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KIF14 Gene

protein-coding GIFtS: 57
GCID: GC01M200521

Kinesin Family Member 14

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Kinesin Family Member 14¹ ²
KIAA0042³ ⁵
Kinesin-Like Protein KIF14²

External Ids:	HGNC: 19181¹	Entrez Gene: 9928²	Ensembl: ENSG00000118193⁷	OMIM: 611279⁵	UniProtKB: Q15058³

Export aliases for KIF14 gene to outside databases

Previous GC identifers: GC01M198251 GC01M195979 GC01M196987 GC01M197809 GC01M197252 GC01M198787 GC01M171687

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KIF14 Gene:

KIF14 is a member of the kinesin superfamily of microtubule-associated motors (see MIM 148760) that play important

roles in intracellular transport and cell division (Nakagawa et al., 1997 (PubMed 9275178)).(supplied by OMIM,

Mar 2008)

GeneCards Summary for KIF14 Gene:

KIF14 (kinesin family member 14) is a protein-coding gene. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIF18A.

UniProtKB/Swiss-Prot: KIF14_HUMAN, Q15058

Function: Plays an essential role in cytokinesis

Gene Wiki entry for KIF14 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000001.10 NC_018912.2 NT_004487.20

Regulatory elements:

Regulatory transcription factor binding sites in the KIF14 gene promoter:
HOXA9 HOXA9B TBP AML1a ATF-2 Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KIF14 promoter sequence

Search Chromatin IP Primers for KIF14

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIF14

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1

KIF14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF14 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M200521: view genomic region (about GC identifiers)

Start:	200,520,625 bp from pter	End:	200,589,862 bp from pter
Size:	69,238 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KIF14_HUMAN, Q15058 (See protein sequence)

Recommended Name: Kinesin-like protein KIF14

Size: 1648 amino acids; 186492 Da

Subunit: Directly interacts with PRC1 within a complex also containing KIF4A, KIF20A and KIF23. Directly interacts

with CIT depending on the activation state of the kinase (stronger interaction with the kinase-dead form).

Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation

Developmental stage: Up-regulated in cells progressing through G2/M phase

Sequence caution: Sequence=BAA05392.2; Type=Erroneous initiation;

Secondary accessions: Q14CI8 Q4G0A5 Q5T1W3

Explore the universe of human proteins at neXtProt for KIF14: NX_Q15058

Explore proteomics data for KIF14 at MOPED

Post-translational modifications:

Ubiquitination² at Lys275, Lys1475, Lys1494

Modification sites at PhosphoSitePlus

See KIF14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_055690.1

ENSEMBL proteins:

ENSP00000356319

KIF14 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

KIF: Kinesins

Selected InterPro protein domains (see all 6):

IPR008984 SMAD_FHA_domain

IPR027417 P-loop_NTPase

IPR000253 FHA_dom

IPR001752 Kinesin_motor_dom

IPR019821 Kinesin_motor_CS

Graphical View of Domain Structure for InterPro Entry Q15058

ProtoNet protein and cluster: Q15058

2 Blocks protein domains:

IPB000253 Forkhead-associated (FHA)

IPB001752 Kinesin

UniProtKB/Swiss-Prot: KIF14_HUMAN, Q15058

Similarity: Belongs to the kinesin-like protein family

Similarity: Contains 1 FHA domain

Similarity: Contains 1 kinesin-motor domain

Find genes that share domains with KIF14 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: KIF14_HUMAN, Q15058

Function: Plays an essential role in cytokinesis

Gene Ontology (GO): 5 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003777	microtubule motor activity	IEA	--
GO:0005515	protein binding	IPI	16820410
GO:0005524	ATP binding	IEA	--
GO:0008017	microtubule binding	IEA	--
GO:0030165	PDZ domain binding	IDA	--

Find genes that share ontologies with KIF14 About GenesLikeMe

Phenotypes:
2 GenomeRNAi human phenotypes for KIF14:

Increased 8N DNA content

Synthetic lethal with Ras

8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Kif14):

behavior/neurological	cellular	craniofacial	growth/size/body	mortality/aging
nervous system	skeleton	vision/eye

Find genes that share phenotypes with KIF14 About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for KIF14

miRNA Products:		miRTarBase miRNAs that target KIF14: hsa-mir-192-5p (MIRT026918), hsa-mir-155-5p (MIRT021036), hsa-mir-615-3p (MIRT016143), hsa-mir-16-5p (MIRT032038), hsa-mir-215-5p (MIRT024477)

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

KIF14_HUMAN, Q15058: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Nuclear localization observed

during interphase in PubMed:16431929 or triggered by entry into mitosis in PubMed:16648480. Cytoplasmic in

interphase (PubMed:16648480) and metaphase cells (PubMed:16431929). From prophase to metaphase, accumulates at

the developing spindle poles and their associated microtubules. During anaphase, accumulates at the spindle

midzone. Localization to the central spindle and midbody during anaphase is dependent upon PRC1 and CIT presence.

