Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIF17 Gene

protein-coding   GIFtS: 60
GCID: GC01M020990

Kinesin Family Member 17

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kinesin Family Member 171 2     KIF17B2
KIF3-Related Motor Protein1 2 3     KLP-22
KIF17 Variant Protein1 2     OSM-32
Kinesin-Like Protein KIF171 2     KIAA14053
KIF3X2 3     

External Ids:    HGNC: 191671   Entrez Gene: 575762   Ensembl: ENSG000001172457   OMIM: 6050375   UniProtKB: Q9P2E23   

Export aliases for KIF17 gene to outside databases

Previous GC identifers: GC01M020560 GC01M020026 GC01M020136 GC01M020459 GC01M020735 GC01M020863 GC01M019236


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KIF17 Gene: 
KIF17 (kinesin family member 17) is a protein-coding gene. Diseases associated with KIF17 include azoospermia, and schizophrenia, and among its related super-pathways are PKA activation in glucagon signalling. GO annotations related to this gene include microtubule motor activity and ATP binding. An important paralog of this gene is KIF3A.

UniProtKB/Swiss-Prot: KIF17_HUMAN, Q9P2E2
Function: Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules (By
similarity)

Gene Wiki entry for KIF17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIF17 gene promoter:
         AML1a   p53   Olf-1   AP-4   Tal-1beta   LCR-F1   CREB   deltaCREB   ITF-2   ATF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KIF17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.12   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.13

KIF17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF17 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M020990:  view genomic region     (about GC identifiers)

Start:
20,990,507 bp from pter      End:
21,044,510 bp from pter
Size:
54,004 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KIF17_HUMAN, Q9P2E2 (See protein sequence)
Recommended Name: Kinesin-like protein KIF17  
Size: 1029 amino acids; 115068 Da
Subunit: Interacts with LIN-10 PDZ domain. Interacts with PIWIL1 (By similarity). Interacts with TBATA (By
similarity)
Subcellular location: Cytoplasm, cytoskeleton (Probable)
Sequence caution: Sequence=AAD01428.1; Type=Frameshift; Positions=970, 990; Sequence=AAD01428.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part;
Sequence=AAH36871.1; Type=Miscellaneous discrepancy; Note=Cloning artifact; Sequence=BAA92643.2;
Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part;
Sequence=CAH73471.1; Type=Erroneous gene model prediction; Sequence=CAI23390.1; Type=Erroneous gene model
prediction;
Secondary accessions: A2A3Q7 A2A3Q8 O95077 Q53YS6 Q5VWA9 Q6GSA8 Q8N411
Alternative splicing: 2 isoforms:  Q9P2E2-1   Q9P2E2-3   

Explore the universe of human proteins at neXtProt for KIF17: NX_Q9P2E2

Explore proteomics data for KIF17 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P2E2

  • KIF17 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KIF17 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001116291.1  NP_065867.2  

    ENSEMBL proteins: 
     ENSP00000364184   ENSP00000383311   ENSP00000247986  

    Human Recombinant Protein Products for KIF17: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KIF17
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for KIF17
    GenScript Custom Purified and Recombinant Proteins Services for KIF17
    Novus Biologicals KIF17 Protein
    Novus Biologicals KIF17 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KIF17 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005871kinesin complex IEA--
    GO:0005874microtubule IEA--

    KIF17 for ontologies           About GeneDecksing



    KIF17 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KIF17
    GenScript Custom Superior Antibodies Services for KIF17
    Novus Biologicals KIF17 Antibodies
    Abcam antibodies for KIF17
    Cloud-Clone Corp. Antibodies for KIF17 
    ThermoFisher Antibodies for KIF17
    Search LSBio for Antibodies for KIF17 

    Assay Products for KIF17: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KIF17
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KIF17
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KIF17 
    Cloud-Clone Corp. CLIAs for KIF17


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KIF: Kinesins

    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR001752 Kinesin_motor_dom
     IPR019821 Kinesin_motor_CS

    Graphical View of Domain Structure for InterPro Entry Q9P2E2

    ProtoNet protein and cluster: Q9P2E2

    1 Blocks protein domain: IPB001752 Kinesin

    UniProtKB/Swiss-Prot: KIF17_HUMAN, Q9P2E2
    Similarity: Belongs to the kinesin-like protein family
    Similarity: Contains 1 kinesin-motor domain


