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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIAA1919 Gene

protein-coding   GIFtS: 40
GCID: GC06P111581

KIAA1919
  Search for KIAA1919
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KIAA1919    

Aliases
for KIAA1919 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
KIAA19191 2
MFSD4B1 2
MGC339531
NaGLT12
Sodium-Dependent Glucose Transporter 12

External Ids:    HGNC: 210531   Entrez Gene: 917492   Ensembl: ENSG000001732147   UniProtKB: Q5TF393   

Export aliases for KIAA1919 gene to outside databases

Previous GC identifers: GC06U990288 GC06P111603 GC06P111626 GC06P111687 GC06P109151


Summaries
for KIAA1919 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NAGT1_HUMAN, Q5TF39
Function: May function as a sodium-dependent glucose transporter (By similarity)




Genomic Views
for KIAA1919 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIAA1919 gene promoter:
         TBP   STAT1   C/EBPbeta   p53   AML1a   FOXD1   Nkx5-1   ZIC2/Zic2   Zic3   LyF-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KIAA1919

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA1919


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q22

KIAA1919 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA1919 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P111581:  view genomic region     (about GC identifiers)

Start:
 111,580,482 bp from pter      End:
 111,592,370 bp from pter
Size:
 11,889 bases      Orientation:
 plus strand

Proteins
for KIAA1919 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NAGT1_HUMAN, Q5TF39 (See protein sequence)
Recommended Name: Sodium-dependent glucose transporter 1  
Size: 518 amino acids; 56218 Da
Subcellular location: Apical cell membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: A8K9M0 Q8IYB6 Q96PW9 Q9P0D6

Explore the universe of human proteins at neXtProt for KIAA1919: NX_Q5TF39

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5TF39

    • KIAA1919 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_699200.2  
    ENSEMBL proteins: 
     ENSP00000357840  

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    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--
    GO:0016324apical plasma membrane IEA--


    KIAA1919 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for KIAA1919 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KIAA1919 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q5TF39

    ProtoNet protein and cluster: Q5TF39

    UniProtKB/Swiss-Prot: NAGT1_HUMAN, Q5TF39
    Similarity: Belongs to the major facilitator superfamily


    Function
    for KIAA1919 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NAGT1_HUMAN, Q5TF39
    Function: May function as a sodium-dependent glucose transporter (By similarity)

    miRNA
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    Inhib. RNA
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015293symporter activity IEA--


    KIAA1919 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for KIAA1919:
     Increased HPV18 LCR reporter a 


    Pathways & Interactions
    for KIAA1919 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA1919

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006814sodium ion transport IEA--
    GO:0008643carbohydrate transport IEA--


    KIAA1919 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KIAA1919 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIAA1919
    Search CenterWatch for drugs/clinical trials and news about KIAA1919 / NAGT1 

    Transcripts
    for KIAA1919 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KIAA1919 gene: 
    NM_153369.2  

    Unigene Cluster for KIAA1919:

    KIAA1919
    Hs.400572  [show with all ESTs]
    Unigene Representative Sequence: AB067506
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368847(uc003puv.4)

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    hsa-miR-3163 hsa-miR-3671 hsa-miR-203 hsa-miR-3607-3p hsa-miR-373* hsa-miR-2117 hsa-miR-9* hsa-miR-654-3p
    SwitchGear 3'UTR luciferase reporter plasmid: KIAA1919 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB067506.1 AF161363.1 AK093136.1 AK292735.1 AK315016.1 BC036115.1 

    2 DOTS entries:

    DT.75188413  DT.86855388 

    24/76 AceView cDNA sequences (see all 76):

    BX399748 NM_153369 CR619381 BG697347 AK025312 CA444774 BU844971 BC036115 
    BQ011806 AI369582 CB991217 AI096577 BI562627 AL135327 CB993652 BE251956 
    AA724056 BM692476 BE048626 AX747946 CB987687 BX955738 BG620043 AB067506 

    GeneLoc Exon Structure


    Expression
    for KIAA1919 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIAA1919 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTTGGGGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KIAA1919 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyLoop of HenleLoop of Henle CellsKidney
    KidneyProximal TubuleProximal Tubule CellsKidney
    KidneyEpithelial TubuleKidney
    KidneyLoop of HenleKidney
    KidneyMetanephrosKidney
    KidneyProximal TubuleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KIAA1919 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIAA1919

