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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIF12 Gene

protein-coding   GIFtS: 49
GCID: GC09M116848

Kinesin Family Member 12

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kinesin Family Member 121 2
RP11-56P10.32
Kinesin-Like Protein KIF122

External Ids:    HGNC: 214951   Entrez Gene: 1132202   Ensembl: ENSG000001368837   OMIM: 6112785   UniProtKB: Q96FN53   

Export aliases for KIF12 gene to outside databases

Previous GC identifers: GC09M110307 GC09M112229 GC09M113933 GC09M115893 GC09M086460


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KIF12 Gene:
KIF12 is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that play
important roles in intracellular transport and cell division (Nakagawa et al., 1997 (PubMed 9275178)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for KIF12 Gene: 
KIF12 (kinesin family member 12) is a protein-coding gene. Diseases associated with KIF12 include kidney disease, and polycystic kidney disease. GO annotations related to this gene include microtubule motor activity and ATP binding. An important paralog of this gene is KIF4A.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIF12 gene promoter:
         NF-1/L   NF-1   SREBP-1c   Pax-2   Pax-2a   SREBP-1b   PPAR-gamma1   SREBP-1a   GATA-6   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIF12 promoter sequence
   Search SABiosciences Chromatin IP Primers for KIF12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32   Ensembl cytogenetic band:  9q32   HGNC cytogenetic band: 9q33.1

KIF12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF12 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M116848:  view genomic region     (about GC identifiers)

Start:
116,848,406 bp from pter      End:
116,861,507 bp from pter
Size:
13,102 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KIF12_HUMAN, Q96FN5 (See protein sequence)
Recommended Name: Kinesin-like protein KIF12  
Size: 646 amino acids; 70660 Da
Subcellular location: Cytoplasm, cytoskeleton (Probable)
Secondary accessions: Q5TBE0

Explore the universe of human proteins at neXtProt for KIF12: NX_Q96FN5

Explore proteomics data for KIF12 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96FN5

  • KIF12 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KIF12 Protein Expression
    REFSEQ proteins: NP_612433.1  
    ENSEMBL proteins: 
     ENSP00000363232   ENSP00000473459  

    Human Recombinant Protein Products for KIF12: 
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    Cloud-Clone Corp. Proteins for KIF12 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005871kinesin complex IEA--
    GO:0005874microtubule IEA--
    GO:0005875microtubule associated complex ----

    KIF12 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KIF: Kinesins

    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR001752 Kinesin_motor_dom
     IPR019821 Kinesin_motor_CS

    Graphical View of Domain Structure for InterPro Entry Q96FN5

    ProtoNet protein and cluster: Q96FN5

    UniProtKB/Swiss-Prot: KIF12_HUMAN, Q96FN5
    Similarity: Belongs to the kinesin-like protein family
    Similarity: Contains 1 kinesin-motor domain


    KIF12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity IEA--
    GO:0005524ATP binding IEA--
    GO:0008017microtubule binding IEA--
         
    KIF12 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KIF12:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KIF12 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIF12

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for KIF12 (Q96FN53 ENSP000003632324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007018microtubule-based movement IEA--

    KIF12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIF12

    Search CenterWatch for drugs/clinical trials and news about KIF12

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIF12 gene: 
    NM_138424.1  

    Unigene Cluster for KIF12:

    Kinesin family member 12
    Hs.28149  [show with all ESTs]
    Unigene Representative Sequence: BC010626
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000498016 ENST00000374118(uc004bif.3) ENST00000468460(uc004big.3)
    ENST00000473174 ENST00000491059
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Additional mRNA sequence: BC010626.1 

    7 DOTS entries:

    DT.91754087  DT.95155814  DT.100672530  DT.426969  DT.212998  DT.97858196  DT.99983438 

    24/58 AceView cDNA sequences (see all 58):

    BC010626 BQ129377 BQ015489 BC036824 CR617868 F10037 CK823607 AW151274 
    T12597 BM470944 AW070898 BQ129240 NM_138424 AI478941 BI829900 AA293123 
    BF431249 BU078740 AA977555 BU079013 BX452373 H61902 AL531520 AI023648 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KIF12 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^
    SP1:                                -     -     -                                                                                               -               
    SP2:                                                                          -                                                                                 
    SP3:                                                                          -           -                                   -                                 
    SP4:        -           -           -                                                                                                                           
    SP5:                                                                                                                          -                 -               

    ExUns: 18 ^ 19a · 19b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for KIF12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIF12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAAGAGA
    KIF12 Expression
    About this image


