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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KIF11 Gene

protein-coding GIFtS: 66
GCID: GC10P094352

kinesin family member 11

(Previous name: kinesin-like 1 )
(Previous symbol: KNSL1)

Explore 18 diseases affiliated with
KIF11 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Kinesin Family Member 11¹ ²		EG5² ³
KNSL1¹ ² ³ ⁵		TRIP-5² ³
TRIP5¹ ² ³		TR-Interacting Protein 5² ³
HKSP¹ ²		Eg5¹
Kinesin-Like Protein 1² ³		Kinesin-Like 1¹
Kinesin-Like Spindle Protein HKSP² ³		MCLMR²
Kinesin-Related Motor Protein Eg5² ³		Kinesin-Like Protein KIF11²
Thyroid Receptor-Interacting Protein 5² ³

External Ids:	HGNC: 6388¹	Entrez Gene: 3832²	Ensembl: ENSG00000138160⁷	OMIM: 148760⁵	UniProtKB: P52732³

Export aliases for KIF11 gene to outside databases

Previous GC identifers: GC10P093574 GC10P094484 GC10P094017 GC10P094342 GC10P087978

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KIF11:

This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are

known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome

positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: KIF11_HUMAN, P52732

Function: Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration

and arrest cells in mitosis with monoastral microtubule arrays

summary for KIF11:

Kinesin superfamily proteins (KIFs) are motor proteins that convert chemical energy, typically in the form

of ATP, into mechanical force. They act upon microtubules to move vesicles and organelles within cells,

cause the beating of flagella and cilia, and act within the mitotic and meiotic spindles to segregate

replicated chromosomes to progeny cells. Generally, kinesins mediate plus-end transport. Kinesins exist as

dimers, with a catalytic head domain and a stalk/tail domain that is important in interactions with the

cargo molecules. The neck attaches the stalk to the head and is essential in determining direction of

motility and regulation of activity. The head and neck (known collectively as the motor domain) are

conserved across the family, whilst the stalk is highly divergent, reflecting the wide range of cellular

functions of kinesins. Some specific kinesins have been implicated in human diseases, including Alzheimer's

(KIF5), polycystic kidney disease (KIF3A / KIF3B) and diabetes (KIF5B).

Gene Wiki entry for KIF11 (Kinesin family member 11)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KIF11 gene promoter:
E2F-4 E2F-3a E2F-5 NF-YC E2F-2 CBF-B E2F E2F-1 CBF-A CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KIF11 promoter sequence

Search SABiosciences Chromatin IP Primers for KIF11

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIF11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.1 Ensembl cytogenetic band: 10q23.33 HGNC cytogenetic band: 10q24.1

KIF11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF11 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P094352: view genomic region (about GC identifiers)

Start:	94,352,825 bp from pter	End:	94,415,152 bp from pter
Size:	62,328 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KIF11_HUMAN, P52732 (See protein sequence)

Recommended Name: Kinesin-like protein KIF11

Size: 1056 amino acids; 119159 Da

Subunit: Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Component of a large chromatin

remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Interacts (via C-terminus) with the

kinase NEK6 in both interphase and mitosis

Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, spindle pole

6/37 PDB 3D structures from and Proteopedia for KIF11 (see all 37):

1II6 (3D)

1Q0B (3D)

1X88 (3D)

1YRS (3D)

2FKY (3D)

2FL2 (3D)

Secondary accessions: A0AV49 B2RMV3 Q15716 Q5VWX0

Explore the universe of human proteins at neXtProt for KIF11: NX_P52732

Post-translational modifications:

Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the

association of KIF11 with the spindle apparatus (probably during early prophase)¹

A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis;

phosphorylation is required for mitotic function¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P52732

KIF11 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004514.2

ENSEMBL proteins:

ENSP00000260731

Reactome Protein details: P52732
Human Recombinant Protein Products:

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	Novus Biologicals KIF11 Protein Novus Biologicals KIF11 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KIF11

