Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIF15 Gene

protein-coding   GIFtS: 51
GCID: GC03P044803

Kinesin Family Member 15

(Previous name: kinesin-like 7)
(Previous symbol: KNSL7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kinesin Family Member 151 2     HKLP22
KNSL71 2 3     NY-BR-622
Kinesin-Like 71 2     Kinesin-Like Protein KIF152
Kinesin-Like Protein 22 3     KLP23
Kinesin-Like Protein 72 3     hKLP23
Serologically Defined Breast Cancer Antigen NY-BR-622 3     

External Ids:    HGNC: 172731   Entrez Gene: 569922   Ensembl: ENSG000001638087   UniProtKB: Q9NS873   

Export aliases for KIF15 gene to outside databases

Previous GC identifer: GC03P044779


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KIF15 Gene: 
KIF15 (kinesin family member 15) is a protein-coding gene. Diseases associated with KIF15 include breast cancer, and lung squamous cell carcinoma, and among its related super-pathways are Immune System and Kinesins. GO annotations related to this gene include motor activity and microtubule motor activity. An important paralog of this gene is KIF3A.

UniProtKB/Swiss-Prot: KIF15_HUMAN, Q9NS87
Function: Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIF15 gene promoter:
         RFX1   Pax-6   IRF-1   HNF-1A   YY1   Nkx6-1   HNF-1   FOXO1a   FOXO1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIF15 promoter sequence
   Search SABiosciences Chromatin IP Primers for KIF15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

KIF15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF15 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P044803:  view genomic region     (about GC identifiers)

Start:
44,803,209 bp from pter      End:
44,914,868 bp from pter
Size:
111,660 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KIF15_HUMAN, Q9NS87 (See protein sequence)
Recommended Name: Kinesin-like protein KIF15  
Size: 1388 amino acids; 160160 Da
Subunit: Interacts with MKI67 and TPX2
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Detected during the interphase in the
cytoplasm as finely punctuate pattern and irregularly shaped dots. Detected during mitosis on the mitotic
spindle. Colocalizes with TPX2 in mitosis. Localizes at the central spindle at anaphase (By similarity).
Localizes at the sites of invaginating cell membranes, a position that corresponds to the location of the
contractile actomyosin ring of dividing cells (By similarity). Colocalizes with actin in interphase (By
similarity). Colocalizes in dendrites and in growth cone of axons with microtubules (By similarity)
Sequence caution: Sequence=AAG48261.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q17RV9 Q69YL6 Q96JX7 Q9H280
Alternative splicing: 4 isoforms:  Q9NS87-1   Q9NS87-2   Q9NS87-3   Q9NS87-4   

Explore the universe of human proteins at neXtProt for KIF15: NX_Q9NS87

Explore proteomics data for KIF15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NS87

  • KIF15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KIF15 Protein Expression
    REFSEQ proteins: NP_064627.1  
    ENSEMBL proteins: 
     ENSP00000324020   ENSP00000406939   ENSP00000425499   ENSP00000389982   ENSP00000400802  
     ENSP00000391205  
    Reactome Protein details: Q9NS87
    Human Recombinant Protein Products for KIF15: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for KIF15
    GenScript Custom Purified and Recombinant Proteins Services for KIF15
    Novus Biologicals KIF15 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KIF15 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome TAS10878014
    GO:0005819spindle IEA--
    GO:0005829cytosol TAS--
    GO:0005873plus-end kinesin complex TAS10878014
    GO:0005874microtubule IEA--

    KIF15 for ontologies           About GeneDecksing



    KIF15 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KIF15
    GenScript Custom Superior Antibodies Services for KIF15
    Novus Biologicals KIF15 Antibodies
    Abcam antibodies for KIF15
    Cloud-Clone Corp. Antibodies for KIF15 
    Search ThermoFisher Antibodies for KIF15
    LSBio Antibodies in human, mouse, rat for KIF15 

    Assay Products for KIF15: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KIF15
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KIF15
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KIF15 
    Cloud-Clone Corp. CLIAs for KIF15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KIF: Kinesins

