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Aliases for KIF15 Gene

Aliases for KIF15 Gene

  • Kinesin Family Member 15 2 3 5
  • Serologically Defined Breast Cancer Antigen NY-BR-62 3 4
  • Kinesin-Like Protein 2 3 4
  • Kinesin-Like Protein 7 3 4
  • Kinesin-Like 7 2 3
  • HKLP2 3 4
  • KNSL7 3 4
  • Kinesin-Like Protein KIF15 3
  • NY-BR-62 3
  • KLP2 4

External Ids for KIF15 Gene

Previous HGNC Symbols for KIF15 Gene

  • KNSL7

Previous GeneCards Identifiers for KIF15 Gene

  • GC03P044779
  • GC03P044803
  • GC03P044804
  • GC03P044838
  • GC03P044846

Summaries for KIF15 Gene

GeneCards Summary for KIF15 Gene

KIF15 (Kinesin Family Member 15) is a Protein Coding gene. Diseases associated with KIF15 include Breast Cancer. Among its related pathways are Immune System and Vesicle-mediated transport. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is CENPE.

UniProtKB/Swiss-Prot for KIF15 Gene

  • Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF15 Gene

Genomics for KIF15 Gene

Regulatory Elements for KIF15 Gene

Enhancers for KIF15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F044685 0.8 ENCODE 11.2 -76.2 -76224 0.8 HDGF PKNOX1 CREB3L1 SIN3A BMI1 ZBTB40 EGR1 POLR2A ZNF143 ZNF207 KIAA1143 KIF15 ZNF501 ZNF35 ZNF197 ZNF660 ZKSCAN7 ZNF445 ENSG00000236869 PIR62310
GH03F044760 1.1 ENCODE 0.8 +0.4 373 2.4 PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5 KIAA1143 LIMD1 KIF15 HNRNPA1P77
GH03F044825 0.4 ENCODE 0.2 +64.1 64080 0.2 FOS SPI1 ZNF197-AS1 ZNF197 HNRNPA1P77 KIF15
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIF15 on UCSC Golden Path with GeneCards custom track

Promoters for KIF15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001362515 386 2600 PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5

Genomic Location for KIF15 Gene

Chromosome:
3
Start:
44,761,714 bp from pter
End:
44,873,376 bp from pter
Size:
111,663 bases
Orientation:
Plus strand

Genomic View for KIF15 Gene

Genes around KIF15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF15 Gene

Proteins for KIF15 Gene

  • Protein details for KIF15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS87-KIF15_HUMAN
    Recommended name:
    Kinesin-like protein KIF15
    Protein Accession:
    Q9NS87
    Secondary Accessions:
    • Q17RV9
    • Q69YL6
    • Q96JX7
    • Q9H280

    Protein attributes for KIF15 Gene

    Size:
    1388 amino acids
    Molecular mass:
    160160 Da
    Quaternary structure:
    • Interacts with MKI67 and TPX2.
    SequenceCaution:
    • Sequence=AAG48261.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIF15 Gene

    Alternative splice isoforms for KIF15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF15 Gene

Post-translational modifications for KIF15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIF15 Gene

Domains & Families for KIF15 Gene

Gene Families for KIF15 Gene

Protein Domains for KIF15 Gene

Suggested Antigen Peptide Sequences for KIF15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS87

UniProtKB/Swiss-Prot:

KIF15_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KLP2 subfamily.
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KLP2 subfamily.
genes like me logo Genes that share domains with KIF15: view

Function for KIF15 Gene

Molecular function for KIF15 Gene

UniProtKB/Swiss-Prot Function:
Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly.

Gene Ontology (GO) - Molecular Function for KIF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 10878014
GO:0003774 motor activity TAS 10878014
GO:0003777 microtubule motor activity IEA,IBA --
GO:0005515 protein binding IPI 10878014
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with KIF15: view
genes like me logo Genes that share phenotypes with KIF15: view

Animal Model Products

miRNA for KIF15 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIF15 Gene

Localization for KIF15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF15 Gene

Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Detected during the interphase in the cytoplasm as finely punctuate pattern and irregularly shaped dots. Detected during mitosis on the mitotic spindle. Colocalizes with TPX2 in mitosis. Localizes at the central spindle at anaphase (By similarity). Localizes at the sites of invaginating cell membranes, a position that corresponds to the location of the contractile actomyosin ring of dividing cells (By similarity). Colocalizes with actin in interphase (By similarity). Colocalizes in dendrites and in growth cone of axons with microtubules (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF15 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for KIF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome TAS 10878014
GO:0005819 spindle IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with KIF15: view

Pathways & Interactions for KIF15 Gene

genes like me logo Genes that share pathways with KIF15: view

Gene Ontology (GO) - Biological Process for KIF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0007018 microtubule-based movement IEA,TAS --
GO:0007067 mitotic nuclear division TAS 10878014
GO:0008283 cell proliferation TAS 10878014
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with KIF15: view

