KIF13B Gene
protein-coding GIFtS: 52
GCID: GC08M028924
|
|
kinesin family member 13B
| |
Aliases
for KIF13B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kinesin Family Member 13B1 2 | | Guanylate Kinase Associated Kinesin2 | | GAKIN1 2 3 5 | | Kinesin 13B2 | | KIAA06391 3 5 | | Kinesin-Like Protein KIF13B2 | | Kinesin-Like Protein GAKIN2 3 | | |
Export aliases for KIF13B gene to outside databasesPrevious GC identifers: GC08M029510 GC08M028745 GC08M028946 GC08M028980 GC08M027469 |
Summaries
for KIF13B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: KI13B_HUMAN, Q9NQT8Function: Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formationof extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated proteincomplexes
|
Genomic Views
for KIF13B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KIF13B gene promoter:
HSF1 (long) CUTL1 AP-2gamma Meis-1b HSF1short AP-2beta Meis-1a AP-2alpha AP-2alphaA Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIF13B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF13B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p12 Ensembl cytogenetic band: 8p12 HGNC cytogenetic band: 8p21KIF13B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M028924: view genomic region
(about GC identifiers)
Start:
|
28,924,795 bp from pter |
End:
|
29,120,641 bp from pter |
Size:
|
195,847 bases |
Orientation:
|
minus strand |
|
Proteins
for KIF13B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KI13B_HUMAN, Q9NQT8 (See
protein sequence)Recommended Name: Kinesin-like protein KIF13B Size: 1826 amino acids; 202666 Da
Subunit: Binds to DLG1 and DLG4. Interacts (when phosphorylated at Ser-1381 and Ser-1410) with 14-3-3
Subcellular location: Cytoplasm, cytoskeleton. Cell projection, axon. Note=accumulates at the distal part of themicrotubules in the tips of axons, but not of dendrites
Sequence caution: Sequence=BAA31614.3; Type=Erroneous initiation;
4 PDB 3D structures from  and Proteopedia  for KIF13B:2COW (3D)
3FM8 (3D)
3GBJ (3D)
3MDB (3D)
Secondary accessions: O75134 Q9BYJ6Explore the universe of human proteins at neXtProt for KIF13B: NX_Q9NQT8
Post-translational modifications:
Phosphorylated at Ser-1381 and Ser-1410 by MARK2, promoting interaction with 14-3-3 and inhibitingmicrotubule-dependent accumulation and formation of axons1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NQT8
KIF13B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056069.2
ENSEMBL proteins: ENSP00000427900 ENSP00000429106 ENSP00000429027 ENSP00000429201 ENSP00000431006 ENSP00000384054
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
KIF13B for ontologies About GeneDecksing
KIF13B Antibody Products:
Assay Products for KIF13B: |
Protein
Domains /
Families
for KIF13B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KIF13B for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9NQT8ProtoNet protein and cluster: Q9NQT8 3 Blocks protein families: IPB000253 Forkhead-associated (FHA) IPB000938 CAP-Gly domain IPB001752 Kinesin
UniProtKB/Swiss-Prot: KI13B_HUMAN, Q9NQT8Similarity: Belongs to the kinesin-like protein familySimilarity: Contains 1 CAP-Gly domainSimilarity: Contains 1 FHA domainSimilarity: Contains 1 kinesin-motor domain |
Function
for KIF13B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KI13B_HUMAN, Q9NQT8Function: Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formationof extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated proteincomplexes
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF13B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF13B |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
KIF13B for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for KIF13B:
|
Pathways & Interactions
for KIF13B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Arf6 signaling events | |
1  BioSystems Pathway for KIF13B
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KIF13B
5 Interacting proteins for KIF13B (Q9NQT81, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
KIF13B for ontologies About GeneDecksing
|
Drugs & Compounds
for KIF13B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KIF13B
Search CenterWatch for drugs/clinical trials and news about KIF13B / KI13B
|
Transcripts
for KIF13B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KIF13B gene: NM_015254.3 Unigene Cluster for KIF13B: Kinesin family member 13B Hs.444767 [show with all ESTs]Unigene Representative Sequence: NM_0152547 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000524189(uc011laz.2 uc003xhh.4) ENST00000523130 ENST00000522355(uc003xhj.2)
ENST00000521515(uc010lvf.1) ENST00000523968 ENST00000522846(uc003xhk.2)
ENST00000404075
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIF13B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIF13B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Synthesis Service for KIF13B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF13B |
