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Aliases for KIF13A Gene

Aliases for KIF13A Gene

  • Kinesin Family Member 13A 2 3
  • Kinesin-Like Protein RBKIN 3 4
  • RBKIN 3 4
  • Homolog Of Mouse KIF13A Mannose-6-Phosphate Receptor Transporter 3
  • Kinesin-Like Protein KIF13A 3
  • BA500C11.2 3

External Ids for KIF13A Gene

Previous GeneCards Identifiers for KIF13A Gene

  • GC06M017818
  • GC06M017868
  • GC06M017871
  • GC06M017705

Summaries for KIF13A Gene

Entrez Gene Summary for KIF13A Gene

  • This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for KIF13A Gene

KIF13A (Kinesin Family Member 13A) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Protein folding. GO annotations related to this gene include microtubule binding and microtubule motor activity. An important paralog of this gene is KIF14.

UniProtKB/Swiss-Prot for KIF13A Gene

  • Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis.

Gene Wiki entry for KIF13A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF13A Gene

Genomics for KIF13A Gene

Genomic Location for KIF13A Gene

Start:
17,759,183 bp from pter
End:
17,987,632 bp from pter
Size:
228,450 bases
Orientation:
Minus strand

Genomic View for KIF13A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF13A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF13A Gene

Proteins for KIF13A Gene

  • Protein details for KIF13A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1H9-KI13A_HUMAN
    Recommended name:
    Kinesin-like protein KIF13A
    Protein Accession:
    Q9H1H9
    Secondary Accessions:
    • A0JP21
    • A0JP22
    • F2Z382
    • Q5THQ2
    • Q5THQ3
    • Q9H193
    • Q9H194
    • Q9H1H8

    Protein attributes for KIF13A Gene

    Size:
    1805 amino acids
    Molecular mass:
    202308 Da
    Quaternary structure:
    • Interacts with AP2B1 (By similarity). Interacts with ZFYVE26. Interacts with AP1G1 and AP1G2.
    SequenceCaution:
    • Sequence=CAI21670.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21671.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40947.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40948.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF13A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF13A Gene

Proteomics data for KIF13A Gene at MOPED

Post-translational modifications for KIF13A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIF13A Gene

Domains for KIF13A Gene

Gene Families for KIF13A Gene

HGNC:
  • KIF :Kinesins

Suggested Antigen Peptide Sequences for KIF13A Gene

Graphical View of Domain Structure for InterPro Entry

Q9H1H9

UniProtKB/Swiss-Prot:

KI13A_HUMAN :
  • Q9H1H9
Domain:
  • Contains 1 FHA domain.
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF13A: view

Function for KIF13A Gene

Molecular function for KIF13A Gene

UniProtKB/Swiss-Prot Function: Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis.

Gene Ontology (GO) - Molecular Function for KIF13A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity ISS --
GO:0005515 protein binding IPI 19841138
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF13A: view

Phenotypes for KIF13A Gene

genes like me logo Genes that share phenotypes with KIF13A: view

Animal Models for KIF13A Gene

MGI Knock Outs for KIF13A:

miRNA for KIF13A Gene

miRTarBase miRNAs that target KIF13A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KIF13A Gene

Localization for KIF13A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF13A Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Endosome membrane. Golgi apparatus membrane. Note=Recruited to the midbody during cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF13A Gene COMPARTMENTS Subcellular localization image for KIF13A gene
Compartment Confidence
cytoskeleton 5
endosome 5
cytosol 3
golgi apparatus 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KIF13A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 20208530
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
GO:0010008 endosome membrane IDA 19841138
GO:0030496 midbody IDA 20208530
genes like me logo Genes that share ontologies with KIF13A: view

Pathways for KIF13A Gene

genes like me logo Genes that share pathways with KIF13A: view

Gene Ontology (GO) - Biological Process for KIF13A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IMP 20208530
GO:0006200 obsolete ATP catabolic process --
GO:0006886 intracellular protein transport IMP 20208530
GO:0007018 microtubule-based movement IBA --
GO:0008152 metabolic process ISS --
genes like me logo Genes that share ontologies with KIF13A: view

Compounds for KIF13A Gene

(1) HMDB Compounds for KIF13A Gene

Compound Synonyms Cas Number PubMed IDs
Mannose 6-phosphate
  • D-Mannose 6-phosphate
3672-15-9
genes like me logo Genes that share compounds with KIF13A: view

