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Aliases for KIF13A Gene

Aliases for KIF13A Gene

  • Kinesin Family Member 13A 2 3 5
  • Kinesin-Like Protein RBKIN 3 4
  • RBKIN 3 4
  • Homolog Of Mouse KIF13A Mannose-6-Phosphate Receptor Transporter 3
  • Kinesin-Like Protein KIF13A 3
  • BA500C11.2 3

External Ids for KIF13A Gene

Previous GeneCards Identifiers for KIF13A Gene

  • GC06M017818
  • GC06M017868
  • GC06M017871
  • GC06M017705

Summaries for KIF13A Gene

Entrez Gene Summary for KIF13A Gene

  • This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for KIF13A Gene

KIF13A (Kinesin Family Member 13A) is a Protein Coding gene. Among its related pathways are Chaperonin-mediated protein folding and Reelin Pathway (Cajal-Retzius cells). GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF13B.

UniProtKB/Swiss-Prot for KIF13A Gene

  • Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis.

Gene Wiki entry for KIF13A Gene

Additional gene information for KIF13A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF13A Gene

Genomics for KIF13A Gene

Regulatory Elements for KIF13A Gene

Enhancers for KIF13A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H017927 2.1 VISTA FANTOM5 Ensembl ENCODE dbSUPER 19.2 +56.4 56413 7 PKNOX1 FOXA2 ATF1 MLX ARID4B YY1 TCF12 GATA2 ATF7 SP5 KIF13A NHLRC1 LOC105374952 RNF144B KDM1B RPS12P12 GC06P017893
GH06H017903 1.6 Ensembl ENCODE dbSUPER 19.5 +80.8 80829 6 HDGF PKNOX1 FOXA2 ARNT SIN3A YBX1 YY1 ZNF766 CBX5 FOS KIF13A NHLRC1 LOC105374952 GC06P017893 RPS12P12
GH06H017875 1.4 Ensembl ENCODE dbSUPER 18.6 +110.6 110620 2 HDAC1 TBP ATF1 TBL1XR1 CHAMP1 RFX5 TCF12 GATA2 ATF7 FOS KIF13A NHLRC1 GC06P017868 GC06P017893
GH06H017964 1.2 Ensembl ENCODE dbSUPER 16.9 +22.4 22364 2 SMARCE1 JUN NCOA1 BRF2 ZNF592 ZFHX2 JUND PRDM6 EGR1 FOS KIF13A LOC105374952 NUP153 GC06P017969 RPS12P12
GH06H017961 1.5 Ensembl ENCODE dbSUPER 12.5 +25.0 25025 1 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 CBX5 GATA2 ELK1 ATF7 NUP153 LOC105374952 KIF13A RPS12P12 GC06P017969
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIF13A on UCSC Golden Path with GeneCards custom track

Promoters for KIF13A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000194224 529 3001 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 JUNB REST ZNF592

Genomic Location for KIF13A Gene

Chromosome:
6
Start:
17,759,183 bp from pter
End:
17,987,629 bp from pter
Size:
228,447 bases
Orientation:
Minus strand

Genomic View for KIF13A Gene

Genes around KIF13A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF13A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF13A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF13A Gene

Proteins for KIF13A Gene

  • Protein details for KIF13A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1H9-KI13A_HUMAN
    Recommended name:
    Kinesin-like protein KIF13A
    Protein Accession:
    Q9H1H9
    Secondary Accessions:
    • A0JP21
    • A0JP22
    • F2Z382
    • Q5THQ2
    • Q5THQ3
    • Q9H193
    • Q9H194
    • Q9H1H8

    Protein attributes for KIF13A Gene

    Size:
    1805 amino acids
    Molecular mass:
    202308 Da
    Quaternary structure:
    • Interacts with AP2B1 (By similarity). Interacts with ZFYVE26. Interacts with AP1G1 and AP1G2.
    SequenceCaution:
    • Sequence=CAI21670.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21671.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40947.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40948.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KIF13A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIF13A Gene

Post-translational modifications for KIF13A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIF13A Gene

Domains & Families for KIF13A Gene

Gene Families for KIF13A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KIF13A Gene

Graphical View of Domain Structure for InterPro Entry

Q9H1H9

UniProtKB/Swiss-Prot:

KI13A_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF13A: view

Function for KIF13A Gene

Molecular function for KIF13A Gene

UniProtKB/Swiss-Prot Function:
Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis.

Phenotypes From GWAS Catalog for KIF13A Gene

Gene Ontology (GO) - Molecular Function for KIF13A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003774 motor activity IEA --
GO:0003777 microtubule motor activity ISS --
GO:0005515 protein binding IPI 19841138
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with KIF13A: view

Phenotypes for KIF13A Gene

genes like me logo Genes that share phenotypes with KIF13A: view

Animal Models for KIF13A Gene

MGI Knock Outs for KIF13A:

Animal Model Products

  • Taconic Biosciences Mouse Models for KIF13A

CRISPR Products

miRNA for KIF13A Gene

miRTarBase miRNAs that target KIF13A

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIF13A Gene

Localization for KIF13A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF13A Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Endosome membrane. Golgi apparatus membrane. Note=Recruited to the midbody during cytokinesis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF13A gene
Compartment Confidence
cytoskeleton 5
endosome 5
cytosol 4
golgi apparatus 4
nucleus 3
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for KIF13A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005623 cell IEA --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with KIF13A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KIF13A Gene

Pathways & Interactions for KIF13A Gene

genes like me logo Genes that share pathways with KIF13A: view

Gene Ontology (GO) - Biological Process for KIF13A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IMP 20208530
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IMP 20208530
GO:0007018 microtubule-based movement IBA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with KIF13A: view

