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KIF11 Gene

protein-coding   GIFtS: 68
GCID: GC10P094352

Kinesin Family Member 11

(Previous name: kinesin-like 1)
(Previous symbol: KNSL1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kinesin Family Member 111 2     TRIP-52 3
KNSL11 2 3 5     TRIP52 3
Kinesin-Like Protein 12 3     TR-Interacting Protein 52 3
Kinesin-Like Spindle Protein HKSP2 3     MCLMR2 5
Kinesin-Related Motor Protein Eg52 3     Kinesin-Like 11
Thyroid Receptor-Interacting Protein 52 3     HKSP2
EG52 3     Kinesin-Like Protein KIF112

External Ids:    HGNC: 63881   Entrez Gene: 38322   Ensembl: ENSG000001381607   OMIM: 1487605   UniProtKB: P527323   

Export aliases for KIF11 gene to outside databases

Previous GC identifers: GC10P093574 GC10P094484 GC10P094017 GC10P094342 GC10P087978


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KIF11 Gene:
This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family
are known to be involved in various kinds of spindle dynamics. The function of this gene product includes
chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. (provided
by RefSeq, Jul 2008)

GeneCards Summary for KIF11 Gene:
KIF11 (kinesin family member 11) is a protein-coding gene. Diseases associated with KIF11 include microcephaly with or without chorioretinopathy, lymphedema, or mental retardation, and autosomal dominant microcephaly. GO annotations related to this gene include microtubule motor activity and protein kinase binding. An important paralog of this gene is KIF4A.

UniProtKB/Swiss-Prot: KIF11_HUMAN, P52732
Function: Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome
migration and arrest cells in mitosis with monoastral microtubule arrays

summary for KIF11 Gene:
Kinesin superfamily proteins (KIFs) are motor proteins that convert chemical energy, typically in the form
of ATP, into mechanical force. They act upon microtubules to move vesicles and organelles within cells,
cause the beating of flagella and cilia, and act within the mitotic and meiotic spindles to segregate
replicated chromosomes to progeny cells. Generally, kinesins mediate plus-end transport. Kinesins exist as
dimers, with a catalytic head domain and a stalk/tail domain that is important in interactions with the
cargo molecules. The neck attaches the stalk to the head and is essential in determining direction of
motility and regulation of activity. The head and neck (known collectively as the motor domain) are
conserved across the family, whilst the stalk is highly divergent, reflecting the wide range of cellular
functions of kinesins. Some specific kinesins have been implicated in human diseases, including Alzheimer's
(KIF5), polycystic kidney disease (KIF3A / KIF3B) and diabetes (KIF5B).

Gene Wiki entry for KIF11 (Kinesin family member 11) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIF11 gene promoter:
         E2F-4   E2F-3a   E2F-5   NF-YC   E2F-2   CBF-B   E2F   E2F-1   CBF-A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIF11 promoter sequence
   Search Chromatin IP Primers for KIF11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIF11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.1   Ensembl cytogenetic band:  10q23.33   HGNC cytogenetic band: 10q24.1

KIF11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF11 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P094352:  view genomic region     (about GC identifiers)

Start:
94,352,825 bp from pter      End:
94,415,152 bp from pter
Size:
62,328 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KIF11_HUMAN, P52732 (See protein sequence)
Recommended Name: Kinesin-like protein KIF11  
Size: 1056 amino acids; 119159 Da
Subunit: Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Component of a large
chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Interacts (via C-terminus)
with the kinase NEK6 in both interphase and mitosis
Selected PDB 3D structures from and Proteopedia for KIF11 (see all 41):
1II6 (3D)        1Q0B (3D)        1X88 (3D)        1YRS (3D)        2FKY (3D)        2FL2 (3D)    
Secondary accessions: A0AV49 B2RMV3 Q15716 Q5VWX0

Explore the universe of human proteins at neXtProt for KIF11: NX_P52732

Explore proteomics data for KIF11 at MOPED

Post-translational modifications: 

  • Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling
    the association of KIF11 with the spindle apparatus (probably during early prophase)1
  • A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis;
    phosphorylation is required for mitotic function1
  • Ubiquitination2 at Lys1034
  • Modification sites at PhosphoSitePlus

  • See KIF11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004514.2  
    ENSEMBL proteins: 
     ENSP00000260731  
    Reactome Protein details: P52732

    KIF11 Human Recombinant Protein Products:

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    KIF11 Assay Products:

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    Cloud-Clone Corp. CLIAs for KIF11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KIF: Kinesins

    5 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR001752 Kinesin_motor_dom
     IPR019821 Kinesin_motor_CS
     IPR025901 Kinesin-assoc_MT-bd_dom
     IPR027640 Kinesin-like_fam

