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Aliases for KIAA1671 Gene

Aliases for KIAA1671 Gene

  • KIAA1671 2 3
  • Uncharacterized Protein KIAA1671 3
  • CTA-221G9.5 3

External Ids for KIAA1671 Gene

Previous GeneCards Identifiers for KIAA1671 Gene

  • GC22P022162
  • GC22P023761
  • GC22P023748
  • GC22P023751
  • GC22P023734
  • GC22P025421
  • GC22P008371
  • GC22P025348

Summaries for KIAA1671 Gene

GeneCards Summary for KIAA1671 Gene

KIAA1671 (KIAA1671) is a Protein Coding gene. An important paralog of this gene is TNKS1BP1.

Additional gene information for KIAA1671 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1671 Gene

Genomics for KIAA1671 Gene

Regulatory Elements for KIAA1671 Gene

Enhancers for KIAA1671 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H025061 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +109.7 109672 2.1 ZNF146 ZNF680 NRF1 ZNF133 ZNF398 ZFHX2 ZNF366 ZBTB48 FOXP2 PRDM10 KIAA1671 CRYBB2 ENSG00000279110 ENSG00000279006
GH22H025085 1.4 Ensembl ENCODE dbSUPER 10.3 +133.7 133694 1.4 PKNOX1 FOXA2 BMI1 ZSCAN9 RAD21 ATF7 RUNX3 IKZF2 SMARCA5 USF2 KIAA1671 CRYBB3 ENSG00000279110 LOC100128531
GH22H024010 1.4 ENCODE dbSUPER 10.1 -941.1 -941060 2.5 PKNOX1 FOXA2 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 ZNF207 FOS ENSG00000272973 ZDHHC8P1 ZNF70 SPECC1L MIF-AS1 SNRPD3 SUSD2 RN7SL268P GNAZ ENSG00000272578
GH22H025067 1.6 FANTOM5 Ensembl ENCODE dbSUPER 7.5 +116.6 116556 4.4 PKNOX1 PLRG1 EBF1 BATF ZIC2 POLR2A ZSCAN5C ATF7 RCOR1 IKZF2 LOC100128531 TMEM211 KIAA1671 CRYBB2 ENSG00000236641 ENSG00000279110
GH22H025049 0.9 ENCODE 10.6 +100.9 100933 8.6 ELF3 PKNOX1 FOXA2 NFIB BATF RAD21 RARA GLIS2 SCRT2 ZNF143 SNRPD3 TMEM211 KIAA1671 ENSG00000279006 ENSG00000279110
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIAA1671 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA1671 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000144457 199 1800 ARID4B SIN3A DMAP1 ZNF2 BRCA1 YY1 GLIS2 ZNF143 ATF7 SP3

Genomic Locations for KIAA1671 Gene

Genomic Locations for KIAA1671 Gene
chr22:24,952,702-25,197,448
(GRCh38/hg38)
Size:
244,747 bases
Orientation:
Plus strand
chr22:25,348,697-25,593,415
(GRCh37/hg19)

Genomic View for KIAA1671 Gene

Genes around KIAA1671 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1671 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1671 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1671 Gene

Proteins for KIAA1671 Gene

  • Protein details for KIAA1671 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY89-K1671_HUMAN
    Recommended name:
    Uncharacterized protein KIAA1671
    Protein Accession:
    Q9BY89
    Secondary Accessions:
    • B0QYF2
    • B7ZW08
    • Q5THZ5

    Protein attributes for KIAA1671 Gene

    Size:
    1806 amino acids
    Molecular mass:
    196711 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Antibodies against KIAA1671 are present in sera from patients with breast cancer who developed several autoantibodies.
    SequenceCaution:
    • Sequence=BAB33341.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1671 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1671 Gene

Post-translational modifications for KIAA1671 Gene

  • Ubiquitination at posLast=17381738
  • Modification sites at PhosphoSitePlus

Other Protein References for KIAA1671 Gene

No data available for DME Specific Peptides for KIAA1671 Gene

Domains & Families for KIAA1671 Gene

Gene Families for KIAA1671 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KIAA1671 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA1671 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA1671: view

No data available for UniProtKB/Swiss-Prot for KIAA1671 Gene

Function for KIAA1671 Gene

Phenotypes From GWAS Catalog for KIAA1671 Gene

Phenotypes for KIAA1671 Gene

genes like me logo Genes that share phenotypes with KIAA1671: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1671 Gene

Localization for KIAA1671 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA1671 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA1671 Gene

Pathways & Interactions for KIAA1671 Gene

SuperPathways for KIAA1671 Gene

No Data Available

Interacting Proteins for KIAA1671 Gene

Gene Ontology (GO) - Biological Process for KIAA1671 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA1671 Gene

Drugs & Compounds for KIAA1671 Gene

No Compound Related Data Available

Transcripts for KIAA1671 Gene

mRNA/cDNA for KIAA1671 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIAA1671 Gene

KIAA1671:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1671 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2:

Relevant External Links for KIAA1671 Gene

GeneLoc Exon Structure for
KIAA1671
ECgene alternative splicing isoforms for
KIAA1671

