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KIAA1804 Gene

protein-coding   GIFtS: 45
GCID: GC01P233463

Mixed Lineage Kinase 4


  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mixed Lineage Kinase 42 3
EC 2.7.11.253 8
MLK42 5
dJ862P8.32
Mitogen-Activated Protein Kinase Kinase Kinase MLK42
EC 2.7.118

External Ids:    Entrez Gene: 844512   Ensembl: ENSG000001436747   OMIM: 6147935   UniProtKB: Q5TCX83   

Export aliases for KIAA1804 gene to outside databases

Previous GC identifers: GC01P231725 GC01P229023 GC01P229791 GC01P230547 GC01P229770 GC01P231530 GC01P203953


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KIAA1804 Gene:
KIAA1804 is a protein-coding gene. Diseases associated with KIAA1804 include diabetic retinopathy, and periodontitis. GO annotations related to this gene include MAP kinase kinase kinase activity and protein homodimerization activity. An important paralog of this gene is FPGT-TNNI3K.

UniProtKB/Swiss-Prot: M3KL4_HUMAN, Q5TCX8
Function: Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1
pathways




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIAA1804 gene promoter:
         AhR   ER-alpha   Tal-1   Lmo2   AP-4   NF-E2 p45   E47   Max   NF-E2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KIAA1804

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIAA1804


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42   Ensembl cytogenetic band:  1q42.2   

KIAA1804 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA1804 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P233463:  view genomic region     (about GC identifiers)

Start:
233,463,514 bp from pter      End:
233,520,894 bp from pter
Size:
57,381 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: M3KL4_HUMAN, Q5TCX8 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase MLK4  
Size: 1036 amino acids; 113957 Da
Cofactor: Magnesium (By similarity)
Subunit: Homodimer (By similarity). Interacts with TLR4
Sequence caution: Sequence=BAB47433.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RN34 Q5TCX7 Q5TCX9 Q8WWN1 Q8WWN2 Q96JM1
Alternative splicing: 3 isoforms:  Q5TCX8-1   Q5TCX8-2   Q5TCX8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KIAA1804: NX_Q5TCX8

Explore proteomics data for KIAA1804 at MOPED

Post-translational modifications: 

  • Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation
    (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for KIAA1804 (Q5TCX8) (see all 8)
     SGDEGWW  ILHRDLK  WMAPEVI  EARLFAML 


    See KIAA1804 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115811.2  
    ENSEMBL proteins: 
     ENSP00000355582   ENSP00000355583   ENSP00000355581  

    KIAA1804 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

    KIAA1804 Antibody Products:

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    KIAA1804 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR016231 MAPKKK9/10/11
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q5TCX8

    ProtoNet protein and cluster: Q5TCX8

    UniProtKB/Swiss-Prot: M3KL4_HUMAN, Q5TCX8
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH3 domain


    KIAA1804 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M3KL4_HUMAN, Q5TCX8
    Function: Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1
    pathways
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Homodimerization via the leucine zipper domains is required for autophosphorylation and
    subsequent activation (By similarity)

         Enzyme Numbers (IUBMB): EC 2.7.11.251 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004709MAP kinase kinase kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
         
    KIAA1804 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for KIAA1804:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased G1 DNA content  Increased cell death in HCC-19 
     Increased colony dispersion (i 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIAA1804
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    miRNA
    Products:
        
    miRTarBase miRNAs that target KIAA1804:
    hsa-mir-196a-5p (MIRT026093), hsa-mir-124-3p (MIRT022351), hsa-mir-186-5p (MIRT021158)

    Block miRNA regulation of human, mouse, rat KIAA1804 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KIAA1804 (see all 47):
    hsa-miR-411* hsa-miR-379* hsa-miR-15a hsa-miR-30d hsa-miR-570 hsa-miR-10b* hsa-miR-374c hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidKIAA1804 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KIAA1804

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: KIAA1804 (NM_032435)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA1804

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1804


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    KIAA1804 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIAA1804
    Interactions:

        Search GeneGlobe Interaction Network for KIAA1804

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for KIAA1804 (Q5TCX83 ENSP000003555834) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K10Q027793, ENSP000002530554I2D: score=3 STRING: ENSP00000253055
    YWHABP319463, ENSP000003001614I2D: score=1 STRING: ENSP00000300161
    DUSP10ENSP000003558664STRING: ENSP00000355866
    JUNENSP000003602664STRING: ENSP00000360266
    JUNDENSP000002528184STRING: ENSP00000252818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ISS--
    GO:0007257activation of JUN kinase activity ISS--
    GO:0046777protein autophosphorylation ISS--

    KIAA1804 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIAA1804 (M3KL4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KIAA1804 gene: 
    NM_032435.2  

    Unigene Cluster for KIAA1804:

    Mixed lineage kinase 4
    Hs.547779  [show with all ESTs]
    Unigene Representative Sequence: NM_032435
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366623(uc001hvs.1) ENST00000366624(uc001hvt.4) ENST00000366622(uc001hvu.4)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate KIAA1804 (see all 47):
    hsa-miR-411* hsa-miR-379* hsa-miR-15a hsa-miR-30d hsa-miR-570 hsa-miR-10b* hsa-miR-374c hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidKIAA1804 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA1804
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KIAA1804
      QuantiTect SYBR Green Assays in human, mouse, rat KIAA1804
      QuantiFast Probe-based Assays in human, mouse, rat KIAA1804

