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KIF14 Gene(Protein Coding)

Kinesin Family Member 14

GCID:
GC01M200521
GIFtS:
55
Genes Participants
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Aliases for KIF14 Gene

Aliases for KIF14 Gene

  • Kinesin Family Member 14 2 3 5
  • Kinesin-Like Protein KIF14 3
  • KIAA0042 4
  • MKS12 3

External Ids for KIF14 Gene

Previous GeneCards Identifiers for KIF14 Gene

  • GC01M198251
  • GC01M195979
  • GC01M196987
  • GC01M197809
  • GC01M197252
  • GC01M198787
  • GC01M171687

Summaries for KIF14 Gene

Entrez Gene Summary for KIF14 Gene

  • This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

GeneCards Summary for KIF14 Gene

KIF14 (Kinesin Family Member 14) is a Protein Coding gene. Diseases associated with KIF14 include Meckel Syndrome 12 and Kif14-Related Meckel Syndrome. Among its related pathways are Semaphorin interactions and Signaling by GPCR. GO annotations related to this gene include protein kinase binding and microtubule binding. An important paralog of this gene is KIF16B.

UniProtKB/Swiss-Prot for KIF14 Gene

  • Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:24784001, PubMed:16648480). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302).

Gene Wiki entry for KIF14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF14 Gene

Genomics for KIF14 Gene

Products:

  1. Regulatory Element

Regulatory Elements for KIF14 Gene

Enhancers for KIF14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F200668 1.2 ENCODE 22.6 -49.2 -49177 3.5 CREB3L1 MLX ZFP64 DMAP1 YY1 ZNF263 SP3 NFYC TBX21 MEF2D DDX59 LOC101929224 KIF14
GH01F200638 1.7 FANTOM5 Ensembl ENCODE 11.1 -20.3 -20334 4.5 HDGF PKNOX1 ATF1 ARNT SIN3A ELK1 GATA2 FOS KLF13 ZNF263 DDX59 LOC101929224 KIF14
GH01F201184 1.3 Ensembl ENCODE 10.9 -564.2 -564210 1.2 HDGF PKNOX1 ARNT SIN3A YY1 ZNF766 ZNF143 ZNF207 CEBPZ SP3 IPO9 ENSG00000229821 IPO9-AS1 DDX59 KIF14 TMEM9 IGFN1 GC01M201173
GH01F201153 1.1 ENCODE 10.9 -533.6 -533602 1.7 HDGF PKNOX1 ARNT SIN3A ARID4B DMAP1 YY1 CBX5 ZNF143 FOS TMEM9 DDX59 IGFN1 ASCL5 CACNA1S KIF14 ENSG00000229821
GH01F200802 0.9 ENCODE 12.1 -182.3 -182277 0.2 ELF3 SIN3A ZNF2 RAD21 RFX5 ZNF366 RCOR1 FOS DEK ZHX1 KIF14 GPR25 LOC101929224 GC01M200787 RPL34P6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIF14 on UCSC Golden Path with GeneCards custom track

Promoters for KIF14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000550617 91 2201 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YBX1 DMAP1 ZNF2 SLC30A9 FOS

Transcription factor binding sites by QIAGEN in the KIF14 gene promoter:

Genomic Location for KIF14 Gene

Chromosome:
1
Start:
200,551,497 bp from pter
End:
200,620,791 bp from pter
Size:
69,295 bases
Orientation:
Minus strand

Genomic View for KIF14 Gene

Genes around KIF14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF14 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for KIF14 Gene

Proteins for KIF14 Gene

Products:

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  • Protein details for KIF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15058-KIF14_HUMAN
    Recommended name:
    Kinesin-like protein KIF14
    Protein Accession:
    Q15058
    Secondary Accessions:
    • Q14CI8
    • Q4G0A5
    • Q5T1W3

    Protein attributes for KIF14 Gene

    Size:
    1648 amino acids
    Molecular mass:
    186492 Da
    Quaternary structure:
    • Directly interacts with PRC1 within a complex also containing KIF4A, KIF20A and KIF23; targets to the central spindle. Directly interacts with CIT depending on the activation state of the kinase (stronger interaction with the kinase-dead form); targets to the midbody. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation. Interacts with AKT1; the interaction is detected in the plasma membrane upon INS stimulation and promotes AKT1 phosphorylation. Interacts with SVIL; at midbody during cytokinesis. Interacts with RADIL (via PDZ domain); recruits RADIL to the microtubule network restricting RADIL from interaction with activated RAP1A (PubMed:23209302).
    Miscellaneous:
    • It is resistant to docetaxel anhydrous.
    SequenceCaution:
    • Sequence=BAA05392.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for KIF14 Gene

