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Aliases for KIF11 Gene

Aliases for KIF11 Gene

  • Kinesin Family Member 11 2 3
  • KNSL1 3 4 6
  • Thyroid Receptor-Interacting Protein 5 3 4
  • Kinesin-Like Spindle Protein HKSP 3 4
  • Kinesin-Related Motor Protein Eg5 3 4
  • TR-Interacting Protein 5 3 4
  • Kinesin-Like Protein 1 3 4
  • TRIP-5 3 4
  • MCLMR 3 6
  • TRIP5 3 4
  • EG5 3 4
  • Kinesin-Like Protein KIF11 3
  • Kinesin-Like 1 2
  • HKSP 3

External Ids for KIF11 Gene

Previous HGNC Symbols for KIF11 Gene

  • KNSL1

Previous GeneCards Identifiers for KIF11 Gene

  • GC10P093574
  • GC10P094484
  • GC10P094017
  • GC10P094342
  • GC10P087978
  • GC10P094352

Summaries for KIF11 Gene

Entrez Gene Summary for KIF11 Gene

  • This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for KIF11 Gene

KIF11 (Kinesin Family Member 11) is a Protein Coding gene. Diseases associated with KIF11 include microcephaly with or without chorioretinopathy, lymphedema, or mental retardation and autosomal dominant microcephaly. Among its related pathways are Class I MHC mediated antigen processing and presentation and Hemostasis. GO annotations related to this gene include protein kinase binding and microtubule motor activity. An important paralog of this gene is KIF5C.

UniProtKB/Swiss-Prot for KIF11 Gene

  • Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.

Tocris Summary for KIF11 Gene

  • Kinesin superfamily proteins (KIFs) are motor proteins that convert chemical energy, typically in the form of ATP, into mechanical force. They act upon microtubules to move vesicles and organelles within cells, cause the beating of flagella and cilia, and act within the mitotic and meiotic spindles to segregate replicated chromosomes to progeny cells. Generally, kinesins mediate plus-end transport. Kinesins exist as dimers, with a catalytic head domain and a stalk/tail domain that is important in interactions with the cargo molecules. The neck attaches the stalk to the head and is essential in determining direction of motility and regulation of activity. The head and neck (known collectively as the motor domain) are conserved across the family, whilst the stalk is highly divergent, reflecting the wide range of cellular functions of kinesins. Some specific kinesins have been implicated in human diseases, including Alzheimer's (KIF5), polycystic kidney disease (KIF3A / KIF3B) and diabetes (KIF5B).

Gene Wiki entry for KIF11 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF11 Gene

Genomics for KIF11 Gene

Regulatory Elements for KIF11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIF11 Gene

Start:
92,593,068 bp from pter
End:
92,655,395 bp from pter
Size:
62,328 bases
Orientation:
Plus strand

Genomic View for KIF11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF11 Gene

Proteins for KIF11 Gene

  • Protein details for KIF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52732-KIF11_HUMAN
    Recommended name:
    Kinesin-like protein KIF11
    Protein Accession:
    P52732
    Secondary Accessions:
    • A0AV49
    • B2RMV3
    • Q15716
    • Q5VWX0

    Protein attributes for KIF11 Gene

    Size:
    1056 amino acids
    Molecular mass:
    119159 Da
    Quaternary structure:
    • Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Interacts (via C-terminus) with the kinase NEK6 in both interphase and mitosis.

    Three dimensional structures from OCA and Proteopedia for KIF11 Gene

neXtProt entry for KIF11 Gene

Proteomics data for KIF11 Gene at MOPED

Post-translational modifications for KIF11 Gene

  • A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis; phosphorylation is required for mitotic function
  • Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase).
  • Ubiquitination at Lys1034
  • Modification sites at PhosphoSitePlus

Other Protein References for KIF11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KIF11 (KIF11)

No data available for DME Specific Peptides for KIF11 Gene

Domains for KIF11 Gene

Gene Families for KIF11 Gene

HGNC:
  • KIF :Kinesins

Suggested Antigen Peptide Sequences for KIF11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52732

UniProtKB/Swiss-Prot:

KIF11_HUMAN :
  • P52732
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.
genes like me logo Genes that share domains with KIF11: view

Function for KIF11 Gene

Molecular function for KIF11 Gene

UniProtKB/Swiss-Prot Function: Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.

