Aliases for KIDINS220 Gene
External Ids for KIDINS220 Gene
Previous GeneCards Identifiers for KIDINS220 Gene
GeneCards Summary for KIDINS220 Gene
KIDINS220 (Kinase D-Interacting Substrate 220kDa) is a Protein Coding gene. Diseases associated with KIDINS220 include rectal prolapse and neurogenic bowel. Among its related pathways are Development HGF signaling pathway and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include PDZ domain binding and protein kinase regulator activity. An important paralog of this gene is RNASEL.
UniProtKB/Swiss-Prot for KIDINS220 Gene
Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.