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000922	colocalizes with spindle pole	IDA	14718566
GO:0005737	cytoplasm	IDA	--
GO:0005819	spindle	IDA	19001501
GO:0005829	cytosol	TAS	--
GO:0005871	kinesin complex	TAS	8548803

KIF11 for ontologies About GeneDecksing

KIF11 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of KIF11
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	ThermoFisher Antibody for KIF11

Assay Products for KIF11:

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KIF11
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KIF11

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KIF11 for domains About GeneDecksing

3 InterPro domains/families:

IPR001752 Kinesin_motor_dom

IPR025901 Kinesin-assoc_MT-bd_dom

IPR019821 Kinesin_motor_CS

Graphical View of Domain Structure for InterPro Entry P52732

ProtoNet protein and cluster: P52732

1 Blocks protein family: IPB001752 Kinesin

UniProtKB/Swiss-Prot: KIF11_HUMAN, P52732

Similarity: Belongs to the kinesin-like protein family. BimC subfamily

Similarity: Contains 1 kinesin-motor domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KIF11_HUMAN, P52732

Function: Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration

and arrest cells in mitosis with monoastral microtubule arrays

miRNA Products:		OriGene 3'-UTR Clone: KIF11 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIF11
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate KIF11 (see all 22):
		hsa-miR-3678-3p hsa-miR-579 hsa-miR-148b* hsa-miR-562 hsa-miR-539 hsa-miR-300 hsa-miR-520a-5p hsa-miR-374c

		SwitchGear 3'UTR luciferase reporter plasmid: KIF11 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIF11 (see all 4) OriGene shRNA RFP: KIF11 OriGene siRNA: KIF11
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIF11

Gene Editing
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DNA2.0 Custom Protein Engineering Service for KIF11

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		GenScript: all cDNA clones in your preferred vector: KIF11 (NM_004523)
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		Search LifeMap BioReagents cell lines for KIF11

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIF11

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003777	microtubule motor activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0008017	microtubule binding	IEA	--
GO:0019901	protein kinase binding	IPI	19001501

KIF11 for ontologies About GeneDecksing

12 GenomeRNAi human phenotypes for KIF11:

Cell cycle / mitosis defect	Cell division defect	Decreased cell number, increas	Decreased influenza A H1N1 (A/
Decreased influenza A/WSN/33 r	Decreased viability of wild-ty	Increased Salmonella enterica	Increased cell number in G2M,
Increased gamma-H2AX phosphory	Increased number of cells in m	Increased number of mitotic ce	Synthetic lethal with Ras

Animal Models:
4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Kif11):

embryogenesis

growth/size

mortality/aging

reproductive system

KIF11 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell cycle_Spindle assembly and chromosome separation

Cell cycle_Spindle assembly and chromosome separation

1.00

Cell cycle Spindle assembly and chromosome separation

0.94

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Kinesins

Kinesins

1.00

Kinesins move along microtubules consuming ATP

0.95

MHC class II antigen presentation

MHC class II antigen presentation

1.00

Transport of antigen loaded MHC II molecules to surface

0.59

Cell Cycle / Checkpoint Control

Cell Cycle / Checkpoint Control

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for KIF11

Cell cycle Spindle assembly and chromosome separation

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KIF11

Mitotic Roles of Polo Like Kinases

1 Cell Signaling Technology (CST) Pathway for KIF11

Cell Cycle / Checkpoint Control

1 GeneGo (Thomson Reuters) Pathway for KIF11

Cell cycle Spindle assembly and chromosome separation

5/8 Reactome Pathways for KIF11 (see all 8)

	Hemostasis
	Adaptive Immune System
	Transport of antigen loaded MHC II molecules to surface
	Kinesins move along microtubules consuming ATP
	Factors involved in megakaryocyte development and platelet production