In cells ready to undergo abscission, concentrates at the contractile ring

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	5
nucleus	5
cytosol	3
plasma membrane	1

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Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005819	spindle	IEA	--
GO:0005871	kinesin complex	IEA	--
GO:0005874	microtubule	IDA	--

Find genes that share ontologies with KIF14 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for KIF14
Interactions:

Search GeneGlobe Interaction Network for KIF14

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

Selected Interacting proteins for KIF14 (Q15058^{1, 2, 3} ENSP00000356319⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 26)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SVIL	O95425³, ENSP00000348128⁴	I2D: score=1 STRING: ENSP00000348128
SUMO1	P63165³, ENSP00000376076⁴	I2D: score=1 STRING: ENSP00000376076
RIPK2	O43353³, ENSP00000220751⁴	I2D: score=1 STRING: ENSP00000220751
PSTPIP1	O43586³, ENSP00000368914⁴	I2D: score=1 STRING: ENSP00000368914
SEPT8	Q92599³	I2D: score=1

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Gene Ontology (GO): Selected biological process terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007018	microtubule-based movement	IEA	--
GO:0030155	regulation of cell adhesion	IMP	--
GO:0030334	regulation of cell migration	IMP	--
GO:0032487	regulation of Rap protein signal transduction	IMP	--
GO:0033624	negative regulation of integrin activation	IMP	--

Find genes that share ontologies with KIF14 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for KIF14

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for KIF14 gene:

NM_014875.2

Unigene Cluster for KIF14:

Kinesin family member 14

Hs.3104 [show with all ESTs]

Unigene Representative Sequence: NM_014875

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000367350(uc010ppj.1 uc010ppk.1)

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Additional mRNA sequence:

BC098582.1 BC113742.1 BC144068.1 D26361.1

1 DOTS entry:

DT.406343

Selected AceView cDNA sequences (see all 31):

AA668857 BG615572 BE644769 D26361 BM480026 BQ425495 CB409937 AA668879

CD652057 BE888525 CD642678 AA477501 BP359286 BX099509 AW183154 BX426204

AA479873 BX646345 BF435707 AW075554 CB136970 BX414768 BE874348 BG528841

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KIF14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AATAAATCTG

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KIF14 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

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KIF14 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.3104

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for KIF14 gene from Selected species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Kif14^{1 , 5}	kinesin family member 14^{1, 5}	77.66(n)¹ 73.63(a)¹		1 (59.80 cM)⁵ 381293¹ NM_001287179.1¹ NP_001274108.1¹ 136467958⁵
chicken (Gallus gallus)	Aves	KIF14¹	kinesin family member 14	65.04(n) 57.26(a)		424347 XM_422190.4 XP_422190.3
lizard (Anolis carolinensis)	Reptilia	KIF14⁶	kinesin family member 14	52(a)	1 ↔ 1	GL343211.1(1820939-1862320)
African clawed frog (Xenopus laevis)	Amphibia	BJ063135.1²	--	75.54(n)		BJ063135.1
zebrafish (Danio rerio)	Actinopterygii	kif14¹	kinesin family member 14	59.8(n) 58(a)		562052 NM_001044976.1 NP_001038441.1
fruit fly (Drosophila melanogaster)	Insecta	neb⁶	nebbish	35(a)	1 ↔ 1	2L(20075757-20089698)
worm (Caenorhabditis elegans)	Secernentea	klp-4⁶	Protein KLP-4, isoform a (klp-4) mRNA, complete cd...	20(a)	1 → many	X(3171419-3178702) WBGene00002217

ENSEMBL Gene Tree for KIF14 (if available)
TreeFam Gene Tree for KIF14 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for KIF14 gene

