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KIAA1755 Gene

protein-coding   GIFtS: 43
GCID: GC20M036838          (predicted)

KIAA1755

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
KIAA17551 2
RP5-1054A22.32
Uncharacterized Protein KIAA17552

External Ids:    HGNC: 293721   Entrez Gene: 854492   Ensembl: ENSG000001496337   UniProtKB: Q5JYT73   

Export aliases for KIAA1755 gene to outside databases

Previous GC identifers: GC20M036567 GC20M037479 GC20M037524 GC20M036272 GC20M033575


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KIAA1755 Gene:
KIAA1755 (KIAA1755) is a protein-coding gene. An important paralog of this gene is KALRN.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIAA1755 gene promoter:
         TBP   p53   Olf-1   FOXD3   STAT5A   HNF-3beta   IRF-2   TFIID   Zic1   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIAA1755 promoter sequence
   Search Chromatin IP Primers for KIAA1755

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIAA1755


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.23

KIAA1755 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA1755 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M036838:  view genomic region     (about GC identifiers)

Start:
36,838,890 bp from pter      End:
36,889,174 bp from pter
Size:
50,285 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: K1755_HUMAN, Q5JYT7 (See protein sequence)
Recommended Name: Uncharacterized protein KIAA1755  
Size: 1200 amino acids; 130846 Da
Secondary accessions: Q9C0A8

Explore the universe of human proteins at neXtProt for KIAA1755: NX_Q5JYT7

Explore proteomics data for KIAA1755 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KIAA1755 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001025035.1  
    ENSEMBL proteins: 
     ENSP00000279024   ENSP00000393503  

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    antibodies-online peptides for KIAA1755

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    antibodies-online kits for KIAA1755 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001251 CRAL-TRIO_dom
     IPR026119 Uncharacterised_KIAA1755

    Graphical View of Domain Structure for InterPro Entry Q5JYT7

    ProtoNet protein and cluster: Q5JYT7


    Find genes that share domains with KIAA1755           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KIAA1755

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIAA1755
    Interactions:

        Search GeneGlobe Interaction Network for KIAA1755

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIAA1755 (K1755)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KIAA1755 gene: 
    NM_001029864.1  

    Unigene Cluster for KIAA1755:

    KIAA1755
    Hs.472690  [show with all ESTs]
    Unigene Representative Sequence: NM_001029864
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000279024(uc002xhv.1 uc002xhw.1 uc002xhx.1 uc002xhy.1)
    ENST00000460881 ENST00000484362 ENST00000487506 ENST00000435901 ENST00000496900(uc002xhz.1)

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    hsa-miR-1287 hsa-miR-892b hsa-miR-3938 hsa-miR-4328 hsa-miR-223 hsa-miR-214* hsa-miR-1193 hsa-miR-31*
    SwitchGear 3'UTR luciferase reporter plasmidKIAA1755 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat KIAA1755

    Additional mRNA sequence: 

    AB051542.1 AK096202.1 BC011516.1 BC029137.1 BC033704.1 BC047031.1 

    8 DOTS entries:

    DT.40122191  DT.95206966  DT.100018960  DT.101959247  DT.101977401  DT.86846471  DT.99940323  DT.95238816 

    Selected AceView cDNA sequences (see all 46):

    AI623212 AI365680 BG057037 AI569989 BQ671533 AK096202 BC011516 BC047031 
    BE858236 AW008607 AI625157 BF347625 BC033704 BF347247 AA701983 BE896669 
    BI756492 AB051542 AI682445 BG818144 BM671316 BC029137 AA324287 CB154749 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1755    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                  -                                       
    SP2:                                                                                          
    SP3:                                            -     -                                       


    ECgene alternative splicing isoforms for KIAA1755

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIAA1755 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAATAGCA
    KIAA1755 Expression
    About this image


    KIAA1755 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Umbilical Cord (Extraembryonic Tissues)
             Wharton's jelly-derived stem cells
    KIAA1755 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIAA1755 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.472690
        Custom PCR Arrays for KIAA1755
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1755

