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Aliases for KIAA1715 Gene

Aliases for KIAA1715 Gene

  • KIAA1715 2 3
  • Limb And Neural Patterns 2 3
  • Lunapark 2 3
  • LNP 3 4
  • 2310011O18Rik 3
  • 4921514L11Rik 3
  • Ulnaless 3
  • LNP1 3
  • Ul 3

External Ids for KIAA1715 Gene

Previous GeneCards Identifiers for KIAA1715 Gene

  • GC02M174842
  • GC02M175451
  • GC02M176995
  • GC02M176992
  • GC02M176615
  • GC02M176496
  • GC02M176788
  • GC02M168667

Summaries for KIAA1715 Gene

GeneCards Summary for KIAA1715 Gene

KIAA1715 (KIAA1715) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KIAA1715 Gene

  • Plays a role in tubular endoplasmic reticulum network formation and maintenance. May be involved in limb and central nervous system development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1715 Gene

Genomics for KIAA1715 Gene

Regulatory Elements for KIAA1715 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIAA1715 Gene

Chromosome:
2
Start:
175,923,862 bp from pter
End:
176,005,388 bp from pter
Size:
81,527 bases
Orientation:
Minus strand

Genomic View for KIAA1715 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIAA1715 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1715 Gene

Proteins for KIAA1715 Gene

  • Protein details for KIAA1715 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0E8-LNP_HUMAN
    Recommended name:
    Protein lunapark
    Protein Accession:
    Q9C0E8
    Secondary Accessions:
    • B7ZLA8
    • Q2M2V8
    • Q2YD99
    • Q658W8
    • Q8N5V9
    • Q96MS5

    Protein attributes for KIAA1715 Gene

    Size:
    428 amino acids
    Molecular mass:
    47740 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB21806.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1715 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1715 Gene

Proteomics data for KIAA1715 Gene at MOPED

Post-translational modifications for KIAA1715 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIAA1715 Gene

Domains & Families for KIAA1715 Gene

Protein Domains for KIAA1715 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA1715 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0E8

UniProtKB/Swiss-Prot:

LNP_HUMAN :
  • Belongs to the lunapark family.
Family:
  • Belongs to the lunapark family.
genes like me logo Genes that share domains with KIAA1715: view

No data available for Gene Families for KIAA1715 Gene

Function for KIAA1715 Gene

Molecular function for KIAA1715 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in tubular endoplasmic reticulum network formation and maintenance. May be involved in limb and central nervous system development.

Gene Ontology (GO) - Molecular Function for KIAA1715 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with KIAA1715: view

Phenotypes for KIAA1715 Gene

genes like me logo Genes that share phenotypes with KIAA1715: view

Animal Model Products

CRISPR Products

miRNA for KIAA1715 Gene

miRTarBase miRNAs that target KIAA1715

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIAA1715

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1715 Gene

Localization for KIAA1715 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA1715 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes to three-way ER tubule junctions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA1715 Gene COMPARTMENTS Subcellular localization image for KIAA1715 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for KIAA1715 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IDA 24223779
GO:0016021 integral component of membrane NAS 12732147
GO:0071782 endoplasmic reticulum tubular network IBA --
genes like me logo Genes that share ontologies with KIAA1715: view

Pathways & Interactions for KIAA1715 Gene

SuperPathways for KIAA1715 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA1715 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation IEA --
GO:0032330 regulation of chondrocyte differentiation IEA --
GO:0035115 embryonic forelimb morphogenesis IEA --
GO:0042733 embryonic digit morphogenesis IEA --
GO:0060173 limb development NAS 12732147
genes like me logo Genes that share ontologies with KIAA1715: view

No data available for Pathways by source and SIGNOR curated interactions for KIAA1715 Gene

Drugs & Compounds for KIAA1715 Gene

No Compound Related Data Available

Transcripts for KIAA1715 Gene

Unigene Clusters for KIAA1715 Gene

KIAA1715:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIAA1715

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1715 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14
SP1: - - -
SP2: -
SP3:

