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Aliases for KIF11 Gene

Aliases for KIF11 Gene

  • Kinesin Family Member 11 2 3 5
  • Thyroid Receptor-Interacting Protein 5 3 4
  • Kinesin-Like Spindle Protein HKSP 3 4
  • Kinesin-Related Motor Protein Eg5 3 4
  • TR-Interacting Protein 5 3 4
  • Kinesin-Like Protein 1 3 4
  • TRIP-5 3 4
  • KNSL1 3 4
  • TRIP5 3 4
  • EG5 3 4
  • Kinesin-Like 1 2
  • MCLMR 3
  • HKSP 3

External Ids for KIF11 Gene

Previous HGNC Symbols for KIF11 Gene

  • KNSL1

Previous GeneCards Identifiers for KIF11 Gene

  • GC10P093574
  • GC10P094484
  • GC10P094017
  • GC10P094342
  • GC10P087978
  • GC10P094352

Summaries for KIF11 Gene

Entrez Gene Summary for KIF11 Gene

  • This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for KIF11 Gene

KIF11 (Kinesin Family Member 11) is a Protein Coding gene. Diseases associated with KIF11 include microcephaly with or without chorioretinopathy, lymphedema, or mental retardation and autosomal dominant microcephaly. Among its related pathways are Platelet activation, signaling and aggregation and Immune System. GO annotations related to this gene include protein kinase binding and protein complex binding. An important paralog of this gene is KIF14.

UniProtKB/Swiss-Prot for KIF11 Gene

  • Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769).

Tocris Summary for KIF11 Gene

  • Kinesin superfamily proteins (KIFs) are motor proteins that convert chemical energy into mechanical force, typically by hydrolysis of ATP. They act upon microtubules to move vesicles and organelles from the cell centre to the periphery and cause the beating of flagella and cilia.

Gene Wiki entry for KIF11 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIF11 Gene

Genomics for KIF11 Gene

Regulatory Elements for KIF11 Gene

Promoters for KIF11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIF11 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIF11 Gene

Chromosome:
10
Start:
92,593,068 bp from pter
End:
92,655,395 bp from pter
Size:
62,328 bases
Orientation:
Plus strand

Genomic View for KIF11 Gene

Genes around KIF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIF11 Gene

Proteins for KIF11 Gene

  • Protein details for KIF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52732-KIF11_HUMAN
    Recommended name:
    Kinesin-like protein KIF11
    Protein Accession:
    P52732
    Secondary Accessions:
    • A0AV49
    • B2RMV3
    • Q15716
    • Q5VWX0

    Protein attributes for KIF11 Gene

    Size:
    1056 amino acids
    Molecular mass:
    119159 Da
    Quaternary structure:
    • Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Interacts (via C-terminus) with the kinase NEK6 in both interphase and mitosis.

    Three dimensional structures from OCA and Proteopedia for KIF11 Gene

neXtProt entry for KIF11 Gene

Proteomics data for KIF11 Gene at MOPED

Post-translational modifications for KIF11 Gene

  • A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis; phosphorylation is required for mitotic function.
  • Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase).
  • Ubiquitination at Lys 1034
  • Modification sites at PhosphoSitePlus

Other Protein References for KIF11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KIF11 (KIF11)

No data available for DME Specific Peptides for KIF11 Gene

Domains & Families for KIF11 Gene

Gene Families for KIF11 Gene

Suggested Antigen Peptide Sequences for KIF11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52732

UniProtKB/Swiss-Prot:

KIF11_HUMAN :
  • Contains 1 kinesin motor domain.
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.
Domain:
  • Contains 1 kinesin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.
genes like me logo Genes that share domains with KIF11: view

Function for KIF11 Gene

Molecular function for KIF11 Gene

UniProtKB/Swiss-Prot Function:
Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769).
genes like me logo Genes that share phenotypes with KIF11: view

Human Phenotype Ontology for KIF11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for KIF11 Gene

MGI Knock Outs for KIF11:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for KIF11 Gene

