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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIF13A Gene

protein-coding   GIFtS: 60
GCID: GC06M017759

Kinesin Family Member 13A

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kinesin Family Member 13A1 2
Kinesin-Like Protein RBKIN2 3
RBKIN2 3
bA500C11.22
Homolog Of Mouse KIF13A Mannose-6-Phosphate Receptor Transporter2
Kinesin-Like Protein KIF13A2

External Ids:    HGNC: 145661   Entrez Gene: 639712   Ensembl: ENSG000001371777   OMIM: 6054335   UniProtKB: Q9H1H93   

Export aliases for KIF13A gene to outside databases

Previous GC identifers: GC06M017818 GC06M017868 GC06M017871 GC06M017705


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KIF13A Gene:
This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the
positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the
trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late
endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the
midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene
results in multiple transcript variants. (provided by RefSeq, Aug 2011)

GeneCards Summary for KIF13A Gene: 
KIF13A (kinesin family member 13A) is a protein-coding gene. Diseases associated with KIF13A include retinoblastoma, and schizophrenia, and among its related super-pathways are Chaperonin-mediated protein folding and Post-translational protein modification. GO annotations related to this gene include microtubule motor activity and ATP binding. An important paralog of this gene is KIF3A.

UniProtKB/Swiss-Prot: KI13A_HUMAN, Q9H1H9
Function: Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating
various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting
during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi
network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation,
required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating
peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis:
mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis

Gene Wiki entry for KIF13A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIF13A gene promoter:
         Sox5   AP-2alpha isoform 3   AML1a   NRSF form 1   NRSF form 2   C/EBPalpha   Evi-1   IRF-7A   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIF13A promoter sequence
   Search SABiosciences Chromatin IP Primers for KIF13A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF13A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p23   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p23

KIF13A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF13A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M017759:  view genomic region     (about GC identifiers)

Start:
17,759,414 bp from pter      End:
17,987,854 bp from pter
Size:
228,441 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KI13A_HUMAN, Q9H1H9 (See protein sequence)
Recommended Name: Kinesin-like protein KIF13A  
Size: 1805 amino acids; 202308 Da
Subunit: Interacts with AP2B1 (By similarity). Interacts with ZFYVE26. Interacts with AP1G1 and AP1G2
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Endosome
membrane. Golgi apparatus membrane (By similarity). Note=Recruited to the midbody during cytokinesis
Developmental stage: Expressed at very low level in most fetal tissues, but at higher levels in skeletal muscle
and lung
Sequence caution: Sequence=CAI21670.1; Type=Erroneous gene model prediction; Sequence=CAI21671.1; Type=Erroneous
gene model prediction; Sequence=CAI40947.1; Type=Erroneous gene model prediction; Sequence=CAI40948.1;
Type=Erroneous gene model prediction;
Secondary accessions: A0JP21 A0JP22 F2Z382 Q5THQ2 Q5THQ3 Q9H193 Q9H194 Q9H1H8
Alternative splicing: 5 isoforms:  Q9H1H9-1   Q9H1H9-2   Q9H1H9-3   Q9H1H9-4   Q9H1H9-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KIF13A: NX_Q9H1H9

Explore proteomics data for KIF13A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H1H9

  • KIF13A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KIF13A Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001099036.1  NP_001099037.1  NP_001099038.1  NP_001230352.1  NP_071396.4  

    ENSEMBL proteins: 
     ENSP00000368091   ENSP00000425616   ENSP00000259711   ENSP00000368120   ENSP00000368103  
     ENSP00000351150   ENSP00000422808   ENSP00000425453   ENSP00000368093  
    Reactome Protein details: Q9H1H9
    Human Recombinant Protein Products for KIF13A: 
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    Cloud-Clone Corp. Proteins for KIF13A 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005813centrosome IDA--
    GO:0005871kinesin complex IEA--
    GO:0005874microtubule IEA--
    GO:0005875microtubule associated complex ----

    KIF13A for ontologies           About GeneDecksing



    KIF13A Antibody Products: 
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    Cloud-Clone Corp. ELISAs for KIF13A 
    Cloud-Clone Corp. CLIAs for KIF13A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KIF: Kinesins

    5/7 InterPro protein domains (see all 7):
     IPR008984 SMAD_FHA_domain
     IPR022140 KIF1B
     IPR022164 Kinesin-like
     IPR027417 P-loop_NTPase
     IPR000253 FHA_dom

    Graphical View of Domain Structure for InterPro Entry Q9H1H9

    ProtoNet protein and cluster: Q9H1H9

    2 Blocks protein domains:
    IPB000253 Forkhead-associated (FHA)
    IPB001752 Kinesin


    UniProtKB/Swiss-Prot: KI13A_HUMAN, Q9H1H9
    Similarity: Belongs to the kinesin-like protein family
    Similarity: Contains 1 FHA domain
    Similarity: Contains 1 kinesin-motor domain


