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Aliases for KIF13B Gene

Aliases for KIF13B Gene

  • Kinesin Family Member 13B 2 3
  • GAKIN 3 4 6
  • Kinesin-Like Protein GAKIN 3 4
  • KIAA0639 4 6
  • Guanylate Kinase Associated Kinesin 3
  • Kinesin-Like Protein KIF13B 3
  • Kinesin 13B 3

External Ids for KIF13B Gene

Previous GeneCards Identifiers for KIF13B Gene

  • GC08M029510
  • GC08M028745
  • GC08M028946
  • GC08M028980
  • GC08M027469
  • GC08M028924

Summaries for KIF13B Gene

GeneCards Summary for KIF13B Gene

KIF13B (Kinesin Family Member 13B) is a Protein Coding gene. Among its related pathways are Arf6 signaling events. GO annotations related to this gene include protein kinase binding and microtubule motor activity. An important paralog of this gene is KIF14.

UniProtKB/Swiss-Prot for KIF13B Gene

  • Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF13B Gene

Genomics for KIF13B Gene

Regulatory Elements for KIF13B Gene

Genomic Location for KIF13B Gene

29,067,278 bp from pter
29,263,303 bp from pter
196,026 bases
Minus strand

Genomic View for KIF13B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF13B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF13B Gene

Proteins for KIF13B Gene

  • Protein details for KIF13B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kinesin-like protein KIF13B
    Protein Accession:
    Secondary Accessions:
    • B4DGY5
    • B5MC45
    • F8VPJ2
    • O75134
    • Q9BYJ6

    Protein attributes for KIF13B Gene

    1826 amino acids
    Molecular mass:
    202789 Da
    Quaternary structure:
    • Binds to DLG1 and DLG4. Interacts (when phosphorylated at Ser-1381 and Ser-1410) with 14-3-3.
    • Sequence=BAA31614.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIF13B Gene

    Alternative splice isoforms for KIF13B Gene


neXtProt entry for KIF13B Gene

Proteomics data for KIF13B Gene at MOPED

Post-translational modifications for KIF13B Gene

  • Phosphorylated at Ser-1381 and Ser-1410 by MARK2, promoting interaction with 14-3-3 and inhibiting microtubule-dependent accumulation and formation of axons.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF13B Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for KIF13B

No data available for DME Specific Peptides for KIF13B Gene

Domains for KIF13B Gene

Gene Families for KIF13B Gene

  • KIF :Kinesins

Graphical View of Domain Structure for InterPro Entry



  • Q9NQT8
  • Contains 1 CAP-Gly domain.
  • Contains 1 FHA domain.
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF13B: view

Function for KIF13B Gene

Molecular function for KIF13B Gene

UniProtKB/Swiss-Prot Function:
Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes.

Gene Ontology (GO) - Molecular Function for KIF13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity NAS 10859302
GO:0005515 protein binding IPI 10859302
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0019901 protein kinase binding IPI 10859302
genes like me logo Genes that share ontologies with KIF13B: view

Phenotypes for KIF13B Gene

GenomeRNAi human phenotypes for KIF13B:
genes like me logo Genes that share phenotypes with KIF13B: view

Animal Model Products

miRNA for KIF13B Gene

miRTarBase miRNAs that target KIF13B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIF13B Gene

Localization for KIF13B Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF13B Gene

Cytoplasm, cytoskeleton. Cell projection, axon. Note=accumulates at the distal part of the microtubules in the tips of axons, but not of dendrites.

Subcellular locations from

Jensen Localization Image for KIF13B Gene COMPARTMENTS Subcellular localization image for KIF13B gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for KIF13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10859302
GO:0005871 kinesin complex IEA --
GO:0005874 microtubule IEA --
GO:0030424 axon IDA 20194617
genes like me logo Genes that share ontologies with KIF13B: view

Pathways for KIF13B Gene

SuperPathways for KIF13B Gene

Superpath Contained pathways
1 Arf6 signaling events
genes like me logo Genes that share pathways with KIF13B: view

Pathways by source for KIF13B Gene

1 BioSystems pathway for KIF13B Gene

Gene Ontology (GO) - Biological Process for KIF13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting TAS 10859302
GO:0007018 microtubule-based movement TAS 10859302
GO:0007165 signal transduction NAS 10859302
GO:0008152 metabolic process NAS 10859302
GO:0042110 T cell activation NAS 12496241
genes like me logo Genes that share ontologies with KIF13B: view

