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Aliases for KIF16B Gene

Aliases for KIF16B Gene

  • Kinesin Family Member 16B 2 3
  • C20orf23 3 4
  • SNX23 3 4
  • Chromosome 20 Open Reading Frame 23 2
  • Kinesin-Like Protein KIF16B 3
  • Kinesin Motor Protein 3
  • Sorting Nexin 23 3
  • Sorting Nexin-23 4
  • KISC20ORF 3
  • KIAA1590 4

External Ids for KIF16B Gene

Previous Symbols for KIF16B Gene

  • C20orf23

Summaries for KIF16B Gene

Entrez Gene Summary for KIF16B Gene

  • The protein encoded by this gene is a kinesin-like protein that may be involved in intracellular trafficking. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for KIF16B Gene

KIF16B (Kinesin Family Member 16B) is a Protein Coding gene. Diseases associated with KIF16B include congenital fibrosis of the extraocular muscles. GO annotations related to this gene include microtubule binding and phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is KIF14.

UniProtKB/Swiss-Prot for KIF16B Gene

  • Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.

Gene Wiki entry for KIF16B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF16B Gene

Genomics for KIF16B Gene

Genomic Location for KIF16B Gene

Start:
16,272,097 bp from pter
End:
16,573,434 bp from pter
Size:
301,338 bases
Orientation:
Minus strand

Genomic View for KIF16B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF16B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF16B Gene

Regulatory Elements for KIF16B Gene

Proteins for KIF16B Gene

  • Protein details for KIF16B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L93-KI16B_HUMAN
    Recommended name:
    Kinesin-like protein KIF16B
    Protein Accession:
    Q96L93
    Secondary Accessions:
    • A6NKJ9
    • A7E2A8
    • B1AKG3
    • B1AKT7
    • C9JDN5
    • C9JI52
    • C9JSM8
    • C9JWJ7
    • Q2TBF5
    • Q5HYC0
    • Q5HYK1
    • Q5JWW3
    • Q5TFK5
    • Q86VL9
    • Q86YS5
    • Q8IYU0
    • Q9BQJ8
    • Q9BQM0
    • Q9BQM1
    • Q9BQM5
    • Q9H5U0
    • Q9HCI2
    • Q9NXN9

    Protein attributes for KIF16B Gene

    Size:
    1317 amino acids
    Molecular mass:
    152011 Da
    Quaternary structure:
    • Interacts with RAB14 (By similarity). Interacts with PTPN21.
    SequenceCaution:
    • Sequence=BAA90971.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA90971.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB13416.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB15530.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI43062.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI43179.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIF16B Gene

    Alternative splice isoforms for KIF16B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF16B Gene

Proteomics data for KIF16B Gene at MOPED

Post-translational modifications for KIF16B Gene

Other Protein References for KIF16B Gene

No data available for DME Specific Peptides for KIF16B Gene

Domains for KIF16B Gene

Gene Families for KIF16B Gene

HGNC:
  • KIF :Kinesins

UniProtKB/Swiss-Prot:

KI16B_HUMAN
Domain:
  • The PX domain mediates binding to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). Does not bind phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).:
    • Q96L93
  • Contains 1 FHA domain.:
    • Q96L93
  • Contains 1 kinesin motor domain.:
    • Q96L93
  • Contains 1 PX (phox homology) domain.:
    • Q96L93
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.:
    • Q96L93
genes like me logo Genes that share domains with KIF16B: view

Function for KIF16B Gene

Molecular function for KIF16B Gene

UniProtKB/Swiss-Prot Function: Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.

Gene Ontology (GO) - Molecular Function for KIF16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 15882625
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with KIF16B: view

Phenotypes for KIF16B Gene

genes like me logo Genes that share phenotypes with KIF16B: view

miRNA for KIF16B Gene

miRTarBase miRNAs that target KIF16B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIF16B Gene

Localization for KIF16B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF16B Gene

Cytoplasm, cytoskeleton. Early endosome membrane. Note=It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding or via its interaction with RAB14.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF16B Gene COMPARTMENTS Subcellular localization image for KIF16B gene
Compartment Confidence
endosome 5
cytoskeleton 4
cytosol 3
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for KIF16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA 17641687
GO:0005769 early endosome IDA 15882625
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with KIF16B: view

Pathways for KIF16B Gene

SuperPathways for KIF16B Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIF16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001704 formation of primary germ layer ISS --
GO:0001919 regulation of receptor recycling IMP 15882625
GO:0006200 obsolete ATP catabolic process --
GO:0006895 Golgi to endosome transport ISS --
GO:0007018 microtubule-based movement IBA --
genes like me logo Genes that share ontologies with KIF16B: view