    See KIF12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIF12

    SOURCE GeneReport for Unigene cluster: Hs.28149

    UniProtKB/Swiss-Prot: KIF12_HUMAN, Q96FN5
    Tissue specificity: Expressed in fetal liver, adult brain and pancreatic islet as well as in kidney tumors, uterus
    cancer and pancreatic cancer

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for KIF12 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kif121 , 5 kinesin family member 121, 5 81.88(n)1
    79.64(a)1
      4 (33.96 cM)5
    165521  NM_010616.21  NP_034746.11 
     631656345 
    chicken
    (Gallus gallus)
    Aves KIF121 kinesin family member 12 63.03(n)
    56.3(a)
      427829  XM_425403.3  XP_425403.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Klp54D1 Kinesin-like protein at 54D 52.32(n)
    43.96(a)
      47216  NM_080144.2  NP_524883.2 
    worm
    (Caenorhabditis elegans)
    Secernentea klp-106
    klp-186
    Protein KLP-18
    12(a)
    10(a)
    possible ortholog
    possible ortholog
    IV(7797121-7800437)
    IV(7040209-7043694)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIP26
    Kinesin-related motor protein involved in mitotic ...
    12(a)
    1 → many
    XVI(257216-259336)


    ENSEMBL Gene Tree for KIF12 (if available)
    TreeFam Gene Tree for KIF12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIF12 gene
    KIF4A2  KIF21A2  KIF21B2  KIF4B2  KIF72  KIF272  
    8 SIMAP similar genes for KIF12 using alignment to 3 protein entries:     KIF12_HUMAN (see all proteins):
    KIF5C    KIF6    KIF1A    KIF5B    KIF2C    KIF5A
    KIF3A    KIF21A

    KIF12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/315 SNPs in KIF12 are shown (see all 315)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1390227041,2
    --116853474(+) CTCACA/GCCTAG 1 -- int10--------
    rs713677461,2
    C--116853572(-) TTTTT-/TTAGTAG 1 -- int11Minor allele frequency- TT:0.00NA 2
    rs1857095051,2
    --116853612(+) GTGGTG/TGCGTG 1 -- int10--------
    rs1890172311,2
    C--116853615(+) GTGGCA/G/TTGTGC 1 -- int10--------
    rs1415521071,2
    C--116853659(+) GAGAAC/TCGCTT 1 -- int10--------
    rs109820631,2
    C,F--116853660(+) AGAATC/TGCTTG 1 -- int15Minor allele frequency- T:0.44NA CSA 9
    rs1392436651,2
    --116853726(+) GGTGAC/TAAAGC 1 -- int10--------
    rs1500165751,2
    C--116853740(+) ACTCCA/GTCTCA 1 -- int10--------
    rs1127273751,2
    C--116853747(+) TCAAA-/AAAAC/A
    AAACAAAAC
    AAAAC
    1 -- int11CSA 2
    rs339668891,2
    C--116853748(+) CAAAA-/AAAA  
      CAAAAC
    AAACA
    1 -- int10--------

    HapMap Linkage Disequilibrium report for KIF12 (116848406 - 116861507 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for KIF12:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv33e196CNV Duplication17116639
    nsv893751CNV Loss21882294
    nsv893750CNV Loss21882294
    nsv471319CNV Gain18288195
    dgv945n27CNV Gain19166990
    nsv528822CNV Gain19592680
    nsv515856CNV Gain+Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611278    OMIM disorders: --

    6 diseases for KIF12:    About MalaCards
    kidney disease    polycystic kidney disease    hepatitis b    pancreatic cancer
    pancreatitis    hepatitis


    KIF12 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: KIF12 (1 document)

    Export disorders for KIF12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIF12 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KIF12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of KIF12 gene in silico. (PubMed id 15643526)1, 2, 9 Katoh M. and Katoh M. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. Genome-wide association study of Tourette's syndrome. (PubMed id 22889924)1 Scharf J.M.... D.L. (2012)
    5. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome. (PubMed id 9275178)1 Nakagawa T....Hirokawa N. (1997)
    8. Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. (PubMed id 15843429)9 Zhu C.... Jiang W. (2005)
    9. Kif15 cooperates with eg5 to promote bipolar spindle assembly. (PubMed id 19818618)9 Tanenbaum M.E....Medema R.H. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 113220 HGNC: 21495 AceView: KIF12 Ensembl:ENSG00000136883 euGenes: HUgn113220
    ECgene: KIF12 H-InvDB: KIF12

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIF12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIF12 gene:
    Search GeneIP for patents involving KIF12

    GeneCards and IP:
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