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KIF16B Gene

protein-coding   GIFtS: 52
GCID: GC20M016252

Kinesin Family Member 16B

(Previous name: chromosome 20 open reading frame 23)
(Previous symbol: C20orf23)
  See KIF16B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kinesin Family Member 16B1 2     Kinesin Motor Protein2
C20orf231 2 3     Kinesin-Like Protein KIF16B2
SNX232 3     Sorting Nexin 232
Chromosome 20 Open Reading Frame 231     KIAA15903
KISC20ORF2     Sorting Nexin-233

External Ids:    HGNC: 158691   Entrez Gene: 556142   Ensembl: ENSG000000891777   UniProtKB: Q96L933   

Export aliases for KIF16B gene to outside databases

Previous GC identifer: GC20M016201


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KIF16B Gene:
The protein encoded by this gene is a kinesin-like protein that may be involved in intracellular trafficking.
Three transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec
2010)

GeneCards Summary for KIF16B Gene:
KIF16B (kinesin family member 16B) is a protein-coding gene. Diseases associated with KIF16B include congenital fibrosis of the extraocular muscles. GO annotations related to this gene include microtubule binding and phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is KIF18A.

UniProtKB/Swiss-Prot: KI16B_HUMAN, Q96L93
Function: Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor
recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling
and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome
transport of FGFR-containing vesicles during early development, a key process for developing basement membrane
and epiblast and primitive endoderm lineages during early postimplantation development

Gene Wiki entry for KIF16B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIF16B gene promoter:
         Oct-B1   oct-B3   oct-B2   POU2F1   POU2F1a   POU2F1b   POU2F1c   POU2F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIF16B promoter sequence
   Search Chromatin IP Primers for KIF16B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIF16B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.23   Ensembl cytogenetic band:  20p12.1   HGNC cytogenetic band: 20p11.23

KIF16B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF16B gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M016252:  view genomic region     (about GC identifiers)

Start:
16,252,749 bp from pter      End:
16,554,079 bp from pter
Size:
301,331 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KI16B_HUMAN, Q96L93 (See protein sequence)
Recommended Name: Kinesin-like protein KIF16B  
Size: 1317 amino acids; 152011 Da
Subunit: Interacts with RAB14 (By similarity). Interacts with PTPN21
Sequence caution: Sequence=BAA90971.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAA90971.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=BAB13416.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB15530.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI43062.1; Type=Erroneous gene model
prediction; Sequence=CAI43179.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for KIF16B:
2V14 (3D)    
Secondary accessions: A6NKJ9 A7E2A8 B1AKG3 B1AKT7 C9JDN5 C9JI52 C9JSM8 C9JWJ7 Q2TBF5 Q5HYC0
Q5HYK1 Q5JWW3 Q5TFK5 Q86VL9 Q86YS5 Q8IYU0 Q9BQJ8 Q9BQM0 Q9BQM1 Q9BQM5 Q9H5U0 Q9HCI2 Q9NXN9
Alternative splicing: 5 isoforms:  Q96L93-1   Q96L93-2   Q96L93-4   Q96L93-5   Q96L93-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KIF16B: NX_Q96L93

Explore proteomics data for KIF16B at MOPED

Post-translational modifications: 

  • Isoform 4 is ubiquitinated at Lys-6851
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KIF16B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001186794.1  NP_001186795.1  NP_078980.3  

    ENSEMBL proteins: 
     ENSP00000347076   ENSP00000384164   ENSP00000396264   ENSP00000347995   ENSP00000367242  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KIF: Kinesins

    Selected InterPro protein domains (see all 7):
     IPR008984 SMAD_FHA_domain
     IPR027417 P-loop_NTPase
     IPR000253 FHA_dom
     IPR001752 Kinesin_motor_dom
     IPR001683 Phox

    Graphical View of Domain Structure for InterPro Entry Q96L93

    ProtoNet protein and cluster: Q96L93

    3 Blocks protein domains:
    IPB000253 Forkhead-associated (FHA)
    IPB001683 Phox-like
    IPB001752 Kinesin


    UniProtKB/Swiss-Prot: KI16B_HUMAN, Q96L93
    Domain: The PX domain mediates binding to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol
    3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol
    3,4,5-trisphosphate (PtdIns(3,4,5)P3). Does not bind phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)
    Similarity: Belongs to the kinesin-like protein family
    Similarity: Contains 1 FHA domain
    Similarity: Contains 1 kinesin-motor domain
    Similarity: Contains 1 PX (phox homology) domain


    Find genes that share domains with KIF16B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KI16B_HUMAN, Q96L93
    Function: Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor
    recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling
    and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome
    transport of FGFR-containing vesicles during early development, a key process for developing basement membrane
    and epiblast and primitive endoderm lineages during early postimplantation development

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity ----
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding IDA15882625
    GO:0008017microtubule binding IEA--
         
