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KIAA1958 Gene

protein-coding   GIFtS: 43
GCID: GC09P115249

KIAA1958

  Search for KIAA1958
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
KIAA19581 2
Uncharacterized Protein KIAA19582

External Ids:    HGNC: 234271   Entrez Gene: 1584052   Ensembl: ENSG000001651857   UniProtKB: Q8N8K93   

Export aliases for KIAA1958 gene to outside databases

Previous GC identifers: GC09P106134 GC09P106981 GC09P108706 GC09P110629 GC09P112328 GC09P114288 GC09P084933


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KIAA1958 Gene:
KIAA1958 (KIAA1958) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIAA1958 gene promoter:
         AML1a   RREB-1   Pax-6   FOXD1   HNF-3beta   C/EBPalpha   GATA-6   STAT3   SEF-1 (1)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KIAA1958

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIAA1958


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32   Ensembl cytogenetic band:  9q32   HGNC cytogenetic band: 9q33.1

KIAA1958 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA1958 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P115249:  view genomic region     (about GC identifiers)

Start:
115,249,127 bp from pter      End:
115,431,677 bp from pter
Size:
182,551 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: K1958_HUMAN, Q8N8K9 (See protein sequence)
Recommended Name: Uncharacterized protein KIAA1958  
Size: 716 amino acids; 79212 Da
Sequence caution: Sequence=BAB71114.1; Type=Erroneous initiation;
Secondary accessions: Q2M336 Q5T252 Q8TF43 Q96N02
Alternative splicing: 2 isoforms:  Q8N8K9-1   Q8N8K9-2   (Gene prediction confirmed by EST data)

Explore the universe of human proteins at neXtProt for KIAA1958: NX_Q8N8K9

Explore proteomics data for KIAA1958 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KIAA1958 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001273965.1  NP_001273967.1  NP_597722.1  

    ENSEMBL proteins: 
     ENSP00000336940   ENSP00000363362   ENSP00000440504  

    KIAA1958 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for KIAA1958 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR021893 DUF3504

    Graphical View of Domain Structure for InterPro Entry Q8N8K9

    ProtoNet protein and cluster: Q8N8K9


    Find genes that share domains with KIAA1958           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIAA1958
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    miRTarBase miRNAs that target KIAA1958:
    hsa-mir-192-5p (MIRT026952)

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    hsa-miR-539 hsa-miR-1261 hsa-miR-124 hsa-miR-649 hsa-miR-376a* hsa-miR-3662 hsa-miR-506 hsa-miR-1914
    SwitchGear 3'UTR luciferase reporter plasmidKIAA1958 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol1
    nucleus1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIAA1958
    Interactions:

        Search GeneGlobe Interaction Network for KIAA1958

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for KIAA1958 (ENSP000003369404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIAA1958 (K1958)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KIAA1958 gene (3 alternative transcripts): 
    NM_001287036.1  NM_001287038.1  NM_133465.3  

    Unigene Cluster for KIAA1958:

    KIAA1958
    Hs.656619  [show with all ESTs]
    Unigene Representative Sequence: AB075838
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337530(uc004bgf.1 uc011lwx.1) ENST00000374244 ENST00000536272

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate KIAA1958 (see all 9):
    hsa-miR-539 hsa-miR-1261 hsa-miR-124 hsa-miR-649 hsa-miR-376a* hsa-miR-3662 hsa-miR-506 hsa-miR-1914
    SwitchGear 3'UTR luciferase reporter plasmidKIAA1958 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat KIAA1958
      QuantiFast Probe-based Assays in human, mouse, rat KIAA1958

    Additional mRNA sequence: 

    AB075838.1 AK056181.1 AK096613.1 BC105048.1 BC113515.1 BC143372.1 BC143424.1 

    1 DOTS entry:

    DT.305569 

    Selected AceView cDNA sequences (see all 43):

    AK096613 AK056181 BU071130 AA894612 AB075838 CB122828 BQ636211 AI478116 
    Z39522 AI885666 BU073139 BE390381 CB852802 BF671022 AA610077 AI955749 
    AA481433 AA365277 BF196303 AA481673 AI624974 AI498819 BE546266 BG026236 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIAA1958 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCAGTGGTT
    KIAA1958 Expression
    About this image


    KIAA1958 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
             Retina
    KIAA1958 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIAA1958 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656619
        Custom PCR Arrays for KIAA1958
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1958

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KIAA1958 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia E130308A19Rik5 RIKEN cDNA E130308A19 gene   --   4 (32.73 cM) 59626211 
    chicken
    (Gallus gallus)
    Aves KIAA19586
    KIAA1958
    47(a)
    1 ↔ 1
    Z(65783774-65806806)
    lizard
    (Anolis carolinensis)
    Reptilia KIAA19586
    KIAA1958
    49(a)
    1 ↔ 1
    2(57727125-57787236)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-126i22.56
    si:ch211-126i22.5
    24(a)
    1 ↔ 1
    10(11248779-11278238) ENSDARG00000060911


    ENSEMBL Gene Tree for KIAA1958 (if available)
    TreeFam Gene Tree for KIAA1958 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIAA1958 (see all 3220)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1416376301,2
    C--115256992(+) ATCCAC/TCTGCC 1 -- int10--------
    rs1469926581,2
    C--115257038(+) CCACCA/GTATCT 1 -- int10--------
    rs1380904381,2
    --115257171(+) AGATTC/GATTTT 1 -- int10--------
    rs1852418091,2
    --115257211(+) TCTTCC/TATAGC 1 -- int10--------
    rs1899212111,2
    C--115257229(+) ATTTAA/GAAATT 1 -- int10--------
    rs1832898491,2
    --115257297(+) AGGCTC/GAAGGG 1 -- int10--------
    rs64779421,2
    C,F,A,H--115257335(+) CTAGGA/GCTGTG 1 -- int111Minor allele frequency- G:0.27NA WA CSA EA 376
    rs1437513521,2
    --115257628(+) TTTCTA/GTGATG 1 -- int10--------
    rs1505794131,2
    --115257642(+) ATGGAA/GATTGA 1 -- int10--------
    rs1383858971,2
    --115257768(+) CACTAA/GAATGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for KIAA1958 (115249127 - 115431677 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KIAA1958 (see all 30):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2738948CNV Deletion23290073
    esv2741005CNV Deletion23290073
    esv2738947CNV Deletion23290073
    esv1050816CNV Deletion17803354
    esv2663019CNV Deletion23128226
    esv1981326CNV Deletion18987734
    esv2667240CNV Deletion23128226
    esv2738949CNV Deletion23290073
    esv3305CNV Deletion18987735
    esv2333544CNV Deletion18987734

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIAA1958
    DNA2.0 Custom Variant and Variant Library Synthesis for KIAA1958

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with KIAA1958           About GenesLikeMe

    Genetic Association Database (GAD): KIAA1958
    Human Genome Epidemiology (HuGE) Navigator: KIAA1958 (1 document)

    Export disorders for KIAA1958 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIAA1958 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with KIAA1958)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    5. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    6. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (Sci Signal 2011)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    8. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (Cell 2006)
    10. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1 Beausoleil S.A.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 158405 HGNC: 23427 AceView: KIAA1958 Ensembl:ENSG00000165185 euGenes: HUgn158405
    ECgene: KIAA1958 H-InvDB: KIAA1958

    (According to HUGE)
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    HUGE: KIAA1958

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIAA1958 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIAA1958 gene:
    Search GeneIP for patents involving KIAA1958

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Custom PCR Arrays for KIAA1958 Search Chromatin IP Primers for KIAA1958
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     Search Addgene for plasmids for KIAA1958
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