No data available for Pathways by source for KIF16B Gene

Compounds for KIF16B Gene

(2) Novoseek inferred chemical compound relationships for KIF16B Gene

Compound -log(P) Hits PubMed IDs
monastrol 71.4 1
atp 51.2 10
genes like me logo Genes that share compounds with KIF16B: view

Transcripts for KIF16B Gene

Unigene Clusters for KIF16B Gene

Kinesin family member 16B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF16B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
SP1: - -
SP2: -
SP3:
SP4:
SP5:
SP6: -

ExUns: 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b
SP1:
SP2: -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for KIF16B Gene

GeneLoc Exon Structure for
KIF16B
ECgene alternative splicing isoforms for
KIF16B

Expression for KIF16B Gene

mRNA expression in normal human tissues for KIF16B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF16B Gene

SOURCE GeneReport for Unigene cluster for KIF16B Gene Hs.101774

mRNA Expression by UniProt/SwissProt for KIF16B Gene

Q96L93-KI16B_HUMAN
Tissue specificity: Primarily expressed in brain. Also present in kidney, liver, intestine, placenta, leukocytes, heart and skeletal muscle (at protein level).
genes like me logo Genes that share expressions with KIF16B: view

Orthologs for KIF16B Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF16B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF16B 37
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIF16B 37
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF16B 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif16b 36
  • 84.29 (n)
  • 86.04 (a)
Kif16b 16
Kif16b 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 81 (a)
OneToMany
-- 37
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia KIF16B 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif16b 36
  • 84.61 (n)
  • 86.87 (a)
chicken
(Gallus gallus)
Aves KIF16B 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF16B 37
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif16b 36
  • 73.05 (n)
  • 79.62 (a)
zebrafish
(Danio rerio)
Actinopterygii kif16ba 37
  • 61 (a)
OneToOne
LOC100334507 36
  • 66.01 (n)
  • 70.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta Klp98A 37
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea klp-4 37
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 22 (a)
ManyToMany
Species with no ortholog for KIF16B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF16B Gene

ENSEMBL:
Gene Tree for KIF16B (if available)
TreeFam:
Gene Tree for KIF16B (if available)

Paralogs for KIF16B Gene

Paralogs for KIF16B Gene

Selected SIMAP similar genes for KIF16B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KIF16B: view

Variants for KIF16B Gene

Sequence variations from dbSNP and Humsavar for KIF16B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs2014 -- 16,272,336(+) GTACA(A/C)AGAAG utr-variant-3-prime
rs718610 -- 16,281,715(-) GAACA(C/T)GTGTG intron-variant
rs718842 -- 16,308,216(-) ATCTT(A/G)TTTTC intron-variant
rs718843 -- 16,308,129(-) TCTGT(A/T)GCTTA intron-variant
rs718844 -- 16,307,970(-) ATATT(A/G)TACGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF16B Gene

Variant ID Type Subtype PubMed ID
nsv833930 CNV Gain 17160897
nsv3305 CNV Insertion 18451855
nsv523556 CNV Loss 19592680
esv2722235 CNV Deletion 23290073
nsv179537 CNV Loss 16902084
esv2722236 CNV Deletion 23290073
esv1729054 CNV Insertion 17803354
nsv833931 CNV Loss 17160897
esv28081 CNV Gain 19812545
nsv179502 CNV Insertion 16902084
esv2722237 CNV Deletion 23290073
esv2286171 CNV Deletion 18987734
esv2825 CNV Deletion 18987735
nsv180138 CNV Loss 16902084
esv2722238 CNV Deletion 23290073

Relevant External Links for KIF16B Gene

HapMap Linkage Disequilibrium report
KIF16B

Disorders for KIF16B Gene

(4) Novoseek inferred disease relationships for KIF16B Gene

Disease -log(P) Hits PubMed IDs
neurodegeneration 12.9 1
stroke 6.28 1
neurological disorders 0 1
cancer 0 2

Relevant External Links for KIF16B

Genetic Association Database (GAD)
KIF16B
Human Genome Epidemiology (HuGE) Navigator
KIF16B
genes like me logo Genes that share disorders with KIF16B: view

No data available for UniProtKB/Swiss-Prot for KIF16B Gene

Publications for KIF16B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B. (PMID: 15882625) Hoepfner S. … Zerial M. (Cell 2005) 3 4
  4. Analysis of the kinesin superfamily: insights into structure and function. (PMID: 16084724) Miki H. … Hirokawa N. (Trends Cell Biol. 2005) 2 3
  5. The Phox (PX) domain proteins and membrane traffic. (PMID: 16782399) Seet L.F. … Hong W. (Biochim. Biophys. Acta 2006) 2 3

Products for KIF16B Gene

Sources for KIF16B Gene

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