Localization for KIF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIF11 Gene

Cytoplasm. Cytoplasm, cytoskeleton, spindle pole.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIF11 Gene COMPARTMENTS Subcellular localization image for KIF11 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3

Gene Ontology (GO) - Cellular Components for KIF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005876 colocalizes_with spindle microtubule IDA 14718566
genes like me logo Genes that share ontologies with KIF11: view

Pathways & Interactions for KIF11 Gene

genes like me logo Genes that share pathways with KIF11: view

Pathways by source for KIF11 Gene

SIGNOR curated interactions for KIF11 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for KIF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IEA,TAS --
GO:0007067 mitotic nuclear division TAS 8548803
GO:0051225 spindle assembly IEA --
GO:0051301 cell division IEA --
GO:0090307 mitotic spindle assembly IMP 15843429
genes like me logo Genes that share ontologies with KIF11: view

Drugs & Compounds for KIF11 Gene

(26) Drugs for KIF11 Gene - From: Novoseek, DrugBank, Tocris, DGIdb, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Monastrol Experimental Pharma Target Selective inhibitor of mitotic kinesin Eg5 0
(1S)-1-CYCLOPROPYL-2-[(2S)-4-(2,5-DIFLUOROPHENYL)-2-PHENYL-2,5-DIHYDRO-1H-PYRROL-1-YL]-2-OXOETHANAMINE Experimental Pharma Target 0
(2S)-4-(2,5-DIFLUOROPHENYL)-N,N-DIMETHYL-2-PHENYL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE Experimental Pharma Target 0
(2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide Experimental Pharma Target 0
(2S)-4-(2,5-DIFLUOROPHENYL)-N-METHYL-2-PHENYL-N-PIPERIDIN-4-YL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE Experimental Pharma Target 0

(5) Additional Compounds for KIF11 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-trityl-l-cysteine
2799-07-7
ARRY 520 trifluoroacetate
885060-09-3
K 858
72926-24-0
Paprotrain
57046-73-8
genes like me logo Genes that share compounds with KIF11: view

Drug Products

Transcripts for KIF11 Gene

mRNA/cDNA for KIF11 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(109) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIF11 Gene

Kinesin family member 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIF11 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^
SP1:
SP2:
SP3: - - - - - - - - - - - - - - - - -
SP4:
SP5:
SP6:
SP7: - - - - - - - - - - - - - - - - - - - - - - - -
SP8:
SP9:

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
SP1:
SP2:
SP3: - - - - - -
SP4:
SP5:
SP6:
SP7: - - -
SP8:
SP9:

Relevant External Links for KIF11 Gene

GeneLoc Exon Structure for
KIF11
ECgene alternative splicing isoforms for
KIF11

Expression for KIF11 Gene

mRNA expression in normal human tissues for KIF11 Gene

mRNA differential expression in normal tissues according to GTEx for KIF11 Gene

This gene is overexpressed in Testis (x4.2).

Protein differential expression in normal tissues from HIPED for KIF11 Gene

This gene is overexpressed in Testis (32.2) and Ovary (21.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIF11 Gene



SOURCE GeneReport for Unigene cluster for KIF11 Gene Hs.8878

genes like me logo Genes that share expression patterns with KIF11: view

Protein tissue co-expression partners for KIF11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KIF11 Gene