    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR001752 Kinesin_motor_dom
     IPR024658 Kinesin-like_KLP2

    Graphical View of Domain Structure for InterPro Entry Q9NS87

    ProtoNet protein and cluster: Q9NS87

    1 Blocks protein domain: IPB001752 Kinesin

    UniProtKB/Swiss-Prot: KIF15_HUMAN, Q9NS87
    Similarity: Belongs to the kinesin-like protein family. KLP2 subfamily
    Similarity: Contains 1 kinesin-motor domain


    KIF15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KIF15_HUMAN, Q9NS87
    Function: Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS10878014
    GO:0003774motor activity TAS10878014
    GO:0003777microtubule motor activity IEA--
    GO:0005524ATP binding IEA--
    GO:0008017microtubule binding IEA--
         
    KIF15 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Kif15):
     cardiovascular system  craniofacial  respiratory system  skeleton 

    KIF15 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KIF15 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KIF15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KIF15 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KIF15 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIF15
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KIF15
    SwitchGear 3'UTR luciferase reporter plasmidKIF15 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KIF15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF15

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KIF15
    Sirion Biotech Customized adenovirus for overexpression of KIF15

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for KIF15 (see all 5)
    OriGene ORF clones in mouse, rat for KIF15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KIF15 (NM_020242)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIF15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF15
    Sirion Biotech Customized lentivirus for stable overexpression of KIF15 
                         Customized lentivirus expression plasmids for stable overexpression of KIF15 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KIF15
    Search LifeMap BioReagents cell lines for KIF15
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF15


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KIF15 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Adaptive Immune System0.56
    2MHC class II antigen presentation
    MHC class II antigen presentation0.32
    Kinesins0.32
    3Platelet activation, signaling and aggregation
    Hemostasis0.43
    4Gastric cancer network 1
    Gastric cancer network 1
    5Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for KIF15
        Gastric cancer network 1

    5/6        Reactome Pathways for KIF15 (see all 6)
        Hemostasis
    Factors involved in megakaryocyte development and platelet production
    Adaptive Immune System
    Immune System
    Kinesins



    KIF15 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIF15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/28 Interacting proteins for KIF15 (Q9NS872, 3 ENSP000003240204) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3AQ9H4922, 3, ENSP000003639704MINT-65629 I2D: score=5 STRING: ENSP00000363970
    CHD3Q128732, 3MINT-65631 I2D: score=5 
    KIAA1377Q9P2H02, 3MINT-65630 I2D: score=5 
    VIMP086702, 3MINT-65628 I2D: score=5 
    MKI67P460132, 3, ENSP000003576434MINT-14343 MINT-14342 I2D: score=3 STRING: ENSP00000357643
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007018microtubule-based movement TAS--
    GO:0007067mitosis TAS10878014
    GO:0007596blood coagulation TAS--
    GO:0008283cell proliferation TAS10878014
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    KIF15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIF15

    Search CenterWatch for drugs/clinical trials and news about KIF15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIF15 gene: 
    NM_020242.2  

    Unigene Cluster for KIF15:

    Kinesin family member 15
    Hs.658939  [show with all ESTs]
    Unigene Representative Sequence: NM_020242
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326047(uc003cnx.4 uc010hiq.3) ENST00000438321 ENST00000481166
    ENST00000425755 ENST00000493134(uc003cny.1) ENST00000453693(uc010hir.3)
    ENST00000422209
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIF15
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate KIF15
    SwitchGear 3'UTR luciferase reporter plasmidKIF15 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KIF15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF15
    Clone
    Products:
         
    OriGene clones in human, mouse for KIF15 (see all 5)
    OriGene ORF clones in mouse, rat for KIF15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KIF15 (NM_020242)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIF15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF15
    Sirion Biotech Customized lentivirus for stable overexpression of KIF15 
                         Customized lentivirus expression plasmids for stable overexpression of KIF15 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KIF15
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIF15
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF15
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF15

    Additional mRNA sequence: 

