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Aliases for KIAA2018 Gene

Aliases for KIAA2018 Gene

  • KIAA2018 2 3

External Ids for KIAA2018 Gene

Previous GeneCards Identifiers for KIAA2018 Gene

  • GC03U900029
  • GC03M114653
  • GC03M114694
  • GC03M114693
  • GC03M114855
  • GC03M113367
  • GC03M110742

Summaries for KIAA2018 Gene

GeneCards Summary for KIAA2018 Gene

KIAA2018 (KIAA2018) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA2018 Gene

Genomics for KIAA2018 Gene

Regulatory Elements for KIAA2018 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIAA2018 Gene

Start:
113,648,385 bp from pter
End:
113,696,646 bp from pter
Size:
48,262 bases
Orientation:
Minus strand

Genomic View for KIAA2018 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIAA2018 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA2018 Gene

Proteins for KIAA2018 Gene

  • Protein details for KIAA2018 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68DE3-K2018_HUMAN
    Recommended name:
    Basic helix-loop-helix domain-containing protein KIAA2018
    Protein Accession:
    Q68DE3
    Secondary Accessions:
    • Q7Z3L9
    • Q8IVF3
    • Q9H8T4

    Protein attributes for KIAA2018 Gene

    Size:
    2245 amino acids
    Molecular mass:
    241681 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14518.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305}; Sequence=CAH18277.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for KIAA2018 Gene

Proteomics data for KIAA2018 Gene at MOPED

Post-translational modifications for KIAA2018 Gene

  • Glycosylation at Asn1223
  • Modification sites at PhosphoSitePlus

Other Protein References for KIAA2018 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIAA2018 Gene

Domains for KIAA2018 Gene

Protein Domains for KIAA2018 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA2018 Gene

Graphical View of Domain Structure for InterPro Entry

Q68DE3

UniProtKB/Swiss-Prot:

K2018_HUMAN :
  • Q68DE3
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with KIAA2018: view

No data available for Gene Families for KIAA2018 Gene

Function for KIAA2018 Gene

Gene Ontology (GO) - Molecular Function for KIAA2018 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with KIAA2018: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIAA2018

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KIAA2018 Gene

Localization for KIAA2018 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA2018 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA2018 Gene COMPARTMENTS Subcellular localization image for KIAA2018 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for KIAA2018 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with KIAA2018: view

Pathways for KIAA2018 Gene

SuperPathways for KIAA2018 Gene

No Data Available

Interacting Proteins for KIAA2018 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000320794%0d%0a9606.ENSP00000396620%0d%0a
Selected Interacting proteins: ENSP00000320794 Q68DE3-K2018_HUMAN for KIAA2018 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for KIAA2018 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with KIAA2018: view

No data available for Pathways by source for KIAA2018 Gene

Transcripts for KIAA2018 Gene

mRNA/cDNA for KIAA2018 Gene

Unigene Clusters for KIAA2018 Gene

KIAA2018:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIAA2018

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KIAA2018

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA2018 Gene

No ASD Table

Relevant External Links for KIAA2018 Gene

GeneLoc Exon Structure for
KIAA2018
ECgene alternative splicing isoforms for
KIAA2018

Expression for KIAA2018 Gene

mRNA expression in normal human tissues for KIAA2018 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KIAA2018 Gene

SOURCE GeneReport for Unigene cluster for KIAA2018 Gene Hs.632570

genes like me logo Genes that share expressions with KIAA2018: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIAA2018 Gene

Orthologs for KIAA2018 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA2018 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA2018 35
  • 99.44 (n)
  • 99.28 (a)
KIAA2018 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA2018 35
  • 89.14 (n)
  • 87.96 (a)
KIAA2018 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA2018 35
  • 90.16 (n)
  • 90.34 (a)
KIAA2018 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm608 35
  • 85.82 (n)
  • 83.79 (a)
Gm608 16
Gm608 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA2018 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA2018 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1560175 35
  • 85.14 (n)
  • 82.74 (a)
chicken
(Gallus gallus)
Aves KIAA2018 35
  • 71.89 (n)
  • 68.92 (a)
KIAA2018 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA2018 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33642 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145754 35
  • 59.73 (n)
  • 55.26 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-196k8.2 36
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToOne
Species with no ortholog for KIAA2018:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA2018 Gene

ENSEMBL:
Gene Tree for KIAA2018 (if available)
TreeFam:
Gene Tree for KIAA2018 (if available)

Paralogs for KIAA2018 Gene

Selected SIMAP similar genes for KIAA2018 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIAA2018: view

No data available for Paralogs for KIAA2018 Gene

Variants for KIAA2018 Gene

Sequence variations from dbSNP and Humsavar for KIAA2018 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs930818 - 113,655,083(+) GAAGC(A/G)CTGTG reference, missense, intron-variant
rs1026364 -- 113,651,163(+) ATAAC(G/T)GACTC utr-variant-3-prime, intron-variant
rs1051463 -- 113,649,517(-) AAAAA(A/C)AAAAA utr-variant-3-prime, nc-transcript-variant
rs1051464 -- 113,649,510(-) aaaaa(A/C)aaaaa utr-variant-3-prime, nc-transcript-variant
rs1464060 -- 113,655,975(-) CTTCC(C/T)CAGGA missense, reference, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA2018 Gene

Variant ID Type Subtype PubMed ID
nsv819838 CNV Loss 19587683

Relevant External Links for KIAA2018 Gene

HapMap Linkage Disequilibrium report
KIAA2018
Human Gene Mutation Database (HGMD)
KIAA2018

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA2018 Gene

Disorders for KIAA2018 Gene

No disorders were found for KIAA2018 Gene.

No data available for UniProtKB/Swiss-Prot for KIAA2018 Gene

Publications for KIAA2018 Gene

  1. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3
  2. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3
  3. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. (PMID: 22504420) Estrada K. … Rivadeneira F. (Nat. Genet. 2012) 3
  4. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for KIAA2018 Gene

Sources for KIAA2018 Gene

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