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Aliases for KIAA1755 Gene

Aliases for KIAA1755 Gene

  • KIAA1755 2 3
  • Uncharacterized Protein KIAA1755 3
  • RP5-1054A22.3 3

External Ids for KIAA1755 Gene

Previous GeneCards Identifiers for KIAA1755 Gene

  • GC20M036567
  • GC20M037479
  • GC20M037524
  • GC20M036272
  • GC20M036838
  • GC20M033575

Summaries for KIAA1755 Gene

GeneCards Summary for KIAA1755 Gene

KIAA1755 (KIAA1755) is a Protein Coding gene. An important paralog of this gene is ARHGEF40.

Additional gene information for KIAA1755 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1755 Gene

Genomics for KIAA1755 Gene

Regulatory Elements for KIAA1755 Gene

Enhancers for KIAA1755 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H038245 1.2 FANTOM5 ENCODE dbSUPER 11.1 +13.7 13708 2 MAX MNT REST ZNF623 ZNF121 ZFHX2 POLR2A HNF4A EGR2 KIAA1755 TGM2 LBP ENSG00000277829 BPI
GH20H038201 1.4 FANTOM5 Ensembl ENCODE dbSUPER 6.3 +59.0 58972 1 TBP SMARCC1 JUN BHLHE40 FOSL1 JUND FOXP2 FOS MAFK KIAA1755 TGM2 BPI ENSG00000277829
GH20H038220 1.4 Ensembl ENCODE dbSUPER 5.9 +39.6 39583 0 ELF3 PTBP1 RB1 ARID4B KLF17 ZNF2 RAD21 ZNF366 ZNF143 RCOR1 RPRD1B TTI1 ENSG00000224635 SNORA71B SNORA71A KIAA1755 ENSG00000277829 TGM2
GH20H038673 1.5 FANTOM5 Ensembl ENCODE 5.1 -413.5 -413549 1 HDAC1 TBP PKNOX1 ATF1 RB1 KLF17 ZNF766 GLIS2 EGR1 ATF7 ARHGAP40 KIAA1755 ACTR5 SLC32A1 PIR44827 GC20M038618
GH20H038195 1.4 Ensembl ENCODE dbSUPER 4.9 +62.3 62296 5 HDAC1 RAD21 ZBTB40 RARA RFX5 TCF12 GATA2 RCOR1 CREM DEK KIAA1755 TGM2 ENSG00000277829
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIAA1755 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA1755 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000136973 -28 401 RFX1 RCOR2 KDM1A BMI1 EZH2

Genomic Location for KIAA1755 Gene

Chromosome:
20
Start:
38,210,488 bp from pter
End:
38,260,772 bp from pter
Size:
50,285 bases
Orientation:
Minus strand

Genomic View for KIAA1755 Gene

Genes around KIAA1755 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1755 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1755 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1755 Gene

Proteins for KIAA1755 Gene

  • Protein details for KIAA1755 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JYT7-K1755_HUMAN
    Recommended name:
    Uncharacterized protein KIAA1755
    Protein Accession:
    Q5JYT7
    Secondary Accessions:
    • Q9C0A8

    Protein attributes for KIAA1755 Gene

    Size:
    1200 amino acids
    Molecular mass:
    130846 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KIAA1755 Gene

Post-translational modifications for KIAA1755 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIAA1755 Gene

No data available for DME Specific Peptides for KIAA1755 Gene

Domains & Families for KIAA1755 Gene

Gene Families for KIAA1755 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KIAA1755 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA1755 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA1755: view

No data available for UniProtKB/Swiss-Prot for KIAA1755 Gene

Function for KIAA1755 Gene

Phenotypes From GWAS Catalog for KIAA1755 Gene

Phenotypes for KIAA1755 Gene

genes like me logo Genes that share phenotypes with KIAA1755: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KIAA1755
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1755 Gene

Localization for KIAA1755 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA1755 gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA1755 Gene

Pathways & Interactions for KIAA1755 Gene

SuperPathways for KIAA1755 Gene

No Data Available

Interacting Proteins for KIAA1755 Gene

Gene Ontology (GO) - Biological Process for KIAA1755 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA1755 Gene

Drugs & Compounds for KIAA1755 Gene

No Compound Related Data Available

Transcripts for KIAA1755 Gene

Unigene Clusters for KIAA1755 Gene

KIAA1755:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KIAA1755
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1755 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2:
SP3: - -

Relevant External Links for KIAA1755 Gene

GeneLoc Exon Structure for
KIAA1755
ECgene alternative splicing isoforms for
KIAA1755

Expression for KIAA1755 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA1755 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIAA1755 Gene

This gene is overexpressed in Breast (30.9), Lung (20.9), and Fetal Brain (17.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KIAA1755 Gene



Protein tissue co-expression partners for KIAA1755 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIAA1755 Gene:

KIAA1755

SOURCE GeneReport for Unigene cluster for KIAA1755 Gene:

Hs.472690

Evidence on tissue expression from TISSUES for KIAA1755 Gene

  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with KIAA1755: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA1755 Gene

Orthologs for KIAA1755 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA1755 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1755 33 34
  • 99.04 (n)
cow
(Bos Taurus)
Mammalia KIAA1755 33 34
  • 83.14 (n)
dog
(Canis familiaris)
Mammalia KIAA1755 33 34
  • 82.93 (n)
mouse
(Mus musculus)
Mammalia D630003M21Rik 33 16 34
  • 74.63 (n)
rat
(Rattus norvegicus)
Mammalia RGD1563354 33
  • 74.55 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1755 34
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1755 33 34
  • 54.76 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA1755 34
  • 41 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkey-65j6.2 34
  • 19 (a)
OneToMany
quo 34
  • 16 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG30456 34
  • 11 (a)
ManyToMany
CG33275 34
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 6 (a)
OneToMany
Species where no ortholog for KIAA1755 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1755 Gene

ENSEMBL:
Gene Tree for KIAA1755 (if available)
TreeFam:
Gene Tree for KIAA1755 (if available)

Paralogs for KIAA1755 Gene

Paralogs for KIAA1755 Gene

(1) SIMAP similar genes for KIAA1755 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIAA1755: view

Variants for KIAA1755 Gene

Sequence variations from dbSNP and Humsavar for KIAA1755 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs193920749 Uncertain significance 38,213,556(-) CCTGG(G/T)CCAGG reference, missense
rs1000037098 -- 38,258,839(+) CCAAT(C/G)TGGAA intron-variant, upstream-variant-2KB
rs1000076789 -- 38,212,021(+) CATGG(A/T)AATTT utr-variant-3-prime
rs1000279994 -- 38,229,223(+) GGTCT(A/G)GGCAA intron-variant
rs1000325566 -- 38,247,367(+) CTCAC(C/T)TCGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1755 Gene

Variant ID Type Subtype PubMed ID
dgv4308n100 CNV gain 25217958
esv2763659 CNV gain 21179565
nsv585963 CNV gain 21841781

Variation tolerance for KIAA1755 Gene

Residual Variation Intolerance Score: 98.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.15; 98.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1755 Gene

Human Gene Mutation Database (HGMD)
KIAA1755
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1755

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1755 Gene

Disorders for KIAA1755 Gene

Relevant External Links for KIAA1755

Genetic Association Database (GAD)
KIAA1755
Human Genome Epidemiology (HuGE) Navigator
KIAA1755
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1755

No disorders were found for KIAA1755 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1755 Gene

Publications for KIAA1755 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PMID: 23583979) den Hoed M … Loos RJ (Nature genetics 2013) 3 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for KIAA1755 Gene

Sources for KIAA1755 Gene

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