    KIF17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KIF17_HUMAN, Q9P2E2
    Function: Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules (By
    similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0008017microtubule binding IEA--
         
    KIF17 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for KIF17:
     Decreased cilium length after   Increased homologous recombina  Upregulation of Wnt/beta-caten 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Kif17):
     behavior/neurological  nervous system 

    KIF17 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Kif17tm1Noh for KIF17

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KIF17 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KIF17

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KIF17 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KIF17 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIF17
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate KIF17 (see all 11):
    hsa-miR-185* hsa-miR-92a-1* hsa-miR-330-5p hsa-miR-200a hsa-miR-141 hsa-miR-654-5p hsa-miR-3202 hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmidKIF17 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KIF17
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF17

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KIF17
    Sirion Biotech Customized adenovirus for overexpression of KIF17

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for KIF17 (see all 12)
    OriGene ORF clones in mouse, rat for KIF17
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): KIF17 (NM_020816)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIF17
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF17
    Sirion Biotech Customized lentivirus for stable overexpression of KIF17 
                         Customized lentivirus expression plasmids for stable overexpression of KIF17 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KIF17
    Search LifeMap BioReagents cell lines for KIF17
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF17


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KIF17 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1PKA activation in glucagon signalling
    Transcription CREM signaling in testis0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KIF17
        Transcription CREM signaling in testis


    1 GeneGo (Thomson Reuters) Pathway for KIF17
        Transcription CREM signaling in testis



    KIF17 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KIF17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/36 Interacting proteins for KIF17 (Q9P2E22, 3 ENSP000002479864) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2875314 I2D: score=3 STRING: ENSP00000344782
    CASKO149363, ENSP000003674084I2D: score=1 STRING: ENSP00000367408
    MAP3K11Q165843, ENSP000003095974I2D: score=1 STRING: ENSP00000309597
    APBA1Q024103, ENSP000002653814I2D: score=1 STRING: ENSP00000265381
    C16orf70Q9BSU13, ENSP000002191394I2D: score=1 STRING: ENSP00000219139
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007017microtubule-based process ----
    GO:0007018microtubule-based movement IEA--
    GO:0015031protein transport IEA--
    GO:0016192vesicle-mediated transport IEA--
    GO:0031503protein complex localization IEA--

    KIF17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIF17

    Search CenterWatch for drugs/clinical trials and news about KIF17

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIF17 gene (2 alternative transcripts): 
    NM_001122819.1  NM_020816.2  

    Unigene Cluster for KIF17:

    Kinesin family member 17
    Hs.130411  [show with all ESTs]
    Unigene Representative Sequence: AY484427
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493818 ENST00000477167(uc001bdp.4) ENST00000490034 ENST00000375044(uc009vpx.3)
    ENST00000400463 ENST00000247986(uc001bds.4 uc001bdr.4) ENST00000462858
    ENST00000498225 ENST00000463389
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIF17
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate KIF17 (see all 11):
    hsa-miR-185* hsa-miR-92a-1* hsa-miR-330-5p hsa-miR-200a hsa-miR-141 hsa-miR-654-5p hsa-miR-3202 hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmidKIF17 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KIF17
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF17
    Clone
    Products:
         
    OriGene clones in human, mouse for KIF17 (see all 12)
    OriGene ORF clones in mouse, rat for KIF17
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): KIF17 (NM_020816)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIF17
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF17
    Sirion Biotech Customized lentivirus for stable overexpression of KIF17 
                         Customized lentivirus expression plasmids for stable overexpression of KIF17 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KIF17
    OriGene qSTAR qPCR primer pairs in human, mouse for KIF17
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIF17
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF17
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF17

    Additional mRNA sequence: 

    AB037826.2 AB290162.1 AF009624.1 AY484427.1 BC036871.1 BC040639.1 BC065927.1 

    7 DOTS entries:

    DT.100724438  DT.95341186  DT.101979597  DT.402757  DT.100770789  DT.91755308  DT.86852594 

    24/33 AceView cDNA sequences (see all 33):