KIF11 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KIF11

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/787 Interacting proteins for KIF11 (P52732^{2, 3} ENSP00000260731⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 787)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCOR1	O75376²^,³, ENSP00000268712⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000268712
DNAJA1	P31689²^,³	MINT-7945693 MINT-7947479 I2D: score=2
EEF1A1	P68104²^,³	MINT-7945693 MINT-7947479 I2D: score=1
ENSG00000258947	Q13509²^,³	MINT-7945693 I2D: score=1
HSP90AA1	P07900²^,³	MINT-7945693 MINT-7947479 I2D: score=1

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007018	microtubule-based movement	TAS	--
GO:0007051	spindle organization	IMP	14718566
GO:0007052	mitotic spindle organization	TAS	8548803
GO:0007067	mitosis	TAS	8548803
GO:0007100	mitotic centrosome separation	IEA	--

KIF11 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KIF11 for compounds About GeneDecksing

EMD Millipore small molecules for KIF11:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for KIF11

Compounds for KIF11 available from Tocris Bioscience About this table

Compound	Action	CAS #
Thymosin beta4	Potent actin polymerization regulator	[77591-33-4]
S-Trityl-L-cysteine	Potent, selective inhibitor of mitotic kinesin Eg5	[2799-07-7]
Monastrol	Selective inhibitor of mitotic kinesin Eg5	[254753-54-3]

10/12 DrugBank Compounds for KIF11 (see all 12) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
3-[(5s)-1-Acetyl-3-(2-Chlorophenyl)-4,5-Dihydro-1h-Pyrazol-5-Yl]Phenol	--	--	target	--	17139284 17016423 10592235
Monastrol	--	--	target	--	17139284 17016423 10592235
Adenosine-5'-Diphosphate	--	20398-34-9	target	--	17139284 17016423
(1S)-1-CYCLOPROPYL-2-[(2S)-4-(2,5-DIFLUOROPHENYL)-2-PHENYL-2,5-DIHYDRO-1H-PYRROL-1-YL]-2-OXOETHANAMINE	--	--	target	--	10592235
(2S)-4-(2,5-DIFLUOROPHENYL)-N,N-DIMETHYL-2-PHENYL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE	--	--	target	--	10592235
(2S)-4-(2,5-DIFLUOROPHENYL)-N-METHYL-2-PHENYL-N-PIPERIDIN-4-YL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE	--	--	target	--	10592235
(2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide	--	--	target	--	10592235
(4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE	--	--	target	--	10592235
(5R)-N,N-DIETHYL-5-METHYL-2-[(THIOPHEN-2-YLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE	--	--	target	--	10592235
(5S)-5-(3-AMINOPROPYL)-3-(2,5-DIFLUOROPHENYL)-N-ETHYL-5-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE	--	--	target	--	10592235

5 Novoseek chemical compound relationships for KIF11 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
monastrol	96.6	28	19896928 (5), 12323373 (4), 17251189 (4), 10973989 (3) (see all 11)
s-trityl-l-cysteine	93.4	6	15476401 (2), 17581299 (1), 18186019 (1)
atp	44.1	13	18678707 (2), 20154092 (2), 10430903 (1), 12323373 (1) (see all 6)
adp	41	4	12323373 (1), 19497292 (1), 18037705 (1)
paclitaxel	10.4	4	15653676 (3)

Search CenterWatch for drugs/clinical trials and news about KIF11

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KIF11 gene:

NM_004523.3

Unigene Cluster for KIF11:

Kinesin family member 11

Hs.8878 [show with all ESTs]

Unigene Representative Sequence: NM_004523

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000260731(uc001kic.3)

miRNA Products:		OriGene 3'-UTR Clone: KIF11 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIF11
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate KIF11 (see all 22):
		hsa-miR-3678-3p hsa-miR-579 hsa-miR-148b* hsa-miR-562 hsa-miR-539 hsa-miR-300 hsa-miR-520a-5p hsa-miR-374c

		SwitchGear 3'UTR luciferase reporter plasmid: KIF11 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIF11 (see all 4) OriGene shRNA RFP: KIF11 OriGene siRNA: KIF11
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		GenScript: all cDNA clones in your preferred vector: KIF11 (NM_004523)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIF11
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIF11