Protein Expression for KIF14 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for KIF14 Gene

  • Ubiquitination at Lys 275, Lys 1475, and Lys 1494
  • Modification sites at PhosphoSitePlus

Other Protein References for KIF14 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for KIF14
  • Santa Cruz Biotechnology (SCBT) Antibodies for KIF14

No data available for DME Specific Peptides for KIF14 Gene

Domains & Families for KIF14 Gene

Gene Families for KIF14 Gene

HGNC:

Protein Domains for KIF14 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KIF14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15058

UniProtKB/Swiss-Prot:

KIF14_HUMAN :
  • The kinesin motor domain binds to microtubules with high affinity and has a robust ATPase activity but a very slow motility. The kinesin motor domain protects microtubules from cold depolymerization. Binds to each tubulin heterodimer resulting in a microtubule complexes. Binds at the tubulin intradimer interface, at the crest of the protofilament, and orients slightly toward the next protofilament.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Domain:
  • The kinesin motor domain binds to microtubules with high affinity and has a robust ATPase activity but a very slow motility. The kinesin motor domain protects microtubules from cold depolymerization. Binds to each tubulin heterodimer resulting in a microtubule complexes. Binds at the tubulin intradimer interface, at the crest of the protofilament, and orients slightly toward the next protofilament.
  • Contains 1 FHA domain.
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF14: view

Function for KIF14 Gene

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  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  7. Flow Cytometry

Molecular function for KIF14 Gene

UniProtKB/Swiss-Prot Function:
Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:24784001, PubMed:16648480). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302).
UniProtKB/Swiss-Prot Induction:
Up-regulated in cells progressing through G2/M phase.

Gene Ontology (GO) - Molecular Function for KIF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IBA --
GO:0005515 protein binding IPI 16431929
GO:0005524 ATP binding ISS --
GO:0008017 microtubule binding ISS --
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed ISS --
genes like me logo Genes that share ontologies with KIF14: view
genes like me logo Genes that share phenotypes with KIF14: view

Human Phenotype Ontology for KIF14 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for KIF14 Gene

MGI Knock Outs for KIF14:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for KIF14 Gene

Localization for KIF14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF14 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Nuclear localization observed during interphase (PubMed:16431929). Nuclear localization triggered by entry into mitosis (PubMed:16648480). Cytoplasmic in interphase (PubMed:16648480). Cytoplasmic in metaphase cells (PubMed:16431929). From prophase to metaphase, accumulates at the developing spindle poles and their associated microtubules. During anaphase, accumulates at the spindle midzone. Localization to the central spindle and midbody during anaphase is dependent upon PRC1 and CIT presence. In cells ready to undergo abscission, concentrates at the contractile ring. {ECO:0000269 PubMed:16431929, ECO:0000269 PubMed:16648480}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF14 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 4

Gene Ontology (GO) - Cellular Components for KIF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with KIF14: view

Pathways & Interactions for KIF14 Gene

genes like me logo Genes that share pathways with KIF14: view

Pathways by source for KIF14 Gene

Gene Ontology (GO) - Biological Process for KIF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IMP 24854087
GO:0007018 microtubule-based movement IBA --
GO:0007019 NOT microtubule depolymerization ISS --
GO:0007080 mitotic metaphase plate congression IMP 15843429
GO:0008284 positive regulation of cell proliferation IMP 24854087
genes like me logo Genes that share ontologies with KIF14: view

No data available for SIGNOR curated interactions for KIF14 Gene

Drugs & Compounds for KIF14 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for KIF14 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for KIF14 Gene

(10) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(31) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIF14 Gene

Kinesin family member 14:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF14 Gene

No ASD Table

Relevant External Links for KIF14 Gene

GeneLoc Exon Structure for
KIF14
ECgene alternative splicing isoforms for
KIF14

Expression for KIF14 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIF14 Gene

mRNA expression in normal human tissues for KIF14 Gene
mRNA expression by BioGPS for KIF14 GenemRNA expression by GTEx for KIF14 Gene