    AB035898.1 AF308294.1 AK027816.1 AK098533.1 AK307674.1 AL832908.1 BC117174.1 BC143752.1 

    6 DOTS entries:

    DT.120892306  DT.40191656  DT.91750896  DT.100748860  DT.101971942  DT.120892289 

    24/57 AceView cDNA sequences (see all 57):

    AK027816 AK098533 CK825434 NM_020242 AL832908 AI863061 AI368883 AW516226 
    CD652405 AI365136 AI623136 AB035898 BG250888 CB119418 AI867345 CD651886 
    BQ268387 BM824722 BE972252 BU175652 AF308294 AA626743 BE873892 AA584266 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIF15 expression in normal human tissues (normalized intensities)      KIF15 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KIF15 Expression
    About this image


    KIF15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Thalamus
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Presumptive Podocytes Podocyte Layer
             Metanephros
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   

    See KIF15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIF15

    SOURCE GeneReport for Unigene cluster: Hs.658939

    UniProtKB/Swiss-Prot: KIF15_HUMAN, Q9NS87
    Tissue specificity: Expressed in testis, colon, thymus and in breast cancer

        SABiosciences Custom PCR Arrays for KIF15
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KIF15
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIF15
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF15
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF15
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KIF15 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kif151 , 5 kinesin family member 151, 5 85.61(n)1
    86.21(a)1
      9 (73.31 cM)5
    2097371  NM_010620.11  NP_034750.11 
     1229510815 
    chicken
    (Gallus gallus)
    Aves KIF151 kinesin family member 15 70.55(n)
    68.62(a)
      420708  XM_418807.3  XP_418807.2 
    lizard
    (Anolis carolinensis)
    Reptilia KIF156
    Uncharacterized protein
    64(a)
    1 ↔ 1
    GL343224.1(249538-296518)
    African clawed frog
    (Xenopus laevis)
    Amphibia klp22 KLP2 protein 74.4(n)    X94082.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kif151 kinesin family member 15 56.3(n)
    50.68(a)
      573988  XM_002666923.1  XP_002666969.1 
    worm
    (Caenorhabditis elegans)
    Secernentea klp-101 Protein KLP-10 45.2(n)
    35.44(a)
      3565411  NM_001027873.4  NP_001023044.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CIN86
    KIP16
    Kinesin motor protein involved in mitotic spindle ...
    Kinesin-related motor protein required for mitotic...
    21(a)
    17(a)
    many ↔ many
    many ↔ many
    V(36535-39537)
    II(101886-105221)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons POK21 phragmoplast orienting kinesin 2 45.3(n)
    35.42(a)
      821439  NM_112791.5  NP_188535.4 
    rice
    (Oryza sativa)
    Liliopsida Os.24132 Oryza sativa subsp. japonica phragmoplast-associated kinesin-related protein 1 mRNA, partial cds less 73.46(n)    AF210816.1 


    ENSEMBL Gene Tree for KIF15 (if available)
    TreeFam Gene Tree for KIF15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIF15 gene
    KIF3A2  KIF5B2  KIF5C2  KIF1C2  KIF112  KIF16B2  KIF3B2  KIF1B2  
    KIF142  KIF13B2  KIF1A2  KIF172  KIF13A2  CENPE2  KIF5A2  KIF3C2  
    7 SIMAP similar genes for KIF15 using alignment to 6 protein entries:     KIF15_HUMAN (see all proteins):
    KIF3A    KIF1A    KIF5C    KIF6    KIF21A    HMMR
    KIF3B

    KIF15 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KIF15
    PGOHUM00000247467