    KIF13A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KI13A_HUMAN, Q9H1H9
    Function: Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating
    various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting
    during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi
    network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation,
    required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating
    peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis:
    mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity ISS--
    GO:0005515protein binding IPI19841138
    GO:0005524ATP binding IEA--
    GO:0008017microtubule binding IEA--
         
    KIF13A for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Kif13a):
     behavior/neurological  homeostasis/metabolism 

    KIF13A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Kif13atm1.1Noh for KIF13A

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KIF13A 
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    SwitchGear 3'UTR luciferase reporter plasmidKIF13A 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF13A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KIF13A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Chaperonin-mediated protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.60
    Protein folding0.91
    2Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    3Reelin Pathway (Cajal-Retzius cells)
    Reelin Pathway (Cajal-Retzius cells)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KIF13A
        Reelin Pathway (Cajal-Retzius cells)

    4        Reactome Pathways for KIF13A
        Association of TriC/CCT with target proteins during biosynthesis
    Chaperonin-mediated protein folding
    Metabolism of proteins
    Protein folding



    KIF13A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KIF13A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/11 Interacting proteins for KIF13A (Q9H1H92, 3 ENSP000002597114) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7IPQ6VMQ62, 3MINT-61908 I2D: score=3 
    AP1B1Q105673, ENSP000003501994I2D: score=2 STRING: ENSP00000350199
    GTF2H1P327803, ENSP000002659634I2D: score=1 STRING: ENSP00000265963
    PIK3R1P279863, ENSP000002743354I2D: score=1 STRING: ENSP00000274335
    PPP1CAP621363, ENSP000003260314I2D: score=1 STRING: ENSP00000326031
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IMP--
    GO:0006886intracellular protein transport IMP--
    GO:0007018microtubule-based movement ----
    GO:0008333endosome to lysosome transport IMP19841138
    GO:0032438melanosome organization IMP19841138

    KIF13A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIF13A (KI13A)

    1 HMDB Compound for KIF13A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Mannose 6-phosphateD-Mannose 6-phosphate (see all 10)3672-15-9--

    Search CenterWatch for drugs/clinical trials and news about KIF13A / KI13A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIF13A gene (5 alternative transcripts): 
    NM_001105566.2  NM_001105567.2  NM_001105568.2  NM_001243423.1  NM_022113.5  

    Unigene Cluster for KIF13A:

    Kinesin family member 13A
    Hs.94499  [show with all ESTs]
    Unigene Representative Sequence: NM_001105568
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378814(uc003nce.2 uc003ncf.3) ENST00000502297 ENST00000259711(uc003ncg.4 uc003nch.4 uc003nci.4)
    ENST00000378843 ENST00000378826 ENST00000358380 ENST00000506044 ENST00000514714
    ENST00000503342 ENST00000507576 ENST00000505588 ENST00000502704(uc003nck.3)
    ENST00000378816
    miRNA
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    Additional mRNA sequence: 

    AJ291578.1 AJ291579.1 AK025303.1 AK225214.1 AY014403.1 AY014404.1 BC001730.1 BC023613.2 
    BC062673.1 BC127115.1 BC127116.1 

    14 DOTS entries:

    DT.111577  DT.95313882  DT.411892  DT.100754528  DT.91667004  DT.100754530  DT.101981997  DT.106057 
    DT.101969609  DT.203423  DT.97815550  DT.121333387  DT.100018241  DT.91660011 

    24/90 AceView cDNA sequences (see all 90):

    AJ291579 BM807994 AI524805 CD721878 BM808168 AJ291578 AI277715 F12986 
    BU634123 BM559010 BU629053 N32528 BM911908 AA927630 F10582 F10583 
    AI741491 BM468655 BE675263 AA633254 AI299223 AI080622 AV654336 AW043963 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KIF13A (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                    -                                                                                                                                       
    SP2:                    -                                                                                                                                       
    SP3:                    -                                                                                                                                       
    SP4:                    -                                                                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37a · 37b ^ 38 ^ 39a · 39b ^ 40
    SP1:                                                                                -                           
    SP2:                                                                                -     -                     
    SP3:        -                                                                       -     -           -         
    SP4:        -                                                                       -     -                     
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for KIF13A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIF13A expression in normal human tissues (normalized intensities)      KIF13A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCCGCCTG
    KIF13A Expression
    About this image


    KIF13A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Peripheral blood-derived hematopoietic stem cells
             neutrophils   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
             ganglion/cranial/facial VII   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/naris   
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive Node Cells Primitive Node
     
     Neural Tube (Nervous System)
             Metencephalon

    See KIF13A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIF13A

    SOURCE GeneReport for Unigene cluster: Hs.94499

    UniProtKB/Swiss-Prot: KI13A_HUMAN, Q9H1H9
    Tissue specificity: Widely expressed, with highest levels in heart, brain and skeletal muscle

