Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KIF12 Gene

Aliases for KIF12 Gene

  • Kinesin Family Member 12 2 3 5

External Ids for KIF12 Gene

Previous GeneCards Identifiers for KIF12 Gene

  • GC09M110307
  • GC09M112229
  • GC09M113933
  • GC09M115893
  • GC09M116848
  • GC09M086460

Summaries for KIF12 Gene

Entrez Gene Summary for KIF12 Gene

  • This gene encodes a member of the kinesin superfamily of microtubule-associated molecular motors with functions related to the microtubule cytosekelton. Members of this superfamily play important roles in intracellular transport and cell division. A similar protein in mouse functions in the beta cell antioxidant signaling cascade, acting as a scaffold for the transcription factor specificity protein 1 (Sp1). Mice that lack this gene exhibit beta cell oxidative stress resulting in hypoinsulinemic glucose intolerance. [provided by RefSeq, Jul 2016]

GeneCards Summary for KIF12 Gene

KIF12 (Kinesin Family Member 12) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Vesicle-mediated transport. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF6.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF12 Gene

Genomics for KIF12 Gene

Regulatory Elements for KIF12 Gene

Enhancers for KIF12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G114097 0.9 ENCODE 17.3 +1.1 1127 3.4 ELF3 ARID4B KLF17 ZNF48 ZSCAN9 RAD21 RARA GLIS2 CREM MIXL1 KIF12 COL27A1 AMBP
GH09G114077 1 ENCODE 8.5 +21.8 21769 1.5 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 SP5 MXD4 NFYC COL27A1 AMBP KIF12 GC09P114396
GH09G114237 1.4 Ensembl ENCODE dbSUPER 5.1 -139.0 -139004 3.2 HDAC1 ATF1 TBL1XR1 RAD21 YY1 TCF12 GATA2 CREM SMARCA5 CEBPB MIR455 COL27A1 KIF12 LOC105376224
GH09G114080 1 ENCODE 6.2 +18.3 18316 3.3 HNRNPUL1 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 SLC30A9 ZNF143 COL27A1 KIF12 AMBP
GH09G113657 1.1 Ensembl ENCODE 4.9 +442.0 441983 0.6 ATF1 RB1 ZSCAN4 WRNIP1 ARID4B SIN3A ZNF2 RAD21 ZNF143 FOS RGS3 ALAD RNF183 TMEM268 KIF12 LOC105376223 LOC100288542
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIF12 on UCSC Golden Path with GeneCards custom track

Promoters for KIF12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000240198 1584 601 CTCF KLF1 SUZ12 KLF17 RBBP5 ZIC2 RAD21 TEAD3 GLIS2 SMC3

Genomic Location for KIF12 Gene

Chromosome:
9
Start:
114,086,126 bp from pter
End:
114,100,084 bp from pter
Size:
13,959 bases
Orientation:
Minus strand

Genomic View for KIF12 Gene

Genes around KIF12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF12 Gene

Proteins for KIF12 Gene

  • Protein details for KIF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FN5-KIF12_HUMAN
    Recommended name:
    Kinesin-like protein KIF12
    Protein Accession:
    Q96FN5
    Secondary Accessions:
    • Q5TBE0

    Protein attributes for KIF12 Gene

    Size:
    646 amino acids
    Molecular mass:
    70660 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KIF12 Gene

Post-translational modifications for KIF12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIF12 Gene

Domains & Families for KIF12 Gene

Gene Families for KIF12 Gene

Protein Domains for KIF12 Gene

Suggested Antigen Peptide Sequences for KIF12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96FN5

UniProtKB/Swiss-Prot:

KIF12_HUMAN :
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF12: view

Function for KIF12 Gene

Gene Ontology (GO) - Molecular Function for KIF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003777 microtubule motor activity IBA --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF12: view
genes like me logo Genes that share phenotypes with KIF12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KIF12

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KIF12 Gene

Localization for KIF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF12 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIF12 gene
Compartment Confidence
extracellular 5
cytoskeleton 4
cytosol 3
mitochondrion 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KIF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KIF12: view

Pathways & Interactions for KIF12 Gene

genes like me logo Genes that share pathways with KIF12: view

Gene Ontology (GO) - Biological Process for KIF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KIF12: view

