Aliases for KIDINS220 Gene
External Ids for KIDINS220 Gene
Previous GeneCards Identifiers for KIDINS220 Gene
GeneCards Summary for KIDINS220 Gene
KIDINS220 (Kinase D-Interacting Substrate, 220kDa) is a Protein Coding gene. Diseases associated with KIDINS220 include rectal prolapse and rectal disease. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include PDZ domain binding and protein kinase regulator activity. An important paralog of this gene is TANC1.
UniProtKB/Swiss-Prot for KIDINS220 Gene
Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.