Expression for KIAA1671 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA1671 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIAA1671 Gene

This gene is overexpressed in Retina (12.6), Gallbladder (12.2), Bone marrow mesenchymal stem cell (7.5), Peripheral blood mononuclear cells (6.7), Heart (6.4), and Pancreas (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIAA1671 Gene



NURSA nuclear receptor signaling pathways regulating expression of KIAA1671 Gene:

KIAA1671

SOURCE GeneReport for Unigene cluster for KIAA1671 Gene:

Hs.419171
genes like me logo Genes that share expression patterns with KIAA1671: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA1671 Gene

Orthologs for KIAA1671 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1671 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1671 33
  • 98.87 (n)
-- 34
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia KIAA1671 33
  • 77.91 (n)
-- 34
  • 67 (a)
OneToMany
cow
(Bos Taurus)
Mammalia KIAA1671 33
  • 73.28 (n)
-- 34
  • 61 (a)
OneToMany
mouse
(Mus musculus)
Mammalia 2900026A02Rik 34
  • 73 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia RGD1306556 33
  • 68.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 59 (a)
ManyToMany
-- 34
  • 53 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 39 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 62 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tnks1bp1 34
  • 29 (a)
ManyToMany
si:ch73-138n13.1 34
  • 16 (a)
ManyToMany
Species where no ortholog for KIAA1671 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1671 Gene

ENSEMBL:
Gene Tree for KIAA1671 (if available)
TreeFam:
Gene Tree for KIAA1671 (if available)

Paralogs for KIAA1671 Gene

Paralogs for KIAA1671 Gene

genes like me logo Genes that share paralogs with KIAA1671: view

Variants for KIAA1671 Gene

Sequence variations from dbSNP and Humsavar for KIAA1671 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000005018 -- 25,183,084(+) TCAGA(C/T)ATCAT intron-variant
rs1000008700 -- 25,064,931(+) AGCCC(A/T)GTGAG intron-variant
rs1000008993 -- 25,141,833(+) AGCCT(A/G)TCTGG intron-variant
rs1000013595 -- 25,183,264(+) TGTTG(C/T)TCCTT intron-variant
rs1000013949 -- 25,105,080(+) ATGCA(A/G)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1671 Gene

Variant ID Type Subtype PubMed ID
nsv9887 CNV loss 18304495
nsv9886 CNV loss 18304495
nsv9885 CNV gain 18304495
nsv834162 CNV loss 17160897
nsv834161 CNV gain 17160897
nsv829131 CNV loss 20364138
nsv7350 OTHER inversion 18451855
nsv588755 CNV loss 21841781
nsv588747 CNV gain 21841781
nsv518136 CNV loss 19592680
nsv512651 CNV loss 21212237
nsv511634 CNV loss 21212237
nsv471188 CNV gain 18288195
nsv469581 CNV loss 16826518
nsv459684 CNV gain 19166990
nsv428388 CNV loss 18775914
nsv3581 CNV insertion 18451855
nsv191604 CNV deletion 16902084
nsv1151112 CNV deletion 26484159
nsv1110863 OTHER inversion 24896259
nsv1072631 CNV deletion 25765185
nsv1057343 CNV gain 25217958
nsv1056865 CNV gain 25217958
esv3434566 CNV insertion 20981092
esv3396049 CNV insertion 20981092
esv33826 CNV loss 17666407
esv3343197 CNV insertion 20981092
esv3308687 CNV mobile element insertion 20981092
esv3305813 CNV mobile element insertion 20981092
esv3234493 CNV deletion 24192839
esv2758829 CNV gain+loss 17122850
esv2724078 CNV deletion 23290073
esv2724077 CNV deletion 23290073
esv2724076 CNV deletion 23290073
esv2724075 CNV deletion 23290073
esv2657573 CNV deletion 23128226
esv24048 CNV loss 19812545
esv2042759 CNV deletion 18987734
dgv8070n54 CNV loss 21841781
dgv8069n54 CNV loss 21841781
dgv284e215 CNV deletion 23714750
dgv24e196 CNV duplication 17116639
dgv2448n106 CNV deletion 24896259
dgv2447n106 CNV deletion 24896259

Variation tolerance for KIAA1671 Gene

Gene Damage Index Score: 3.34; 53.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1671 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1671

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1671 Gene

Disorders for KIAA1671 Gene

Relevant External Links for KIAA1671

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1671

No disorders were found for KIAA1671 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1671 Gene

Publications for KIAA1671 Gene

  1. Autoantibodies to Annexin XI-A and Other Autoantigens in the Diagnosis of Breast Cancer. (PMID: 15289310) Fernández-Madrid F … Karvonen RL (Cancer research 2004) 2 3 4 60
  2. Proteomic Analysis Reveals a Novel Mutator S (MutS) Partner Involved in Mismatch Repair Pathway. (PMID: 27037360) Chen Z … Chen J (Molecular & cellular proteomics : MCP 2016) 2 3 60
  3. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PMID: 11258795) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60

Products for KIAA1671 Gene

Sources for KIAA1671 Gene

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