    CR623989 CR604951 BM988195 BX387401 BX370065 BC036871 BX111384 AA897432 
    BX381851 BI832015 F08025 AY484427 BX338069 AB037826 BX377709 BC065927 
    BX338070 AL041980 BU151155 BU189788 AL529044 BM920801 BC040639 NM_020816 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KIF17 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
    SP1:              -                                                           -                 -                                 
    SP2:              -                                                           -                 -                                 
    SP3:                                                                          -                 -                                 
    SP4:                                                                                            -                                 
    SP5:                                                              -           -                                                   


    ECgene alternative splicing isoforms for KIF17

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIF17 expression in normal human tissues (normalized intensities)      KIF17 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTGGCACA
    KIF17 Expression
    About this image


    KIF17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             seminal vesicle ; glandular cells   
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Islets of Langerhans
             pancreas ; exocrine glandular cells   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex

    See KIF17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIF17

    SOURCE GeneReport for Unigene cluster: Hs.130411
        SABiosciences Expression via Pathway-Focused PCR Array including KIF17: 
              Synaptic Plasticity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KIF17
    OriGene qSTAR qPCR primer pairs in human, mouse for KIF17
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIF17
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF17
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF17
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KIF17 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kif171 , 5 kinesin family member 171, 5 82(n)1
    80.9(a)1
      4 (70.07 cM)5
    165591  NM_010623.41  NP_034753.11 
     1382504355 
    lizard
    (Anolis carolinensis)
    Reptilia KIF176
    Uncharacterized protein
    55(a)
    1 ↔ 1
    GL343414.1(600475-625702)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.155382 Xenopus laevis transcribed sequence with weak similarity more 82.53(n)    BJ040393.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kif171 kinesin family member 17 61.73(n)
    60.1(a)
      557863  XM_001919111.2  XP_001919146.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Kif3C1 CG17461-PA 50.74(n)
    49.81(a)
      43820  NM_143682.4  NP_651939.4 
    worm
    (Caenorhabditis elegans)
    Secernentea osm-31 Protein OSM-3 57.19(n)
    54.53(a)
      177141  NM_001028137.2  NP_001023308.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CIN86
    KIP16
    Kinesin motor protein involved in mitotic spindle ...
    Kinesin-related motor protein required for mitotic...
    17(a)
    15(a)
    many ↔ many
    many ↔ many
    V(36535-39537)
    II(101886-105221)


    ENSEMBL Gene Tree for KIF17 (if available)
    TreeFam Gene Tree for KIF17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIF17 gene
    KIF3A2  KIF5B2  KIF5C2  KIF1C2  KIF112  KIF16B2  KIF3B2  KIF1B2  
    KIF142  KIF13B2  KIF1A2  KIF13A2  CENPE2  KIF152  KIF5A2  KIF3C2  
    10 SIMAP similar genes for KIF17 using alignment to 1 protein entry:     KIF17_HUMAN:
    KIF3A    KIF21A    KIF6    DKFZp686G1646    KIF3C    KIF5C
    KIF5A    KIF5B    KIF3B    KIF4A

    KIF17 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1531 SNPs in KIF17 are shown (see all 1531)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1419858681,2
    C,Funtested120998491(+) ATCTTC/TGTCCC 4 K E mis11Minor allele frequency- T:0.00NA 4552
    rs1439097061,2
    --19262965(-) GTTCTA/GTATTG 2 -- int10--------
    rs121315891,2
    C,F--19263068(-) aacaaC/Aacaaa 2 -- int11Minor allele frequency- A:0.00NA 2
    rs779578551,2
    F--19263068(+) TTTGTG/TTTGTT 2 -- int12Minor allele frequency- T:0.33NA 6
    rs29853161,2
    C,A--19263227(+) AAAAAT/ATTTTT 2 -- int11Minor allele frequency- A:0.00NA 2
    rs121203921,2
    C--19263253(-) agagcA/Gagact 2 -- int10--------
    rs66579781,2
    C--19263297(-) tgcagC/Tgagcc 2 -- int10--------
    rs3720165221,2
    C--19263324(-) AATGGC/TTGAAC 2 -- int10--------
    rs8181921,2
    C,F,A--19263371(+) gcatcC/Tgccac 2 -- int13Minor allele frequency- T:0.50NA WA 6
    rs710105991,2
    C--19282420(+) CAGCT-/ATCTCAT 2 -- int11Minor allele frequency- AT:0.00NA 2

