Aliases for KIF11 Gene
External Ids for KIF11 Gene
Previous HGNC Symbols for KIF11 Gene
Previous GeneCards Identifiers for KIF11 Gene
This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for KIF11 Gene
KIF11 (Kinesin Family Member 11) is a Protein Coding gene. Diseases associated with KIF11 include microcephaly with or without chorioretinopathy, lymphedema, or mental retardation and autosomal dominant microcephaly. Among its related pathways are Class I MHC mediated antigen processing and presentation and Hemostasis. GO annotations related to this gene include protein kinase binding and microtubule motor activity. An important paralog of this gene is KIF5C.
UniProtKB/Swiss-Prot for KIF11 Gene
Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.
Kinesin superfamily proteins (KIFs) are motor proteins that convert chemical energy, typically in the form of ATP, into mechanical force. They act upon microtubules to move vesicles and organelles within cells, cause the beating of flagella and cilia, and act within the mitotic and meiotic spindles to segregate replicated chromosomes to progeny cells. Generally, kinesins mediate plus-end transport. Kinesins exist as dimers, with a catalytic head domain and a stalk/tail domain that is important in interactions with the cargo molecules. The neck attaches the stalk to the head and is essential in determining direction of motility and regulation of activity. The head and neck (known collectively as the motor domain) are conserved across the family, whilst the stalk is highly divergent, reflecting the wide range of cellular functions of kinesins. Some specific kinesins have been implicated in human diseases, including Alzheimer's (KIF5), polycystic kidney disease (KIF3A / KIF3B) and diabetes (KIF5B).