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Aliases for KIF16B Gene

Aliases for KIF16B Gene

  • Kinesin Family Member 16B 2 3
  • C20orf23 3 4
  • SNX23 3 4
  • Chromosome 20 Open Reading Frame 23 2
  • Kinesin Motor Protein 3
  • Sorting Nexin 23 3
  • Sorting Nexin-23 4
  • KISC20ORF 3
  • KIAA1590 4

External Ids for KIF16B Gene

Previous HGNC Symbols for KIF16B Gene

  • C20orf23

Previous GeneCards Identifiers for KIF16B Gene

  • GC20M016201

Summaries for KIF16B Gene

Entrez Gene Summary for KIF16B Gene

  • The protein encoded by this gene is a kinesin-like protein that may be involved in intracellular trafficking. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for KIF16B Gene

KIF16B (Kinesin Family Member 16B) is a Protein Coding gene. Diseases associated with KIF16B include congenital fibrosis of the extraocular muscles. GO annotations related to this gene include ATPase activity and Rab GTPase binding. An important paralog of this gene is KIF14.

UniProtKB/Swiss-Prot for KIF16B Gene

  • Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.

Gene Wiki entry for KIF16B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF16B Gene

Genomics for KIF16B Gene

Regulatory Elements for KIF16B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIF16B Gene

Chromosome:
20
Start:
16,272,097 bp from pter
End:
16,573,434 bp from pter
Size:
301,338 bases
Orientation:
Minus strand

Genomic View for KIF16B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF16B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF16B Gene

Proteins for KIF16B Gene

  • Protein details for KIF16B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L93-KI16B_HUMAN
    Recommended name:
    Kinesin-like protein KIF16B
    Protein Accession:
    Q96L93
    Secondary Accessions:
    • A6NKJ9
    • A7E2A8
    • B1AKG3
    • B1AKT7
    • C9JDN5
    • C9JI52
    • C9JSM8
    • C9JWJ7
    • Q2TBF5
    • Q5HYC0
    • Q5HYK1
    • Q5JWW3
    • Q5TFK5
    • Q86VL9
    • Q86YS5
    • Q8IYU0
    • Q9BQJ8
    • Q9BQM0
    • Q9BQM1
    • Q9BQM5
    • Q9H5U0
    • Q9HCI2
    • Q9NXN9

    Protein attributes for KIF16B Gene

    Size:
    1317 amino acids
    Molecular mass:
    152011 Da
    Quaternary structure:
    • Interacts with RAB14 (By similarity). Interacts with PTPN21.
    SequenceCaution:
    • Sequence=BAA90971.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA90971.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB13416.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB15530.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI43062.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI43179.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIF16B Gene

    Alternative splice isoforms for KIF16B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF16B Gene

Proteomics data for KIF16B Gene at MOPED

Post-translational modifications for KIF16B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF16B Gene

No data available for DME Specific Peptides for KIF16B Gene

Domains & Families for KIF16B Gene

Gene Families for KIF16B Gene

Suggested Antigen Peptide Sequences for KIF16B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96L93

UniProtKB/Swiss-Prot:

KI16B_HUMAN :
  • The PX domain mediates binding to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). Does not bind phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Domain:
  • The PX domain mediates binding to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). Does not bind phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).
  • Contains 1 FHA domain.
  • Contains 1 kinesin motor domain.
  • Contains 1 PX (phox homology) domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF16B: view

Function for KIF16B Gene

Molecular function for KIF16B Gene

UniProtKB/Swiss-Prot Function:
Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.

Gene Ontology (GO) - Molecular Function for KIF16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 15882625
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with KIF16B: view
genes like me logo Genes that share phenotypes with KIF16B: view

Animal Model Products

CRISPR Products

miRNA for KIF16B Gene

miRTarBase miRNAs that target KIF16B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF16B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF16B Gene

Localization for KIF16B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF16B Gene

Cytoplasm, cytoskeleton. Early endosome membrane. Note=It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding or via its interaction with RAB14.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF16B Gene COMPARTMENTS Subcellular localization image for KIF16B gene
Compartment Confidence
endosome 5
cytoskeleton 3
mitochondrion 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KIF16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA 17641687
GO:0005769 early endosome IDA 15882625
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
GO:0031901 early endosome membrane IEA --
genes like me logo Genes that share ontologies with KIF16B: view

Pathways & Interactions for KIF16B Gene

SuperPathways for KIF16B Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIF16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001704 formation of primary germ layer ISS --
GO:0001919 regulation of receptor recycling IMP 15882625
GO:0006895 Golgi to endosome transport ISS --
GO:0007018 microtubule-based movement IBA --
GO:0007173 epidermal growth factor receptor signaling pathway IMP 15882625
genes like me logo Genes that share ontologies with KIF16B: view

No data available for Pathways by source and SIGNOR curated interactions for KIF16B Gene

Drugs & Compounds for KIF16B Gene

(2) Drugs for KIF16B Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Monastrol Experimental Pharma Selective inhibitor of mitotic kinesin Eg5 0
ATP Pharma Activator 0
genes like me logo Genes that share compounds with KIF16B: view