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF11
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF11

Additional cDNA sequence:

AB208964.1 AK314258.1 BC050421.1 BC050667.1 BC126211.1 BC136474.1 L40372.1 U37426.1

X85137.1

5 DOTS entries:

DT.95265500 DT.100021024 DT.121290511 DT.425083 DT.100775537

24/109 AceView cDNA sequences (see all 109):

AI559454 BU170096 AA307194 AI086253 CB116460 BU163995 AA504625 BM742618

AI281057 AI346635 AA401791 AA447117 AI476546 CF147477 BM800579 L40372

BQ959682 AA676413 AW576532 BX482200 BC050667 BP364466 AA307125 BQ949030

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for KIF11 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13a	·	13b	^	14a	·	14b	^	15a	·	15b	^	16	^	17a	·	17b	^
SP1:
SP2:
SP3:																			-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP4:
SP5:

ExUns:	18	^	19	^	20	^	21	^	22	^	23	^	24
SP1:
SP2:
SP3:	-		-		-		-		-		-
SP4:
SP5:

ECgene alternative splicing isoforms for KIF11

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KIF11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTAATAAAT

About this image

KIF11 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Epicardium

Kidney Endothelial Cells

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

See KIF11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIF11

SOURCE GeneReport for Unigene cluster: Hs.8878

SABiosciences Custom PCR Arrays for KIF11

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIF11 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIF11
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIF11

In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for KIF11 gene from 9/30 species (see all 30) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KIF11¹	kinesin family member 11	66.48(n) 60.96(a)		423809 NM_001031230.1 NP_001026401.1
lizard (Anolis carolinensis)	Reptilia	KIF11⁶	--	56(a)	1 ↔ 1	GL343219.1(2536877-2564687)
African clawed frog (Xenopus laevis)	Amphibia	MGC52588²	similar to kinesin-like 1	73.72(n)		BC042218.1
zebrafish (Danio rerio)	Actinopterygii	kif11²	kinesin family member 11	77.58(n)		195818 BC048061.1
fruit fly (Drosophila melanogaster)	Insecta	Klp61F¹	Kinesin-like protein at 61F	45.83(n) 37.5(a)		38135 NM_057470.4 NP_476818.1
worm (Caenorhabditis elegans)	Secernentea	bmk-1¹	Protein BMK-1	47.05(n) 38.15(a)		179948 NM_074181.5 NP_506582.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	KIP1(YBL063W)⁴ KIP1¹	Kinesin-related motor protein required for mitotic more⁴ Kip1p¹	46.03(n)¹ 36.03(a)¹		2(101886-105221)⁴ 852216^{1, 4} NP_009490.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G36200⁶ AT2G28620⁶ (see all 4)	kinesin family member 11 P-loop containing nucleoside triphosphate hydrolas... (see all 4)	30(a) 30(a) (see all 4)	1 ↔ many 1 ↔ many (see all 4)	2(15179869-15185314) 2(12265167-12270020)
rice (Oryza sativa)	Liliopsida	Os.8746²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	72.98(n)		AK068757.1

ENSEMBL Gene Tree for KIF11 (if available)
TreeFam Gene Tree for KIF11 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for KIF11 gene