Transcripts for KIF13B Gene

Unigene Clusters for KIF13B Gene

Kinesin family member 13B:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF13B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF13B Gene

No ASD Table

Relevant External Links for KIF13B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIF13B Gene

mRNA expression in normal human tissues for KIF13B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for KIF13B Gene

This gene is overexpressed in Nasal epithelium (10.6), Islet of Langerhans (7.1), and Salivary gland (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF13B Gene

SOURCE GeneReport for Unigene cluster for KIF13B Gene Hs.444767

mRNA Expression by UniProt/SwissProt for KIF13B Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with KIF13B: view

Expression partners for KIF13B Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KIF13B Gene

Orthologs for KIF13B Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF13B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KIF13B 35
  • 84.64 (n)
  • 90.13 (a)
KIF13B 36
  • 86 (a)
(Canis familiaris)
Mammalia KIF13B 35
  • 87.02 (n)
  • 91.1 (a)
KIF13B 36
  • 89 (a)
(Mus musculus)
Mammalia Kif13b 35
  • 83.35 (n)
  • 89.54 (a)
Kif13b 16
Kif13b 36
  • 88 (a)
(Pan troglodytes)
Mammalia KIF13B 35
  • 99.45 (n)
  • 99.62 (a)
KIF13B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Kif13b 35
  • 82.48 (n)
  • 88.4 (a)
(Monodelphis domestica)
Mammalia KIF13B 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia KIF13B 36
  • 88 (a)
(Gallus gallus)
Aves KIF13B 35
  • 75.5 (n)
  • 82.12 (a)
KIF13B 36
  • 76 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 79 (a)
-- 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kif13b 35
  • 71.81 (n)
  • 78.26 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24569 35
(Danio rerio)
Actinopterygii kif13ba 35
  • 67.7 (n)
  • 72.1 (a)
kif13ba 36
  • 69 (a)
kif13bb 36
  • 72 (a)
fruit fly
(Drosophila melanogaster)
Insecta Khc-73 37
  • 51 (a)
Kif19A 37
  • 34 (a)
Khc-73 35
  • 56.21 (n)
  • 54.94 (a)
Khc-73 36
  • 44 (a)
(Caenorhabditis elegans)
Secernentea klp-4 37
  • 42 (a)
klp-6 37
  • 43 (a)
Species with no ortholog for KIF13B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF13B Gene

Gene Tree for KIF13B (if available)
Gene Tree for KIF13B (if available)

Paralogs for KIF13B Gene

Paralogs for KIF13B Gene

genes like me logo Genes that share paralogs with KIF13B: view

Variants for KIF13B Gene

Sequence variations from dbSNP and Humsavar for KIF13B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1350 -- 29,216,802(+) GCCTG(A/C)GACTG intron-variant
rs2692 -- 29,067,377(+) ACATG(A/G)TACAA utr-variant-3-prime
rs2693 -- 29,067,341(-) GTACC(A/G)TATGT utr-variant-3-prime
rs20516 -- 29,163,558(+) GACTT(A/G)TTAAC intron-variant
rs20517 -- 29,163,648(+) GGTTT(C/T)TTCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF13B Gene

Variant ID Type Subtype PubMed ID
nsv831276 CNV Gain 17160897
esv2736816 CNV Deletion 23290073
esv5693 CNV Gain 19470904
nsv528871 CNV Loss 19592680
esv2501473 CNV Deletion 19546169

Relevant External Links for KIF13B Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF13B Gene

Disorders for KIF13B Gene

Relevant External Links for KIF13B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for KIF13B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KIF13B Gene

Publications for KIF13B Gene

  1. GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes. (PMID: 10859302) Hanada T. … Chishti A.H. (J. Biol. Chem. 2000) 2 3 4 23
  2. Transport of PIP3 by GAKIN, a kinesin-3 family protein, regulates neuronal cell polarity. (PMID: 16864656) Horiguchi K. … Chishti A.H. (J. Cell Biol. 2006) 2 3 23
  3. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  4. Direct interaction with a kinesin-related motor mediates transport of mammalian discs large tumor suppressor homologue in epithelial cells. (PMID: 12496241) Asaba N. … Chishti A.H. (J. Biol. Chem. 2003) 3 23
  5. The effector domain of human Dlg tumor suppressor acts as a switch that relieves autoinhibition of kinesin-3 motor GAKIN/KIF13B. (PMID: 17696365) Yamada K.H. … Chishti A.H. (Biochemistry 2007) 3 23

Products for KIF13B Gene

Sources for KIF13B Gene

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