Relevant External Links for KIAA1715 Gene

GeneLoc Exon Structure for
KIAA1715
ECgene alternative splicing isoforms for
KIAA1715

Expression for KIAA1715 Gene

mRNA expression in normal human tissues for KIAA1715 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIAA1715 Gene

This gene is overexpressed in Bone (17.7), Pancreas (8.2), and Prostate (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIAA1715 Gene



SOURCE GeneReport for Unigene cluster for KIAA1715 Gene Hs.209561

genes like me logo Genes that share expression patterns with KIAA1715: view

Protein tissue co-expression partners for KIAA1715 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIAA1715 Gene

Orthologs for KIAA1715 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA1715 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIAA1715 35
  • 90.61 (n)
  • 88.5 (a)
KIAA1715 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA1715 35
  • 92.81 (n)
  • 90.28 (a)
KIAA1715 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lnp 35
  • 88.73 (n)
  • 85.34 (a)
Lnp 16
Lnp 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIAA1715 35
  • 99.61 (n)
  • 99.13 (a)
KIAA1715 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lnp 35
  • 90.85 (n)
  • 90.75 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1715 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1715 35
  • 76.1 (n)
  • 75.66 (a)
KIAA1715 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1715 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1715 35
  • 69.66 (n)
  • 66.01 (a)
Str.3943 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23923 35
zebrafish
(Danio rerio)
Actinopterygii lnp 35
lnpa 35
  • 63.09 (n)
  • 64.67 (a)
lnpa 36
  • 51 (a)
OneToMany
lnpb 36
  • 56 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4759 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007983 35
  • 48.23 (n)
  • 43.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8735 35
  • 44.48 (n)
  • 36.9 (a)
CG8735 36
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lnp-1 35
  • 42.93 (n)
  • 34.32 (a)
lnp-1 36
  • 27 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14484 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8149 36
  • 40 (a)
OneToOne
Species with no ortholog for KIAA1715:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIAA1715 Gene

ENSEMBL:
Gene Tree for KIAA1715 (if available)
TreeFam:
Gene Tree for KIAA1715 (if available)

Paralogs for KIAA1715 Gene

(1) SIMAP similar genes for KIAA1715 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with KIAA1715: view

No data available for Paralogs for KIAA1715 Gene

Variants for KIAA1715 Gene

Sequence variations from dbSNP and Humsavar for KIAA1715 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs15813 -- 175,923,964(+) CTGTC(G/T)ACATT utr-variant-3-prime, nc-transcript-variant
rs747051 -- 176,002,403(-) CCTAA(C/T)CTCCC upstream-variant-2KB, intron-variant
rs819031 -- 175,983,889(+) CACCT(C/T)GACCT intron-variant
rs819032 -- 175,983,980(+) gaaaa(C/T)cttca intron-variant
rs819033 -- 175,985,716(+) tatag(C/G)gattt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1715 Gene

Variant ID Type Subtype PubMed ID
nsv521343 CNV Loss 19592680
nsv875436 CNV Loss 21882294
nsv508120 CNV Loss 20534489

Variation tolerance for KIAA1715 Gene

Residual Variation Intolerance Score: 81.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1715 Gene

HapMap Linkage Disequilibrium report
KIAA1715

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1715 Gene

Disorders for KIAA1715 Gene

Relevant External Links for KIAA1715

Genetic Association Database (GAD)
KIAA1715
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1715
genes like me logo Genes that share disorders with KIAA1715: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1715 Gene

Publications for KIAA1715 Gene

  1. ER network formation requires a balance of the dynamin-like GTPase Sey1p and the Lunapark family member Lnp1p. (PMID: 22729086) Chen S. … Ferro-Novick S. (Nat. Cell Biol. 2012) 2 67
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  5. Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum. (PMID: 25548161) Chen S. … Ferro-Novick S. (Proc. Natl. Acad. Sci. U.S.A. 2015) 67

Products for KIAA1715 Gene

Sources for KIAA1715 Gene

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