No data available for SIGNOR curated interactions for KIF13A Gene

Drugs & Compounds for KIF13A Gene

(1) Drugs for KIF13A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mannose 6-phosphate Investigational Pharma 0
genes like me logo Genes that share compounds with KIF13A: view

Transcripts for KIF13A Gene

Unigene Clusters for KIF13A Gene

Kinesin family member 13A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF13A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37a · 37b ^ 38 ^ 39a · 39b ^ 40
SP1: -
SP2: - -
SP3: - - - -
SP4: - - -
SP5:
SP6:

Relevant External Links for KIF13A Gene

GeneLoc Exon Structure for
KIF13A
ECgene alternative splicing isoforms for
KIF13A

Expression for KIF13A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF13A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIF13A Gene

This gene is overexpressed in Plasma (14.6), Stomach (7.5), and Heart (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIF13A Gene



NURSA nuclear receptor signaling pathways regulating expression of KIF13A Gene:

KIF13A

SOURCE GeneReport for Unigene cluster for KIF13A Gene:

Hs.94499

mRNA Expression by UniProt/SwissProt for KIF13A Gene:

Q9H1H9-KI13A_HUMAN
Tissue specificity: Widely expressed, with highest levels in heart, brain and skeletal muscle.

Evidence on tissue expression from TISSUES for KIF13A Gene

  • Nervous system(4.3)
  • Liver(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with KIF13A: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF13A Gene

Orthologs for KIF13A Gene

This gene was present in the common ancestor of animals.

Orthologs for KIF13A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF13A 33 34
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia KIF13A 33 34
  • 89.91 (n)
cow
(Bos Taurus)
Mammalia KIF13A 33 34
  • 89.31 (n)
rat
(Rattus norvegicus)
Mammalia Kif13a 33
  • 85.63 (n)
mouse
(Mus musculus)
Mammalia Kif13a 33 16 34
  • 85.58 (n)
oppossum
(Monodelphis domestica)
Mammalia KIF13A 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF13A 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF13A 33 34
  • 79.43 (n)
lizard
(Anolis carolinensis)
Reptilia KIF13A 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kif13a 33
  • 73.47 (n)
zebrafish
(Danio rerio)
Actinopterygii kif13a 33 34
  • 68.87 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007592 33
  • 58.16 (n)
fruit fly
(Drosophila melanogaster)
Insecta Khc-73 35
  • 57 (a)
neb 35
  • 35 (a)
Kif19A 35
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea klp-4 35 33
  • 55.39 (n)
klp-6 35
  • 43 (a)
Species where no ortholog for KIF13A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF13A Gene

ENSEMBL:
Gene Tree for KIF13A (if available)
TreeFam:
Gene Tree for KIF13A (if available)

Paralogs for KIF13A Gene

Paralogs for KIF13A Gene

(10) SIMAP similar genes for KIF13A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KIF13A: view

Variants for KIF13A Gene

Sequence variations from dbSNP and Humsavar for KIF13A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs483352706 Uncertain significance 17,800,057(-) GAGCG(C/T)GTGGT reference, synonymous-codon
rs1000007476 -- 17,956,895(+) TTTTT(C/T)TTTTT intron-variant
rs1000009911 -- 17,852,079(+) TCACA(A/C)CAAAG intron-variant
rs1000017271 -- 17,763,601(+) ACCTA(C/T)GGGCA intron-variant, downstream-variant-500B
rs1000025471 -- 17,977,838(+) CTAAT(A/G)CTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF13A Gene

Variant ID Type Subtype PubMed ID
dgv5922n100 CNV gain 25217958
esv23172 CNV loss 19812545
esv2658979 CNV deletion 23128226
esv2678875 CNV deletion 23128226
esv3567336 CNV deletion 23714750
esv3576102 CNV gain 25503493
esv3608221 CNV gain 21293372
esv3608223 CNV gain 21293372
esv3608224 CNV loss 21293372
esv3608227 CNV loss 21293372
esv3608228 CNV loss 21293372
esv3890794 CNV gain 25118596
nsv1015140 CNV gain 25217958
nsv1032900 CNV gain 25217958
nsv1074915 CNV deletion 25765185
nsv1109762 CNV deletion 24896259
nsv1114782 CNV deletion 24896259
nsv1145093 CNV deletion 24896259
nsv516012 CNV gain+loss 19592680
nsv601046 CNV gain 21841781
nsv601047 CNV gain 21841781
nsv830596 CNV gain 17160897
nsv830597 CNV loss 17160897
nsv950134 CNV duplication 24416366

Variation tolerance for KIF13A Gene

Residual Variation Intolerance Score: 28.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF13A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF13A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF13A Gene

Disorders for KIF13A Gene

Relevant External Links for KIF13A

Genetic Association Database (GAD)
KIF13A
Human Genome Epidemiology (HuGE) Navigator
KIF13A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF13A

No disorders were found for KIF13A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF13A Gene

Publications for KIF13A Gene

  1. Genomic amplification in retinoblastoma narrowed to 0.6 megabase on chromosome 6p containing a kinesin-like gene, RBKIN. (PMID: 11861365) Chen D … Gallie BL (Cancer research 2002) 3 4 22 60
  2. A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex. (PMID: 11106728) Nakagawa T … Hirokawa N (Cell 2000) 2 3 22 60
  3. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S … Sun J (Carcinogenesis 2012) 3 45 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. (PMID: 20208530) Sagona AP … Stenmark H (Nature cell biology 2010) 3 4 60

Products for KIF13A Gene

Sources for KIF13A Gene

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