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KIAA2013 Gene

protein-coding   GIFtS: 44
GCID: GC01M011979

KIAA2013

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
KIAA20131 2
RP5-1077B9.12
Uncharacterized Protein KIAA20132

External Ids:    HGNC: 285131   Entrez Gene: 902312   Ensembl: ENSG000001166857   UniProtKB: Q8IYS23   

Export aliases for KIAA2013 gene to outside databases

Previous GC identifers: GC01M011908 GC01M011782 GC01M011902 GC01M011971 GC01M011135


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KIAA2013 Gene:
KIAA2013 (KIAA2013) is a protein-coding gene. Diseases associated with KIAA2013 include malaria.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIAA2013 gene promoter:
         STAT5B   TBP   Sp1   FOXO1a   GR-alpha   Nkx2-5   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KIAA2013

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIAA2013


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.22

KIAA2013 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA2013 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M011979:  view genomic region     (about GC identifiers)

Start:
11,979,645 bp from pter      End:
11,986,485 bp from pter
Size:
6,841 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: K2013_HUMAN, Q8IYS2 (See protein sequence)
Recommended Name: Uncharacterized protein KIAA2013 precursor  
Size: 634 amino acids; 69157 Da
Sequence caution: Sequence=BAC23109.1; Type=Erroneous initiation;
Secondary accessions: Q5JXC1 Q8IVF8 Q8NDI7 Q9BSY1
Alternative splicing: 2 isoforms:  Q8IYS2-1   Q8IYS2-2   

Explore the universe of human proteins at neXtProt for KIAA2013: NX_Q8IYS2

Explore proteomics data for KIAA2013 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr224, Asn363
  • Modification sites at PhosphoSitePlus

  • See KIAA2013 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612355.1  
    ENSEMBL proteins: 
     ENSP00000365756   ENSP00000365760  

    KIAA2013 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

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    LSBio Antibodies in human, mouse, rat for KIAA2013

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR018795 DUF2152

    Graphical View of Domain Structure for InterPro Entry Q8IYS2

    ProtoNet protein and cluster: Q8IYS2


    KIAA2013 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIAA2013
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    miRNA
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    miRTarBase miRNAs that target KIAA2013:
    hsa-mir-148b-3p (MIRT043585), hsa-mir-16-5p (MIRT051246)

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    Selected qRT-PCR Assays for microRNAs that regulate KIAA2013 (see all 16):
    hsa-miR-498 hsa-miR-607 hsa-miR-1297 hsa-miR-9 hsa-miR-124 hsa-miR-1323 hsa-miR-548x hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidKIAA2013 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KIAA2013

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    Clone
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    GenScript: all cDNA clones in your preferred vector: KIAA2013 (NM_138346)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA2013

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA2013


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    K2013_HUMAN, Q8IYS2: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    KIAA2013 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIAA2013
    Interactions:

        Search GeneGlobe Interaction Network for KIAA2013

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for KIAA2013 (ENSP000003657564) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP6V0E2ENSP000004116724STRING: ENSP00000411672
    ATP6V0E1ENSP000002650934STRING: ENSP00000265093
    ATP6AP1ENSP000003587774STRING: ENSP00000358777
    ZFP36L1ENSP000003373864STRING: ENSP00000337386
    ZFP36L2ENSP000002823884STRING: ENSP00000282388
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIAA2013 (K2013)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KIAA2013 gene: 
    NM_138346.2  

    Unigene Cluster for KIAA2013:

    KIAA2013
    Hs.520094  [show with all ESTs]
    Unigene Representative Sequence: NM_138346
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376572(uc001atk.3) ENST00000376576(uc001atl.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KIAA2013 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KIAA2013 (see all 16):
    hsa-miR-498 hsa-miR-607 hsa-miR-1297 hsa-miR-9 hsa-miR-124 hsa-miR-1323 hsa-miR-548x hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidKIAA2013 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KIAA2013
    Predesigned siRNA for gene silencing in human, mouse, rat KIAA2013
    Clone
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    OriGene clones in human, mouse for KIAA2013 (see all 6)
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    GenScript: all cDNA clones in your preferred vector: KIAA2013 (NM_138346)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA2013
    Primer
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    OriGene qPCR primer pairs and template standards for KIAA2013
    OriGene qSTAR qPCR primer pairs in human, mouse for KIAA2013
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KIAA2013
      QuantiTect SYBR Green Assays in human, mouse, rat KIAA2013
      QuantiFast Probe-based Assays in human, mouse, rat KIAA2013

    Additional mRNA sequence: 

