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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIAA2013 Gene

protein-coding   GIFtS: 39
GCID: GC01M011979

KIAA2013

  Search for KIAA2013
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
KIAA20131 2
Uncharacterized Protein KIAA20132

External Ids:    HGNC: 285131   Entrez Gene: 902312   Ensembl: ENSG000001166857   UniProtKB: Q8IYS23   

Export aliases for KIAA2013 gene to outside databases

Previous GC identifers: GC01M011908 GC01M011782 GC01M011902 GC01M011971 GC01M011135


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KIAA2013 Gene: 
KIAA2013 (KIAA2013) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_021937.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIAA2013 gene promoter:
         STAT5B   TBP   Sp1   FOXO1a   GR-alpha   Nkx2-5   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KIAA2013

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA2013


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.22

KIAA2013 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA2013 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M011979:  view genomic region     (about GC identifiers)

Start:
11,979,645 bp from pter      End:
11,986,485 bp from pter
Size:
6,841 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K2013_HUMAN, Q8IYS2 (See protein sequence)
Recommended Name: Uncharacterized protein KIAA2013 precursor  
Size: 634 amino acids; 69157 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=BAC23109.1; Type=Erroneous initiation;
Secondary accessions: Q5JXC1 Q8IVF8 Q8NDI7 Q9BSY1
Alternative splicing: 2 isoforms:  Q8IYS2-1   Q8IYS2-2   

Explore the universe of human proteins at neXtProt for KIAA2013: NX_Q8IYS2

Explore proteomics data for KIAA2013 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IYS2

  • KIAA2013 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KIAA2013 Protein Expression
    REFSEQ proteins: NP_612355.1  
    ENSEMBL proteins: 
     ENSP00000365756   ENSP00000365760  

    Human Recombinant Protein Products for KIAA2013: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    KIAA2013 for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR018795 DUF2152

    Graphical View of Domain Structure for InterPro Entry Q8IYS2

    ProtoNet protein and cluster: Q8IYS2


    KIAA2013 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KIAA2013 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KIAA2013 
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    SwitchGear 3'UTR luciferase reporter plasmidKIAA2013 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA2013

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for KIAA2013 (ENSP000003657564) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIAA2013 (K2013)

    Search CenterWatch for drugs/clinical trials and news about KIAA2013 / K2013

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIAA2013 gene: 
    NM_138346.2  

    Unigene Cluster for KIAA2013:

    KIAA2013
    Hs.520094  [show with all ESTs]
    Unigene Representative Sequence: NM_138346
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376572(uc001atk.3) ENST00000376576(uc001atl.2)
    miRNA
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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate KIAA2013 (see all 16):
    hsa-miR-498 hsa-miR-607 hsa-miR-1297 hsa-miR-9 hsa-miR-124 hsa-miR-1323 hsa-miR-548x hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidKIAA2013 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KIAA2013
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIAA2013
    Clone
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    GenScript: all cDNA clones in your preferred vector: KIAA2013 (NM_138346)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIAA2013
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA2013
    Sirion Biotech Customized lentivirus for stable overexpression of KIAA2013 
                         Customized lentivirus expression plasmids for stable overexpression of KIAA2013 
    Primer
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    OriGene qPCR primer pairs and template standards for KIAA2013
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA2013
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA2013

    Additional mRNA sequence: 

    AB095933.1 AL833697.1 AL833891.1 BC004501.2 BC035033.1 

    7 DOTS entries:

    DT.217252  DT.436194  DT.70103608  DT.101970907  DT.120692588  DT.121341914  DT.121341933 

    24/236 AceView cDNA sequences (see all 236):

    AI301870 BM692071 BE018968 BU683383 AI222785 BM970658 AW873159 BE276209 
    CD367196 AI278735 AI348255 BG056655 CA428693 CA307102 BQ687334 CA416666 
    BE531135 C02552 BM909739 CA427065 CB305446 BQ232333 AI805179 BU629449 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIAA2013 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCAGCAGG
    KIAA2013 Expression
    About this image


    See KIAA2013 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIAA2013

    SOURCE GeneReport for Unigene cluster: Hs.520094
        SABiosciences Custom PCR Arrays for KIAA2013
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA2013

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KIAA2013 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2510039O18Rik1 , 5 RIKEN cDNA 2510039O18 gene1, 5 87.96(n)1
    91.96(a)1
      4 (78.57 cM)5
    770341  NM_029841.31  NP_084117.21 
     1479408955 
    chicken
    (Gallus gallus)
    Aves KIAA20131 KIAA2013 67.96(n)
    67.03(a)
      428195  XM_425754.3  XP_425754.3 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA20136
    Uncharacterized protein
    57(a)
    1 ↔ 1
    AAWZ02038117(2163-11118)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.167702 Xenopus laevis transcribed sequence with weak similarity more 72.12(n)    CA793011.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-104h9.51 si:dkeyp-104h9.5 62.26(n)
    58.29(a)
      568307  NM_001113612.1  NP_001107084.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG72891 CG7289 47.47(n)
    31.56(a)
      33372  NM_134791.3  NP_608635.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_C17H12.21 Protein C17H12.2 37.9(n)
    29.19(a)
      177441  NM_068638.2  NP_501039.1 


    ENSEMBL Gene Tree for KIAA2013 (if available)
    TreeFam Gene Tree for KIAA2013 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIAA2013 gene
    1 SIMAP similar gene for KIAA2013 using alignment to 2 protein entries:     K2013_HUMAN (see all proteins):
    LOC728138

    KIAA2013 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/253 SNPs in KIAA2013 are shown (see all 253)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830327781,2
    --11979199(+) TGGACC/TGCCAT 1 -- ds50010--------
    rs1879197821,2
    --11979214(+) GGCTCA/GGCCCC 1 -- ds50010--------
    rs66914991,2
    C,F,A,H--11979231(+) GTCCCC/TAGAGT 1 -- ds500117Minor allele frequency- T:0.06NS EA NA WA 2510
    rs1394089241,2
    C--11979236(+) CAGAGC/TGGACC 1 -- ds50010--------
    rs1135655781,2
    C,F--11979312(+) CTCAGG/AGTTTG 1 -- ds50012Minor allele frequency- A:0.04CSA WA 120
    rs1168025921,2
    C,F--11979466(+) CCTGGC/TGAGCA 1 -- ds50012Minor allele frequency- T:0.03WA EA 238
    rs20380281,2
    C,F,A,H--11979556(+) ACAGCG/AGGGCC 1 -- ds500127Minor allele frequency- A:0.34MN NS EA NA WA CSA 2626
    rs1915381301,2
    --11979561(+) AGGGCC/TGGGTG 1 -- ds50010--------
    rs577642501,2
    C,F--11979615(+) TGCATG/ATCTCC 1 -- ds50012Minor allele frequency- A:0.07WA 120
    rs1827877461,2
    --11979643(+) AAACCA/GGTCGT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for KIAA2013 (11979645 - 11986485 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KIAA2013:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv870926CNV Loss21882294
    dgv142n71CNV Loss21882294
    nsv870723CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KIAA2013 for disorders           About MalaCards

    KIAA2013 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KIAA2013

    Export disorders for KIAA2013 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIAA2013 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KIAA2013)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
    10. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90231 HGNC: 28513 AceView: MGC33867 Ensembl:ENSG00000116685 euGenes: HUgn90231
    ECgene: KIAA2013 H-InvDB: KIAA2013

    (According to HUGE)
    About This Section
    HUGE: KIAA2013

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIAA2013 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIAA2013 gene:
    Search GeneIP for patents involving KIAA2013

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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