    HapMap Linkage Disequilibrium report for KIF17 (20990507 - 21044510 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for KIF17:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667782CNV Deletion23128226
    nsv870993CNV Loss21882294
    nsv522796CNV Loss19592680
    nsv834369CNV Loss17160897
    dgv188n71CNV Loss21882294
    nsv520013CNV Loss19592680
    nsv870827CNV Gain21882294


    Human Gene Mutation Database (HGMD): KIF17
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KIF17
    DNA2.0 Custom Variant and Variant Library Synthesis for KIF17

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605037    OMIM disorders: --

    3 diseases for KIF17:    About MalaCards
    azoospermia    schizophrenia    neuronitis


    KIF17 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KIF17
    Human Genome Epidemiology (HuGE) Navigator: KIF17 (2 documents)

    Export disorders for KIF17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIF17 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with KIF17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Evaluation of 172 candidate polymorphisms for associa tion with oligozoospermia or azoospermia in a large cohort of men of European d escent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells. (PubMed id 14673085)1, 2 Chennathukuzhi V.... Hecht N.B. (2003)
    6. Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. (PubMed id 10846156)1, 3 Setou M....Hirokawa N. (2000)
    7. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    8. KIF17 stabilizes microtubules and contributes to epit helial morphogenesis by acting at MT plus ends with EB1 and APC. (PubMed id 20696710)1 Jaulin F. and Kreitzer G. (2010)
    9. Autoinhibition of the kinesin-2 motor KIF17 via dual intramolecular mechanisms. (PubMed id 20530208)1 Hammond J.W....Verhey K.J. (2010)
    10. De novo truncating mutation in Kinesin 17 associated with schizophrenia. (PubMed id 20646681)1 Tarabeux J....Rouleau G.A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57576 HGNC: 19167 AceView: KIF17 Ensembl:ENSG00000117245 euGenes: HUgn57576
    ECgene: KIF17 H-InvDB: KIF17

    (According to HUGE)
    About This Section
    HUGE: KIAA1405

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIF17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIF17 gene:
    Search GeneIP for patents involving KIF17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KIF17  
     OriGene qPCR primer pairs and template standards for KIF17   OriGene Protein Over-expression Lysate for KIF17  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KIF17  
     OriGene qSTAR qPCR primer pairs in human, mouse for KIF17   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KIF17   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KIF17   OriGene Custom Protein Services for KIF17  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIF17
     QIAGEN SeqTarget long-range PCR primers for resequencing KIF17
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF17
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF17
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF17
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF17
     GenScript Custom Purified and Recombinant Proteins Services for KIF17 GenScript cDNA clones with any tag delivered in your preferred vector for KIF17
     GenScript Custom Assay Services for KIF17 GenScript Custom Superior Antibodies Services for KIF17
     GenScript Custom overexpressing Cell Line Services for KIF17 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KIF17 promoter
     Search Chromatin IP Primers for KIF17
     RT2 qPCR Primer Assay in human, mouse, rat KIF17
     GNC Network for KIF17
     SABiosciences PCR Arrays including human, mouse, rat KIF17
     Search Tocris compounds for KIF17
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KIF17 antibodies
     KIF17 proteins
     KIF17 lysates
     Antibodies for KIF17
     See all of Abcam's Antibodies, Kits and Proteins for KIF17
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for KIF17
     Antibodies for KIF17
     ELISAs for KIF17
     CLIAs for KIF17
     Search LifeMap BioReagents cell lines for KIF17
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF17
     SwitchGear 3'UTR luciferase reporter plasmids for KIF17
     Browse SwitchGear Promoter luciferase reporter plasmids for KIF17
     ThermoFisher Antibodies for KIF17
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF17
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KIF17
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KIF17
    Customized:
     lentivirus for stable overexpression of KIF17
     lentivirus expression plasmids for stable overexpression of KIF17
     adenovirus for overexpression of KIF17
     Search LSBio for Antibodies for KIF17
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KIF17 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4