    AB095933.1 AL833697.1 AL833891.1 BC004501.2 BC035033.1 

    7 DOTS entries:

    DT.217252  DT.436194  DT.70103608  DT.101970907  DT.120692588  DT.121341914  DT.121341933 

    Selected AceView cDNA sequences (see all 236):

    BM970658 AI278842 BQ687334 BM796213 AA425955 BE276209 CA307102 BI862090 
    AI222785 BU629449 BU683383 AI206104 BM692071 AI301870 AI520678 BQ679148 
    BE018968 BM909739 AI805179 BQ772435 AW873159 CA427065 C02552 CK903389 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIAA2013 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCAGCAGG
    KIAA2013 Expression
    About this image

    KIAA2013 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIAA2013 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520094
        Custom PCR Arrays for KIAA2013
    Primer
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    OriGene qPCR primer pairs and template standards for KIAA2013
    OriGene qSTAR qPCR primer pairs in human, mouse for KIAA2013
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KIAA2013
    QuantiTect SYBR Green Assays in human, mouse, rat KIAA2013
    QuantiFast Probe-based Assays in human, mouse, rat KIAA2013
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA2013

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KIAA2013 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2510039O18Rik1 , 5 RIKEN cDNA 2510039O18 gene1, 5 87.96(n)1
    91.96(a)1
      4 (78.57 cM)5
    770341  NM_029841.31  NP_084117.21 
     1479408955 
    chicken
    (Gallus gallus)
    Aves KIAA20131 KIAA2013 69.27(n)
    69.27(a)
      428195  XM_425754.4  XP_425754.4 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA20136
    KIAA2013
    59(a)
    1 ↔ 1
    AAWZ02038117(2163-11118)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.167702 Xenopus laevis transcribed sequence with weak similarity more 72.12(n)    CA793011.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-104h9.51 si:dkeyp-104h9.5 62.2(n)
    58.29(a)
      568307  NM_001113612.1  NP_001107084.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG72891 CG7289 48.16(n)
    31.06(a)
      33372  NM_134791.4  NP_608635.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_C17H12.21 CELE_C17H12.2 37.65(n)
    28.93(a)
      177441  NM_068638.3  NP_501039.1 


    ENSEMBL Gene Tree for KIAA2013 (if available)
    TreeFam Gene Tree for KIAA2013 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIAA2013 gene
    1 SIMAP similar gene for KIAA2013 using alignment to 2 protein entries:     K2013_HUMAN (see all proteins):
    LOC728138

    KIAA2013 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIAA2013 (see all 253)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830327781,2
    --11979199(+) TGGACC/TGCCAT 1 -- ds50010--------
    rs1879197821,2
    --11979214(+) GGCTCA/GGCCCC 1 -- ds50010--------
    rs66914991,2
    C,F,A,H--11979231(+) GTCCCC/TAGAGT 1 -- ds500117Minor allele frequency- T:0.06NS EA NA WA 2510
    rs1394089241,2
    C--11979236(+) CAGAGC/TGGACC 1 -- ds50010--------
    rs1135655781,2
    C,F--11979312(+) CTCAGG/AGTTTG 1 -- ds50012Minor allele frequency- A:0.04CSA WA 120
    rs1168025921,2
    C,F--11979466(+) CCTGGC/TGAGCA 1 -- ds50012Minor allele frequency- T:0.03WA EA 238
    rs20380281,2
    C,F,A,H--11979556(+) ACAGCG/AGGGCC 1 -- ds500127Minor allele frequency- A:0.34MN NS EA NA WA CSA 2626
    rs1915381301,2
    --11979561(+) AGGGCC/TGGGTG 1 -- ds50010--------
    rs577642501,2
    C,F--11979615(+) TGCATG/ATCTCC 1 -- ds50012Minor allele frequency- A:0.07WA 120
    rs1827877461,2
    --11979643(+) AAACCA/GGTCGT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for KIAA2013 (11979645 - 11986485 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KIAA2013:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv870926CNV Loss21882294
    dgv142n71CNV Loss21882294
    nsv870723CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIAA2013
    DNA2.0 Custom Variant and Variant Library Synthesis for KIAA2013

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for KIAA2013:    
    About MalaCards
    malaria


    KIAA2013 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KIAA2013

    Export disorders for KIAA2013 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIAA2013 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KIAA2013)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    10. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90231 HGNC: 28513 AceView: MGC33867 Ensembl:ENSG00000116685 euGenes: HUgn90231
    ECgene: KIAA2013 H-InvDB: KIAA2013

    (According to HUGE)
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    HUGE: KIAA2013

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIAA2013 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIAA2013 gene:
    Search GeneIP for patents involving KIAA2013

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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