    Find genes that share ontologies with KIF16B           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Kif16b):
     embryogenesis  mortality/aging 

    Find genes that share phenotypes with KIF16B           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIF16B
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    Selected qRT-PCR Assays for microRNAs that regulate KIF16B (see all 20):
    hsa-miR-579 hsa-miR-3678-3p hsa-miR-30c hsa-miR-30d hsa-miR-221 hsa-miR-218 hsa-miR-124 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidKIF16B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KIF16B

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KI16B_HUMAN, Q96L93: Cytoplasm, cytoskeleton (Probable). Early endosome membrane. Note=It is unclear whether
    association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding or via its
    interaction with RAB14
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytoskeleton4
    cytosol3
    mitochondrion2
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome IDA17641687
    GO:0005769early endosome IDA15882625
    GO:0005871kinesin complex IEA--
    GO:0005874microtubule IEA--
    GO:0031901early endosome membrane IEA--

    Find genes that share ontologies with KIF16B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIF16B
    Interactions:

        Search GeneGlobe Interaction Network for KIF16B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for KIF16B (Q96L932, 3 ENSP000003470764) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEA1Q150752, 3, ENSP000003179554MINT-5225389 MINT-5225409 MINT-5225437 MINT-5225458 I2D: score=1 STRING: ENSP00000317955
    ITSN1ENSP000003707194STRING: ENSP00000370719
    BUB1ENSP000003025304STRING: ENSP00000302530
    BUB1BENSP000002875984STRING: ENSP00000287598
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001704formation of primary germ layer ISS--
    GO:0001919regulation of receptor recycling IMP15882625
    GO:0006895Golgi to endosome transport ISS--
    GO:0007018microtubule-based movement IEA--
    GO:0007154cell communication ----

    Find genes that share ontologies with KIF16B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIF16B (KI16B)

    2 Novoseek inferred chemical compound relationships for KIF16B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    monastrol 71.4 1 17191952 (1)
    atp 51.2 11 10704233 (1), 15286375 (1), 19893487 (1), 7991536 (1) (see all 10)



    Find genes that share compounds with KIF16B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KIF16B gene (3 alternative transcripts): 
    NM_001199865.1  NM_001199866.1  NM_024704.4  

    Unigene Cluster for KIF16B:

    Kinesin family member 16B
    Hs.101774  [show with all ESTs]
    Unigene Representative Sequence: AY166853
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354981(uc002wpe.1 uc002wpf.1 uc002wpg.2 uc010gch.2)
    ENST00000408042(uc010gci.2 uc010gcj.2) ENST00000450176 ENST00000355755
    ENST00000378003
    miRNA
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    hsa-miR-579 hsa-miR-3678-3p hsa-miR-30c hsa-miR-30d hsa-miR-221 hsa-miR-218 hsa-miR-124 hsa-miR-30a
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    Additional mRNA sequence: 

    AB046810.2 AK000142.1 AK026698.1 AK095322.1 AK307399.1 AY044654.1 AY166853.1 BC015384.1 
    BC034984.1 BC050577.1 BC110317.1 BC150261.1 BX647572.1 BX648426.1 

    6 DOTS entries:

    DT.211945  DT.100021770  DT.40307280  DT.100746710  DT.120807725  DT.95149788 

    Selected AceView cDNA sequences (see all 77):

    CA431004 BM853074 CB069523 CA312739 BF726373 BF726372 AB046810 H19151 
    BQ068428 AY044654 BF336169 BM981237 CD673737 NM_024704 AI445643 BC050577 
    H23453 BG216672 H18484 C00804 BF941178 AV701232 AK000142 BI869262 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KIF16B (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
    SP1:                                                                          -     -                                                                           
    SP2:                                                                                                                                                        -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b
    SP1:                                                
    SP2:  -                                             
    SP3:                          -                     
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for KIF16B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIF16B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KIF16B Expression
    About this image


    KIF16B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neurons
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer
    KIF16B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIF16B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.101774

    UniProtKB/Swiss-Prot: KI16B_HUMAN, Q96L93
    Tissue specificity: Primarily expressed in brain. Also present in kidney, liver, intestine, placenta, leukocytes,
    heart and skeletal muscle (at protein level)

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF16B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KIF16B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kif16b1 , 5 kinesin family member 16B1, 5 84.29(n)1
    86.04(a)1
      2 (70.67 cM)5
    165581  NM_001081133.21  NP_001074602.11 
     1426174745 
    chicken
    (Gallus gallus)
    Aves KIF16B6
    kinesin family member 16B
    75(a)
    1 ↔ 1
    3(5413297-5548544)
    lizard
    (Anolis carolinensis)
    Reptilia KIF16B6
    kinesin family member 16B
    74(a)
    1 ↔ 1
    1(127344168-127504132)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kif16b1 kinesin family member 16B 73.05(n)
    79.62(a)
      100489716  XM_002931754.2  XP_002931800.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003345071 axonal transport of synaptic vesicles-like 66.01(n)
    70.31(a)
      100334507  XM_002660556.3  XP_002660602.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Klp98A6
    Kinesin-like protein at 98A
    33(a)
    1 ↔ 1
    3R(23373497-23384862)
    worm
    (Caenorhabditis elegans)
    Secernentea klp-46
    Protein KLP-4, isoform a (klp-4) mRNA, complete cd...
    20(a)
    1 → many
    X(3171419-3178702) WBGene00002217


