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Aliases for KIAA1804 Gene

Aliases for KIAA1804 Gene

  • Mixed Lineage Kinase 4 3 4
  • EC 2.7.11.25 4 63
  • MLK4 3 4
  • Mitogen-Activated Protein Kinase Kinase Kinase MLK4 5
  • RP5-862P8.2 5
  • DJ862P8.3 3
  • EC 2.7.11 63

External Ids for KIAA1804 Gene

Previous GeneCards Identifiers for KIAA1804 Gene

  • GC01P231725
  • GC01P229023
  • GC01P229791
  • GC01P230547
  • GC01P229770
  • GC01P231530
  • GC01P233463
  • GC01P203953

Summaries for KIAA1804 Gene

GeneCards Summary for KIAA1804 Gene

KIAA1804 (Mixed Lineage Kinase 4) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is KSR1.

UniProtKB/Swiss-Prot for KIAA1804 Gene

  • Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1804 Gene

Genomics for KIAA1804 Gene

Regulatory Elements for KIAA1804 Gene

Enhancers for KIAA1804 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KIAA1804 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA1804 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIAA1804 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIAA1804 Gene

Chromosome:
1
Start:
233,327,743 bp from pter
End:
233,385,148 bp from pter
Size:
57,406 bases
Orientation:
Plus strand

Genomic View for KIAA1804 Gene

Genes around KIAA1804 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1804 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1804 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1804 Gene

Proteins for KIAA1804 Gene

  • Protein details for KIAA1804 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TCX8-M3KL4_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase MLK4
    Protein Accession:
    Q5TCX8
    Secondary Accessions:
    • B2RN34
    • Q5TCX7
    • Q5TCX9
    • Q8WWN1
    • Q8WWN2
    • Q96JM1

    Protein attributes for KIAA1804 Gene

    Size:
    1036 amino acids
    Molecular mass:
    113957 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer (By similarity). Interacts with TLR4.
    SequenceCaution:
    • Sequence=BAB47433.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KIAA1804 Gene

    Alternative splice isoforms for KIAA1804 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1804 Gene

Proteomics data for KIAA1804 Gene at MOPED

Selected DME Specific Peptides for KIAA1804 Gene

Post-translational modifications for KIAA1804 Gene

  • Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIAA1804 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for KIAA1804 (MLK4 alpha)

Domains & Families for KIAA1804 Gene

Suggested Antigen Peptide Sequences for KIAA1804 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TCX8

UniProtKB/Swiss-Prot:

M3KL4_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with KIAA1804: view

No data available for Gene Families for KIAA1804 Gene

Function for KIAA1804 Gene

Molecular function for KIAA1804 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.
UniProtKB/Swiss-Prot Function:
Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.

Enzyme Numbers (IUBMB) for KIAA1804 Gene

Gene Ontology (GO) - Molecular Function for KIAA1804 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004709 MAP kinase kinase kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with KIAA1804: view
genes like me logo Genes that share phenotypes with KIAA1804: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1804 Gene

Localization for KIAA1804 Gene

Gene Ontology (GO) - Cellular Components for KIAA1804 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with KIAA1804: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for KIAA1804 Gene

Pathways & Interactions for KIAA1804 Gene

SuperPathways for KIAA1804 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA1804 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0046777 protein autophosphorylation ISS --
genes like me logo Genes that share ontologies with KIAA1804: view

No data available for Pathways by source and SIGNOR curated interactions for KIAA1804 Gene

Drugs & Compounds for KIAA1804 Gene

(1) Drugs for KIAA1804 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0
genes like me logo Genes that share compounds with KIAA1804: view

Transcripts for KIAA1804 Gene

mRNA/cDNA for KIAA1804 Gene

Unigene Clusters for KIAA1804 Gene

Mixed lineage kinase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1804 Gene

No ASD Table

Relevant External Links for KIAA1804 Gene

GeneLoc Exon Structure for
KIAA1804

Expression for KIAA1804 Gene

mRNA expression in normal human tissues for KIAA1804 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIAA1804 Gene

This gene is overexpressed in Pancreas (x7.2) and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for KIAA1804 Gene

This gene is overexpressed in Testis (25.0), Platelet (22.1), and Pancreatic juice (21.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIAA1804 Gene



SOURCE GeneReport for Unigene cluster for KIAA1804 Gene Hs.547779

genes like me logo Genes that share expression patterns with KIAA1804: view

Protein tissue co-expression partners for KIAA1804 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KIAA1804 Gene

Orthologs for KIAA1804 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA1804 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC616014 35
  • 82.92 (n)
  • 81.37 (a)
-- 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA1804 35
  • 83.32 (n)
  • 80.36 (a)
-- 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC021891 35
  • 73.98 (n)
  • 71.33 (a)
BC021891 16
BC021891 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC469711 35
  • 99 (n)
  • 98.65 (a)
-- 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1306091 35
  • 73.75 (n)
  • 72.79 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC428586 35
  • 71.43 (n)
  • 69.88 (a)
-- 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-120p12.3 35
  • 63.99 (n)
  • 64.21 (a)
si:ch211-120p12.3 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta slpr 37
  • 49 (a)
slpr 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K11D12.10b 37
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8999 36
  • 34 (a)
OneToMany
Species with no ortholog for KIAA1804:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KIAA1804 Gene

ENSEMBL:
Gene Tree for KIAA1804 (if available)
TreeFam:
Gene Tree for KIAA1804 (if available)

Paralogs for KIAA1804 Gene

Paralogs for KIAA1804 Gene

genes like me logo Genes that share paralogs with KIAA1804: view

Variants for KIAA1804 Gene

Sequence variations from dbSNP and Humsavar for KIAA1804 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs962786 -- 233,353,308(-) TGTTT(A/C)TCTTC intron-variant
rs962787 -- 233,352,996(-) TACCA(C/T)ATCCA intron-variant
rs963981 -- 233,379,356(-) CCCAC(A/C/T)GGTGG reference, missense
rs963982 -- 233,379,325(-) CTGGC(A/G)CTTCT reference, synonymous-codon
rs926005 -- 233,347,542(-) tgtag(A/T)attcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1804 Gene

Variant ID Type Subtype PubMed ID
esv22442 CNV Gain 19812545
esv2431778 CNV Insertion 19546169
esv273887 CNV Insertion 20981092
esv269665 CNV Insertion 20981092

Variation tolerance for KIAA1804 Gene

Residual Variation Intolerance Score: 87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.70; 93.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1804 Gene

HapMap Linkage Disequilibrium report
KIAA1804

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1804 Gene

Disorders for KIAA1804 Gene

Relevant External Links for KIAA1804

Genetic Association Database (GAD)
KIAA1804
Human Genome Epidemiology (HuGE) Navigator
KIAA1804

No disorders were found for KIAA1804 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1804 Gene

Publications for KIAA1804 Gene

  1. MLK4 has negative effect on TLR4 signaling. (PMID: 21602844) Seit-Nebi A. … Han J. (Cell. Mol. Immunol. 2012) 3 4 67
  2. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Mixed lineage kinase MLK4 is activated in colorectal cancers where it synergistically cooperates with activated RAS signaling in driving tumorigenesis. (PMID: 23319808) Martini M. … Bardelli A. (Cancer Res. 2013) 3
  5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3

Products for KIAA1804 Gene

Sources for KIAA1804 Gene

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