KIF18A² KIF16B² KIF1C² STARD9² KIF1B² KIF19² KIF22² KIF13B²

KIF1A² KIF13A² KIF18B²

1 SIMAP similar gene for KIF14 using alignment to 1 protein entry: KIF14_HUMAN:

KIF1C

Find genes that share paralogs with KIF14 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142925892^1,2	C	--	200520250(+)	`ATGAGA/GTGGGT`	1	--	int¹		0	--	--	--	--
rs74977188^1,2	C,F	--	200520256(+)	`TGGGTA/GTTACT`	1	--	int¹		3		CSA WA NA	239
rs146606274^1,2	C	--	200520300(+)	`ACAGTA/GACATG`	1	--	int¹		0	--	--	--	--
rs78424900^1,2	C,F	--	200520334(+)	`CAGTCC/TAGCTG`	1	--	int¹		1		NA	120
rs184052417^1,2		--	200520351(+)	`ACACTC/TCAAAC`	1	--	int¹		0	--	--	--	--
rs10919973^1,2	C,F,A,H	--	200520443(+)	`CTAAAC/GAGAGG`	1	--	int¹		17		NA NS EA WA CSA	929
rs113387252^1,2	C	--	200520460(+)	`ATGTTA/-AAAAA`	1	--	int¹		1		CSA	2
rs141469696^1,2		--	200520563(+)	`GCTATC/TCTGAA`	1	--	int¹		0	--	--	--	--
rs145154704^1,2		--	200520621(+)	`ACCACA/GAAGCA`	1	--	int¹		0	--	--	--	--
rs114339113^1,2	C,F	--	200520698(+)	`TCCAAT/CAGCAA`	1	--	ut3¹		1		NA	120

HapMap Linkage Disequilibrium report for KIF14 (200520625 - 200589862 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for KIF14: About this table

Variant ID	Type	Subtype	PubMed ID
nsv873094	CNV	Gain	21882294
nsv873095	CNV	Gain	21882294
dgv172e1	CNV	Complex	17122850

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing KIF14

DNA2.0 Custom Variant and Variant Library Synthesis for KIF14

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611279 OMIM disorders: --

Find genes that share disorders with KIF14 About GenesLikeMe

3 Novoseek inferred disease relationships for KIF14 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	34.7	10	17962437 (6)
breast cancer	8.52	1	16570270 (1)
tumors	0	10	17962437 (5), 17099872 (1)

Human Genome Epidemiology (HuGE) Navigator: KIF14 (1 document)

Export disorders for KIF14 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KIF14 gene, integrated from 10 sources (see all 50):
(articles sorted by number of sources associating them with KIF14)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)^{1, 2, 3} Nomura N.... Tabata S. (DNA Res. 1994)
The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973)^{1, 2} Vasilescu J.... Figeys D. (J. Proteome Res. 2007)
Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. (PubMed id 16820410)^{1, 2} Neuhaus E.M.... Hatt H. (J. Cell Sci. 2006)
RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure. (PubMed id 16648480)^{1, 2} Carleton M.... Linsley P.S. (Mol. Cell. Biol. 2006)
KIF14 and citron kinase act together to promote efficient cytokinesis. (PubMed id 16431929)^{1, 2} Gruneberg U.... Barr F.A. (J. Cell Biol. 2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (Cell 2006)
High expression of KIF14 in retinoblastoma: association with older age at diagnosis. (PubMed id 17962437)^{1, 9} Madhavan J....Kumaramanickavel G. (amp 2007)
Profiling genomic copy number changes in retinoblastoma beyond loss of RB1. (PubMed id 17099872)^{1, 9} Bowles E....Gallie B.L. (amp 2007)
Metal-proteinase ADAM12, kinesin 14 and checkpoint suppressor 1 as new molecular markers of laryngeal carcinoma. (PubMed id 19609547)^{1, 9} Markowski J....Jarzab B. (Eur Arch Otorhinolaryngol 2009)
Consensus transcriptome signature of perineural invasion in pancreatic carcinoma. (PubMed id 19509238)^{1, 9} Abiatari I....Kleeff J. (Mol. Cancer Ther. 2009)

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Aliases
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9928	HGNC: 19181	AceView: KIF14	Ensembl:ENSG00000118193	euGenes: HUgn9928
ECgene: KIF14	H-InvDB: KIF14

(According to HUGE)
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HUGE: KIAA0042

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for KIF14	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for KIF14	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for KIF14 gene
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KIF14 Gene

Kinesin Family Member 14

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KIF14 Gene

Kinesin Family Member 14

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