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KIF14 Gene

protein-coding   GIFtS: 56

GC01M198787
kinesin family member 14
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
KIAA0042 1, 2, 3, 5
MGC142302 2
OTTHUMP00000033836 2
Descriptions
kinesin family member 14 2
External Ids
HGNC: 191811
Entrez Gene: 99282
UniProtKB: Q150583
Ensembl: ENSG000001181937
Search outside databases for aliases for KIF14 gene

Previous GC identifers: GC01M198251 GC01M195979 GC01M196987 GC01M197809 GC01M197252

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KIF14:
KIF14 is a member of the kinesin superfamily of microtubule-associated motors (see MIM 148760) that
play important roles in intracellular transport and cell division (Nakagawa et al., 1997 [PubMed
9275178]).[supplied by OMIM]

UniProtKB/Swiss-Prot: KIF14_HUMAN, Q15058
Function: Plays an essential role in cytokinesis

Gene Wiki entry for KIF14

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the KIF14 gene  

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

KIF14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M198787:     (about GC identifiers)

Start:
198,787,930 bp from pter
End:
198,856,485 bp from pter
Size:
68,556 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_004487.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KIF14_HUMAN, Q15058 (See protein sequence)
Recommended Name: Kinesin-like protein KIF14  
Size: 1648 amino acids; 186492 Da
Subunit: Directly interacts with PRC1 within a complex also containing KIF4A, KIF20A and KIF23.
Directly interacts with CIT depending on the activation state of the kinase (stronger interaction
with the kinase-dead form)
Subcellular location: Nucleus. Cytoplasm. Spindle. Note=Nuclear localization observed during
interphase in PubMed:16431929 or triggered by entry into mitosis in PubMed:16648480. Cytoplasmic
in interphase (PubMed:16648480) and metaphase cells (PubMed:16431929). From prophase to metaphase,
accumulates at the developing spindle poles and their associated microtubules. During anaphase,
accumulates at the spindle midzone. Localization to the central spindle and midbody during
anaphase is dependent upon PRC1 and CIT presence. In cells ready to undergo abscission,
concentrates at the contractile ring
Developmental stage: Up-regulated in cells progressing through G2/M phase
Secondary accessions: Q14CI8 Q4G0A5 Q5T1W3

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_055690.1  

    ENSEMBL proteins: 
    ENSP00000356319 


    Human Recombinant Proteins 
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    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (KIF14)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    GO:0005819 spindle IEA--
    GO:0005874 microtubule IEA--
    GO:0005875 microtubule associated complex IEA--
    About this table

    Antibodies for KIF14: 
    Browse Antibodies Central at Invitrogen
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    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (KIF14), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (KIF14)
    Novus Biologicals Antibodies for KIF14

    Assays for KIF14: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR001752 Kinesin_motor
     IPR000253 FHA
     IPR019821 Kinesin_motor_CS


       GeneDecks  KIF14 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q15058

    ProtoNet protein and cluster: Q15058

    2 Blocks protein families:
    IPB000253 Forkhead-associated (FHA)
    IPB001752 Kinesin


    UniProtKB/Swiss-Prot: KIF14_HUMAN, Q15058
    Similarity: Belongs to the kinesin-like protein family
    Similarity: Contains 1 FHA domain
    Similarity: Contains 1 kinesin-motor domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (KIF14)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014875

                  Applied Biosystems Silencer® siRNAs for KIF14

                  Sigma-Aldrich siRNA and siRNA Panels for KIF14  
                         Sigma-Aldrich shRNA Panels and shRNA for KIF14  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for KIF14
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_014875
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_014875
                                     untagged cDNA clone in CMV expression vector: NM_014875 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_014875

    UniProtKB/Swiss-Prot: KIF14_HUMAN, Q15058
    Function: Plays an essential role in cytokinesis

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003777 microtubule motor activity IEA--
    GO:0005524 ATP binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    4 Interacting proteins for KIF14 (ENSP000003563193) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRC1ENSP000003546183STRING (score=.821)
    CDH11ENSP000002686033STRING (score=.706)
    DEKENSP000002447763STRING (score=.706)
    --ENSP000003679333STRING (score=.722)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007018 microtubule-based movement IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for KIF14

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (KIF14)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014875

                  Sigma-Aldrich siRNA and siRNA Panels for KIF14  
                         Sigma-Aldrich shRNA Panels and shRNA for KIF14  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_014875  

    REFSEQ mRNAs for KIF14 gene: 

    NM_014875.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_014875  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_014875
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_014875
                                     untagged cDNA clone in CMV expression vector: NM_014875 

    Additional cDNA sequence: 

    BC098582.1 BC113742.1 BC144068.1 D26361.1 

    1 DOTS entry:

    DT.406343 

    24/31 AceView cDNA sequences (see all 31 ):