Gene Ontology (GO) - Molecular Function for KIF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity TAS 8548803
GO:0005524 ATP binding IEA --
GO:0008017 microtubule binding IEA --
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA --
GO:0016887 ATPase activity IBA --
genes like me logo Genes that share ontologies with KIF11: view
genes like me logo Genes that share phenotypes with KIF11: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIF11 Gene

Localization for KIF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF11 Gene

Cytoplasm. Cytoplasm, cytoskeleton, spindle pole.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF11 Gene COMPARTMENTS Subcellular localization image for KIF11 gene
Compartment Confidence
cytoskeleton 5
cytosol 4

Gene Ontology (GO) - Cellular Components for KIF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 colocalizes_with spindle pole IDA 14718566
GO:0005737 cytoplasm IDA --
GO:0005819 spindle IDA 19001501
GO:0005829 cytosol TAS --
GO:0005871 kinesin complex IBA --
genes like me logo Genes that share ontologies with KIF11: view

Pathways for KIF11 Gene

genes like me logo Genes that share pathways with KIF11: view

Pathways by source for KIF11 Gene

1 Qiagen pathway for KIF11 Gene
1 Cell Signaling Technology pathway for KIF11 Gene

Gene Ontology (GO) - Biological Process for KIF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0007018 microtubule-based movement TAS --
GO:0007051 spindle organization IMP 14718566
GO:0007052 mitotic spindle organization TAS 8548803
GO:0007059 chromosome segregation IBA --
genes like me logo Genes that share ontologies with KIF11: view

Compounds for KIF11 Gene

(5) Tocris Compounds for KIF11 Gene

Compound Action Cas Number
ARRY 520 trifluoroacetate Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation [885060-09-3]
K 858 Selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor [72926-24-0]
Monastrol Selective inhibitor of mitotic kinesin Eg5 [254753-54-3]
Paprotrain Reversible inhibitor of MKLP-2 [57046-73-8]
SB 743921 hydrochloride Potent kinesin spindle protein (KSP) inhibitor [940929-33-9]

(5) Novoseek inferred chemical compound relationships for KIF11 Gene

Compound -log(P) Hits PubMed IDs
monastrol 96.6 23
s-trityl-l-cysteine 93.4 4
atp 44.1 8
adp 41 3
paclitaxel 10.4 3
genes like me logo Genes that share compounds with KIF11: view

Transcripts for KIF11 Gene

mRNA/cDNA for KIF11 Gene

(109) Selected AceView cDNA sequences:
(9) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIF11 Gene

Kinesin family member 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIF11

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KIF11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF11 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^
SP1:
SP2:
SP3: - - - - - - - - - - - - - - - - -
SP4:
SP5:
SP6:
SP7: - - - - - - - - - - - - - - - - - - - - - - - -
SP8:
SP9:

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
SP1:
SP2:
SP3: - - - - - -
SP4:
SP5:
SP6:
SP7: - - -
SP8:
SP9:

Relevant External Links for KIF11 Gene

GeneLoc Exon Structure for
KIF11
ECgene alternative splicing isoforms for
KIF11

Expression for KIF11 Gene

mRNA expression in normal human tissues for KIF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIF11 Gene

This gene is overexpressed in Testis (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF11 Gene

SOURCE GeneReport for Unigene cluster for KIF11 Gene Hs.8878

genes like me logo Genes that share expressions with KIF11: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KIF11 Gene

