREM KIF17 EIF4G3 GC01P020706
GH01G020695 1.4 Ensembl ENCODE 5.7 +20.2 20184 4.1 MLX DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 SP3 TBX21 MEF2D EIF4G3 KIF17 HP1BP3 ENSG00000235432 GC01P020706
GH01G021187 0.7 FANTOM5 10.9 -469.9 -469889 0.1 PKNOX1 MTA2 NR2F1 BHLHE40 GATAD2B DPF2 TBX21 ZSCAN16 IKZF1 ZNF600 KIF17 MIR1256 EIF4G3 GC01M021203
GH01G020366 0.5 FANTOM5 8.5 +351.3 351346 0.1 SUZ12 ZNF76 ZBTB26 EZH2 KIF17 PINK1 GC01P020350 PIR44198
GH01G020730 1.1 ENCODE 0.4 -14.3 -14288 4.2 PKNOX1 MLX AGO1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 ZNF143 HP1BP3 EIF4G3 SH2D5 KIF17
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIF17 on UCSC Golden Path with GeneCards custom track

Promoters for KIF17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000002652 117 1001 HDAC1 ATF1 RB1 ZNF76 SIN3A BMI1 GLIS2 SCRT2 CREM SP1

Genomic Location for KIF17 Gene

Chromosome:
1
Start:
20,661,643 bp from pter
End:
20,718,017 bp from pter
Size:
56,375 bases
Orientation:
Minus strand

Genomic View for KIF17 Gene

Genes around KIF17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF17 Gene

Proteins for KIF17 Gene

  • Protein details for KIF17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2E2-KIF17_HUMAN
    Recommended name:
    Kinesin-like protein KIF17
    Protein Accession:
    Q9P2E2
    Secondary Accessions:
    • A2A3Q7
    • A2A3Q8
    • O95077
    • Q53YS6
    • Q5VWA9
    • Q6GSA8
    • Q8N411

    Protein attributes for KIF17 Gene

    Size:
    1029 amino acids
    Molecular mass:
    115068 Da
    Quaternary structure:
    • Interacts with LIN-10 PDZ domain. Interacts with PIWIL1 (By similarity). Interacts with TBATA (By similarity).
    SequenceCaution:
    • Sequence=AAD01428.1; Type=Frameshift; Positions=970, 990; Evidence={ECO:0000305}; Sequence=AAD01428.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAH36871.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA92643.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=CAH73471.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23390.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF17 Gene

Post-translational modifications for KIF17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIF17 Gene

Domains & Families for KIF17 Gene

Gene Families for KIF17 Gene

Protein Domains for KIF17 Gene

Suggested Antigen Peptide Sequences for KIF17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2E2

UniProtKB/Swiss-Prot:

KIF17_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF17: view

Function for KIF17 Gene

Molecular function for KIF17 Gene

UniProtKB/Swiss-Prot Function:
Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules.

Gene Ontology (GO) - Molecular Function for KIF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IEA --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA --
genes like me logo Genes that share ontologies with KIF17: view
genes like me logo Genes that share phenotypes with KIF17: view

Animal Models for KIF17 Gene

MGI Knock Outs for KIF17:

Animal Model Products

CRISPR Products

miRNA for KIF17 Gene

miRTarBase miRNAs that target KIF17

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF17 Gene

Localization for KIF17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF17 Gene

Cytoplasm, cytoskeleton. Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF17 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
plasma membrane 3
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KIF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex IEA,IBA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KIF17: view

Pathways & Interactions for KIF17 Gene

genes like me logo Genes that share pathways with KIF17: view

Pathways by source for KIF17 Gene

1 GeneGo (Thomson Reuters) pathway for KIF17 Gene

Gene Ontology (GO) - Biological Process for KIF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007017 microtubule-based process IEA --
GO:0007018 microtubule-based movement IBA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with KIF17: view