    BG615572 AA668857 D26361 BE644769 CD652057 CB409937 BE888525 BQ425495 
    BM480026 AA668879 BX426204 AA479873 AW075554 BX099509 CD642678 BF435707 
    CB136970 BP359286 BX646345 AW183154 AA477501 BX414768 BG528841 BE874348 

    highest scoring ESTs for KIF14:

    D26361 AA477501 AA668879 AW371859 AW371861 AW371866 AW374063 AW804687 BE565983 BE567495 

    Unigene Cluster for KIF14:

    Kinesin family member 14
    Hs.3104  [show with all ESTs]
    Unigene Representative Sequence: NM_014875


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000367350  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    KIF14 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for KIF14

    1 / 2 / 3

    6 probe-sets matching KIF14 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    56461_at2, 3 U95-C 1 1.00 1.00 0.99 1.02 AA668879 0.60 1.00 0.82 1
    34563_at2, 3 U95-A 1 1.00 1.00 0.94 1.02 D26361 1.00 1.00 1.00 1

    236641_at2, 3 U133-B 1 1.00 1.00 -- -- AW183154 0.40 1.00 0.76 1

    206364_at2, 3 U133-A 1 1.00 1.00 -- -- NM_014875 0.60 1.00 0.82 1

    236641_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    206364_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  KIF14 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AATAAATCTG

    SOURCE GeneReport for Unigene cluster: Hs.3104

    Expression variation in blood from EXPOLDB for KIF14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for KIF14 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    KIF141   -- kinesin family member 14 87.49(n)
    82.24(a)
    490248  XM_547369.2  XP_547369.2 
    rat
    (Rattus norvegicus)
    Kif141   -- kinesin family member 14 72.92(n)
    66.44(a)
    360849  XM_341126.3  XP_341127.3 
    mouse
    (Mus musculus)
    Kif141, 5 1 (78.80 cM)5
    kinesin family member 141, 5 77.7(n)1
    73.21(a)1
    3812931  NM_001081258.11  NP_001074727.11 
     AB0014315  AI4270505  (see all 10)
    chicken
    (Gallus gallus)
    KIF141   -- kinesin family member 14 64.88(n)
    57.41(a)
    424347  XM_422190.2  XP_422190.2 
    zebrafish
    (Danio rerio)
    kif141   -- kinesin family member 14 59.61(n)
    57.73(a)
    562052  NM_001044976.1  NP_001038441.1 
    About this table        Species with no ortholog for KIF14

    ENSEMBL Gene Tree for KIF14
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for KIF14 gene
    KIF16B2  ENSG000001849352  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/377 NCBI SNPs in KIF14 are shown (see all 377 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 117)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs38063611,2
    A,C,F,H198856436(-) TCGAGG/TGGGTC 1 -- ut517Minor allele frequency- T:0.28NA EU EA WA 546
    rs120607931,2
    A,C,F,H198788035(+) TTTCCA/GTAATG 1 -- ut31 ese38Minor allele frequency- N:0.00EU EA WA NA 634
    rs121200841,2
    C,F,H198789189(+) TGCTGC/GGGATG 1 P/A mis1 ese316Minor allele frequency- N:0.00EA NA EU WA 1404
    rs107375721,2
    A,C,F198787754(+) ATGACC/TGTATT 1 -- ut313Minor allele frequency- T:0.15NA 142
    --
    rs66677751,2
    A,C198788892(+) gtttcA/Gccatg 1 -- ut310--------
    rs43046191,2
    A,C198788662(+) AAAAAG/TATATt 1 -- ut310--------
    --
    rs38063621,2
    F,H198856433(-) AGGGGG/ATCCCC 1 -- ut51 ese33Minor allele frequency- A:0.04EA WA 300
    rs28082441,2
    C,F198856454(+) CCCACG/ACCACT 1 -- ut513Minor allele frequency- A:0.05NA 132
    --
    rs109199741,2
    A,C198787917(+) TTTTTC/TTTCTT 1 -- ut31 trp30--------
    rs174502171,2
    F,H198857475(+) TGTAAA/TGCAAC 1 -- ng31 tfbs37Minor allele frequency- T:0.28NA EU EA WA 548
    About this table

    HapMap Linkage Disequilibrium images for KIF14 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 611279

    3 Novoseek disease relationships for KIF14 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 38.76 10 17962437 (6)
    breast cancer 13.93 1 16570270 (1)
    tumors 0.00 10 17962437 (5), 17099872 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/28 PubMed articles for KIF14 gene (see all 28 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 9928 HGNC: 19181 AceView: KIF14 Ensembl:ENSG00000118193 euGenes: HUgn9928
    ECgene: KIF14 H-InvDB: KIF14
    (According to HUGE)
    About This Section

    HUGE: KIAA0042
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for KIF14 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for KIF14:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for KIF14 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for KIF14 Browse small molecules at Sigma-Aldrich
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     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for KIF14

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