KIF5C² KIF21A² KIF3B² KIF21B² KIF9² KIF17² KIF4B² KIF27²

KIF3A² KIF4A² KIF5B² KIF6² KIF15² CENPE² KIF5A² KIF7²

KIF3C²

KIF11 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113032613^1,2		--	87977062(+)	`ATAGTG/ACCCTC`	1	--	us2k¹		1		CSA	2
rs11595187^1,2	C,F,H,	--	87978096(+)	`ttcccC/Ttctat`	1	--	us2k¹ tfbs³ trp³		9		NS EA NA CSA WA	769
rs11595260^1,2	H	--	87978316(+)	`tttggC/Gaggcc`	1	--	us2k¹		0	--	--	--	--
rs11599701^1,2	H	--	87978317(+)	`ttgggA/Gggccg`	1	--	us2k¹		0	--	--	--	--
rs7092778^1,2	C,H	--	87978587(+)	`acacaA/CaGACT`	1	--	us2k¹		4		NS EA	388
rs74151659^1,2	C,	--	87978897(+)	`CAAGCA/GGACAG`	1	--	us2k¹		3		WA NA EA	242
rs74151660^1,2	C,	--	87978908(+)	`ACCACG/CTCTTT`	1	--	us2k¹		1		WA	2
rs2297743^1,2	C,F,A,H,	--	87978984(-)	`CGCTGG/CCGCGC`	1	--	us2k¹		10		EA NS WA CSA NA	2262
rs113197692^1,2	C,	--	87979079(+)	`AGATTA/GGTGAT`	1	--	ut5¹		2		CSA WA	120
rs12256435^1,2	C,F,H,	--	87979439(+)	`GTCCAG/TGGAGA`	1	--	int¹ trp³		17		NS EA NA CSA WA	1894

HapMap Linkage Disequilibrium report for KIF11 (94352825 - 94415152 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KIF11: --
Human Gene Mutation Database (HGMD): KIF11

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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KIF11 for disorders About GeneDecksing

OMIM gene information: 148760 OMIM disorders: --

UniProtKB/Swiss-Prot: KIF11_HUMAN, P52732

Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental

retardation (MCLMR) [MIM:152950]. An autosomal dominant disorder that involves an overlapping but variable spectrum of

central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often

associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral

fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears.

Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic

astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when

present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive

isotope uptake from the webspaces between the toes

18 diseases for KIF11: About MalaCards

polycystic kidney disease kidney disease autosomal dominant microcephaly thyroiditis

gangliosidosis multiple myeloma microcephaly myeloma

alzheimer's disease ovarian cancer prostate cancer breast cancer

glioblastoma obesity prostatitis malaria

carcinoma lymphedema

2 diseases from the University of Copenhagen DISEASES database for KIF11:

Autosomal dominant microcephaly Gangliosidosis

2 Novoseek disease relationships for KIF11 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	8	16489005 (2), 19896928 (1), 18186019 (1)
cancer	0	3	19497292 (1), 16780877 (1)

Genetic Association Database (GAD): KIF11
Human Genome Epidemiology (HuGE) Navigator: KIF11 (9 documents)

Export disorders for KIF11 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KIF11 gene, integrated from 9 sources (see all 140):
(articles sorted by number of sources associating them with KIF11)

Utopia: connect your pdf to the dynamic
world of online information

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. (PubMed id 8548803)^{1, 2, 3, 9} Blangy A.... Nigg E.A. (1995)
The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. (PubMed id 19001501)^{1, 2, 9} Rapley J....Roig J. (2008)
Mutation screening of a haplotype block around the insulin degrading enzyme gene and association with Alzheimer's disease. (PubMed id 15858821)^{1, 4, 9} Feuk L....Brookes A.J. (2005)
Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy. (PubMed id 22284827)^{1, 2} Ostergaard P.... Jeffery S. (2012)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)^{1, 2} Dephoure N.... Gygi S.P. (2008)
A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation. (PubMed id 17707232)^{1, 2} Zhu P....Rosenfeld M.G. (2007)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (2004)
Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease. (PubMed id 15024728)^{1, 4} Ertekin-Taner N....Younkin S.G. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genetic variation in a haplotype block spanning IDE influences Alzheimer disease. (PubMed id 14517947)^{1, 4} Prince J.A....Brookes A.J. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3832	HGNC: 6388	AceView: KIF11	Ensembl:ENSG00000138160	euGenes: HUgn3832
ECgene: KIF11	H-InvDB: KIF11

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for KIF11	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KIF11 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KIF11 gene:
Search GeneIP for patents involving KIF11

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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KIF11 Gene

kinesin family member 11

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KIF11 Gene

kinesin family member 11

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