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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIAA1875 Gene

protein-coding   GIFtS: 36
GCID: GC08P145162

KIAA1875

  Search for KIAA1875
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
KIAA18751 2

External Ids:    HGNC: 269591   Entrez Gene: 3403902   Ensembl: ENSG000001796987   UniProtKB: A6NE523   
ORGUL members:         
NONCODE14:n406668 n341638 n346546      

Export aliases for KIAA1875 gene to outside databases

Previous GC identifers: GC00U990996 GC08P144938 GC08P145268 GC08P145234 GC08P140438


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KIAA1875 Gene:
The function and protein-coding potential of this gene is unknown. The exon combination is based on AB058778.1 for
which two possible open reading frames can be predicted (with start codons at nucleotide 26 or 2614). The
position of the first ORF stop codon is consistent with a prediction of nonsense-mediated decay. Given the
observation of the first ORF and its length, a predicted translation of the second ORF is inconsistent with the
translation leaky scanning theory. Therefore, this gene is represented as a non-protein-coding transcript.
(provided by RefSeq, Oct 2008)

GeneCards Summary for KIAA1875 Gene: 
KIAA1875 (KIAA1875) is a protein-coding gene, and is affiliated with the lncRNA class.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIAA1875 gene promoter:
         NF-1   STAT1   Elk-1   COUP   STAT1beta   E47   STAT1alpha   Max   COUP-TF   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KIAA1875

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA1875


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

KIAA1875 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA1875 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P145162:  view genomic region     (about GC identifiers)

Start:
145,162,629 bp from pter      End:
145,173,218 bp from pter
Size:
10,590 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for KIAA1875

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K1875_HUMAN, A6NE52 (See protein sequence)
Recommended Name: WD repeat-containing protein KIAA1875  
Size: 1622 amino acids; 180307 Da
Sequence caution: Sequence=BAB47504.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: Q96JF2
Alternative splicing: 2 isoforms:  A6NE52-1   A6NE52-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KIAA1875: NX_A6NE52

Explore proteomics data for KIAA1875 at MOPED 

KIAA1875 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

KIAA1875 Protein Expression

ENSEMBL proteins: 
 ENSP00000435391   ENSP00000320648  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
WDR: WD repeat domain containing

4 InterPro protein domains:
 IPR019775 WD40_repeat_CS
 IPR001680 WD40_repeat
 IPR017986 WD40_repeat_dom
 IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry A6NE52

ProtoNet protein and cluster: A6NE52

UniProtKB/Swiss-Prot: K1875_HUMAN, A6NE52
Similarity: Contains 6 WD repeats


KIAA1875 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
KIAA1875 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for KIAA1875:
 Synthetic lethal with Ras 

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA1875

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for KIAA1875 (A6NE523 ENSP000003206484) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
FBXW7Q969H03, ENSP000002817084I2D: score=2 STRING: ENSP00000281708
FBXO30ENSP000002372814STRING: ENSP00000237281
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KIAA1875 (K1875)

Search CenterWatch for drugs/clinical trials and news about KIAA1875 / K1875

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KIAA1875 gene: 
NM_032529.1  

Unigene Cluster for KIAA1875:

KIAA1875
Hs.98723  [show with all ESTs]
Unigene Representative Sequence: AB058778
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000534167(uc011lky.1 uc003zbd.3) ENST00000323662(uc011lkz.1)
ENST00000525150 ENST00000533108 ENST00000528691 ENST00000529209
miRNA
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Additional mRNA sequence: 

AB058778.1 AK302485.1 NR_024207.1 

5 DOTS entries:

DT.95362899  DT.101979801  DT.97794176  DT.75189170  DT.452756 

9 AceView cDNA sequences:

AL044846 AI567202 AL137446 AK124611 AK095597 AB058778 AA860909 AA431662 
AA431309 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KIAA1875 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACTTACAATC
KIAA1875 Expression
About this image


See KIAA1875 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIAA1875

SOURCE GeneReport for Unigene cluster: Hs.98723
    SABiosciences Custom PCR Arrays for KIAA1875
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1875 gene from 2/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia 155 predicted gene 6661   --   N/A -
lizard
(Anolis carolinensis)
Reptilia KIAA18756
Uncharacterized protein
35(a)
1 ↔ 1
GL344432.1(9445-28346)


ENSEMBL Gene Tree for KIAA1875 (if available)
TreeFam Gene Tree for KIAA1875 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for KIAA1875 gene
2 SIMAP similar genes for KIAA1875 using alignment to 2 protein entries:     K1875_HUMAN (see all proteins):
DKFZp434F0427    POC1B

KIAA1875 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/207 SNPs in KIAA1875 are shown (see all 207)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs49771961,2,4
C,F,A,H--145163414(-) AAGCCC/GGACAG 1 -- nc-transcript-variantese313Minor allele frequency- G:0.14NS EA NA WA CSA 788
rs766623471,2
C,F--145163428(+) GGGCTG/AGTGAC 1 -- nc-transcript-variant2Minor allele frequency- A:0.10CSA WA 120
rs125475901,2
H--145163595(+) CCTCAC/GGCTGC 1 -- nc-transcript-variantese30--------
rs726954341,2
C--145163621(+) TGAACA/GGCAGC 1 -- nc-transcript-variant1Minor allele frequency- G:0.01NA 120
rs49771951,2
C,A--145163647(-) CCTGAG/ACGGAA 1 -- nc-transcript-variant10Minor allele frequency- A:0.14NA CSA WA EA 370
rs1878985991,2
--145163809(+) CATGCC/TTGGAC 1 -- nc-transcript-variant0--------
rs1919860291,2
--145163892(+) GCACAC/GGGCCC 1 -- int10--------
rs1512256511,2
--145163919(+) GTTAAA/GTCCAT 1 -- int10--------
rs1410924481,2
--145163977(+) ACTGCA/GAGGAA 1 -- nc-transcript-variant0--------
rs1852299411,2
--145163994(+) GCAATG/TGTGAC 1 -- nc-transcript-variant0--------

HapMap Linkage Disequilibrium report for KIAA1875 (145162629 - 145173218 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/23 variations for KIAA1875 (see all 23):    About this table     
Variant IDTypeSubtypePubMed ID
nsv6448CNV Insertion18451855
nsv891809CNV Loss21882294
dgv7949n71CNV Loss21882294
dgv7950n71CNV Loss21882294
dgv906n27CNV Loss19166990
nsv891812CNV Loss21882294
dgv7955n71CNV Loss21882294
nsv891807CNV Loss21882294
dgv7954n71CNV Loss21882294
esv29971CNV Loss17803354

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for KIAA1875 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KIAA1875)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2, 3 Nagase T.... Ohara O. (2001)
  2. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
  3. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 340390 HGNC: 26959 AceView: KIAA1875 Ensembl:ENSG00000179698 euGenes: HUgn340390
ECgene: KIAA1875 H-InvDB: KIAA1875

(According to HUGE)
About This Section
HUGE: KIAA1875

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for KIAA1875 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for KIAA1875 gene:
Search GeneIP for patents involving KIAA1875

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Search for Antibodies for KIAA1875 at Abcam
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 Browse Proteins at Cloud-Clone Corp.
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 Browse SwitchGear 3'UTR luciferase reporter plasmids for KIAA1875
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 inGenious Targeting Laboratory - Custom generated mouse model solutions for KIAA1875
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KIAA1875
Customized:
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category
(GIFtS: 73)
transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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