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Aliases for KIAA1841 Gene

Aliases for KIAA1841 Gene

  • KIAA1841 2 3

External Ids for KIAA1841 Gene

Previous GeneCards Identifiers for KIAA1841 Gene

  • GC02P061432
  • GC02P061250
  • GC02P061267
  • GC02P061205
  • GC02P061293

Summaries for KIAA1841 Gene

GeneCards Summary for KIAA1841 Gene

KIAA1841 (KIAA1841) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1841 Gene

Genomics for KIAA1841 Gene

Regulatory Elements for KIAA1841 Gene

Enhancers for KIAA1841 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F060514 1.2 FANTOM5 Ensembl ENCODE 12.5 -549.6 -549554 3.1 CTCF TBL1XR1 WRNIP1 EBF1 RELA ZNF157 PATZ1 EED PRDM10 ETV6 KIAA1841 REL GC02P060512 GC02P060545
GH02F061126 0.3 FANTOM5 11.4 +60.9 60908 0.0 ZBTB33 TRIM24 ZNF558 TRIM28 KIAA1841 RNU6-1145P ENSG00000274769 LOC105374759
GH02F060837 1.1 FANTOM5 ENCODE 11.4 -226.0 -226030 4.3 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF48 ZNF121 GLIS2 KLF13 PAPOLG REL LINC01185 KIAA1841 AHSA2 PUS10 ENSG00000232713 C2orf74 PEX13 RN7SL632P
GH02F061165 0.7 ENCODE 10.8 +100.3 100257 0.6 CTCF ATF1 TEAD2 DPF2 ARID1B IKZF1 HMBOX1 ZNF24 AHSA2 KIAA1841 LOC105374758
GH02F060836 1.1 Ensembl 10.1 -229.0 -228970 0.6 TBL1XR1 MTA2 CEBPB EBF1 TBX21 EP300 RELA ATF3 IKZF1 REL LINC01185 PAPOLG KIAA1841 RN7SL632P RPL21P33
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KIAA1841 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA1841 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000122475 330 2401 ARID4B SIN3A DMAP1 GLIS2 FOS KLF13 ZNF263 ZNF202 SP3 NFYC

Genomic Location for KIAA1841 Gene

Chromosome:
2
Start:
61,065,870 bp from pter
End:
61,157,942 bp from pter
Size:
92,073 bases
Orientation:
Plus strand

Genomic View for KIAA1841 Gene

Genes around KIAA1841 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1841 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1841 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1841 Gene

Proteins for KIAA1841 Gene

  • Protein details for KIAA1841 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NSI8-K1841_HUMAN
    Recommended name:
    Uncharacterized protein KIAA1841
    Protein Accession:
    Q6NSI8
    Secondary Accessions:
    • Q49AF0
    • Q6ZND0
    • Q96JI6

    Protein attributes for KIAA1841 Gene

    Size:
    718 amino acids
    Molecular mass:
    82007 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47470.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1841 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1841 Gene

Post-translational modifications for KIAA1841 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIAA1841 Gene

Domains & Families for KIAA1841 Gene

Protein Domains for KIAA1841 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6NSI8

UniProtKB/Swiss-Prot:

K1841_HUMAN :
  • Belongs to the KIAA1841 family.
Family:
  • Belongs to the KIAA1841 family.
genes like me logo Genes that share domains with KIAA1841: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for KIAA1841 Gene

Function for KIAA1841 Gene

Phenotypes for KIAA1841 Gene

GenomeRNAi human phenotypes for KIAA1841:
genes like me logo Genes that share phenotypes with KIAA1841: view

Animal Model Products

miRNA for KIAA1841 Gene

miRTarBase miRNAs that target KIAA1841

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1841 Gene

Localization for KIAA1841 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA1841 Gene COMPARTMENTS Subcellular localization image for KIAA1841 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA1841 Gene

Pathways & Interactions for KIAA1841 Gene

SuperPathways for KIAA1841 Gene

No Data Available

Interacting Proteins for KIAA1841 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000349154%0d%0a9606.ENSP00000362931%0d%0a
Selected Interacting proteins: ENSP00000349154 Q6NSI8-K1841_HUMAN for KIAA1841 Gene via STRING IID

Gene Ontology (GO) - Biological Process for KIAA1841 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA1841 Gene

Transcripts for KIAA1841 Gene

Unigene Clusters for KIAA1841 Gene

KIAA1841:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1841 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4:
SP5:
SP6:
SP7:

ExUns: 23b ^ 24 ^ 25
SP1: -
SP2: - -
SP3: -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for KIAA1841 Gene

GeneLoc Exon Structure for
KIAA1841
ECgene alternative splicing isoforms for
KIAA1841

Expression for KIAA1841 Gene

mRNA expression in normal human tissues for KIAA1841 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIAA1841 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KIAA1841 Gene



Protein tissue co-expression partners for KIAA1841 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KIAA1841 Gene:

KIAA1841

SOURCE GeneReport for Unigene cluster for KIAA1841 Gene:

Hs.468653
genes like me logo Genes that share expression patterns with KIAA1841: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIAA1841 Gene

Orthologs for KIAA1841 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA1841 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1841 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia KIAA1841 34 35
  • 92.15 (n)
mouse
(Mus musculus)
Mammalia 0610010F05Rik 34 16 35
  • 88.21 (n)
rat
(Rattus norvegicus)
Mammalia RGD1305110 34
  • 87.19 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1841 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1841 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1841 34 35
  • 77.11 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA1841 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1841 34
  • 70.35 (n)
Str.19410 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.34417 34
zebrafish
(Danio rerio)
Actinopterygii LOC793832 34
  • 62.82 (n)
si:ch211-189k9.2 35
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6761 36 35
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToOne
Species where no ortholog for KIAA1841 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1841 Gene

ENSEMBL:
Gene Tree for KIAA1841 (if available)
TreeFam:
Gene Tree for KIAA1841 (if available)

Paralogs for KIAA1841 Gene

No data available for Paralogs for KIAA1841 Gene

Variants for KIAA1841 Gene

Sequence variations from dbSNP and Humsavar for KIAA1841 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10168258 -- 61,109,685(+) tgttt(G/T)ttttt intron-variant, downstream-variant-500B
rs10169031 -- 61,113,518(+) ttgta(G/T)tttca intron-variant
rs10171258 -- 61,149,574(+) CCttt(C/T)ttttt intron-variant
rs10172306 -- 61,077,242(+) TGGAA(A/T)ATTGT intron-variant
rs10174244 -- 61,150,064(+) TCGCC(A/G)AATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1841 Gene

Variant ID Type Subtype PubMed ID
esv2760616 CNV loss 21179565
nsv1116381 CNV deletion 24896259
nsv1131468 CNV deletion 24896259

Variation tolerance for KIAA1841 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1841 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1841

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1841 Gene

Disorders for KIAA1841 Gene

Relevant External Links for KIAA1841

Genetic Association Database (GAD)
KIAA1841
Human Genome Epidemiology (HuGE) Navigator
KIAA1841
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1841

No disorders were found for KIAA1841 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1841 Gene

Publications for KIAA1841 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  3. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3 64
  4. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny E.E. … Peter I. (PLoS Genet. 2012) 3 64
  5. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3 64

Products for KIAA1841 Gene

Sources for KIAA1841 Gene

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