    Graphical View of Domain Structure for InterPro Entry P52732

    ProtoNet protein and cluster: P52732

    1 Blocks protein domain: IPB001752 Kinesin

    UniProtKB/Swiss-Prot: KIF11_HUMAN, P52732
    Similarity: Belongs to the kinesin-like protein family. BimC subfamily
    Similarity: Contains 1 kinesin-motor domain


    KIF11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KIF11_HUMAN, P52732
    Function: Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome
    migration and arrest cells in mitosis with monoastral microtubule arrays

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity IEA--
    GO:0005524ATP binding IEA--
    GO:0008017microtubule binding IEA--
    GO:0019901protein kinase binding IPI19001501
    GO:0032403protein complex binding IDA17707232
         
    KIF11 for ontologies           About GeneDecksing


    Phenotypes:
         12 GenomeRNAi human phenotypes for KIF11:
     Cell cycle / mitosis defect  Cell division defect  Decreased cell number, increas  Decreased influenza A H1N1 (A/ 
     Decreased influenza A/WSN/33 r  Decreased viability of wild-ty  Increased Salmonella enterica   Increased cell number in G2M,  
     Increased gamma-H2AX phosphory  Increased number of cells in m  Increased number of mitotic ce  Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Kif11):
     embryogenesis  growth/size/body  mortality/aging  reproductive system 

    KIF11 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIF11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KIF11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KIF11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KIF11

    miRNA
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    miRTarBase miRNAs that target KIF11:
    hsa-mir-34a-5p (MIRT025295), hsa-mir-30a-5p (MIRT028535), hsa-mir-186-5p (MIRT021126), hsa-mir-340-5p (MIRT019584), hsa-mir-193b-3p (MIRT016382)

    Block miRNA regulation of human, mouse, rat KIF11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KIF11 (see all 22):
    hsa-miR-3678-3p hsa-miR-579 hsa-miR-148b* hsa-miR-562 hsa-miR-539 hsa-miR-300 hsa-miR-520a-5p hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidKIF11 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KIF11

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: KIF11 (NM_004523)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF11

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KIF11_HUMAN, P52732: Cytoplasm. Cytoplasm, cytoskeleton, spindle pole
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922colocalizes with spindle pole IDA14718566
    GO:0005737cytoplasm IDA--
    GO:0005819spindle IDA19001501
    GO:0005829cytosol TAS--
    GO:0005871kinesin complex IEA--

    KIF11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KIF11 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    3Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    4Mitotic Roles of Polo Like Kinases
    Mitotic Roles of Polo Like Kinases
    5MHC class II antigen presentation
    MHC class II antigen presentation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for KIF11
        Mitotic Roles of Polo Like Kinases

    1 Cell Signaling Technology (CST) Pathway for KIF11
        Cell Cycle / Checkpoint Control

    1 GeneGo (Thomson Reuters) Pathway for KIF11
        Cell cycle Spindle assembly and chromosome separation

    2 Reactome Pathways for KIF11
        MHC class II antigen presentation
    Kinesins



    KIF11 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIF11
    Interactions:

        GeneGlobe Interaction Network for KIF11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KIF11 (P527322, 3 ENSP000002607314) via UniProtKB, MINT, STRING, and/or I2D (see all 957)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCOR1O753762, 3, ENSP000002687124MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000268712
    DNAJA1P316892, 3MINT-7945693 MINT-7947479 I2D: score=2 
    EEF1A1P681042, 3MINT-7945693 MINT-7947479 I2D: score=1 
    HSP90AA1P079002, 3MINT-7945693 MINT-7947479 I2D: score=1 
    TUBB3Q135092, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007018microtubule-based movement TAS--
    GO:0007051spindle organization IMP14718566
    GO:0007052mitotic spindle organization TAS8548803
    GO:0007067mitosis TAS8548803
    GO:0007100mitotic centrosome separation IEA--

    KIF11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for KIF11
      Browse compounds at ApexBio 

    Compounds for KIF11 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PaprotrainReversible inhibitor of MKLP-2[57046-73-8]
    K 858Selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor[72926-24-0]
    ARRY 520 trifluoroacetatePotent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation[885060-09-3]
    MonastrolSelective inhibitor of mitotic kinesin Eg5[254753-54-3]