Additional cDNA sequence: AB014539.3 AF279865.1 AK000240.1 AK129580.1 AK294837.1 AK307848.1 AL583912.1 BC005977.1 BC014350.1 BC028056.1 BX537898.1 8 DOTS entries: DT.454091 DT.102829454 DT.92429492 DT.100730679 DT.121467291 DT.101976336 DT.95357358 DT.97842013 24/159 AceView cDNA sequences (see all 159): AI308764 BQ181806 CA748955 AA256530 AI751027 CD368901 NM_015254 BM987425 BI007011 CA314862 BM310678 AI760125 AI336606 AL583912 AI857401 CB122646 BF912652 AK129580 AA502298 AA630040 CA313993 BU621480 CK825206 W73267
GeneLoc Exon Structure
|
Expression
for KIF13B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIF13B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATGAACTA
About this image
See KIF13B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIF13B
SOURCE GeneReport for Unigene cluster: Hs.444767
UniProtKB/Swiss-Prot: KI13B_HUMAN, Q9NQT8Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for KIF13B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIF13B
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF13B |
Orthologs
for KIF13B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KIF13B gene from 5/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
KIF13B1 |
kinesin family member 13B |
73.87(n)
80.63(a) |
|
422026 XM_003641072.1 XP_003641120.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.245692 |
Xenopus laevis transcribed sequence with moderate similarity more |
78.44(n) |
|
48059171 |
zebrafish
(Danio rerio) |
Actinopterygii |
kif13ba1 |
kinesin family member 13Ba |
67.32(n)
71.44(a) |
|
571520 XM_695118.3 XP_700210.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Khc-733 |
microtubule-based movement kinesin motor |
51(a)
(best of 2) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
klp-63 |
-- |
43(a)
(best of 2) |
|
III(5102738-5108133) -- |
ENSEMBL Gene Tree for KIF13B (if available)
TreeFam Gene Tree for KIF13B (if available) |
Paralogs
for KIF13B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KIF13B gene
- KIF18A2 KIF1C2 KIF16B2 KIF1B2 KIF192 KIF142 KIF222 KIF13A2
- KIF1A2 KIF122 KIF18B2
18/22 SIMAP similar genes for KIF13B using alignment to 9 protein entries: KI13B_HUMAN (see all proteins)
(see all similar genes):KIF13A KIF1A KIF1C KIF3B KIF3A KLP6
KIF5C KIF5B KIF23 KIF5A KIF18B KIF3C
KIF5B-ALK KIFC3 STARD9 KIF6 KIF2C DCTN1
KIF13B for paralogs About GeneDecksing
|
Genomic Variants
for KIF13B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KIF13B (28924795 - 29120641 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for KIF13B
1 CNV: 100305
1 Indel: 60694 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIF13B |
|
Disorders
/ Diseases
for KIF13B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KIF13B for disorders About GeneDecksing
OMIM gene information: 607350
OMIM disorders: --
6  diseases for KIF13B: About MalaCardsspastic paraplegia hereditary spastic paraplegia paraplegia spasticity
malaria neuronitis
Human Genome Epidemiology (HuGE) Navigator: KIF13B (2 documents)
Export disorders for KIF13B gene to outside databases
|
Publications
for KIF13B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIF13B gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with KIF13B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes. (PubMed id 10859302)1, 2, 3, 9 Hanada T.... Chishti A.H. (2000)
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (1998)
- Transport of PIP3 by GAKIN, a kinesin-3 family protein, regulates neuronal cell polarity. (PubMed id 16864656)1, 3, 9 Horiguchi K....Chishti A.H. (2006)
- Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation. (PubMed id 20194617)1, 2 Yoshimura Y....Miki H. (2010)
- Direct interaction with a kinesin-related motor mediates transport of mammalian discs large tumor suppressor homologue in epithelial cells. (PubMed id 12496241)1, 9 Asaba N....Chishti A.H. (2003)
- The effector domain of human Dlg tumor suppressor acts as a switch that relieves autoinhibition of kinesin-3 motor GAKIN/KIF13B. (PubMed id 17696365)1, 9 Yamada K.H....Chishti A.H. (2007)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536)1 Barber M.J....Krauss R.M. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
|
External Searches for KIF13B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KIF13B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KIF13B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KIF13B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KIF13B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KIF13B gene:
Search GeneIP for patents involving KIF13B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIF13B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF13B |
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