    ENSEMBL Gene Tree for KIF16B (if available)
    TreeFam Gene Tree for KIF16B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIF16B gene
    KIF18A2  KIF1C2  STARD92  KIF1B2  KIF192  KIF142  KIF222  KIF13B2  
    KIF1A2  KIF13A2  KIF18B2  
    9 SIMAP similar genes for KIF16B using alignment to 3 protein entries:     KI16B_HUMAN (see all proteins):
    STARD9    KIF1A    KIF3A    KIF5C    KIF1C    KIF5A
    KIF1Bbeta    KIF21A    KIF3B

    Find genes that share paralogs with KIF16B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIF16B (see all 6903)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362184
    A breast cancer sample4--see VAR_0362182 K T mis40--------
    rs1389018401,2
    C,Funtested116310180(+) TGCGGC/TGTTTG 6 H R mis11Minor allele frequency- T:0.00NA 4550
    rs1915690361,2
    --16201879(+) AGTTTA/GAAATT 2 -- ds50010--------
    rs1833069711,2
    --16201989(+) TACTAC/TGATAT 2 -- ds50010--------
    rs1425664321,2
    --16202158(+) CTGCAA/TCTTCT 2 -- ds50010--------
    rs731103241,2
    C,F--16202188(+) ATACAT/CTATGC 2 -- ds50013Minor allele frequency- C:0.03CSA WA NA 240
    rs767944041,2
    F--16202226(+) TTAAAC/TAGACT 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1875969221,2
    --16202237(+) AGTATA/GAATGA 2 -- ds50010--------
    rs1923624291,2
    --16202315(+) CAGCTC/TAATTT 2 -- ut310--------
    rs1834061971,2
    --16202339(+) GCAAAC/TACATT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for KIF16B (16252749 - 16502749 bp, first 250kb of KIF16B)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KIF16B (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2286171CNV Deletion18987734
    esv2722237CNV Deletion23290073
    esv2825CNV Deletion18987735
    esv2722235CNV Deletion23290073
    esv2722236CNV Deletion23290073
    esv2722238CNV Deletion23290073
    nsv179502CNV Insertion16902084
    nsv3305CNV Insertion18451855
    esv1729054CNV Insertion17803354
    nsv833931CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIF16B
    DNA2.0 Custom Variant and Variant Library Synthesis for KIF16B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for KIF16B:    
    About MalaCards
    congenital fibrosis of the extraocular muscles


    Find genes that share disorders with KIF16B           About GenesLikeMe

    4 Novoseek inferred disease relationships for KIF16B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurodegeneration 12.9 1 10505649 (1)
    stroke 6.28 1 19717019 (1)
    neurological disorders 0 1 16884297 (1)
    cancer 0 2 19156502 (1), 16884297 (1)

    Genetic Association Database (GAD): KIF16B
    Human Genome Epidemiology (HuGE) Navigator: KIF16B (1 document)

    Export disorders for KIF16B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIF16B gene, integrated from 10 sources (see all 127):
    (articles sorted by number of sources associating them with KIF16B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A pilot genome-wide association study shows genomic variants enriched in the non-tumor cells of patients with well-differentiated neuroendocrine tumors of the ileum. (PubMed id 21139019)1, 4 Walsh K.M....Hoh J. (Endocr. Relat. Cancer 2011)
    2. The structural basis of novel endosome anchoring activity of KIF16B kinesin. (PubMed id 17641687)1, 2 Blatner N.R....Cho W. (EMBO J. 2007)
    3. The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973)1, 2 Vasilescu J.... Figeys D. (J. Proteome Res. 2007)
    4. The Phox (PX) domain proteins and membrane traffic. (PubMed id 16782399)1, 3 Seet L.F. and Hong W. (Biochim. Biophys. Acta 2006)
    5. Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B. (PubMed id 15882625)1, 2 Hoepfner S.... Zerial M. (Cell 2005)
    6. Analysis of the kinesin superfamily: insights into structure and function. (PubMed id 16084724)1, 3 Miki H....Hirokawa N. (Trends Cell Biol. 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    10. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55614 HGNC: 15869 AceView: C20orf23 Ensembl:ENSG00000089177 euGenes: HUgn55614
    ECgene: KIF16B H-InvDB: KIF16B

    (According to HUGE)
    About This Section

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    HUGE: KIAA1590

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KIF16B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KIF16B gene:
    Search GeneIP for patents involving KIF16B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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