    Selected DrugBank Compounds for KIF11 (see all 12)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3-[(5s)-1-Acetyl-3-(2-Chlorophenyl)-4,5-Dihydro-1h-Pyrazol-5-Yl]Phenol-- --target--17139284 17016423 10592235
    Monastrol-- --target--17139284 17016423 10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423
    (1S)-1-CYCLOPROPYL-2-[(2S)-4-(2,5-DIFLUOROPHENYL)-2-PHENYL-2,5-DIHYDRO-1H-PYRROL-1-YL]-2-OXOETHANAMINE-- --target--10592235
    (2S)-4-(2,5-DIFLUOROPHENYL)-N,N-DIMETHYL-2-PHENYL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE-- --target--10592235
    (2S)-4-(2,5-DIFLUOROPHENYL)-N-METHYL-2-PHENYL-N-PIPERIDIN-4-YL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE-- --target--10592235
    (2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide-- --target--10592235
    (4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE-- --target--10592235
    (5R)-N,N-DIETHYL-5-METHYL-2-[(THIOPHEN-2-YLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE-- --target--10592235
    (5S)-5-(3-AMINOPROPYL)-3-(2,5-DIFLUOROPHENYL)-N-ETHYL-5-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE-- --target--10592235

    5 Novoseek inferred chemical compound relationships for KIF11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    monastrol 96.6 28 19896928 (5), 12323373 (4), 17251189 (4), 10973989 (3) (see all 11)
    s-trityl-l-cysteine 93.4 6 15476401 (2), 17581299 (1), 18186019 (1)
    atp 44.1 13 18678707 (2), 20154092 (2), 10430903 (1), 12323373 (1) (see all 6)
    adp 41 4 12323373 (1), 19497292 (1), 18037705 (1)
    paclitaxel 10.4 4 15653676 (3)



    KIF11 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KIF11 gene: 
    NM_004523.3  

    Unigene Cluster for KIF11:

    Kinesin family member 11
    Hs.8878  [show with all ESTs]
    Unigene Representative Sequence: NM_004523
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000260731(uc001kic.3)

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    Selected qRT-PCR Assays for microRNAs that regulate KIF11 (see all 22):
    hsa-miR-3678-3p hsa-miR-579 hsa-miR-148b* hsa-miR-562 hsa-miR-539 hsa-miR-300 hsa-miR-520a-5p hsa-miR-374c
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    GenScript: all cDNA clones in your preferred vector: KIF11 (NM_004523)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat KIF11
      QuantiFast Probe-based Assays in human, mouse, rat KIF11

    Additional mRNA sequence: 

    AB208964.1 AK314258.1 BC050421.1 BC050667.1 BC126211.1 BC136474.1 L40372.1 U37426.1 
    X85137.1 

    5 DOTS entries:

    DT.95265500  DT.100021024  DT.121290511  DT.425083  DT.100775537 

    Selected AceView cDNA sequences (see all 109):

    BC050667 BU163995 CB116460 AA307194 AI086253 AW576532 AA504625 BM742618 
    AI281057 AI346635 AA447117 AA401791 AI476546 CF147477 L40372 BM800579 
    BQ959682 AA676413 BX482200 BU170096 AI559454 AU128399 BG118803 BF984650 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KIF11 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                        -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
    SP1:                                          
    SP2:                                          
    SP3:  -     -     -     -     -     -         
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for KIF11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIF11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTAATAAAT
    KIF11 Expression
    About this image


    KIF11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Cerebellum
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Presumptive Podocytes Podocyte Layer
             Metanephros
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
             Lens
    KIF11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIF11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.8878
        Custom PCR Arrays for KIF11
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KIF11
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KIF11 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kif111 , 5 kinesin family member 111, 5 83.24(n)1
    80.04(a)1
      19 (32.27 cM)5
    165511  NM_010615.11  NP_034745.11 
     373764035 
    chicken
    (Gallus gallus)
    Aves KIF111 kinesin family member 11 66.54(n)
    61.38(a)
      423809  NM_001031230.1  NP_001026401.1 
    lizard
    (Anolis carolinensis)
    Reptilia KIF116
    kinesin family member 11
    56(a)
    1 ↔ 1
    GL343219.1(2533223-2565024)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC525882 similar to kinesin-like 1 73.72(n)    BC042218.1 
    zebrafish
    (Danio rerio)
    Actinopterygii kif112 kinesin family member 11 77.58(n)   195818  BC048061.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Klp61F1 Kinesin-like protein at 61F 47.86(n)
    39.91(a)
      38135  NM_057470.5  NP_476818.1 
    worm
    (Caenorhabditis elegans)
    Secernentea bmk-16
    Protein BMK-1, isoform a (bmk-1) mRNA, complete cd...
    34(a)
    1 ↔ 1
    V(14453303-14456916) WBGene00000257
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIP1(YBL063W)4 Kinesin-related motor protein required for mitotic more   --   2(101886-105221) 852216  NP_009490.1 
    rice
    (Oryza sativa)
    Liliopsida Os.87462 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.98(n)    AK068757.1 


