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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIAA1737 Gene

protein-coding   GIFtS: 39
GCID: GC14P077564

KIAA1737

  Search for KIAA1737
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
KIAA17371 2
Uncharacterized Protein KIAA17372

External Ids:    HGNC: 203651   Entrez Gene: 854572   Ensembl: ENSG000001988947   UniProtKB: Q9C0C63   

Export aliases for KIAA1737 gene to outside databases

Previous GC identifers: GC14P075070 GC14P071381 GC14P075554 GC14P076634 GC14P057732


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KIAA1737 Gene: 
KIAA1737 (KIAA1737) is a protein-coding gene. An important paralog of this gene is ENSG00000259164.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIAA1737 gene promoter:
         NF-1   AML1a   MEF-2   Ik-3   LCR-F1   Arnt   MEF-2A   SRY   Cart-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKIAA1737 promoter sequence
   Search SABiosciences Chromatin IP Primers for KIAA1737

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA1737


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

KIAA1737 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA1737 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P077564:  view genomic region     (about GC identifiers)

Start:
77,564,440 bp from pter      End:
77,583,630 bp from pter
Size:
19,191 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K1737_HUMAN, Q9C0C6 (See protein sequence)
Recommended Name: Uncharacterized protein KIAA1737  
Size: 399 amino acids; 42692 Da
Sequence caution: Sequence=BAB21828.1; Type=Erroneous initiation;
Secondary accessions: B2RCI1 Q8N389 Q8NDZ1

Explore the universe of human proteins at neXtProt for KIAA1737: NX_Q9C0C6

Explore proteomics data for KIAA1737 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9C0C6

  • KIAA1737 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KIAA1737 Protein Expression
    REFSEQ proteins: NP_219494.2  
    ENSEMBL proteins: 
     ENSP00000355319   ENSP00000451997   ENSP00000450972   ENSP00000451522   ENSP00000452589  
     ENSP00000452380   ENSP00000451493  

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9C0C6


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KIAA1737 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KIAA1737

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KIAA1737 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KIAA1737 

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    SwitchGear 3'UTR luciferase reporter plasmidKIAA1737 3' UTR sequence
    Inhib. RNA
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1737


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA1737

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for KIAA1737 (Q9C0C63 ENSP000003553194) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SHC1P293533I2D: score=2 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIAA1737 (K1737)

    Search CenterWatch for drugs/clinical trials and news about KIAA1737 / K1737

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIAA1737 gene: 
    NM_033426.2  

    Unigene Cluster for KIAA1737:

    KIAA1737
    Hs.709066  [show with all ESTs]
    Unigene Representative Sequence: NM_033426
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361786(uc001xtc.1 uc001xtd.3) ENST00000555437 ENST00000556863
    ENST00000555611 ENST00000554658 ENST00000557115 ENST00000554447 ENST00000555200

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KIAA1737
    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate KIAA1737 (see all 56):
    hsa-miR-3164 hsa-miR-4291 hsa-miR-302d hsa-miR-520e hsa-miR-513a-5p hsa-miR-218-1* hsa-miR-128 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidKIAA1737 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KIAA1737
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIAA1737
    Clone
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    OriGene clones in human, mouse for KIAA1737 (see all 7)
    OriGene ORF clones in mouse, rat for KIAA1737
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KIAA1737 (NM_033426)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KIAA1737
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA1737
    Sirion Biotech Customized lentivirus for stable overexpression of KIAA1737 
                         Customized lentivirus expression plasmids for stable overexpression of KIAA1737 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for KIAA1737
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA1737
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA1737

    Additional mRNA sequence: 

    AB051524.1 AK024737.1 AK096603.1 AK315124.1 AL834514.1 BC037300.2 

    7 DOTS entries:

    DT.214665  DT.100750038  DT.97811165  DT.120748757  DT.120748778  DT.120748755  DT.91647668 

    24/113 AceView cDNA sequences (see all 113):

    N46190 AI056269 CA430899 AA904427 AA757352 NM_033426 BP362944 N36912 
    BU619760 CK823405 CA313709 BU734091 AI858359 AW167032 AA897170 AI745356 
    BG231726 BE856270 AA991303 AA961922 AA829349 CK005246 BM887819 BM967085 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1737 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g
    SP1:                                -     -                 -           -                                       
    SP2:                                -     -     -           -           -                                       
    SP3:                                -     -     -           -           -                                       
    SP4:                                -     -     -           -                                                   
    SP5:                                -     -     -           -                                                   


    ECgene alternative splicing isoforms for KIAA1737

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIAA1737 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KIAA1737 Expression
    About this image


    See KIAA1737 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIAA1737

    SOURCE GeneReport for Unigene cluster: Hs.709066
        SABiosciences Custom PCR Arrays for KIAA1737
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1737

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KIAA1737 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2310044G17Rik1 , 5 RIKEN cDNA 2310044G17 gene1, 5 85.22(n)1
    86.4(a)1
      12 (41.13 cM)5
    2177321  NM_173735.31  NP_776096.21 
     869473435 
    chicken
    (Gallus gallus)
    Aves KIAA17371 KIAA1737 60.25(n)
    55.52(a)
      771996  XM_001235196.1  XP_001235197.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    59(a)
    possible ortholog
    GL343868.1(108930-109133)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1420064282   -- 76.97(n)    142006428 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005358641 uncharacterized protein KIAA1737-like 46.87(n)
    34.46(a)
      100535864  XM_003200374.1  XP_003200422.1 


    ENSEMBL Gene Tree for KIAA1737 (if available)
    TreeFam Gene Tree for KIAA1737 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KIAA1737 gene
    ENSG000002591642  

    KIAA1737 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/485 SNPs in KIAA1737 are shown (see all 485)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1841236501,2
    --77562700(+) CCAAAA/GAAAAA 1 -- us2k10--------
    rs2005901971,2
    C--77562719(+) TTTTT-/CCTCCC 1 -- us2k10--------
    rs3750022891,2
    --77562905(+) ACGGT-/TTTC  
            
    TTTCG
    1 -- us2k10--------
    rs777046691,2
    C--77562909(+) GTTTTC/TGTTTG 1 -- us2k10--------
    rs347676381,2
    C--77562910(+) TTTCG-/TTT   
       
    /TTTT
    TTTGT
    2 -- us2k1 cds10--------
    rs742489371,2
    C--77562910(+) TTTTCT/GTTTGT 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1181108411,2
    C,F--77562931(+) GAGACG/AGAGAT 1 -- us2k11Minor allele frequency- A:0.03EA 120
    rs1470264911,2
    --77562934(+) ACGGAA/GATTTG 1 -- us2k10--------
    rs1883773571,2
    --77563040(+) ACAGGA/CATGTG 1 -- us2k10--------
    rs1385743671,2
    C--77563192(+) GCCTGA/GCCAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KIAA1737 (77564440 - 77583630 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for KIAA1737:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832834CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KIAA1737
    DNA2.0 Custom Variant and Variant Library Synthesis for KIAA1737

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KIAA1737 for disorders           About MalaCards

    KIAA1737 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KIAA1737

    Export disorders for KIAA1737 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIAA1737 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KIAA1737)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (2000)
    4. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    7. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (2007)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 85457 HGNC: 20365 AceView: KIAA1737 Ensembl:ENSG00000198894 euGenes: HUgn85457
    ECgene: KIAA1737 H-InvDB: KIAA1737

    (According to HUGE)
    About This Section
    HUGE: KIAA1737

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIAA1737 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIAA1737 gene:
    Search GeneIP for patents involving KIAA1737

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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