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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIAA1644 Gene

protein-coding   GIFtS: 36
GCID: GC22M044639          (predicted)

KIAA1644

  Search for KIAA1644
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
KIAA16441 2
Uncharacterized Protein KIAA16442

External Ids:    HGNC: 293351   Entrez Gene: 853522   Ensembl: ENSG000001389447   UniProtKB: Q3SXP73   

Export aliases for KIAA1644 gene to outside databases

Previous GC identifers: GC22M041256 GC22M042901 GC22U900118 GC22M042897 GC22M042964 GC22M027592


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KIAA1644 Gene: 
KIAA1644 (KIAA1644) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIAA1644 gene promoter:
         Oct-B1   oct-B3   oct-B2   Lmo2   POU3F2   Roaz   AREB6   HEN1   Sox9   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KIAA1644

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA1644


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  22q13.31   HGNC cytogenetic band: 22q13

KIAA1644 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA1644 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M044639:  view genomic region     (about GC identifiers)

Start:
44,639,547 bp from pter      End:
44,708,731 bp from pter
Size:
69,185 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K1644_HUMAN, Q3SXP7 (See protein sequence)
Recommended Name: Uncharacterized protein KIAA1644 precursor  
Size: 199 amino acids; 22573 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: A6NHP0 A9Z1Z0 Q3SXP8 Q5JZ71 Q9BYB5

Explore the universe of human proteins at neXtProt for KIAA1644: NX_Q3SXP7

Explore proteomics data for KIAA1644 at MOPED 

KIAA1644 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

KIAA1644 Protein Expression

REFSEQ proteins: NP_001092764.1  
ENSEMBL proteins: 
 ENSP00000370568  

Human Recombinant Protein Products for KIAA1644: 
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

KIAA1644 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q3SXP7


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA1644

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KIAA1644 (K1644)

Search CenterWatch for drugs/clinical trials and news about KIAA1644 / K1644

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KIAA1644 gene: 
NM_001099294.1  

Unigene Cluster for KIAA1644:

KIAA1644
Hs.6829  [show with all ESTs]
Unigene Representative Sequence: NM_001099294
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000381176(uc003bet.2)
miRNA
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Additional mRNA sequence: 

AB051431.1 AK090953.1 BC068280.1 BC104183.1 BC104184.1 

2 DOTS entries:

DT.95157574  DT.92407473 

24/70 AceView cDNA sequences (see all 70):

BQ931474 BM970429 BM662042 BM713334 AI207922 BU739788 BM718569 Z45383 
BE910231 BF054986 Z41100 AW069525 BF108887 AA663744 AI494141 BQ014664 
BF516072 BI668901 AA127895 CA440909 AI378186 T16816 BQ958904 BM716046 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KIAA1644 expression in normal human tissues (normalized intensities)      KIAA1644 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TCAACTGTTC
KIAA1644 Expression
About this image


KIAA1644 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/8 selected tissues (see all 8) fully expand
 
 Brain (Nervous System)    fully expand to see all 18 entries
         Adult Oligodendrocyte Precursor Cells Lateral Ventricle
         Thalamus
         Septum   
 
 Uncategorized (Uncategorized)    fully expand to see all 3 entries
         PureStem Progenitor E44
 
 Mesenchymal Stem Cells (Muscoskeletal System)    fully expand to see all 2 entries
         Human Mesenchymal Stem Cells (hMSC)   
 
 Paraxial Mesoderm (Gastrulation Derivatives)
         PureStem E15, Meso-prx/latp Progenitor
 
 Ectoderm (Gastrulation Derivatives)
         PureStem ES-210, Ecto-ntu Progenitor

See KIAA1644 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIAA1644

SOURCE GeneReport for Unigene cluster: Hs.6829
    SABiosciences Custom PCR Arrays for KIAA1644
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1644

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1644 gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia 1810041L15Rik1 , 5 RIKEN cDNA 1810041L15 gene1, 5 87.54(n)1
94.44(a)1
  15 (39.78 cM)5
723011  NM_001163145.11  NP_001156617.11 
 843792055 
chicken
(Gallus gallus)
Aves LOC1008572761 uncharacterized LOC100857276 72.19(n)
75.69(a)
  100857276  XM_003640423.1  XP_003640471.1 
lizard
(Anolis carolinensis)
Reptilia KIAA16446
KIAA1644
65(a)
1 ↔ 1
5(85399532-85613240)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-14k9.21 si:dkey-14k9.2 65.81(n)
63.59(a)
  560435  NM_001030141.1  NP_001025312.1 


ENSEMBL Gene Tree for KIAA1644 (if available)
TreeFam Gene Tree for KIAA1644 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/2048 SNPs in KIAA1644 are shown (see all 2048)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1354421,2
C--27602301(-) aaaaa-/CATGCAC 1 -- int10--------
rs588251391,2
C--27602302(+) TGCAT-/G/GT  
        
TTTTT
1 -- int11NA 2
rs1354301,2
C--28573601(-) CTGTT-/GTTAAGAG 1 -- int10--------
rs130585191,2
C,F,A--44639120(+) CCCAGT/CGTGAG 1 -- ds50019Minor allele frequency- C:0.28NA WA CSA EA 369
rs1409644361,2
--44639206(+) AGAGGC/TACCTG 1 -- ds50010--------
rs558103501,2
C--44639261(+) CCCCC-/CACCCT 1 -- ds50010--------
rs1156193051,2
C,F--44639261(+) TGCCCG/ACCCCC 1 -- ds50011Minor allele frequency- A:0.09WA 118
rs601399601,2
C--44639269(+) CCCCC-/CACCCT 1 -- ds50010--------
rs2012521951,2
C--44639314(+) TGCCA-/GATT  
        
GATTC
1 -- ds50010--------
rs768444961,2
C--44639408(+) GGACTC/TGTGTG 1 -- ds50010--------

HapMap Linkage Disequilibrium report for KIAA1644 (44639547 - 44708731 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/16 variations for KIAA1644 (see all 16):    About this table     
Variant IDTypeSubtypePubMed ID
esv2742673CNV Deletion23290073
esv2724351CNV Deletion23290073
esv2554291CNV Deletion19546169
esv2677488CNV Deletion23128226
esv2724348CNV Deletion23290073
esv2724346CNV Deletion23290073
esv2657182CNV Deletion23128226
dgv784e201CNV Deletion23290073
esv2724353CNV Deletion23290073
esv2724347CNV Deletion23290073

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for KIAA1644 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KIAA1644)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PubMed id 11258795)1, 2, 3 Hirosawa M....Ohara O. (2001)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  5. The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 85352 HGNC: 29335 AceView: KIAA1644 Ensembl:ENSG00000138944 euGenes: HUgn85352
ECgene: KIAA1644 H-InvDB: KIAA1644

(According to HUGE)
About This Section
HUGE: KIAA1644

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for KIAA1644 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for KIAA1644 gene:
Search GeneIP for patents involving KIAA1644

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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