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Aliases for KIAA1804 Gene

Aliases for KIAA1804 Gene

  • Mixed Lineage Kinase 4 3 4
  • EC 2.7.11.25 4 63
  • MLK4 3 4
  • Mitogen-Activated Protein Kinase Kinase Kinase MLK4 3
  • DJ862P8.3 3
  • EC 2.7.11 63
  • MLK4, 6

External Ids for KIAA1804 Gene

Previous GeneCards Identifiers for KIAA1804 Gene

  • GC01P231725
  • GC01P229023
  • GC01P229791
  • GC01P230547
  • GC01P229770
  • GC01P231530
  • GC01P233463
  • GC01P203953

Summaries for KIAA1804 Gene

GeneCards Summary for KIAA1804 Gene

KIAA1804 (Mixed Lineage Kinase 4) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and MAP kinase kinase kinase activity. An important paralog of this gene is MAP3K9.

UniProtKB/Swiss-Prot for KIAA1804 Gene

  • Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1804 Gene

Genomics for KIAA1804 Gene

Regulatory Elements for KIAA1804 Gene

Genomic Location for KIAA1804 Gene

Start:
233,327,768 bp from pter
End:
233,385,148 bp from pter
Size:
57,381 bases
Orientation:
Plus strand

Genomic View for KIAA1804 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIAA1804 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1804 Gene

Proteins for KIAA1804 Gene

  • Protein details for KIAA1804 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TCX8-M3KL4_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase MLK4
    Protein Accession:
    Q5TCX8
    Secondary Accessions:
    • B2RN34
    • Q5TCX7
    • Q5TCX9
    • Q8WWN1
    • Q8WWN2
    • Q96JM1

    Protein attributes for KIAA1804 Gene

    Size:
    1036 amino acids
    Molecular mass:
    113957 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer (By similarity). Interacts with TLR4.
    SequenceCaution:
    • Sequence=BAB47433.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1804 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1804 Gene

Proteomics data for KIAA1804 Gene at MOPED

Selected DME Specific Peptides for KIAA1804 Gene

Post-translational modifications for KIAA1804 Gene

  • Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIAA1804 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for KIAA1804 Gene

Graphical View of Domain Structure for InterPro Entry

Q5TCX8

UniProtKB/Swiss-Prot:

M3KL4_HUMAN :
  • Q5TCX8
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with KIAA1804: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for KIAA1804 Gene

Function for KIAA1804 Gene

Molecular function for KIAA1804 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.
UniProtKB/Swiss-Prot Function: Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.

Enzyme Numbers (IUBMB) for KIAA1804 Gene

Gene Ontology (GO) - Molecular Function for KIAA1804 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004709 MAP kinase kinase kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with KIAA1804: view
genes like me logo Genes that share phenotypes with KIAA1804: view

miRNA for KIAA1804 Gene

miRTarBase miRNAs that target KIAA1804

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for KIAA1804 Gene

Localization for KIAA1804 Gene

Gene Ontology (GO) - Cellular Components for KIAA1804 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with KIAA1804: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for KIAA1804 Gene

Pathways for KIAA1804 Gene

SuperPathways for KIAA1804 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA1804 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0006468 protein phosphorylation ISS --
GO:0007257 activation of JUN kinase activity ISS --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0046777 protein autophosphorylation ISS --
genes like me logo Genes that share ontologies with KIAA1804: view

No data available for Pathways by source for KIAA1804 Gene

Transcripts for KIAA1804 Gene

Unigene Clusters for KIAA1804 Gene

Mixed lineage kinase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1804 Gene

No ASD Table

Relevant External Links for KIAA1804 Gene

GeneLoc Exon Structure for
KIAA1804

Expression for KIAA1804 Gene

mRNA expression in normal human tissues for KIAA1804 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIAA1804 Gene

This gene is overexpressed in Pancreas (7.2) and Brain - Cerebellar Hemisphere (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KIAA1804 Gene

SOURCE GeneReport for Unigene cluster for KIAA1804 Gene Hs.547779

genes like me logo Genes that share expressions with KIAA1804: view

No data available for mRNA Expression by UniProt/SwissProt for KIAA1804 Gene

Orthologs for KIAA1804 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA1804 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
OneToOne
LOC469711 35
  • 99 (n)
  • 98.65 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 76 (a)
OneToOne
LOC616014 35
  • 82.92 (n)
  • 81.37 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 84 (a)
OneToOne
KIAA1804 35
  • 83.32 (n)
  • 80.36 (a)
mouse
(Mus musculus)
Mammalia BC021891 35
  • 73.98 (n)
  • 71.33 (a)
BC021891 16
BC021891 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1306091 35
  • 73.75 (n)
  • 72.79 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 66 (a)
OneToOne
LOC428586 35
  • 71.43 (n)
  • 69.88 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-120p12.3 35
  • 63.99 (n)
  • 64.21 (a)
si:ch211-120p12.3 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta slpr 36
  • 30 (a)
OneToMany
slpr 37
  • 49 (a)
worm
(Caenorhabditis elegans)
Secernentea K11D12.10b 37
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8999 36
  • 34 (a)
OneToMany
Species with no ortholog for KIAA1804:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KIAA1804 Gene

ENSEMBL:
Gene Tree for KIAA1804 (if available)
TreeFam:
Gene Tree for KIAA1804 (if available)

Paralogs for KIAA1804 Gene

genes like me logo Genes that share paralogs with KIAA1804: view

Variants for KIAA1804 Gene

Sequence variations from dbSNP and Humsavar for KIAA1804 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs926005 -- 233,347,542(-) tgtag(A/T)attcc intron-variant
rs926006 -- 233,347,527(-) tgtac(A/G)tgcac intron-variant
rs926007 -- 233,347,260(-) TTAAA(C/T)TCCTT intron-variant
rs962786 -- 233,353,308(-) TGTTT(A/C)TCTTC intron-variant
rs962787 -- 233,352,996(-) TACCA(C/T)ATCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1804 Gene

Variant ID Type Subtype PubMed ID
esv22442 CNV Gain 19812545
esv2431778 CNV Insertion 19546169
esv273887 CNV Insertion 20981092
esv269665 CNV Insertion 20981092

Relevant External Links for KIAA1804 Gene

HapMap Linkage Disequilibrium report
KIAA1804

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1804 Gene

Disorders for KIAA1804 Gene

Relevant External Links for KIAA1804

Genetic Association Database (GAD)
KIAA1804
Human Genome Epidemiology (HuGE) Navigator
KIAA1804
genes like me logo Genes that share disorders with KIAA1804: view

No data available for UniProtKB/Swiss-Prot for KIAA1804 Gene

Publications for KIAA1804 Gene

  1. MLK4 has negative effect on TLR4 signaling. (PMID: 21602844) Seit-Nebi A. … Han J. (Cell. Mol. Immunol. 2012) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for KIAA1804 Gene

  • antibodies-online peptides for KIAA1804
  • antibodies-online antibodies for KIAA1804
  • antibodies-online kits for KIAA1804

Sources for KIAA1804 Gene

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