No data available for SIGNOR curated interactions for KIF12 Gene

Transcripts for KIF12 Gene

Unigene Clusters for KIF12 Gene

Kinesin family member 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF12 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^
SP1: - - - -
SP2: -
SP3: - - -
SP4: - - -
SP5: - -
SP6:
SP7: - -
SP8:

ExUns: 18 ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for KIF12 Gene

GeneLoc Exon Structure for
KIF12
ECgene alternative splicing isoforms for
KIF12

Expression for KIF12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIF12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF12 Gene

This gene is overexpressed in Kidney - Cortex (x17.1) and Pancreas (x12.8).

Protein differential expression in normal tissues from HIPED for KIF12 Gene

This gene is overexpressed in Urine (61.4) and Heart (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIF12 Gene



Protein tissue co-expression partners for KIF12 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIF12 Gene:

KIF12

SOURCE GeneReport for Unigene cluster for KIF12 Gene:

Hs.28149

mRNA Expression by UniProt/SwissProt for KIF12 Gene:

Q96FN5-KIF12_HUMAN
Tissue specificity: Expressed in fetal liver, adult brain and pancreatic islet as well as in kidney tumors, uterus cancer and pancreatic cancer.

Evidence on tissue expression from TISSUES for KIF12 Gene

  • Liver(4.4)
  • Eye(4)
  • Kidney(2.7)
genes like me logo Genes that share expression patterns with KIF12: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KIF12 Gene

Orthologs for KIF12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF12 34 35
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia KIF12 34 35
  • 88.15 (n)
cow
(Bos Taurus)
Mammalia KIF12 34 35
  • 86.48 (n)
mouse
(Mus musculus)
Mammalia Kif12 34 16 35
  • 81.88 (n)
rat
(Rattus norvegicus)
Mammalia Kif12 34
  • 81.16 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KIF12 35
  • 43 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF12 35
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF12 35
  • 29 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Klp54D 34 35
  • 53.52 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011874 34
  • 52.69 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIP2 35
  • 15 (a)
OneToOne
Species where no ortholog for KIF12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KIF12 Gene

ENSEMBL:
Gene Tree for KIF12 (if available)
TreeFam:
Gene Tree for KIF12 (if available)

Paralogs for KIF12 Gene

Paralogs for KIF12 Gene

(8) SIMAP similar genes for KIF12 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KIF12: view

Variants for KIF12 Gene

Sequence variations from dbSNP and Humsavar for KIF12 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs193920925 Uncertain significance 114,092,455(-) CTGGC(A/C)CAGGA intron-variant, downstream-variant-500B
rs1000414319 -- 114,095,642(+) CCACA(A/G)AGGAA intron-variant
rs1000615225 -- 114,100,907(+) AGAGG(-/A)AAAAA upstream-variant-2KB
rs1000765221 -- 114,100,276(+) GGGAA(C/G)CAGGA upstream-variant-2KB
rs1001133802 -- 114,101,144(+) TTAGT(C/G)AGATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KIF12 Gene

Variant ID Type Subtype PubMed ID
dgv12855n54 CNV gain 21841781
dgv33e196 CNV duplication 17116639
dgv945n27 CNV gain 19166990
esv2761285 CNV gain 21179565
esv3621549 CNV gain 21293372
nsv1122242 CNV deletion 24896259
nsv471319 CNV gain 18288195
nsv515856 CNV gain+loss 19592680
nsv528822 CNV gain 19592680

Variation tolerance for KIF12 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.05; 75.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF12 Gene

Human Gene Mutation Database (HGMD)
KIF12
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIF12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF12 Gene

Disorders for KIF12 Gene

Relevant External Links for KIF12

Human Genome Epidemiology (HuGE) Navigator
KIF12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF12

No disorders were found for KIF12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF12 Gene

Publications for KIF12 Gene

  1. Characterization of KIF12 gene in silico. (PMID: 15643526) Katoh M. … Katoh M. (Oncol. Rep. 2005) 3 4 22 64
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for KIF12 Gene

Sources for KIF12 Gene

Content
Loading form....