No data available for SIGNOR curated interactions for KIF17 Gene

Drugs & Compounds for KIF17 Gene

No Compound Related Data Available

Transcripts for KIF17 Gene

Unigene Clusters for KIF17 Gene

Kinesin family member 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF17 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - -
SP6:

Relevant External Links for KIF17 Gene

GeneLoc Exon Structure for
KIF17
ECgene alternative splicing isoforms for
KIF17

Expression for KIF17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF17 Gene

This gene is overexpressed in Testis (x9.8), Spleen (x4.3), and Brain - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for KIF17 Gene

This gene is overexpressed in Stomach (33.3), Cervix (18.1), and Heart (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIF17 Gene



Protein tissue co-expression partners for KIF17 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIF17 Gene:

KIF17

SOURCE GeneReport for Unigene cluster for KIF17 Gene:

Hs.130411

Evidence on tissue expression from TISSUES for KIF17 Gene

  • Nervous system(4.5)
  • Eye(4.4)
genes like me logo Genes that share expression patterns with KIF17: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF17 Gene

Orthologs for KIF17 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF17 34 35
  • 99.07 (n)
dog
(Canis familiaris)
Mammalia KIF17 34 35
  • 86 (n)
cow
(Bos Taurus)
Mammalia KIF17 34 35
  • 83.78 (n)
mouse
(Mus musculus)
Mammalia Kif17 34 16 35
  • 82 (n)
rat
(Rattus norvegicus)
Mammalia Kif17 34
  • 81.22 (n)
oppossum
(Monodelphis domestica)
Mammalia KIF17 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF17 35
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF17 35
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15538 34
zebrafish
(Danio rerio)
Actinopterygii kif17 34 35
  • 66.13 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003323 34
  • 56.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta Kif3C 34 35
  • 50.65 (n)
worm
(Caenorhabditis elegans)
Secernentea osm-3 34 35
  • 57.55 (n)
Species where no ortholog for KIF17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KIF17 Gene

ENSEMBL:
Gene Tree for KIF17 (if available)
TreeFam:
Gene Tree for KIF17 (if available)

Paralogs for KIF17 Gene

(10) SIMAP similar genes for KIF17 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KIF17: view

Variants for KIF17 Gene

Sequence variations from dbSNP and Humsavar for KIF17 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000014120 -- 20,702,703(+) AGGGA(A/G)ATTTC intron-variant
rs1000046022 -- 20,665,798(+) AAAAG(C/T)GTGTG intron-variant
rs1000130630 -- 20,717,062(+) CGGCC(C/G)GACGC intron-variant
rs1000180022 -- 20,689,278(+) GTGCT(A/G)GGAAG intron-variant, upstream-variant-2KB
rs1000270889 -- 20,688,270(+) GTCTC(G/T)ATCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF17 Gene

Variant ID Type Subtype PubMed ID
esv2667782 CNV deletion 23128226
esv3585428 CNV loss 21293372
esv3585429 CNV loss 21293372
esv3585430 CNV loss 21293372
nsv1003348 CNV gain 25217958
nsv1113087 CNV deletion 24896259
nsv520013 CNV loss 19592680
nsv522796 CNV loss 19592680
nsv545731 CNV gain 21841781
nsv834369 CNV loss 17160897

Variation tolerance for KIF17 Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.52; 82.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF17 Gene

Human Gene Mutation Database (HGMD)
KIF17
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF17 Gene

Disorders for KIF17 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF17 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
sulfhemoglobinemia
  • sulfemoglobinemia
- elite association - COSMIC cancer census association via MalaCards
Search KIF17 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KIF17

Genetic Association Database (GAD)
KIF17
Human Genome Epidemiology (HuGE) Navigator
KIF17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF17
genes like me logo Genes that share disorders with KIF17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF17 Gene

Publications for KIF17 Gene

  1. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston K.I. … Carrell D.T. (Hum. Reprod. 2010) 3 46 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells. (PMID: 14673085) Chennathukuzhi V. … Hecht N.B. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 64

Products for KIF17 Gene

  • Addgene plasmids for KIF17

Sources for KIF17 Gene

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