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Aliases for KIF12 Gene

Aliases for KIF12 Gene

  • Kinesin Family Member 12 2 3

External Ids for KIF12 Gene

Previous GeneCards Identifiers for KIF12 Gene

  • GC09M110307
  • GC09M112229
  • GC09M113933
  • GC09M115893
  • GC09M116848
  • GC09M086460

Summaries for KIF12 Gene

Entrez Gene Summary for KIF12 Gene

  • KIF12 is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that play important roles in intracellular transport and cell division (Nakagawa et al., 1997 [PubMed 9275178]).[supplied by OMIM, Mar 2008]

GeneCards Summary for KIF12 Gene

KIF12 (Kinesin Family Member 12) is a Protein Coding gene. GO annotations related to this gene include microtubule binding and microtubule motor activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF12 Gene

Genomics for KIF12 Gene

Regulatory Elements for KIF12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIF12 Gene

Start:
114,086,126 bp from pter
End:
114,099,320 bp from pter
Size:
13,195 bases
Orientation:
Minus strand

Genomic View for KIF12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF12 Gene

Proteins for KIF12 Gene

  • Protein details for KIF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FN5-KIF12_HUMAN
    Recommended name:
    Kinesin-like protein KIF12
    Protein Accession:
    Q96FN5
    Secondary Accessions:
    • Q5TBE0

    Protein attributes for KIF12 Gene

    Size:
    646 amino acids
    Molecular mass:
    70660 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KIF12 Gene

Proteomics data for KIF12 Gene at MOPED

Post-translational modifications for KIF12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIF12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIF12 Gene

Domains for KIF12 Gene

Gene Families for KIF12 Gene

HGNC:
  • KIF :Kinesins

Protein Domains for KIF12 Gene

Suggested Antigen Peptide Sequences for KIF12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96FN5

UniProtKB/Swiss-Prot:

KIF12_HUMAN :
  • Q96FN5
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
genes like me logo Genes that share domains with KIF12: view

Function for KIF12 Gene

Gene Ontology (GO) - Molecular Function for KIF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003777 microtubule motor activity IBA --
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF12: view

Phenotypes for KIF12 Gene

GenomeRNAi human phenotypes for KIF12:
genes like me logo Genes that share phenotypes with KIF12: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KIF12 Gene

Localization for KIF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF12 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF12 Gene COMPARTMENTS Subcellular localization image for KIF12 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
mitochondrion 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KIF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005871 kinesin complex IBA --
GO:0005874 microtubule IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with KIF12: view

Pathways for KIF12 Gene

SuperPathways for KIF12 Gene

No Data Available

Interacting Proteins for KIF12 Gene

Gene Ontology (GO) - Biological Process for KIF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0007018 microtubule-based movement IBA --
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with KIF12: view

No data available for Pathways by source for KIF12 Gene

Transcripts for KIF12 Gene

Unigene Clusters for KIF12 Gene

Kinesin family member 12:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF12

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF12 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^
SP1: - - - -
SP2: -
SP3: - - -
SP4: - - -
SP5: - -
SP6:
SP7: - -
SP8:

ExUns: 18 ^ 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for KIF12 Gene

GeneLoc Exon Structure for
KIF12
ECgene alternative splicing isoforms for
KIF12

Expression for KIF12 Gene

mRNA expression in normal human tissues for KIF12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF12 Gene

This gene is overexpressed in Kidney - Cortex (17.1) and Pancreas (12.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KIF12 Gene

SOURCE GeneReport for Unigene cluster for KIF12 Gene Hs.28149

mRNA Expression by UniProt/SwissProt for KIF12 Gene

Q96FN5-KIF12_HUMAN
Tissue specificity: Expressed in fetal liver, adult brain and pancreatic islet as well as in kidney tumors, uterus cancer and pancreatic cancer.
genes like me logo Genes that share expressions with KIF12: view

In Situ Assay Products

Orthologs for KIF12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIF12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF12 35
  • 99.68 (n)
  • 99.42 (a)
KIF12 36
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIF12 35
  • 86.48 (n)
  • 82.87 (a)
KIF12 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF12 35
  • 88.15 (n)
  • 85.66 (a)
KIF12 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif12 35
  • 81.88 (n)
  • 79.64 (a)
Kif12 16
Kif12 36
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF12 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF12 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif12 35
  • 81.16 (n)
  • 77.87 (a)
chicken
(Gallus gallus)
Aves KIF12 36
  • 29 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011874 35
  • 52.69 (n)
  • 42.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta Klp54D 35
  • 53.52 (n)
  • 45.43 (a)
Klp54D 36
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIP2 36
  • 15 (a)
OneToOne
Species with no ortholog for KIF12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KIF12 Gene

ENSEMBL:
Gene Tree for KIF12 (if available)
TreeFam:
Gene Tree for KIF12 (if available)

Paralogs for KIF12 Gene

Selected SIMAP similar genes for KIF12 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KIF12: view

No data available for Paralogs for KIF12 Gene

Variants for KIF12 Gene

Sequence variations from dbSNP and Humsavar for KIF12 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1465657 -- 114,101,068(+) ATGAA(C/G)AAGGT upstream-variant-2KB
rs1465658 -- 114,101,077(+) GTGCT(C/G)CTTTA upstream-variant-2KB
rs1465659 -- 114,101,080(+) CTCCT(C/T)TAAAA upstream-variant-2KB
rs1465660 -- 114,094,609(+) CTGGA(A/G)GGGGC intron-variant
rs1560539 -- 114,099,803(+) GCTGA(C/G)CTGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KIF12 Gene

Variant ID Type Subtype PubMed ID
nsv893750 CNV Loss 21882294
dgv33e196 CNV Duplication 17116639
dgv945n27 CNV Gain 19166990
nsv471319 CNV Gain 18288195
nsv528822 CNV Gain 19592680
nsv893751 CNV Loss 21882294
nsv515856 CNV Gain+Loss 19592680

Relevant External Links for KIF12 Gene

HapMap Linkage Disequilibrium report
KIF12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF12 Gene

Disorders for KIF12 Gene

Relevant External Links for KIF12

Human Genome Epidemiology (HuGE) Navigator
KIF12
genes like me logo Genes that share disorders with KIF12: view

No data available for UniProtKB/Swiss-Prot for KIF12 Gene

Publications for KIF12 Gene

  1. Characterization of KIF12 gene in silico. (PMID: 15643526) Katoh M. … Katoh M. (Oncol. Rep. 2005) 3 4 23
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3

Products for KIF12 Gene

Sources for KIF12 Gene

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