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Aliases & Descriptions for KIF14
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| KIAA0042 1, 2, 3, 5 | | MGC142302 2 | | OTTHUMP00000033836 2 |
| | | Descriptions |
|---|
| kinesin family member 14 2 |
|
| | Search outside databases for aliases for KIF14 genePrevious GC identifers: GC01M198251 GC01M195979 GC01M196987 GC01M197809 GC01M197252 |
Summaries for KIF14(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for KIF14: KIF14 is a member of the kinesin superfamily of microtubule-associated motors (see MIM 148760) that play important roles in intracellular transport and cell division (Nakagawa et al., 1997 [PubMed 9275178]).[supplied by OMIM] UniProtKB/Swiss-Prot: KIF14_HUMAN, Q15058Function: Plays an essential role in cytokinesisGene Wiki entry for KIF14 |
Genomic Location for KIF14
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the KIF14 gene 
Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1KIF14 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M198787:
(about GC identifiers)
Start:
|
198,787,930 bp from pter |
End:
|
198,856,485 bp from pter |
Size:
|
68,556 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004487.18
| Proteins for KIF14
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: KIF14_HUMAN, Q15058 (See
protein sequence)Recommended Name: Kinesin-like protein KIF14 Size: 1648 amino acids; 186492 Da
Subunit: Directly interacts with PRC1 within a complex also containing KIF4A, KIF20A and KIF23. Directly interacts with CIT depending on the activation state of the kinase (stronger interaction with the kinase-dead form)
Subcellular location: Nucleus. Cytoplasm. Spindle. Note=Nuclear localization observed during interphase in PubMed:16431929 or triggered by entry into mitosis in PubMed:16648480. Cytoplasmic in interphase (PubMed:16648480) and metaphase cells (PubMed:16431929). From prophase to metaphase, accumulates at the developing spindle poles and their associated microtubules. During anaphase, accumulates at the spindle midzone. Localization to the central spindle and midbody during anaphase is dependent upon PRC1 and CIT presence. In cells ready to undergo abscission, concentrates at the contractile ring
Developmental stage: Up-regulated in cells progressing through G2/M phase
Secondary accessions: Q14CI8 Q4G0A5 Q5T1W3Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_055690.1
ENSEMBL proteins: ENSP00000356319
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for KIF14: Assays for KIF14: | Protein
Domains/ Families for KIF14(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q15058
ProtoNet protein and cluster: Q15058 2 Blocks protein families: IPB000253 Forkhead-associated (FHA) IPB001752 Kinesin
UniProtKB/Swiss-Prot: KIF14_HUMAN, Q15058Similarity: Belongs to the kinesin-like protein familySimilarity: Contains 1 FHA domainSimilarity: Contains 1 kinesin-motor domain | Gene Function for KIF14
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014875
Applied Biosystems Silencer® siRNAs for KIF14
Sigma-Aldrich siRNA and siRNA Panels for KIF14  Sigma-Aldrich shRNA Panels and shRNA for KIF14  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014875                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014875                                  untagged cDNA clone in CMV expression vector: NM_014875 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014875
UniProtKB/Swiss-Prot: KIF14_HUMAN, Q15058Function: Plays an essential role in cytokinesis3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for KIF14
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Interacting proteins for KIF14 (ENSP000003563193) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007018 | microtubule-based movement |
IEA | -- | About this table
|
Drugs & Compounds for KIF14(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for KIF14
|
Transcripts for KIF14(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014875
Sigma-Aldrich siRNA and siRNA Panels for KIF14  Sigma-Aldrich shRNA Panels and shRNA for KIF14  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014875 REFSEQ mRNAs for KIF14 gene: NM_014875.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014875               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014875                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014875                                  untagged cDNA clone in CMV expression vector: NM_014875  Additional cDNA sequence: BC098582.1 BC113742.1 BC144068.1 D26361.1 1 DOTS entry: DT.406343 24/31 AceView cDNA sequences (see all 31
):BG615572 AA668857 D26361 BE644769 CD652057 CB409937 BE888525 BQ425495 BM480026 AA668879 BX426204 AA479873 AW075554 BX099509 CD642678 BF435707 CB136970 BP359286 BX646345 AW183154 AA477501 BX414768 BG528841 BE874348
highest scoring ESTs for KIF14:D26361 AA477501 AA668879 AW371859 AW371861 AW371866 AW374063 AW804687 BE565983 BE567495 Unigene Cluster for KIF14: Kinesin family member 14 Hs.3104 [show with all ESTs]Unigene Representative Sequence: NM_014875
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000367350
|
Expression for KIF14
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| KIF14 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for KIF14
1 / 2 / 3 6 probe-sets matching KIF14 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AATAAATCTG
SOURCE GeneReport for Unigene cluster: Hs.3104
Expression variation in blood from EXPOLDB for KIF14 |
Orthologs for KIF14
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KIF14 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for KIF14
ENSEMBL Gene Tree for KIF14 | Paralogs for KIF14(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for KIF14 gene
- KIF16B2 ENSG000001849352
|
SNPs/Variants for KIF14(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for KIF14 (up to first 250kb)
|
Disorders & Mutations for KIF14
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 611279
3 Novoseek disease relationships for KIF14 gene
About this table
|
Medical News for KIF14(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for KIF14 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/28 PubMed articles for KIF14 gene (see all 28
):- Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)2, 3, 4 Nomura N....Tabata S. (1994)
- The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973)3, 4 Vasilescu J.... Figeys D. (2007)
- RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure. (PubMed id 16648480)3, 4 Carleton M....Linsley P.S. (2006)
- KIF14 and citron kinase act together to promote efficient cytokinesis. (PubMed id 16431929)3, 4 Gruneberg U.... Barr F.A. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- High expression of KIF14 in retinoblastoma: association with older age at diagnosis. (PubMed id 17962437)1, 3 Madhavan J....Kumaramanickavel G. (2007)
- Profiling genomic copy number changes in retinoblastoma beyond loss of RB1. (PubMed id 17099872)1, 3 Bowles E....Gallie B.L. (2007)
- KIF14 mRNA expression is a predictor of grade and outcome in breast cancer. (PubMed id 16570270)1, 3 Corson T.W. and Gallie B.L. (2006)
- KIF14 and E2F3 mRNA expression in human retinoblastoma and its phenotype association. (PubMed id 19190782)3 Madhavan J....Kumaramanickavel G. (2009)
- Three genetic developmental stages of papillary renal cell tumors: duplication of chromosome 1q marks fatal progression. (PubMed id 19123481)3 Szponar A....Kovacs G. (2009)
|
Search for KIF14
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing KIF14
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing KIF14
(According to HUGE)
About This Section
| |
Specialized Databases showing KIF14(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for KIF14(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for KIF14:

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