Protein differential expression in normal tissues from HIPED for KIF14 Gene

This gene is overexpressed in Ovary (48.1) and Stomach (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIF14 Gene



Protein tissue co-expression partners for KIF14 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIF14 Gene:

KIF14

SOURCE GeneReport for Unigene cluster for KIF14 Gene:

Hs.3104
genes like me logo Genes that share expression patterns with KIF14: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIF14 Gene

Orthologs for KIF14 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia KIF14 34 35
  • 99.35 (n)
dog
(Canis familiaris)
 Mammalia KIF14 34 35
  • 87.47 (n)
mouse
(Mus musculus)
 Mammalia Kif14 34 16 35
  • 77.66 (n)
rat
(Rattus norvegicus)
 Mammalia Kif14 34
  • 76.7 (n)
cow
(Bos Taurus)
 Mammalia KIF14 35
  • 73 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia KIF14 35
  • 69 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia KIF14 35
  • 67 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves KIF14 34 35
  • 65.04 (n)
lizard
(Anolis carolinensis)
 Reptilia KIF14 35
  • 52 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100493263 34
  • 61.05 (n)
zebrafish
(Danio rerio)
 Actinopterygii kif14 34 35
  • 59.8 (n)
fruit fly
(Drosophila melanogaster)
 Insecta neb 35
  • 35 (a)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea klp-4 35
  • 20 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 58 (a)
 OneToOne
Species where no ortholog for KIF14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF14 Gene

ENSEMBL:
Gene Tree for KIF14 (if available)
TreeFam:
Gene Tree for KIF14 (if available)

Paralogs for KIF14 Gene

Paralogs for KIF14 Gene

(1) SIMAP similar genes for KIF14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KIF14: view

Variants for KIF14 Gene

Sequence variations from dbSNP and Humsavar for KIF14 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs786201012 Pathogenic 200,603,951(-) AGACA(-/GA)ATTTG reference, frameshift-variant
rs786201013 Pathogenic 200,603,922(-) ATCAC(A/T)GAATA reference, stop-gained
rs10494822 -- 200,606,128(-) AGGTG(C/T)TTCAT intron-variant
rs10494823 -- 200,602,833(-) GTTGT(A/G)TAAAG intron-variant
rs10494824 -- 200,594,843(-) AACTA(C/T)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF14 Gene

Variant ID Type Subtype PubMed ID
nsv998889 CNV gain 25217958
nsv947465 CNV duplication 23825009
nsv478280 CNV novel sequence insertion 20440878
esv2758991 CNV loss 17122850
dgv559n100 CNV gain 25217958

Variation tolerance for KIF14 Gene

Residual Variation Intolerance Score: 78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF14 Gene

Human Gene Mutation Database (HGMD)
KIF14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF14 Gene

Disorders for KIF14 Gene

MalaCards: The human disease database

(3) MalaCards diseases for KIF14 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, and GeneCards

Disorder Aliases PubMed IDs
meckel syndrome 12
  • mks12
kif14-related meckel syndrome
  • meckel syndrome 12
encephalocele
  • bifid cranium
- elite association - COSMIC cancer census association via MalaCards
Search KIF14 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

KIF14_HUMAN
  • Meckel syndrome 12 (MKS12) [MIM:616258]: A form of Meckel syndrome, a disorder characterized by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly. {ECO:0000269 PubMed:24128419}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for KIF14

Human Genome Epidemiology (HuGE) Navigator
KIF14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF14
genes like me logo Genes that share disorders with KIF14: view

No data available for Genatlas for KIF14 Gene

Publications for KIF14 Gene

  1. Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. (PMID: 15843429) Zhu C. … Jiang W. (Mol. Biol. Cell 2005) 3 4 22 64
  2. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4 64
  3. Exome sequencing identifies mutations in KIF14 as a novel cause of an autosomal recessive lethal fetal ciliopathy phenotype. (PMID: 24128419) Filges I. … Friedman J.M. (Clin. Genet. 2014) 3 4 64
  4. KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer. (PMID: 24784001) Singel S.M. … Shay J.W. (Neoplasia 2014) 3 4 64
  5. Silencing of KIF14 interferes with cell cycle progression and cytokinesis by blocking the p27(Kip1) ubiquitination pathway in hepatocellular carcinoma. (PMID: 24854087) Xu H. … Chung Y.J. (Exp. Mol. Med. 2014) 3 4 64

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