Orthologs for KIF11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIF11 35
  • 99.84 (n)
  • 99.81 (a)
KIF11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIF11 36
  • 86 (a)
OneToOne
KIF11 35
  • 88.72 (n)
  • 85.78 (a)
dog
(Canis familiaris)
Mammalia KIF11 35
  • 90.47 (n)
  • 88.35 (a)
KIF11 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kif11 36
  • 80 (a)
OneToOne
Kif11 16
Kif11 35
  • 83.24 (n)
  • 80.04 (a)
oppossum
(Monodelphis domestica)
Mammalia KIF11 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIF11 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kif11 35
  • 83.16 (n)
  • 80.38 (a)
chicken
(Gallus gallus)
Aves KIF11 36
  • 57 (a)
OneToOne
KIF11 35
  • 66.54 (n)
  • 61.38 (a)
lizard
(Anolis carolinensis)
Reptilia KIF11 36
  • 56 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52588 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kif11 35
  • 61.82 (n)
  • 57.32 (a)
Str.3480 35
zebrafish
(Danio rerio)
Actinopterygii kif11 35
  • 56.42 (n)
  • 51.12 (a)
kif11 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Klp61F 36
  • 34 (a)
OneToOne
Klp61F 35
  • 47.86 (n)
  • 39.91 (a)
worm
(Caenorhabditis elegans)
Secernentea bmk-1 36
  • 34 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIP1 36
  • 27 (a)
OneToOne
KIP1 38
corn
(Zea mays)
Liliopsida Zm.4944 35
rice
(Oryza sativa)
Liliopsida Os.8746 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToOne
Species with no ortholog for KIF11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIF11 Gene

ENSEMBL:
Gene Tree for KIF11 (if available)
TreeFam:
Gene Tree for KIF11 (if available)

Paralogs for KIF11 Gene

genes like me logo Genes that share paralogs with KIF11: view

Variants for KIF11 Gene

Sequence variations from dbSNP and Humsavar for KIF11 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs34417963 - 92,653,751(+) GTAAC(C/G)AAGTG reference, missense
VAR_067829 Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR)
VAR_067830 Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR)
VAR_067831 Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR)
VAR_067832 Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR)

Structural Variations from Database of Genomic Variants (DGV) for KIF11 Gene

Variant ID Type Subtype PubMed ID
nsv895894 CNV Loss 21882294
nsv895895 CNV Gain 21882294
dgv168n67 CNV Gain 20364138

Variation tolerance for KIF11 Gene

Residual Variation Intolerance Score: 72.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIF11 Gene

HapMap Linkage Disequilibrium report
KIF11
Human Gene Mutation Database (HGMD)
KIF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIF11 Gene

Disorders for KIF11 Gene

MalaCards: The human disease database

(14) MalaCards diseases for KIF11 Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
microcephaly with or without chorioretinopathy, lymphedema, or mental retardation
  • chorioretinal dysplasia-microcephaly-mental retardation syndrome
autosomal dominant microcephaly
  • microcephaly autosomal dominant
exudative vitreoretinopathy 6
  • vitreoretinopathy, exudative 6
congenital lymphedema
  • milroy disease
microcephaly nonsyndromal
  • nonsyndromal microcephaly
- elite association - COSMIC cancer census association via MalaCards
Search KIF11 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

KIF11_HUMAN
  • Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:152950]: An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes. {ECO:0000269 PubMed:22284827}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for KIF11

Genetic Association Database (GAD)
KIF11
Human Genome Epidemiology (HuGE) Navigator
KIF11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIF11
genes like me logo Genes that share disorders with KIF11: view

No data available for Genatlas for KIF11 Gene

Publications for KIF11 Gene

  1. Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. (PMID: 8548803) Blangy A. … Nigg E.A. (Cell 1995) 2 3 4 23 67
  2. Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-L-cysteine in tumor derived cell lines. (PMID: 19896928) Tcherniuk S. … Skoufias D.A. (Biochem. Pharmacol. 2010) 3 23
  3. Real-time structural transitions are coupled to chemical steps in ATP hydrolysis by Eg5 kinesin. (PMID: 20154092) Jun B. … Kim S. (J. Biol. Chem. 2010) 3 23
  4. Truncated form of tenascin-X, XB-S, interacts with mitotic motor kinesin Eg5. (PMID: 18679583) Endo T. … Matsumoto K. (Mol. Cell. Biochem. 2009) 3 23
  5. KIF11 inhibition for glioblastoma treatment: reason to hope or a struggle with the brain? (PMID: 19545421) Valensin S. … Bakker A. (BMC Cancer 2009) 3 23

Products for KIF11 Gene

Sources for KIF11 Gene

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