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Aliases for KIF13B Gene

Aliases for KIF13B Gene

  • Kinesin Family Member 13B 2 3 5
  • Kinesin-Like Protein GAKIN 3 4
  • GAKIN 3 4
  • Guanylate Kinase Associated Kinesin 3
  • Kinesin 13B 3
  • KIAA0639 4

External Ids for KIF13B Gene

Previous GeneCards Identifiers for KIF13B Gene

  • GC08M029510
  • GC08M028745
  • GC08M028946
  • GC08M028980
  • GC08M027469
  • GC08M028924

Summaries for KIF13B Gene

GeneCards Summary for KIF13B Gene

KIF13B (Kinesin Family Member 13B) is a Protein Coding gene. Diseases associated with KIF13B include corticobasal degeneration. Among its related pathways are Platelet activation, signaling and aggregation and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include protein kinase binding and microtubule motor activity. An important paralog of this gene is KIF14.

UniProtKB/Swiss-Prot for KIF13B Gene

  • Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF13B Gene

Genomics for KIF13B Gene

Regulatory Elements for KIF13B Gene

Promoters for KIF13B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIF13B on UCSC Golden Path with GeneCards custom track

Genomic Location for KIF13B Gene

Chromosome:
8
Start:
29,067,278 bp from pter
End:
29,263,304 bp from pter
Size:
196,027 bases
Orientation:
Minus strand

Genomic View for KIF13B Gene

Genes around KIF13B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF13B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF13B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF13B Gene

Proteins for KIF13B Gene

  • Protein details for KIF13B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQT8-KI13B_HUMAN
    Recommended name:
    Kinesin-like protein KIF13B
    Protein Accession:
    Q9NQT8
    Secondary Accessions:
    • B4DGY5
    • B5MC45
    • F8VPJ2
    • O75134
    • Q9BYJ6

    Protein attributes for KIF13B Gene

    Size:
    1826 amino acids
    Molecular mass:
    202789 Da
    Quaternary structure:
    • Binds to DLG1 and DLG4. Interacts (when phosphorylated at Ser-1381 and Ser-1410) with 14-3-3.
    SequenceCaution:
    • Sequence=BAA31614.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIF13B Gene

    Alternative splice isoforms for KIF13B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF13B Gene

Proteomics data for KIF13B Gene at MOPED

Post-translational modifications for KIF13B Gene

  • Phosphorylated at Ser-1381 and Ser-1410 by MARK2, promoting interaction with 14-3-3 and inhibiting microtubule-dependent accumulation and formation of axons.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF13B Gene

No data available for DME Specific Peptides for KIF13B Gene

Domains & Families for KIF13B Gene

Gene Families for KIF13B Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQT8

UniProtKB/Swiss-Prot:

KI13B_HUMAN :
  • Contains 1 CAP-Gly domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Domain:
  • Contains 1 CAP-Gly domain.
  • Contains 1 FHA domain.
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF13B: view

Function for KIF13B Gene

Molecular function for KIF13B Gene

UniProtKB/Swiss-Prot Function:
Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes.

Gene Ontology (GO) - Molecular Function for KIF13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 10859302
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with KIF13B: view
genes like me logo Genes that share phenotypes with KIF13B: view

Animal Models for KIF13B Gene

MGI Knock Outs for KIF13B:

Animal Model Products

miRNA for KIF13B Gene

miRTarBase miRNAs that target KIF13B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF13B Gene

Localization for KIF13B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF13B Gene

Cytoplasm, cytoskeleton. Cell projection, axon. Note=accumulates at the distal part of the microtubules in the tips of axons, but not of dendrites.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF13B Gene COMPARTMENTS Subcellular localization image for KIF13B gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for KIF13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030424 axon IDA 20194617
genes like me logo Genes that share ontologies with KIF13B: view

Pathways & Interactions for KIF13B Gene

genes like me logo Genes that share pathways with KIF13B: view

Gene Ontology (GO) - Biological Process for KIF13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting TAS 10859302
GO:0042110 T cell activation NAS 12496241
GO:0050770 regulation of axonogenesis IDA 20194617
genes like me logo Genes that share ontologies with KIF13B: view

No data available for SIGNOR curated interactions for KIF13B Gene

Drugs & Compounds for KIF13B Gene

No Compound Related Data Available

Transcripts for KIF13B Gene

Unigene Clusters for KIF13B Gene

Kinesin family member 13B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF13B Gene

No ASD Table

Relevant External Links for KIF13B Gene

GeneLoc Exon Structure for
KIF13B
ECgene alternative splicing isoforms for
KIF13B

