KIAA1804 Gene
protein-coding GIFtS: 41
GCID: GC01P233463
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KIAA1804
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Aliases
for KIAA1804 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mixed Lineage Kinase 42 3 | | DJ862P8.31 | | EC 2.7.11.253 8 | | Mitogen-Activated Protein Kinase Kinase Kinase MLK42 | | MLK42 | | EC 2.7.118 | | RP5-862P8.22 | | |
Export aliases for KIAA1804 gene to outside databasesPrevious GC identifers: GC01P231725 GC01P229023 GC01P229791 GC01P230547 GC01P229770 GC01P231530 GC01P203953 |
Summaries
for KIAA1804 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: M3KL4_HUMAN, Q5TCX8Function: Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1pathways
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Genomic Views
for KIAA1804 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KIAA1804 gene promoter:
AhR ER-alpha Tal-1 Lmo2 AP-4 NF-E2 p45 E47 Max NF-E2
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIAA1804
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA1804 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q42 Ensembl cytogenetic band: 1q42.2 KIAA1804 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P233463: view genomic region
(about GC identifiers)
Start:
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233,463,514 bp from pter |
End:
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233,520,894 bp from pter |
Size:
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57,381 bases |
Orientation:
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plus strand |
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Proteins
for KIAA1804 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: M3KL4_HUMAN, Q5TCX8 (See
protein sequence)Recommended Name: Mitogen-activated protein kinase kinase kinase MLK4 Size: 1036 amino acids; 113957 Da
Cofactor: Magnesium (By similarity)
Subunit: Homodimer (By similarity). Interacts with TLR4
Sequence caution: Sequence=BAB47433.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RN34 Q5TCX7 Q5TCX9 Q8WWN1 Q8WWN2 Q96JM1Alternative splicing: 3 isoforms: Q5TCX8-1 Q5TCX8-2 Q5TCX8-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KIAA1804: NX_Q5TCX8
Post-translational modifications:
Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation (Bysimilarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5TCX8
4/8 DME Specific Peptides for KIAA1804 (Q5TCX8) (see all 8)
KIAA1804 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115811.2
ENSEMBL proteins: ENSP00000355582 ENSP00000355583 ENSP00000355581
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
KIAA1804 for ontologies About GeneDecksing
KIAA1804 Antibody Products:
Assay Products for KIAA1804: |
Protein
Domains /
Families
for KIAA1804 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KIAA1804 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry Q5TCX8ProtoNet protein and cluster: Q5TCX8 UniProtKB/Swiss-Prot: M3KL4_HUMAN, Q5TCX8Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinasesubfamilySimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 SH3 domain |
Function
for KIAA1804 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: M3KL4_HUMAN, Q5TCX8Function: Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1pathwaysCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequentactivation (By similarity)Enzyme Numbers (IUBMB): EC 2.7.11.251 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1804 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1804
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KIAA1804 (NM_032435) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIAA1804 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA1804 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1804 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004709 | MAP kinase kinase kinase activity |
IEA | -- | | GO:0004713 | protein tyrosine kinase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- | | GO:0042803 | protein homodimerization activity |
ISS | -- |
KIAA1804 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for KIAA1804:
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Pathways & Interactions
for KIAA1804 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA1804
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for KIAA1804 (Q5TCX83 ENSP000003555834) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006468 | protein phosphorylation |
ISS | -- | | GO:0007257 | activation of JUN kinase activity |
ISS | -- | | GO:0046777 | protein autophosphorylation |
ISS | -- |
KIAA1804 for ontologies About GeneDecksing
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Drugs & Compounds
for KIAA1804 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KIAA1804
Search CenterWatch for drugs/clinical trials and news about KIAA1804 / M3KL4
|
Transcripts
for KIAA1804 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KIAA1804 gene: NM_032435.2 Unigene Cluster for KIAA1804: Mixed lineage kinase 4 Hs.547779 [show with all ESTs]Unigene Representative Sequence: NM_0324353 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000366623(uc001hvs.1) ENST00000366624(uc001hvt.4) ENST00000366622(uc001hvu.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1804 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1804
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KIAA1804 (NM_032435) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIAA1804 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA1804 |
Additional cDNA sequence: AB058707.1 AJ311797.1 AJ311798.1 AK309811.1 BC136648.1 BC136649.1 3 DOTS entries: DT.408499 DT.100747405 DT.97838553 24/55 AceView cDNA sequences (see all 55): AW296283 BU679677 AL710353 BX281297 AL135712 BE464090 AI522215 AI807109 AA458908 AW241505 BI963872 BI964128 BQ271916 W38497 BQ776546 AJ311797 BF434222 BF223096 AI671270 BU162152 AB058707 N80207 AW473218 AA961822
GeneLoc Exon Structure
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Expression
for KIAA1804 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIAA1804 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See KIAA1804 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIAA1804
SOURCE GeneReport for Unigene cluster: Hs.547779
SABiosciences Custom PCR Arrays for KIAA1804
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIAA1804
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIAA1804 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA1804 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA1804 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1804 |
Orthologs
for KIAA1804 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KIAA1804 gene from 6/22 species (see all 22) About this table
ENSEMBL Gene Tree for KIAA1804 (if available)
TreeFam Gene Tree for KIAA1804 (if available) |
Paralogs
for KIAA1804 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KIAA1804 gene
- MAP3K112 MAP3K122 RAF12 KSR22 KSR12 MOS2 BRAF2 MAP3K102
- MAP3K92 ARAF2 MAP3K72 MAP3K7CL2 TNNI3K2 ZAK2 MAP3K132 ILK2
KIAA1804 for paralogs About GeneDecksing
|
Genomic Variants
for KIAA1804 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KIAA1804 (233463514 - 233520894 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for KIAA1804
2 Indels: 66131 97672 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIAA1804 |
|
Disorders
/ Diseases
for KIAA1804 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 KIAA1804 for disorders About MalaCards
KIAA1804 for disorders About GeneDecksing
OMIM gene information: 614793
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: KIAA1804 (1 document)
Export disorders for KIAA1804 gene to outside databases
|
Publications
for KIAA1804 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIAA1804 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with KIAA1804) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MLK4 has negative effect on TLR4 signaling. (PubMed id 21602844)1, 2 Seit-Nebi A....Han J. (2012)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
- Genome-wide meta-analysis for severe diabetic retinop athy. (PubMed id 21441570)1 Grassi M.A....Nicolae D.L. (2011)
- A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
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External Searches for KIAA1804 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KIAA1804 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KIAA1804 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KIAA1804 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for KIAA1804 gene:
Search GeneIP for patents involving KIAA1804
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIAA1804 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KIAA1804 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KIAA1804 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIAA1804 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KIAA1804 | | OriGene 3'-UTR Clone for KIAA1804 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1804 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1804 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIAA1804 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIAA1804 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA1804 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIAA1804 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA1804 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA1804 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1804 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA1804 |
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