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Aliases for KIF12 Gene

Aliases for KIF12 Gene

  • Kinesin Family Member 12 2 3 5

External Ids for KIF12 Gene

Previous GeneCards Identifiers for KIF12 Gene

  • GC09M110307
  • GC09M112229
  • GC09M113933
  • GC09M115893
  • GC09M116848
  • GC09M086460

Summaries for KIF12 Gene

Entrez Gene Summary for KIF12 Gene

  • KIF12 is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that play important roles in intracellular transport and cell division (Nakagawa et al., 1997 [PubMed 9275178]).[supplied by OMIM, Mar 2008]

GeneCards Summary for KIF12 Gene

KIF12 (Kinesin Family Member 12) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Platelet activation, signaling and aggregation. GO annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF6.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF12 Gene

Genomics for KIF12 Gene

Regulatory Elements for KIF12 Gene

Enhancers for KIF12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KIF12 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIF12 Gene

Chromosome:
9
Start:
114,086,126 bp from pter
End:
114,100,084 bp from pter
Size:
13,959 bases
Orientation:
Minus strand

Genomic View for KIF12 Gene

Genes around KIF12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF12 Gene

Proteins for KIF12 Gene

  • Protein details for KIF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FN5-KIF12_HUMAN
    Recommended name:
    Kinesin-like protein KIF12
    Protein Accession:
    Q96FN5
    Secondary Accessions:
    • Q5TBE0

    Protein attributes for KIF12 Gene

    Size:
    646 amino acids
    Molecular mass:
    70660 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KIF12 Gene

Proteomics data for KIF12 Gene at MOPED

Post-translational modifications for KIF12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIF12 Gene

Domains & Families for KIF12 Gene

Gene Families for KIF12 Gene

Protein Domains for KIF12 Gene

Suggested Antigen Peptide Sequences for KIF12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96FN5

UniProtKB/Swiss-Prot:

KIF12_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF12: view

Function for KIF12 Gene

Gene Ontology (GO) - Molecular Function for KIF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with KIF12: view
genes like me logo Genes that share phenotypes with KIF12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KIF12

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KIF12 Gene

Localization for KIF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF12 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF12 Gene COMPARTMENTS Subcellular localization image for KIF12 gene
Compartment Confidence
extracellular 5
cytoskeleton 4
cytosol 3
mitochondrion 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KIF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with KIF12: view

Pathways & Interactions for KIF12 Gene

genes like me logo Genes that share pathways with KIF12: view

Interacting Proteins for KIF12 Gene

Gene Ontology (GO) - Biological Process for KIF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with KIF12: view

No data available for SIGNOR curated interactions for KIF12 Gene

Drugs & Compounds for KIF12 Gene

No Compound Related Data Available

Transcripts for KIF12 Gene

Unigene Clusters for KIF12 Gene

Kinesin family member 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIF12 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^
SP1: - - - -
SP2: -
SP3: - - -
SP4: - - -
SP5: - -
SP6:
SP7: - -
SP8:

ExUns: 18 ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for KIF12 Gene

GeneLoc Exon Structure for
KIF12
ECgene alternative splicing isoforms for
KIF12

Expression for KIF12 Gene

mRNA expression in normal human tissues for KIF12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF12 Gene

This gene is overexpressed in Kidney - Cortex (x17.1) and Pancreas (x12.8).

Protein differential expression in normal tissues from HIPED for KIF12 Gene

This gene is overexpressed in Urine (61.4) and Heart (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIF12 Gene



SOURCE GeneReport for Unigene cluster for KIF12 Gene Hs.28149

mRNA Expression by UniProt/SwissProt for KIF12 Gene

Q96FN5-KIF12_HUMAN
Tissue specificity: Expressed in fetal liver, adult brain and pancreatic islet as well as in kidney tumors, uterus cancer and pancreatic cancer.
genes like me logo Genes that share expression patterns with KIF12: view

Protein tissue co-expression partners for KIF12 Gene

Primer Products

Orthologs for KIF12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIF12 35
  • 86.48 (n)
  • 82.87 (a)
KIF12 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF12 35
  • 88.15 (n)
  • 85.66 (a)
KIF12 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif12 35
  • 81.88 (n)
  • 79.64 (a)
Kif12 16
Kif12 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIF12 35
  • 99.68 (n)
  • 99.42 (a)
KIF12 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif12 35
  • 81.16 (n)
  • 77.87 (a)
oppossum
(Monodelphis domestica)
Mammalia KIF12 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF12 36
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIF12 36
  • 29 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011874 35
  • 52.69 (n)
  • 42.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta Klp54D 35
  • 53.52 (n)
  • 45.43 (a)
Klp54D 36
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIP2 36
  • 15 (a)
OneToOne
Species with no ortholog for KIF12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KIF12 Gene

ENSEMBL:
Gene Tree for KIF12 (if available)
TreeFam:
Gene Tree for KIF12 (if available)

Paralogs for KIF12 Gene

Paralogs for KIF12 Gene

(8) SIMAP similar genes for KIF12 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KIF12: view

Variants for KIF12 Gene

Sequence variations from dbSNP and Humsavar for KIF12 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs7853169 -- 114,094,885(+) CATGA(C/T)ACCGA intron-variant
rs7854030 -- 114,091,517(+) GATGG(A/G)AGCTT downstream-variant-500B
rs1465657 -- 114,101,068(+) ATGAA(C/G)AAGGT upstream-variant-2KB
rs1465658 -- 114,101,077(+) GTGCT(C/G)CTTTA upstream-variant-2KB
rs1465659 -- 114,101,080(+) CTCCT(C/T)TAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KIF12 Gene

Variant ID Type Subtype PubMed ID
nsv893750 CNV Loss 21882294
dgv33e196 CNV Duplication 17116639
dgv945n27 CNV Gain 19166990
nsv471319 CNV Gain 18288195
nsv528822 CNV Gain 19592680
nsv893751 CNV Loss 21882294
nsv515856 CNV Gain+Loss 19592680

Variation tolerance for KIF12 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.05; 75.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KIF12 Gene

Disorders for KIF12 Gene

Relevant External Links for KIF12

Human Genome Epidemiology (HuGE) Navigator
KIF12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF12

No disorders were found for KIF12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIF12 Gene

Publications for KIF12 Gene

  1. Characterization of KIF12 gene in silico. (PMID: 15643526) Katoh M. … Katoh M. (Oncol. Rep. 2005) 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genome-wide association study of Tourette's syndrome. (PMID: 22889924) Scharf J.M. … Pauls D.L. (Mol. Psychiatry 2013) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3

Products for KIF12 Gene

Sources for KIF12 Gene

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