No data available for SIGNOR curated interactions for KIF15 Gene

Drugs & Compounds for KIF15 Gene

(2) Drugs for KIF15 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Kif15-IN-1 Pharma 0
Kif15-IN-2 Pharma 0

(2) ApexBio Compounds for KIF15 Gene

Compound Action Cas Number
Kif15-IN-1 672926-32-8
Kif15-IN-2 672926-33-9
genes like me logo Genes that share compounds with KIF15: view

Transcripts for KIF15 Gene

Unigene Clusters for KIF15 Gene

Kinesin family member 15:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF15 Gene

No ASD Table

Relevant External Links for KIF15 Gene

GeneLoc Exon Structure for
KIF15
ECgene alternative splicing isoforms for
KIF15

Expression for KIF15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIF15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF15 Gene

This gene is overexpressed in Testis (x9.9).

Protein differential expression in normal tissues from HIPED for KIF15 Gene

This gene is overexpressed in Heart (23.9), Lung (23.1), and Urine (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIF15 Gene



NURSA nuclear receptor signaling pathways regulating expression of KIF15 Gene:

KIF15

SOURCE GeneReport for Unigene cluster for KIF15 Gene:

Hs.658939

mRNA Expression by UniProt/SwissProt for KIF15 Gene:

Q9NS87-KIF15_HUMAN
Tissue specificity: Expressed in testis, colon, thymus and in breast cancer.
genes like me logo Genes that share expression patterns with KIF15: view

Primer Products

No data available for Protein tissue co-expression partners for KIF15 Gene

Orthologs for KIF15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIF15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF15 34 35
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia KIF15 34 35
  • 89.84 (n)
cow
(Bos Taurus)
Mammalia KIF15 34 35
  • 88.94 (n)
mouse
(Mus musculus)
Mammalia Kif15 34 16 35
  • 85.61 (n)
rat
(Rattus norvegicus)
Mammalia Kif15 34
  • 85.08 (n)
oppossum
(Monodelphis domestica)
Mammalia KIF15 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF15 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF15 34 35
  • 70.52 (n)
lizard
(Anolis carolinensis)
Reptilia KIF15 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487512 34
  • 65.28 (n)
Str.17744 34
African clawed frog
(Xenopus laevis)
Amphibia klp2 34
zebrafish
(Danio rerio)
Actinopterygii kif15 34 35
  • 56.36 (n)
worm
(Caenorhabditis elegans)
Secernentea klp-10 35
  • 32 (a)
OneToMany
klp-18 35
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CIN8 35
  • 22 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.2413 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
OneToOne
Species where no ortholog for KIF15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF15 Gene

ENSEMBL:
Gene Tree for KIF15 (if available)
TreeFam:
Gene Tree for KIF15 (if available)

Paralogs for KIF15 Gene

(6) SIMAP similar genes for KIF15 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for KIF15 Gene

genes like me logo Genes that share paralogs with KIF15: view

Variants for KIF15 Gene

Sequence variations from dbSNP and Humsavar for KIF15 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10018720 -- 44,819,592(+) gattg(C/T)actgt intron-variant
rs10049341 -- 44,829,124(+) aggct(A/G)aggcg intron-variant
rs10510743 -- 44,812,323(+) TGTAT(C/G)AAGTA intron-variant
rs10510744 -- 44,812,615(+) TTAAT(A/C)ATCTT intron-variant
rs10514710 -- 44,842,479(+) CAAGG(A/G)ATGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF15 Gene

Variant ID Type Subtype PubMed ID
esv3596039 CNV loss 21293372
nsv3791 CNV insertion 18451855
nsv3792 CNV deletion 18451855
nsv822071 CNV loss 20364138
nsv834675 CNV gain 17160897
nsv967011 CNV duplication 23825009

Variation tolerance for KIF15 Gene

Residual Variation Intolerance Score: 88.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.42; 71.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF15 Gene

Disorders for KIF15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF15 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search KIF15 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KIF15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF15
genes like me logo Genes that share disorders with KIF15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF15 Gene

Publications for KIF15 Gene

  1. The forkhead-associated domain of Ki-67 antigen interacts with the novel kinesin-like protein Hklp2. (PMID: 10878014) Sueishi M. … Yoneda Y. (J. Biol. Chem. 2000) 2 3 4 22 64
  2. Kif15 cooperates with eg5 to promote bipolar spindle assembly. (PMID: 19818618) Tanenbaum M.E. … Medema R.H. (Curr. Biol. 2009) 3 22 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PMID: 12747765) Scanlan M.J. … Old L.J. (Cancer Immun. 2001) 3 4 64
  5. Kinesin-12 motors cooperate to suppress microtubule catastrophes and drive the formation of parallel microtubule bundles. (PMID: 26969727) Drechsler H. … McAinsh A.D. (Proc. Natl. Acad. Sci. U.S.A. 2016) 3 64

Products for KIF15 Gene

Sources for KIF15 Gene

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