    SOURCE GeneReport for Unigene cluster: Hs.400572
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    In Situ
    Assay Products:     
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    Orthologs
    for KIAA1919 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for KIAA1919 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia AI3173951 , 5 expressed sequence AI3173951, 5 77.88(n)1
    77.25(a)1    		   10 (21.43 cM)5
    2159291  NM_144821.41  NP_659070.21 
     400015755 
    chicken
    (Gallus gallus)    		 Aves KIAA19191 KIAA1919 62.66(n)
    57.88(a)    		   428623  XM_426180.2  XP_426180.2 
    lizard
    (Anolis carolinensis)    		 Reptilia KIAA19196
    		 --
    		 56(a)
    		 1 ↔ 1
    		 1(192183850-192186426)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.108322 Xenopus laevis transcribed sequences 73.66(n)    CA788089.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1621611 zgc:162161 56.32(n)
    52.2(a)    		   100037368  NM_001089520.1  NP_001082989.1 


    ENSEMBL Gene Tree for KIAA1919 (if available)
    TreeFam Gene Tree for KIAA1919 (if available) 

    Paralogs
    for KIAA1919 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIAA1919 gene
    MFSD42  

    KIAA1919 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KIAA1919
    PGOHUM00000235220


    Genomic Variants
    for KIAA1919 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/232 NCBI SNPs in KIAA1919 are shown (see all 232)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2409991,2
    		C,F,A,--111578490(-) ACAAAA/CAAAAC 1 -- us2k1 tfbs310Minor allele frequency- C:0.16MN NA WA EA 554
    rs93742581,2
    		H--111578692(+) AGAAAC/ACTGCA 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs1867726271,2
    		--111579031(+) CGAGAA/CCAGCC 1 -- us2k10--------
    rs77741771,2
    		C,A,--111579045(+) CCAACG/ATGGTG 1 -- us2k13Minor allele frequency- A:0.17NA 6
    rs1923984961,2
    		--111579163(+) CAGAGG/TTTGCA 1 -- us2k10--------
    rs1384369931,2
    		C,--111579227(+) GTCTC-/AAAT  
                AAATA     		1 -- us2k10--------
    rs1842258341,2
    		--111579288(+) CTTGGC/TGGGGC 1 -- us2k10--------
    rs2410001,2
    		C,A,H,--111579345(-) GTGATC/TCGCCT 1 -- us2k16Minor allele frequency- T:0.08NA WA CSA EA 129
    rs1883337211,2
    		--111579474(+) AAACAA/CAAAAA 1 -- us2k10--------
    rs1931618081,2
    		--111579475(+) AACAAA/CAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KIAA1919 (111580482 - 111592370 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KIAA1919: --

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    Disorders / Diseases
    for KIAA1919 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for KIAA1919 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIAA1919 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KIAA1919)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2 Nagase T....Ohara O. (2001)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    6. Cloning and characterization of a novel Na+-dependent glucose transporter (NaGLT1) in rat kidney. (PubMed id 12590146)1 Horiba N....Inui K. (2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for KIAA1919 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KIAA1919 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91749 HGNC: 21053 AceView: KIAA1919 Ensembl:ENSG00000173214 euGenes: HUgn91749
    ECgene: KIAA1919 H-InvDB: KIAA1919

    Other Databases showing KIAA1919 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1919

    Specialized Databases showing KIAA1919 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIAA1919 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KIAA1919 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KIAA1919 gene:
    Search GeneIP for patents involving KIAA1919

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for KIAA1919 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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     Browse OriGene Antibodies   OriGene shRNA RFP for KIAA1919  
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIAA1919
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     GenScript Custom Purified and Recombinant Proteins Services for KIAA1919 GenScript cDNA clones with any tag delivered in your preferred vector for KIAA1919
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     Regulatory tfbs in KIAA1919 promoter
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
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     Search for Antibodies for KIAA1919 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for KIAA1919
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     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for KIAA1919
     Gene Synthesis
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     SwitchGear 3'UTR luciferase reporter plasmids for KIAA1919
     Browse SwitchGear Promoter luciferase reporter plasmids for KIAA1919
     ThermoFisher Antibody for KIAA1919
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA1919
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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