Orthologs for KIF11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF11 35
  • 99.84 (n)
  • 99.81 (a)
KIF11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIF11 35
  • 88.72 (n)
  • 85.78 (a)
KIF11 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIF11 35
  • 90.47 (n)
  • 88.35 (a)
KIF11 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif11 35
  • 83.24 (n)
  • 80.04 (a)
Kif11 16
Kif11 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIF11 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF11 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif11 35
  • 83.16 (n)
  • 80.38 (a)
chicken
(Gallus gallus)
Aves KIF11 35
  • 66.54 (n)
  • 61.38 (a)
KIF11 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIF11 36
  • 56 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52588 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kif11 35
  • 61.82 (n)
  • 57.32 (a)
Str.3480 35
zebrafish
(Danio rerio)
Actinopterygii kif11 35
  • 56.42 (n)
  • 51.12 (a)
kif11 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Klp61F 35
  • 47.86 (n)
  • 39.91 (a)
Klp61F 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea bmk-1 36
  • 34 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIP1 36
  • 27 (a)
OneToOne
KIP1 38
corn
(Zea mays)
Liliopsida Zm.4944 35
rice
(Oryza sativa)
Liliopsida Os.8746 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToOne
Species with no ortholog for KIF11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF11 Gene

ENSEMBL:
Gene Tree for KIF11 (if available)
TreeFam:
Gene Tree for KIF11 (if available)

Paralogs for KIF11 Gene

genes like me logo Genes that share paralogs with KIF11: view

Variants for KIF11 Gene

Sequence variations from dbSNP and Humsavar for KIF11 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1044146 -- 92,654,180(+) aaaaa(C/T)aaaat utr-variant-3-prime
rs1044153 -- 92,655,321(+) ATGTC(A/C)GCATA utr-variant-3-prime
rs1547818 -- 92,637,635(-) GTATT(C/G)AGATT intron-variant
rs1573051 -- 92,627,577(-) GAAAA(A/G)CATAA intron-variant
rs1972360 -- 92,636,831(+) AGTTC(C/T)AGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIF11 Gene

Variant ID Type Subtype PubMed ID
nsv895894 CNV Loss 21882294
nsv895895 CNV Gain 21882294
dgv168n67 CNV Gain 20364138

Relevant External Links for KIF11 Gene

HapMap Linkage Disequilibrium report
KIF11
Human Gene Mutation Database (HGMD)
KIF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF11 Gene

Disorders for KIF11 Gene

(1) OMIM Diseases for KIF11 Gene (148760)

UniProtKB/Swiss-Prot

KIF11_HUMAN
  • Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:152950]: An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes. {ECO:0000269 PubMed:22284827}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for KIF11 Gene

(2) Novoseek inferred disease relationships for KIF11 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 4
cancer 0 2

Relevant External Links for KIF11

Genetic Association Database (GAD)
KIF11
Human Genome Epidemiology (HuGE) Navigator
KIF11
genes like me logo Genes that share disorders with KIF11: view

Publications for KIF11 Gene

  1. Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. (PMID: 8548803) Blangy A. … Nigg E.A. (Cell 1995) 2 3 4 23
  2. Mutation screening of a haplotype block around the insulin degrading enzyme gene and association with Alzheimer's disease. (PMID: 15858821) Feuk L. … Brookes A.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005) 3 23 48
  3. The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. (PMID: 19001501) Rapley J. … Roig J. (J. Cell Sci. 2008) 3 4 23
  4. Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-L-cysteine in tumor derived cell lines. (PMID: 19896928) Tcherniuk S. … Skoufias D.A. (Biochem. Pharmacol. 2010) 3 23
  5. Antimitotic effect of the retinoid 4-oxo-fenretinide through inhibition of tubulin polymerization: a novel mechanism of retinoid growth-inhibitory activity. (PMID: 19996280) Appierto V. … Formelli F. (Mol. Cancer Ther. 2009) 3 23

Products for KIF11 Gene

Sources for KIF11 Gene

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