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1754 SNPs in KIF15 are shown (see all 1754)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs606421601,2
    C,F--44805241(+) GTGACG/ACAATC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1423982521,2
    --44805307(+) CCCAAC/GTAGCT 1 -- int10--------
    rs1829994891,2
    --44805329(+) CGTGCA/GCCACC 1 -- int10--------
    rs1479388981,2
    --44805397(+) CTGGTC/GTTGAA 1 -- int10--------
    rs1884377771,2
    --44805425(+) TCCACC/TTGCCT 1 -- int10--------
    rs1395348471,2
    --44805607(+) GTTTTG/TTTGAG 1 -- int10--------
    rs1159260491,2
    F--44805731(+) TCCAGA/CAAGTT 1 -- int11Minor allele frequency- C:0.01NA 120
    rs1912289151,2
    --44805739(+) GTTCCC/TTGTGA 1 -- int10--------
    rs76533921,2
    C,F,A,H--44805876(+) ttcttT/Caactg 1 -- int122Minor allele frequency- C:0.30NS EA NA WA CSA 2344
    rs1385315121,2
    C--44806048(+) TGAGA-/ATAGA 
     CTTAAGC
    ATATT
    1 -- int10--------

    HapMap Linkage Disequilibrium report for KIF15 (44803209 - 44914868 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KIF15:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3791CNV Insertion18451855
    nsv3792CNV Loss18451855
    nsv822071CNV Loss20364138
    nsv834675CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KIF15
    DNA2.0 Custom Variant and Variant Library Synthesis for KIF15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for KIF15:    About MalaCards
    breast cancer    lung squamous cell carcinoma    gout    squamous cell carcinoma


    KIF15 for disorders           About GeneDecksing


    Export disorders for KIF15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIF15 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with KIF15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The forkhead-associated domain of Ki-67 antigen interacts with the novel kinesin-like protein Hklp2. (PubMed id 10878014)1, 2, 3, 9 Sueishi M.... Yoneda Y. (2000)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PubMed id 12747765)1, 2 Scanlan M.J.... Old L.J. (2001)
    4. Kif15 cooperates with eg5 to promote bipolar spindle assembly. (PubMed id 19818618)1, 9 Tanenbaum M.E....Medema R.H. (2009)
    5. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    6. Modulated microtubule dynamics enable Hklp2/Kif15 to a ssemble bipolar spindles. (PubMed id 22024925)1 Florian S. and Mayer T.U. (2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    10. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56992 HGNC: 17273 AceView: KNSL7 Ensembl:ENSG00000163808 euGenes: HUgn56992
    ECgene: KIF15 H-InvDB: KIF15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIF15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIF15 gene:
    Search GeneIP for patents involving KIF15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KIF15  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KIF15  
     OriGene qSTAR qPCR primer pairs in human, mouse for KIF15   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KIF15   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KIF15   OriGene Custom Protein Services for KIF15  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIF15
     QIAGEN SeqTarget long-range PCR primers for resequencing KIF15
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF15
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF15
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF15
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF15
     GenScript Custom Purified and Recombinant Proteins Services for KIF15 GenScript cDNA clones with any tag delivered in your preferred vector for KIF15
     GenScript Custom Assay Services for KIF15 GenScript Custom Superior Antibodies Services for KIF15
     GenScript Custom overexpressing Cell Line Services for KIF15 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KIF15 promoter
     Search Chromatin IP Primers for KIF15
     RT2 qPCR Primer Assay in human, mouse, rat KIF15
     Search GNC Networks for KIF15
     SABiosciences Custom PCR Arrays for KIF15
     Search Tocris compounds for KIF15
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KIF15 antibodies
     KIF15 proteins
     Antibodies for KIF15
     See all of Abcam's Antibodies, Kits and Proteins for KIF15
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for KIF15
     Antibodies for KIF15
     ELISAs for KIF15
     CLIAs for KIF15
     Search LifeMap BioReagents cell lines for KIF15
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF15
     SwitchGear 3'UTR luciferase reporter plasmids for KIF15
     SwitchGear Promoter luciferase reporter plasmids for KIF15
     Search ThermoFisher Antibodies for KIF15
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF15
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KIF15
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KIF15
    Customized:
     lentivirus for stable overexpression of KIF15
     lentivirus expression plasmids for stable overexpression of KIF15
     adenovirus for overexpression of KIF15
     LSBio Antibodies in human, mouse, rat for KIF15
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KIF15 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4