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KIF13A gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kif13a1 , 5 kinesin family member 13A1, 5 85.53(n)1
    92.51(a)1
      13 (24.49 cM)5
    165531  NM_010617.21  NP_034747.21 
     467490875 
    chicken
    (Gallus gallus)
    Aves KIF13A1 kinesin family member 13A 79.44(n)
    88.99(a)
      420832  XM_418923.2  XP_418923.2 
    lizard
    (Anolis carolinensis)
    Reptilia KIF13A6
    Uncharacterized protein
    86(a)
    1 ↔ 1
    4(56974379-57043208)
    zebrafish
    (Danio rerio)
    Actinopterygii kif13a1 kinesin family member 13A 69.39(n)
    76.19(a)
      100331282  XM_002665062.1  XP_002665108.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Khc-731 , 3 microtubule-based movement kinesin
    motor3
    Kinesin-731
    57(a)
    (best of 3)3
    53.75(n)1
    53.18(a)1
      367181  NM_135357.31  NP_609201.31 
    worm
    (Caenorhabditis elegans)
    Secernentea klp-41 , 3 kinesin-related protein3
    Protein KLP-41
    45(a)
    (best of 2)3
    54.44(n)1
    51.72(a)1
      X(3207003-3213963)3
    1806081  NM_076145.21  NP_508546.21 


    ENSEMBL Gene Tree for KIF13A (if available)
    TreeFam Gene Tree for KIF13A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIF13A gene
    KIF3A2  KIF5B2  KIF5C2  KIF1C2  KIF112  KIF16B2  KIF3B2  KIF1B2  
    KIF142  KIF13B2  KIF1A2  KIF172  CENPE2  KIF152  KIF5A2  KIF3C2  
    10 SIMAP similar genes for KIF13A using alignment to 5 protein entries:     KI13A_HUMAN (see all proteins):
    KIF13B    KIF6    KIF3A    KIF1C    KIF5C    KIF5B
    KIF23    KIF5A    KIF21A    KIF27

    KIF13A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4847 SNPs in KIF13A are shown (see all 4847)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1511101811,2
    --17704140(+) ATCGTC/GAACAG 1 -- ds50010--------
    rs795238851,2
    F--17704185(+) CCCCCC/TTCCAC 1 -- ds50011Minor allele frequency- T:0.05NA 120
    rs1399178821,2
    --17704204(+) GATTGA/GTCTGT 1 -- ds50010--------
    rs1498291201,2
    --17704225(+) TGACAC/TTCACC 1 -- ds50010--------
    rs1920288811,2
    --17704271(+) AAAGGA/CCTGTC 1 -- ds50010--------
    rs1457988631,2
    --17704520(+) TTTTTA/CACACT 1 -- ds50010--------
    rs20387441,2
    C,H--17704596(-) TAATCG/ATTTGT 1 -- ut3114Minor allele frequency- A:0.02NS EA WA NA CSA 648
    rs1412331461,2
    --17704613(+) TAAAAA/TCTGAA 1 -- ut310--------
    rs1454289571,2
    C--17704645(+) CACAT-/ACACACA 1 -- ut310--------
    rs3696358101,2
    C--17704646(+) CACAT-/ACACACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KIF13A (17759414 - 17987854 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for KIF13A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2658979CNV Deletion23128226
    esv2678875CNV Deletion23128226
    nsv883459CNV Loss21882294
    esv23172CNV Loss19812545
    nsv830597CNV Loss17160897
    nsv830596CNV Gain17160897
    nsv516012CNV Gain+Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605433    OMIM disorders: --

    2 diseases for KIF13A:    About MalaCards
    retinoblastoma    schizophrenia


    KIF13A for disorders           About GeneDecksing

    Genetic Association Database (GAD): KIF13A
    Human Genome Epidemiology (HuGE) Navigator: KIF13A (3 documents)

    Export disorders for KIF13A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIF13A gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with KIF13A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex. (PubMed id 11106728)1, 3, 9 Nakagawa T....Hirokawa N. (2000)
    2. Genomic amplification in retinoblastoma narrowed to 0.6 megabase on chromosome 6p containing a kinesin-like gene, RBKIN. (PubMed id 11861365)1, 2, 9 Chen D.... Gallie B.L. (2002)
    3. A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)1, 4 Tao S....Sun J. (2012)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. PtdIns(3)P controls cytokinesis through KIF13A-mediat ed recruitment of FYVE-CENT to the midbody. (PubMed id 20208530)1, 2 Sagona A.P....Stenmark H. (2010)
    6. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PubMed id 19328558)1, 4 Yosifova A....Nakamura Y. (2009)
    7. AP-1 and KIF13A coordinate endosomal sorting and posi tioning during melanosome biogenesis. (PubMed id 19841138)1, 2 Delevoye C....Raposo G. (2009)
    8. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (2008)
    9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    10. Identification of the human KIF13A gene homologous to Drosophila kinesin-73 and candidate for schizophrenia. (PubMed id 11374900)1, 2 Jamain S.... Bourgeron T. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 63971 HGNC: 14566 AceView: KIF13A Ensembl:ENSG00000137177 euGenes: HUgn63971
    ECgene: KIF13A H-InvDB: KIF13A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIF13A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIF13A gene:
    Search GeneIP for patents involving KIF13A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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