Aliases for KIF11 Gene
External Ids for KIF11 Gene
Previous HGNC Symbols for KIF11 Gene
Previous GeneCards Identifiers for KIF11 Gene
This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for KIF11 Gene
KIF11 (Kinesin Family Member 11) is a Protein Coding gene. Diseases associated with KIF11 include microcephaly with or without chorioretinopathy, lymphedema, or mental retardation and congenital lymphedema. Among its related pathways are Immune System and Hemostasis. GO annotations related to this gene include protein kinase binding and protein complex binding. An important paralog of this gene is KIF5C.
UniProtKB/Swiss-Prot for KIF11 Gene
Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.
Kinesin superfamily proteins (KIFs) are motor proteins that convert chemical energy into mechanical force, typically by hydrolysis of ATP. They act upon microtubules to move vesicles and organelles from the cell centre to the periphery and cause the beating of flagella and cilia.