Expression for KIF13B Gene

mRNA expression in normal human tissues for KIF13B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIF13B Gene

This gene is overexpressed in Nasal epithelium (10.6), Islet of Langerhans (7.1), and Salivary gland (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF13B Gene



SOURCE GeneReport for Unigene cluster for KIF13B Gene Hs.444767

mRNA Expression by UniProt/SwissProt for KIF13B Gene

Q9NQT8-KI13B_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with KIF13B: view

Protein tissue co-expression partners for KIF13B Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KIF13B Gene

Orthologs for KIF13B Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF13B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIF13B 35
  • 84.64 (n)
  • 90.13 (a)
KIF13B 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF13B 35
  • 87.02 (n)
  • 91.1 (a)
KIF13B 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif13b 35
  • 83.35 (n)
  • 89.54 (a)
Kif13b 16
Kif13b 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIF13B 35
  • 99.45 (n)
  • 99.62 (a)
KIF13B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif13b 35
  • 82.48 (n)
  • 88.4 (a)
oppossum
(Monodelphis domestica)
Mammalia KIF13B 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF13B 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF13B 35
  • 75.5 (n)
  • 82.12 (a)
KIF13B 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 79 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia kif13b 35
  • 71.81 (n)
  • 78.26 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24569 35
zebrafish
(Danio rerio)
Actinopterygii kif13ba 35
  • 67.7 (n)
  • 72.1 (a)
kif13ba 36
  • 69 (a)
OneToMany
kif13bb 36
  • 72 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Khc-73 37
  • 51 (a)
Kif19A 37
  • 34 (a)
Khc-73 35
  • 56.21 (n)
  • 54.94 (a)
Khc-73 36
  • 44 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea klp-4 37
  • 42 (a)
klp-6 37
  • 43 (a)
Species with no ortholog for KIF13B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF13B Gene

ENSEMBL:
Gene Tree for KIF13B (if available)
TreeFam:
Gene Tree for KIF13B (if available)

Paralogs for KIF13B Gene

Paralogs for KIF13B Gene

genes like me logo Genes that share paralogs with KIF13B: view

Variants for KIF13B Gene

Sequence variations from dbSNP and Humsavar for KIF13B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs17526980 - 29,092,792(+) GCGGA(C/T)GGGAA reference, missense
rs20516 -- 29,163,558(+) GACTT(A/G)TTAAC intron-variant
rs20517 -- 29,163,648(+) GGTTT(C/T)TTCAA intron-variant
rs613670 -- 29,240,006(-) tttta(A/G)attcc intron-variant
rs876058 -- 29,167,914(+) TACTC(A/G)GAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF13B Gene

Variant ID Type Subtype PubMed ID
nsv831276 CNV Gain 17160897
esv2736816 CNV Deletion 23290073
esv5693 CNV Gain 19470904
nsv528871 CNV Loss 19592680
esv2501473 CNV Deletion 19546169

Variation tolerance for KIF13B Gene

Residual Variation Intolerance Score: 2.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF13B Gene

HapMap Linkage Disequilibrium report
KIF13B
Human Gene Mutation Database (HGMD)
KIF13B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF13B Gene

Disorders for KIF13B Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIF13B Gene - From: GeneCards

Disorder Aliases PubMed IDs
corticobasal degeneration
  • cbgd
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for KIF13B

Genetic Association Database (GAD)
KIF13B
Human Genome Epidemiology (HuGE) Navigator
KIF13B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF13B
genes like me logo Genes that share disorders with KIF13B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIF13B Gene

Publications for KIF13B Gene

  1. GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes. (PMID: 10859302) Hanada T. … Chishti A.H. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. Transport of PIP3 by GAKIN, a kinesin-3 family protein, regulates neuronal cell polarity. (PMID: 16864656) Horiguchi K. … Chishti A.H. (J. Cell Biol. 2006) 2 3 23
  3. The effector domain of human Dlg tumor suppressor acts as a switch that relieves autoinhibition of kinesin-3 motor GAKIN/KIF13B. (PMID: 17696365) Yamada K.H. … Chishti A.H. (Biochemistry 2007) 3 23
  4. Direct interaction with a kinesin-related motor mediates transport of mammalian discs large tumor suppressor homologue in epithelial cells. (PMID: 12496241) Asaba N. … Chishti A.H. (J. Biol. Chem. 2003) 3 23
  5. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3

Products for KIF13B Gene

Sources for KIF13B Gene

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