Transcripts for KIF16B Gene

Unigene Clusters for KIF16B Gene

Kinesin family member 16B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF16B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF16B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
SP1: - -
SP2: -
SP3:
SP4:
SP5:
SP6: -

ExUns: 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b
SP1:
SP2: -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for KIF16B Gene

GeneLoc Exon Structure for
KIF16B
ECgene alternative splicing isoforms for
KIF16B

Expression for KIF16B Gene

mRNA expression in normal human tissues for KIF16B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIF16B Gene

This gene is overexpressed in Plasma (22.6), Liver (17.8), and Stomach (17.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF16B Gene



SOURCE GeneReport for Unigene cluster for KIF16B Gene Hs.101774

mRNA Expression by UniProt/SwissProt for KIF16B Gene

Q96L93-KI16B_HUMAN
Tissue specificity: Primarily expressed in brain. Also present in kidney, liver, intestine, placenta, leukocytes, heart and skeletal muscle (at protein level).
genes like me logo Genes that share expression patterns with KIF16B: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for KIF16B Gene

Orthologs for KIF16B Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF16B Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Kif16b 35
  • 84.29 (n)
  • 86.04 (a)
Kif16b 16
Kif16b 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif16b 35
  • 84.61 (n)
  • 86.87 (a)
cow
(Bos Taurus)
Mammalia KIF16B 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF16B 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia KIF16B 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIF16B 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF16B 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF16B 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif16b 35
  • 73.05 (n)
  • 79.62 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100334507 35
  • 66.01 (n)
  • 70.31 (a)
kif16ba 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Klp98A 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea klp-4 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
ManyToMany
Species with no ortholog for KIF16B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF16B Gene

ENSEMBL:
Gene Tree for KIF16B (if available)
TreeFam:
Gene Tree for KIF16B (if available)

Paralogs for KIF16B Gene

Paralogs for KIF16B Gene

(9) SIMAP similar genes for KIF16B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KIF16B: view

Variants for KIF16B Gene

Sequence variations from dbSNP and Humsavar for KIF16B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs2014 -- 16,272,336(+) GTACA(A/C)AGAAG utr-variant-3-prime
rs718610 -- 16,281,715(-) GAACA(C/T)GTGTG intron-variant
rs718842 -- 16,308,216(-) ATCTT(A/G)TTTTC intron-variant
rs718843 -- 16,308,129(-) TCTGT(A/G/T)GCTTA intron-variant
rs718844 -- 16,307,970(-) ATATT(A/G)TACGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF16B Gene

Variant ID Type Subtype PubMed ID
nsv833930 CNV Gain 17160897
nsv3305 CNV Insertion 18451855
nsv523556 CNV Loss 19592680
esv2722235 CNV Deletion 23290073
nsv179537 CNV Loss 16902084
esv2722236 CNV Deletion 23290073
esv1729054 CNV Insertion 17803354
nsv833931 CNV Loss 17160897
esv28081 CNV Gain 19812545
nsv179502 CNV Insertion 16902084
esv2722237 CNV Deletion 23290073
esv2286171 CNV Deletion 18987734
esv2825 CNV Deletion 18987735
nsv180138 CNV Loss 16902084
esv2722238 CNV Deletion 23290073

Variation tolerance for KIF16B Gene

Residual Variation Intolerance Score: 96.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.05; 75.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF16B Gene

HapMap Linkage Disequilibrium report
KIF16B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF16B Gene

Disorders for KIF16B Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF16B Gene - From: GeneCards

Disorder Aliases PubMed IDs
congenital fibrosis of the extraocular muscles
  • cfeom
- elite association

Relevant External Links for KIF16B

Genetic Association Database (GAD)
KIF16B
Human Genome Epidemiology (HuGE) Navigator
KIF16B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF16B
genes like me logo Genes that share disorders with KIF16B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF16B Gene

Publications for KIF16B Gene

  1. During hypoxia, HUMMR joins the mitochondrial dance. (PMID: 20016276) Li Y. … Rempe D.A. (Cell Cycle 2010) 23 67
  2. How kinesin motor proteins drive mitotic spindle function: Lessons from molecular assays. (PMID: 20109570) Wordeman L. (Semin. Cell Dev. Biol. 2010) 23 67
  3. Recovery of tubulin functions after freeze-drying in the presence of trehalose. (PMID: 19825359) DrA!berovA! E. … DrA!ber P. (Anal. Biochem. 2010) 23 67
  4. Directional control of WAVE2 membrane targeting by EB1 and phosphatidylinositol 3,4,5-triphosphate. (PMID: 19925864) Takahashi K. … Suzuki K. (Cell. Signal. 2010) 23 67
  5. Two-stage capture employing active transport enables sensitive and fast biosensors. (PMID: 20055432) Katira P. … Hess H. (Nano Lett. 2010) 23 67

Products for KIF16B Gene

Sources for KIF16B Gene

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