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Aliases for KIF17 Gene

Aliases for KIF17 Gene

  • Kinesin Family Member 17 2 3
  • KIF3-Related Motor Protein 2 3 4
  • Kinesin-Like Protein KIF17 2 3
  • KIF17 Variant Protein 2 3
  • KIAA1405 4 6
  • KIF3X 3 4
  • KIF17B 3
  • KLP-2 3
  • OSM-3 3

External Ids for KIF17 Gene

Summaries for KIF17 Gene

GeneCards Summary for KIF17 Gene

KIF17 (Kinesin Family Member 17) is a Protein Coding gene. Among its related pathways are Transcription_CREM signaling in testis. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIF5C.

UniProtKB/Swiss-Prot for KIF17 Gene

  • Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules.

Gene Wiki entry for KIF17 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF17 Gene

Genomics for KIF17 Gene

Genomic Location for KIF17 Gene

Start:
20,663,981 bp from pter
End:
20,718,017 bp from pter
Size:
54,037 bases
Orientation:
Minus strand

Genomic View for KIF17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF17 Gene

Regulatory Elements for KIF17 Gene

Proteins for KIF17 Gene

  • Protein details for KIF17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2E2-KIF17_HUMAN
    Recommended name:
    Kinesin-like protein KIF17
    Protein Accession:
    Q9P2E2
    Secondary Accessions:
    • A2A3Q7
    • A2A3Q8
    • O95077
    • Q53YS6
    • Q5VWA9
    • Q6GSA8
    • Q8N411

    Protein attributes for KIF17 Gene

    Size:
    1029 amino acids
    Molecular mass:
    115068 Da
    Quaternary structure:
    • Interacts with LIN-10 PDZ domain. Interacts with PIWIL1 (By similarity). Interacts with TBATA (By similarity).
    SequenceCaution:
    • Sequence=AAD01428.1; Type=Frameshift; Positions=970, 990; Evidence={ECO:0000305}; Sequence=AAD01428.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAH36871.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA92643.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=CAH73471.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23390.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF17 Gene

Proteomics data for KIF17 Gene at MOPED

Post-translational modifications for KIF17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF17 Gene

No data available for DME Specific Peptides for KIF17 Gene

Domains for KIF17 Gene

Gene Families for KIF17 Gene

HGNC:
  • KIF :Kinesins

Protein Domains for KIF17 Gene

UniProtKB/Swiss-Prot:

KIF17_HUMAN
Domain:
  • Contains 1 kinesin motor domain.:
    • Q9P2E2
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.:
    • Q9P2E2
genes like me logo Genes that share domains with KIF17: view

Function for KIF17 Gene

Molecular function for KIF17 Gene

UniProtKB/Swiss-Prot Function: Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules.

Gene Ontology (GO) - Molecular Function for KIF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA --
genes like me logo Genes that share ontologies with KIF17: view
genes like me logo Genes that share phenotypes with KIF17: view

Animal Models for KIF17 Gene

MGI Knock Outs for KIF17:

miRNA for KIF17 Gene

miRTarBase miRNAs that target KIF17

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KIF17 Gene

Localization for KIF17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF17 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF17 Gene COMPARTMENTS Subcellular localization image for KIF17 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KIF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
GO:0005930 axoneme IEA --
genes like me logo Genes that share ontologies with KIF17: view

Pathways for KIF17 Gene

genes like me logo Genes that share pathways with KIF17: view

Pathways by source for KIF17 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for KIF17 Gene

Gene Ontology (GO) - Biological Process for KIF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006996 organelle organization TAS --
GO:0007017 microtubule-based process --
GO:0007018 microtubule-based movement IBA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with KIF17: view

Transcripts for KIF17 Gene

Unigene Clusters for KIF17 Gene

Kinesin family member 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF17 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - -
SP6:

Relevant External Links for KIF17 Gene

GeneLoc Exon Structure for
KIF17
ECgene alternative splicing isoforms for
KIF17

Expression for KIF17 Gene

mRNA expression in normal human tissues for KIF17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF17 Gene

This gene is overexpressed in Testis (9.8), Spleen (4.3), and Brain - Cortex (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KIF17 Gene

SOURCE GeneReport for Unigene cluster for KIF17 Gene Hs.130411

genes like me logo Genes that share expressions with KIF17: view

Orthologs for KIF17 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF17 36
  • 99.07 (n)
  • 98.93 (a)
KIF17 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIF17 36
  • 83.78 (n)
  • 80.2 (a)
KIF17 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF17 36
  • 86 (n)
  • 82.34 (a)
KIF17 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif17 36
  • 82 (n)
  • 80.9 (a)
Kif17 16
Kif17 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF17 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF17 37
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif17 36
  • 81.22 (n)
  • 81.15 (a)
lizard
(Anolis carolinensis)
Reptilia KIF17 37
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15538 36
zebrafish
(Danio rerio)
Actinopterygii kif17 36
  • 66.13 (n)
  • 65.64 (a)
kif17 37
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003323 36
  • 56.98 (n)
  • 48.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta Kif3C 36
  • 50.65 (n)
  • 50.28 (a)
Kif3C 37
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea osm-3 36
  • 57.55 (n)
  • 56.8 (a)
osm-3 37
  • 53 (a)
OneToOne
Species with no ortholog for KIF17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KIF17 Gene

ENSEMBL:
Gene Tree for KIF17 (if available)
TreeFam:
Gene Tree for KIF17 (if available)

Paralogs for KIF17 Gene

Selected SIMAP similar genes for KIF17 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KIF17: view

Variants for KIF17 Gene

Sequence variations from dbSNP and Humsavar for KIF17 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs479323 -- 20,686,082(+) GCTTC(A/G)GGCCT reference, synonymous-codon, nc-transcript-variant
rs480676 -- 20,702,154(+) gcagg(G/T)gtcgc intron-variant
rs486011 -- 20,678,384(+) ACACA(A/C)ATACG intron-variant
rs489334 -- 20,689,994(+) GTTAC(C/T)TACCC intron-variant
rs493018 -- 20,690,413(+) TTTTT(G/T)GTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF17 Gene

Variant ID Type Subtype PubMed ID
nsv834369 CNV Loss 17160897
nsv870827 CNV Gain 21882294
nsv522796 CNV Loss 19592680
nsv520013 CNV Loss 19592680
esv2667782 CNV Deletion 23128226
nsv870993 CNV Loss 21882294
dgv188n71 CNV Loss 21882294

Relevant External Links for KIF17 Gene

HapMap Linkage Disequilibrium report
KIF17
Human Gene Mutation Database (HGMD)
KIF17

Disorders for KIF17 Gene

Relevant External Links for KIF17

Genetic Association Database (GAD)
KIF17
Human Genome Epidemiology (HuGE) Navigator
KIF17
genes like me logo Genes that share disorders with KIF17: view

No data available for UniProtKB/Swiss-Prot for KIF17 Gene

Publications for KIF17 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  2. Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. (PMID: 10846156) Setou M. … Hirokawa N. (Science 2000) 2 3
  3. The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells. (PMID: 14673085) Chennathukuzhi V. … Hecht N.B. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for KIF17 Gene

Sources for KIF17 Gene

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