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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIAA2026 Gene

protein-coding   GIFtS: 40
GCID: GC09M005919          (predicted)

KIAA2026

 Explore 1 disease affiliated with
KIAA2026 via our new
 Human Malady Compendium 
Biological research products
for KIAA2026
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
KIAA20261 2
FLJ203751
Putative Uncharacterized Protein ENSP000003828132
Uncharacterized Protein KIAA20262

External Ids:    HGNC: 233781   Entrez Gene: 1583582   Ensembl: ENSG000001833547   UniProtKB: Q5HYC23   

Export aliases for KIAA2026 gene to outside databases

Previous GC identifers: GC09M005900 GC09M005909 GC09M005874


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIAA2026 gene promoter:
         AhR   Pax-5   p300   FOXL1   Arnt   C/EBPalpha   CHOP-10   MZF-1   TFIID   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KIAA2026

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA2026


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.1   Ensembl cytogenetic band:  9p24.1   HGNC cytogenetic band: 9p24.1

KIAA2026 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA2026 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M005919:  view genomic region     (about GC identifiers)

Start:
5,881,596 bp from pter      End:
6,008,003 bp from pter
Size:
126,408 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: K2026_HUMAN, Q5HYC2 (See protein sequence)
Recommended Name: Uncharacterized protein KIAA2026  
Size: 2103 amino acids; 228087 Da
Sequence caution: Sequence=AAI36847.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAI45993.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI95313.1;
Type=Erroneous gene model prediction;
Secondary accessions: A8MTP2 B9EGW7 Q4VXA2 Q8IVE5
Alternative splicing: 2 isoforms:  Q5HYC2-1   Q5HYC2-2   

Explore the universe of human proteins at neXtProt for KIAA2026: NX_Q5HYC2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5HYC2

  • KIAA2026 Protein expression data from MOPED and PaxDb:    About this image 
    KIAA2026 Protein Expression
    REFSEQ proteins: NP_001017969.2  
    ENSEMBL proteins: 
     ENSP00000438370   ENSP00000382815   ENSP00000370870   ENSP00000444949   ENSP00000444993  

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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    KIAA2026 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001487 Bromodomain

    Graphical View of Domain Structure for InterPro Entry Q5HYC2

    ProtoNet protein and cluster: Q5HYC2


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for KIAA2026 

    miRNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA2026

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for KIAA2026 (Q5HYC22, 3 ENSP000003828154) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2878930 I2D: score=3 STRING: ENSP00000244769
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    CREB1P162203, ENSP000003876994I2D: score=2 STRING: ENSP00000387699
    CDC42P609533, ENSP000003144584I2D: score=2 STRING: ENSP00000314458
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIAA2026
    Search CenterWatch for drugs/clinical trials and news about KIAA2026 / K2026 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIAA2026 gene: 
    NM_001017969.2  

    Unigene Cluster for KIAA2026:

    KIAA2026
    Hs.535060  [show with all ESTs]
    Unigene Representative Sequence: NM_001017969
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436015 ENST00000443149 ENST00000399933(uc010mht.3 uc003zjq.4)
    ENST00000381461 ENST00000540714 ENST00000513355

    miRNA
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    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate KIAA2026 (see all 24):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-30c hsa-miR-217 hsa-miR-379* hsa-miR-1288 hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidKIAA2026 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    OriGene shRNA RFP: KIAA2026
    OriGene siRNA: KIAA2026
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA2026
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    Additional cDNA sequence: 

    AB095946.1 AL833370.1 BC128087.1 BC136846.1 BX648372.1 

    6 DOTS entries:

    DT.40125629  DT.112137  DT.40280944  DT.121145302  DT.75145857  DT.91801743 

    24/81 AceView cDNA sequences (see all 81):

    AA428531 BM992657 AI290134 BG109896 BX648372 BX417704 AL833370 AW450313 
    BM661626 AW467489 BG028655 AB095946 AW959408 AA731176 AI659345 BE842639 
    AA779658 T16254 AI887465 BQ215718 AL601655 AA830050 R02828 BG622910 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIAA2026 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAATAAACTG
    KIAA2026 Expression
    About this image
    See KIAA2026 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIAA2026

    SOURCE GeneReport for Unigene cluster: Hs.535060
        SABiosciences Custom PCR Arrays for KIAA2026

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA2026

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KIAA2026 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 9930021J03Rik1 , 5 RIKEN cDNA 9930021J03 gene1, 5 86.06(n)1
    80.27(a)1
      19 (24.30 cM)5
    2406131  NM_172836.31  NP_766424.21 
     297144025 
    chicken
    (Gallus gallus)
    Aves KIAA20261 KIAA2026 69.66(n)
    61.5(a)
      427227  XM_424814.3  XP_424814.3 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA20266
    --
    58(a)
    1 ↔ 1
    2(52523327-52573579)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.187192 Xenopus laevis transcribed sequences 74.28(n)    CA985257.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01073380.26
    --
    42(a)
    1 ↔ 1
    21(784812-796376)
    honey bee
    (Apis mellifera)
    Insecta --
    --
    --
    16(a)
    16(a)
    many → 1
    many → 1
    GroupUn.77(89085-95086)
    GroupUn.77(89082-95086)


    ENSEMBL Gene Tree for KIAA2026 (if available)
    TreeFam Gene Tree for KIAA2026 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1697 NCBI SNPs in KIAA2026 are shown (see all 1697    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs78740321,2
    C,F,A--5918513(+) GAGTTC/GAAGAC 1 -- ds50014Minor allele frequency- G:0.10WA NA 242
    rs1172197231,2
    --5918585(+) ATGCCC/TGTAGT 1 -- ds50011Minor allele frequency- T:0.01EA 120
    rs713261971,2
    C--5918816(-) TTTTT-/TGACTC 1 -- ds50011Minor allele frequency- T:0.00NA 2
    rs764215321,2
    F--5918853(+) CACAAG/AATTTA 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1450808031,2
    --5918873(+) AGTATC/TTGTAA 1 -- ds50010--------
    rs1509630961,2
    --5918925(+) CCCACA/CCTTAA 1 -- ds50010--------
    rs1822651301,2
    --5918945(+) GTAAAA/GGACTG 1 -- ds50010--------
    rs1854963701,2
    --5919250(+) ATGTAG/TTTTTT 1 -- ut310--------
    rs1408111811,2
    --5919308(+) TATCAC/TAGATA 1 -- ut310--------
    rs726973951,2
    --5919350(+) TGTCAA/GTGTAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KIAA2026 (5881596 - 6008003 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KIAA2026: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIAA2026
    DNA2.0 Custom Variant and Variant Library Synthesis for KIAA2026

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KIAA2026 for disorders           About GeneDecksing

    1 disease for KIAA2026:    About MalaCards
    ataxia


    Export disorders for KIAA2026 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIAA2026 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KIAA2026)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    2. Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
    3. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    5. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 158358 HGNC: 23378 AceView: KIAA2026 Ensembl:ENSG00000183354 euGenes: HUgn158358
    ECgene: KIAA2026 H-InvDB: KIAA2026

    (According to HUGE)
    About This Section
    HUGE: KIAA2026

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIAA2026 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIAA2026 gene:
    Search GeneIP for patents involving KIAA2026

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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