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KIAA1755 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia D630003M21Rik1 , 5 RIKEN cDNA D630003M21 gene1, 5 74.63(n)1
    65.65(a)1
      2 (78.72 cM)5
    2288461  NM_177657.51  NP_808325.21 
     1581825335 
    chicken
    (Gallus gallus)
    Aves KIAA17551 KIAA1755 ortholog 54.76(n)
    42.21(a)
      101750666  XM_004947188.1  XP_004947245.1 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA17556
    KIAA1755
    41(a)
    1 ↔ 1
    GL343886.1(79736-130414)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-65j6.26
    quo6
    quattro
    19(a)
    16(a)
    1 ↔ many
    1 ↔ many
    23(43569328-43619921) ENSDARG00000038119
    6(1865205-1928617) ENSDARG00000073684
    fruit fly
    (Drosophila melanogaster)
    Insecta CG332756
    CG304566
    --
    11(a)
    11(a)
    many ↔ many
    many ↔ many
    3L(7586191-7632673)
    2R(12987746-12995047)


    ENSEMBL Gene Tree for KIAA1755 (if available)
    TreeFam Gene Tree for KIAA1755 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIAA1755 gene
    KALRN2  ARHGEF252  MCF2L22  PLEKHG4B2  TRIO2  MCF2L2  PLEKHG42  ARHGEF402  
    MCF22  
    1 SIMAP similar gene for KIAA1755 using alignment to 2 protein entries:     K1755_HUMAN (see all proteins):
    PLEKHG4B

    Find genes that share paralogs with KIAA1755           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIAA1755 (see all 1291)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs61274481,2
    C,F,A--36838422(+) CCCCTT/CGAGCT 1 -- ds500110Minor allele frequency- C:0.38NA WA CSA EA 508
    rs1840231191,2
    --36838433(+) TGAAAA/GAAGTG 1 -- ds50010--------
    rs1459904591,2
    --36838512(+) CTTCCA/GCCACA 1 -- ds50010--------
    rs721379911,2
    C--36838651(+) GGGAG-/GCCAT 
            
    GCCAT
    1 -- ds50010--------
    rs355501701,2
    C--36838668(+) ATGCC-/ATGCC 
            
    CCTAC
    1 -- ds50010--------
    rs1887787421,2
    --36839066(+) CCTCCC/TGCCCA 1 -- ut310--------
    rs1930265321,2
    --36839088(+) ATTACC/TTGTGC 1 -- ut310--------
    rs1395823941,2
    --36839102(+) CTTTGC/TCCCCC 1 -- ut310--------
    rs37464671,2
    C,F,A,H--36839297(+) GCATCT/CTTGGG 1 -- ut31 ese323Minor allele frequency- C:0.41EA NS NA WA 3950
    rs1834856821,2
    --36839427(+) GAAGAG/TCACTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KIAA1755 (36838890 - 36889174 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for KIAA1755:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912867CNV Gain21882294

    Human Gene Mutation Database (HGMD): KIAA1755
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIAA1755
    DNA2.0 Custom Variant and Variant Library Synthesis for KIAA1755

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with KIAA1755           About GenesLikeMe

    Genetic Association Database (GAD): KIAA1755
    Human Genome Epidemiology (HuGE) Navigator: KIAA1755 (1 document)

    Export disorders for KIAA1755 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIAA1755 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KIAA1755)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PubMed id 23583979)1 den Hoed M....Loos R.J. (Nat. Genet. 2013)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)2 Deloukas P....Rogers J. (Nature 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85449 HGNC: 29372 AceView: KIAA1755 Ensembl:ENSG00000149633 euGenes: HUgn85449
    ECgene: KIAA1755 H-InvDB: KIAA1755

    (According to HUGE)
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    HUGE: KIAA1755

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIAA1755 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIAA1755 gene:
    Search GeneIP for patents involving KIAA1755

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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