    ENSEMBL Gene Tree for KIF11 (if available)
    TreeFam Gene Tree for KIF11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIF11 gene
    KIF4A2  KIF3A2  KIF5B2  KIF5C2  KIF21A2  KIF3B2  KIF21B2  KIF172  
    KIF152  CENPE2  KIF5A2  KIF72  KIF4B2  KIF272  KIF3C2  

    KIF11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIF11 (see all 1504)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0678324
    Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR)4--see VAR_0678322 R C mis40--------
    VAR_0678304
    Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR)4--see VAR_0678302 R C mis40--------
    VAR_0678314
    Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR)4--see VAR_0678312 S C mis40--------
    VAR_0678294
    Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR)4--see VAR_0678292 F L mis40--------
    rs1430330531,2
    Cuntested194761227(+) TGGAAA/TTGATT 2 M L mis10--------
    rs1406080571,2
    C--87987568(+) TATTT-/GTTA  
            
    GTTTG
    1 -- int10--------
    rs679686131,2
    --87987571(+) TTGTTA/TGTTTG 1 -- int10--------
    rs1496811881,2
    C--88004231(+) TGATG-/TTTTTTT 1 -- int11Minor allele frequency- TT:0.00CSA 2
    rs1130921211,2
    C--88010709(+) GTATT-/CTC   
      T
    /TCTC
    TTCTG
    1 -- int11CSA 2
    rs1478100861,2
    C--88017612(+) TGTAC-/TTTTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for KIF11 (94352825 - 94415152 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KIF11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv895894CNV Loss21882294
    nsv895895CNV Gain21882294
    dgv168n67CNV Gain20364138

    Human Gene Mutation Database (HGMD): KIF11
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIF11
    DNA2.0 Custom Variant and Variant Library Synthesis for KIF11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 148760   
    OMIM disorders: 152950  
    UniProtKB/Swiss-Prot: KIF11_HUMAN, P52732
  • Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:152950]:
    An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and
    ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to
    moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose
    with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the
    most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have
    also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is
    typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope
    uptake from the webspaces between the toes. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • Selected diseases for KIF11 (see all 26):    
    About MalaCards
    microcephaly with or without chorioretinopathy, lymphedema, or mental retardation    autosomal dominant microcephaly    xeroderma pigmentosum, group f    polycystic kidney disease
    lymphedema    gangliosidosis    kidney disease    microcephaly
    astigmatism    xeroderma pigmentosum    thyroiditis    microphthalmia
    mental retardation    multiple myeloma    myeloma    choroiditis
    obesity    alzheimer's disease    retinitis    renal cell carcinoma

    2 diseases from the University of Copenhagen DISEASES database for KIF11:
    Autosomal dominant microcephaly     Gangliosidosis

    KIF11 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for KIF11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 8 16489005 (2), 19896928 (1), 18186019 (1)
    cancer 0 3 19497292 (1), 16780877 (1)

    Genetic Association Database (GAD): KIF11
    Human Genome Epidemiology (HuGE) Navigator: KIF11 (9 documents)

    Export disorders for KIF11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIF11 gene, integrated from 10 sources (see all 158):
    (articles sorted by number of sources associating them with KIF11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. (PubMed id 8548803)1, 2, 3, 9 Blangy A.... Nigg E.A. (Cell 1995)
    2. The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. (PubMed id 19001501)1, 2, 9 Rapley J.... Roig J. (J. Cell Sci. 2008)
    3. Mutation screening of a haplotype block around the insulin degrading enzyme gene and association with Alzheimer's disease. (PubMed id 15858821)1, 4, 9 Feuk L....Brookes A.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005)
    4. Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy. (PubMed id 22284827)1, 2 Ostergaard P.... Jeffery S. (Am. J. Hum. Genet. 2012)
    5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    6. PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population. (PubMed id 19862325)1, 4 Hu C....Jia W. (PLoS ONE 2009)
    7. Polymorphisms in the IDE-KIF11-HHEX gene locus are reproducibly associated with type 2 diabetes in a Japanese population. (PubMed id 17971426)1, 4 Furukawa Y....Nanjo K. (J. Clin. Endocrinol. Metab. 2008)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)1, 2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies. (PubMed id 17827400)1, 4 Grarup N....Pedersen O. (Diabetes 2007)
    10. A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation. (PubMed id 17707232)1, 2 Zhu P.... Rosenfeld M.G. (Mol. Cell 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3832 HGNC: 6388 AceView: KIF11 Ensembl:ENSG00000138160 euGenes: HUgn3832
    ECgene: KIF11 H-InvDB: KIF11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KIF11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIF11 gene:
    Search GeneIP for patents involving KIF11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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