KIAA1875 Gene
protein-coding GIFtS: 36
GCID: GC08P145162
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KIAA1875
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Aliases
for KIAA1875 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| External Ids: | HGNC: 269591 | Entrez Gene: 3403902 | Ensembl: ENSG000001796987 | UniProtKB: A6NE523 | | ORGUL members: | |
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| NONCODE:n406668 n346546 | |
Export aliases for KIAA1875 gene to outside databasesPrevious GC identifers: GC00U990996 GC08P144938 GC08P145268 GC08P145234 GC08P140438
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Summaries
for KIAA1875 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KIAA1875:
The function and protein-coding potential of this gene is unknown. The exon combination is based on AB058778.1 forwhich two possible open reading frames can be predicted (with start codons at nucleotide 26 or 2614). The position ofthe first ORF stop codon is consistent with a prediction of nonsense-mediated decay. Given the observation of thefirst ORF and its length, a predicted translation of the second ORF is inconsistent with the translation leakyscanning theory. Therefore, this gene is represented as a non-protein-coding transcript. (provided by RefSeq, Oct2008)
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Genomic Views
for KIAA1875 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KIAA1875 gene promoter:
NF-1 STAT1 Elk-1 COUP STAT1beta E47 STAT1alpha Max COUP-TF c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIAA1875
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA1875 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3KIAA1875 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P145162: view genomic region
(about GC identifiers)
Start:
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145,162,629 bp from pter |
End:
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145,173,218 bp from pter |
Size:
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10,590 bases |
Orientation:
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plus strand |
ORGUL member locations:
Legend (see complete legend)
145162628 145167923 145173218 chr8
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Proteins
for KIAA1875 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: K1875_HUMAN, A6NE52 (See
protein sequence)Recommended Name: WD repeat-containing protein KIAA1875 Size: 1622 amino acids; 180307 Da
Sequence caution: Sequence=BAB47504.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: Q96JF2Alternative splicing: 2 isoforms: A6NE52-1 A6NE52-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KIAA1875: NX_A6NE52
KIAA1875 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000435391 ENSP00000320648 ENSP00000436966
Human Recombinant Protein Products:
KIAA1875 Antibody Products:
Assay Products for KIAA1875: |
Protein
Domains /
Families
for KIAA1875 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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KIAA1875 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NE52ProtoNet protein and cluster: A6NE52 UniProtKB/Swiss-Prot: K1875_HUMAN, A6NE52Similarity: Contains 6 WD repeats |
Function
for KIAA1875 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1875 |
1 GenomeRNAi human phenotype for KIAA1875:
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Pathways & Interactions
for KIAA1875 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA1875
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for KIAA1875 (A6NE523 ENSP000003206484) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for KIAA1875 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KIAA1875
Search CenterWatch for drugs/clinical trials and news about KIAA1875 / K1875 
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Transcripts
for KIAA1875 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for KIAA1875 gene: NM_032529.1 Unigene Cluster for KIAA1875: KIAA1875 Hs.98723 [show with all ESTs]Unigene Representative Sequence: AB0587786 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000534167(uc011lky.1 uc003zbd.3) ENST00000323662(uc011lkz.1)
ENST00000525150 ENST00000533108 ENST00000528691 ENST00000529209
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIAA1875
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat KIAA1875 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA1875 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA1875 |
Additional cDNA sequence: AB058778.1 AK302485.1 NR_024207.1 5 DOTS entries: DT.95362899 DT.101979801 DT.97794176 DT.75189170 DT.452756 9 AceView cDNA sequences: AI567202 AL044846 AK095597 AK124611 AL137446 AB058778 AA860909 AA431662 AA431309
GeneLoc Exon Structure
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Expression
for KIAA1875 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIAA1875 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTACAATC
About this image
See KIAA1875 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIAA1875
SOURCE GeneReport for Unigene cluster: Hs.98723
SABiosciences Custom PCR Arrays for KIAA1875
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIAA1875
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat KIAA1875 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA1875 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA1875 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1875 |
Orthologs
for KIAA1875 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for KIAA1875 gene from 2/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
155 |
predicted gene 6661 |
-- |
|
N/A - |
lizard
(Anolis carolinensis) |
Reptilia |
KIAA18756 |
-- |
36(a) |
1 ↔ 1 |
GL344432.1(9445-28346) |
ENSEMBL Gene Tree for KIAA1875 (if available)
TreeFam Gene Tree for KIAA1875 (if available) |
Paralogs
for KIAA1875 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for KIAA1875 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for KIAA1875 (145162629 - 145173218 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for KIAA1875
6 CNVs: 23290 30304 53614 30305 3751 30306 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIAA1875 |
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Disorders
/ Diseases
for KIAA1875 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for KIAA1875 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIAA1875 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KIAA1875) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2, 3 Nagase T.... Ohara O. (2001)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
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External Searches for KIAA1875 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing KIAA1875 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing KIAA1875 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KIAA1875 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KIAA1875 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for KIAA1875 gene:
Search GeneIP for patents involving KIAA1875
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIAA1875 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIAA1875 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIAA1875 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA1875 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIAA1875 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA1875 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA1875 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1875 |
|  |  |  | | | | Search ThermoFisher Antibodies for KIAA1875 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KIAA1875 |
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Last full update: 18 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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