    Additional mRNA sequence: 

    AB058707.1 AJ311797.1 AJ311798.1 AK309811.1 BC136648.1 BC136649.1 

    3 DOTS entries:

    DT.408499  DT.100747405  DT.97838553 

    Selected AceView cDNA sequences (see all 55):

    AI522215 BU679677 AW296283 BE464090 BX281297 AL135712 AL710353 AI807109 
    BG824246 AI809005 BQ776861 AI936383 BU162152 AA458908 AA459127 BM788456 
    BI963837 BU619993 AW473218 AA961822 AB058707 BQ271916 AW241448 BU685509 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIAA1804 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KIAA1804 Expression
    About this image


    KIAA1804 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Ureteric Bud Cells Ureteric Bud
             Ureteric Bud
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
    KIAA1804 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIAA1804 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.547779
        Custom PCR Arrays for KIAA1804
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1804

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KIAA1804 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia BC0218911 , 5 cDNA sequence BC0218911, 5 73.98(n)1
    71.33(a)1
      8 (73.65 cM)5
    2348781  NM_145608.21  NP_663583.21 
     1259104505 
    chicken
    (Gallus gallus)
    Aves LOC4285861 mitogen-activated protein kinase kinase kinase MLK4-like 71.43(n)
    69.88(a)
      428586  XM_003640952.2  XP_003641000.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    64(a)
    1 ↔ 1
    1(220625817-220682809)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-120p12.31 si:ch211-120p12.3 63.99(n)
    64.21(a)
      561518  XM_684924.3  XP_690016.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta slpr3 JNK cascade protein kinase 49(a)   7D17   --


    ENSEMBL Gene Tree for KIAA1804 (if available)
    TreeFam Gene Tree for KIAA1804 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIAA1804 gene
    FPGT-TNNI3K2  MAP3K122  MAP3K112  RAF12  KSR22  KSR12  MOS2  BRAF2  
    MAP3K92  MAP3K102  ARAF2  MAP3K72  TNNI3K2  ZAK2  MAP3K132  ILK2  

    KIAA1804 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIAA1804 (see all 1410)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1919259531,2
    --233461597(+) TCCAAA/TTTTGA 1 -- us2k10--------
    rs1843096671,2
    --233461724(+) CCATAA/GCCACT 1 -- us2k10--------
    rs1510517151,2
    --233461890(+) AGACAC/TAATGC 1 -- us2k10--------
    rs351769431,2
    C,F--233461946(+) ATATAT/CATGCA 1 -- us2k18Minor allele frequency- C:0.16NA WA 250
    rs1905838801,2
    --233462038(+) TACTTC/TAAATA 1 -- us2k10--------
    rs1402973991,2
    --233462068(+) CTAATA/GTAATG 1 -- us2k10--------
    rs1822992651,2
    --233462153(+) AAACAC/TTTTTG 1 -- us2k10--------
    rs1844891221,2
    --233462233(+) AAAAAC/TCCTAT 1 -- us2k10--------
    rs1503418491,2
    --233462416(+) TCCTAG/TCCTCA 1 -- us2k10--------
    rs1451044611,2
    --233462512(+) TTTTAG/TAATTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KIAA1804 (233463514 - 233520894 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KIAA1804:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv273887CNV Insertion20981092
    esv2431778CNV Insertion19546169
    esv269665CNV Insertion20981092
    esv22442CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIAA1804
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614793    OMIM disorders: --

    3 diseases for KIAA1804:    
    About MalaCards
    diabetic retinopathy    periodontitis    colorectal cancer


    KIAA1804 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KIAA1804
    Human Genome Epidemiology (HuGE) Navigator: KIAA1804 (1 document)

    Export disorders for KIAA1804 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIAA1804 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with KIAA1804)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MLK4 has negative effect on TLR4 signaling. (PubMed id 21602844)1, 2 Seit-Nebi A.... Han J. (Cell. Mol. Immunol. 2012)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    4. Mixed lineage kinase MLK4 is activated in colorectal cancers where it synergistically cooperates with activated RAS signaling in driving tumorigenesis. (PubMed id 23319808)1 Martini M....Bardelli A. (Cancer Res. 2013)
    5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    6. Genome-wide association study of periodontal pathogen colonization. (PubMed id 22699663)1 Divaris K....Offenbacher S. (J. Dent. Res. 2012)
    7. Genome-wide meta-analysis for severe diabetic retinopathy. (PubMed id 21441570)1 Grassi M.A....Nicolae D.L. (Hum. Mol. Genet. 2011)
    8. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    10. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84451 AceView: KIAA1804 Ensembl:ENSG00000143674 euGenes: HUgn84451

    (According to HUGE)
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    HUGE: KIAA1804

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIAA1804 gene:
    Search GeneIP for patents involving KIAA1804

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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