Transcripts for KIF13A Gene

Unigene Clusters for KIF13A Gene

Kinesin family member 13A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF13A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37a · 37b ^ 38 ^ 39a · 39b ^ 40
SP1: -
SP2: - -
SP3: - - - -
SP4: - - -
SP5:
SP6:

Relevant External Links for KIF13A Gene

GeneLoc Exon Structure for
KIF13A
ECgene alternative splicing isoforms for
KIF13A

Expression for KIF13A Gene

mRNA expression in normal human tissues for KIF13A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF13A Gene

SOURCE GeneReport for Unigene cluster for KIF13A Gene Hs.94499

mRNA Expression by UniProt/SwissProt for KIF13A Gene

Q9H1H9-KI13A_HUMAN
Tissue specificity: Widely expressed, with highest levels in heart, brain and skeletal muscle.
genes like me logo Genes that share expressions with KIF13A: view

No data available for mRNA differential expression in normal tissues for KIF13A Gene

Orthologs for KIF13A Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF13A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF13A 35
  • 99.65 (n)
  • 100 (a)
KIF13A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIF13A 35
  • 89.31 (n)
  • 95.14 (a)
KIF13A 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF13A 35
  • 89.91 (n)
  • 95.31 (a)
KIF13A 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif13a 35
  • 85.58 (n)
  • 92.71 (a)
Kif13a 16
Kif13a 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF13A 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF13A 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif13a 35
  • 85.63 (n)
  • 92.64 (a)
chicken
(Gallus gallus)
Aves KIF13A 35
  • 79.43 (n)
  • 88.32 (a)
KIF13A 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF13A 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif13a 35
  • 73.47 (n)
  • 80.11 (a)
zebrafish
(Danio rerio)
Actinopterygii kif13a 35
  • 68.87 (n)
  • 75.36 (a)
kif13a 36
  • 64 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007592 35
  • 58.16 (n)
  • 61.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta Khc-73 37
  • 57 (a)
Kif19A 37
  • 34 (a)
neb 37
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea klp-4 35
  • 55.39 (n)
  • 52.95 (a)
klp-6 37
  • 43 (a)
klp-4 37
  • 45 (a)
Species with no ortholog for KIF13A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF13A Gene

ENSEMBL:
Gene Tree for KIF13A (if available)
TreeFam:
Gene Tree for KIF13A (if available)

Paralogs for KIF13A Gene

Paralogs for KIF13A Gene

Selected SIMAP similar genes for KIF13A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KIF13A: view

Variants for KIF13A Gene

Sequence variations from dbSNP and Humsavar for KIF13A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1084 -- 17,759,506(+) TCTAC(C/G)CATTC utr-variant-3-prime
rs585918 -- 17,848,333(-) ttttc(C/T)gtagc intron-variant
rs589764 -- 17,867,196(-) CAGCA(A/G)CCCTC intron-variant
rs591827 -- 17,859,640(-) aaaaa(A/T)atata intron-variant
rs594115 -- 17,860,176(-) AGTGT(A/G)ATGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF13A Gene

Variant ID Type Subtype PubMed ID
nsv516012 CNV Gain+Loss 19592680
nsv830596 CNV Gain 17160897
esv2658979 CNV Deletion 23128226
esv2678875 CNV Deletion 23128226
nsv830597 CNV Loss 17160897
nsv883459 CNV Loss 21882294
esv23172 CNV Loss 19812545

Relevant External Links for KIF13A Gene

HapMap Linkage Disequilibrium report
KIF13A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF13A Gene

Disorders for KIF13A Gene

Relevant External Links for KIF13A

Genetic Association Database (GAD)
KIF13A
Human Genome Epidemiology (HuGE) Navigator
KIF13A
genes like me logo Genes that share disorders with KIF13A: view

No data available for UniProtKB/Swiss-Prot for KIF13A Gene

Publications for KIF13A Gene

  1. A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex. (PMID: 11106728) Nakagawa T. … Hirokawa N. (Cell 2000) 2 3 23
  2. Genomic amplification in retinoblastoma narrowed to 0.6 megabase on chromosome 6p containing a kinesin-like gene, RBKIN. (PMID: 11861365) Chen D. … Gallie B.L. (Cancer Res. 2002) 3 4 23
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. Identification of the human KIF13A gene homologous to Drosophila kinesin-73 and candidate for schizophrenia. (PMID: 11374900) Jamain S. … Bourgeron T. (Genomics 2001) 3 4
  5. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48

Products for KIF13A Gene

Sources for KIF13A Gene

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