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Aliases for KIAA1644 Gene

Aliases for KIAA1644 Gene

  • KIAA1644 2 3

External Ids for KIAA1644 Gene

Previous GeneCards Identifiers for KIAA1644 Gene

  • GC22M041256
  • GC22M042901
  • GC22U900118
  • GC22M042897
  • GC22M042964
  • GC22M044639
  • GC22M027592

Summaries for KIAA1644 Gene

GeneCards Summary for KIAA1644 Gene

KIAA1644 (KIAA1644) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1644 Gene

Genomics for KIAA1644 Gene

Regulatory Elements for KIAA1644 Gene

Enhancers for KIAA1644 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G044684 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -354.3 -354292 3.4 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF207 ZNF143 ZNF263 SP3 ARHGAP8 KIAA1644 PRR5 PRR5-ARHGAP8
GH22G044289 1.5 Ensembl ENCODE dbSUPER 11.7 +42.1 42062 1.2 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF143 ZNF207 ZNF263 SP3 JUNB KIAA1644 ENSG00000220702 PIR35275 LOC101927499
GH22G044020 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +310.0 309985 2.2 ZNF473 ZSCAN4 INSM2 GLI4 ZEB1 ZNF366 FOS ZNF391 YY2 TSHZ1 ENSG00000261251 LOC100506679 SAMM50 RPL35AP36 RTL6 KIAA1644 PARVB GC22M044040
GH22G044357 1.5 FANTOM5 Ensembl ENCODE 11.3 -29.8 -29815 7.6 HDGF SIN3A GLIS2 FOS DEK ZNF263 TSHZ1 REST ZNF623 MAFF KIAA1644 FAM118A GC22P044366
GH22G044351 1.2 Ensembl ENCODE 11.7 -20.3 -20271 1.7 ZSCAN4 INSM2 RAD21 RFX5 GLIS2 ZNF766 ZNF366 SCRT2 RCOR1 FOS KIAA1644 RTL6 GC22P044366
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIAA1644 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIAA1644 Gene

Chromosome:
22
Start:
44,243,665 bp from pter
End:
44,331,695 bp from pter
Size:
88,031 bases
Orientation:
Minus strand

Genomic View for KIAA1644 Gene

Genes around KIAA1644 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1644 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1644 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1644 Gene

Proteins for KIAA1644 Gene

  • Protein details for KIAA1644 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SXP7-K1644_HUMAN
    Recommended name:
    Uncharacterized protein KIAA1644
    Protein Accession:
    Q3SXP7
    Secondary Accessions:
    • A6NHP0
    • A9Z1Z0
    • Q3SXP8
    • Q5JZ71
    • Q9BYB5

    Protein attributes for KIAA1644 Gene

    Size:
    199 amino acids
    Molecular mass:
    22573 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KIAA1644 Gene

Post-translational modifications for KIAA1644 Gene

  • Glycosylation at isoforms=53 and isoforms=95

Other Protein References for KIAA1644 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIAA1644 Gene

Domains & Families for KIAA1644 Gene

Protein Domains for KIAA1644 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA1644: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for KIAA1644 Gene

Function for KIAA1644 Gene

Phenotypes for KIAA1644 Gene

GenomeRNAi human phenotypes for KIAA1644:
genes like me logo Genes that share phenotypes with KIAA1644: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1644 Gene

Localization for KIAA1644 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA1644 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA1644 gene
Compartment Confidence
plasma membrane 3
extracellular 3
lysosome 1

Gene Ontology (GO) - Cellular Components for KIAA1644 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KIAA1644: view

Pathways & Interactions for KIAA1644 Gene

SuperPathways for KIAA1644 Gene

No Data Available

Interacting Proteins for KIAA1644 Gene

Gene Ontology (GO) - Biological Process for KIAA1644 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA1644 Gene

Drugs & Compounds for KIAA1644 Gene

No Compound Related Data Available

Transcripts for KIAA1644 Gene

mRNA/cDNA for KIAA1644 Gene

Unigene Clusters for KIAA1644 Gene

KIAA1644:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1644 Gene

No ASD Table

Relevant External Links for KIAA1644 Gene

GeneLoc Exon Structure for
KIAA1644
ECgene alternative splicing isoforms for
KIAA1644

Expression for KIAA1644 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA1644 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIAA1644 Gene

This gene is overexpressed in Brain - Amygdala (x5.5), Brain - Cortex (x5.0), Brain - Anterior cingulate cortex (BA24) (x4.9), Uterus (x4.5), and Brain - Frontal Cortex (BA9) (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of KIAA1644 Gene:

KIAA1644

SOURCE GeneReport for Unigene cluster for KIAA1644 Gene:

Hs.6829

Evidence on tissue expression from TISSUES for KIAA1644 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with KIAA1644: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA1644 Gene

Orthologs for KIAA1644 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1644 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1644 34 35
  • 99.33 (n)
cow
(Bos Taurus)
Mammalia KIAA1644 34 35
  • 91.58 (n)
dog
(Canis familiaris)
Mammalia KIAA1644 34 35
  • 90.07 (n)
mouse
(Mus musculus)
Mammalia 1810041L15Rik 16 35 34
  • 87.54 (n)
rat
(Rattus norvegicus)
Mammalia RGD1566029 34
  • 86.36 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1644 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1644 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1644 34 35
  • 73.37 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA1644 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733025 34
  • 72.04 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-14k9.2 34 35
  • 65.16 (n)
si:ch73-66d24.2 35
  • 55 (a)
OneToMany
Species where no ortholog for KIAA1644 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1644 Gene

ENSEMBL:
Gene Tree for KIAA1644 (if available)
TreeFam:
Gene Tree for KIAA1644 (if available)

Paralogs for KIAA1644 Gene

No data available for Paralogs for KIAA1644 Gene

Variants for KIAA1644 Gene

Sequence variations from dbSNP and Humsavar for KIAA1644 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000022620 -- 44,283,144(+) GGGAC(A/G)GTGCC intron-variant
rs1000023444 -- 44,314,127(+) CTCGT(C/G)CTGGG intron-variant, upstream-variant-2KB
rs1000045153 -- 44,299,288(+) TCAAC(C/T)ATGAA intron-variant
rs1000143667 -- 44,281,750(+) GAGAA(A/T)CTGAG intron-variant
rs1000197417 -- 44,280,678(+) GATGC(A/C)TGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1644 Gene

Variant ID Type Subtype PubMed ID
dgv737e201 CNV deletion 23290073
esv2554291 CNV deletion 19546169
esv25690 CNV gain 19812545
esv2657182 CNV deletion 23128226
esv2677488 CNV deletion 23128226
esv2724346 CNV deletion 23290073
esv2724347 CNV deletion 23290073
esv2724348 CNV deletion 23290073
esv2724351 CNV deletion 23290073
esv2724353 CNV deletion 23290073
esv2742673 CNV deletion 23290073
esv2758841 CNV gain+loss 17122850
esv3558214 CNV deletion 23714750
esv3558216 CNV deletion 23714750
esv3558217 CNV deletion 23714750
esv3647892 CNV gain 21293372
esv3647894 CNV loss 21293372
nsv1071796 CNV deletion 25765185
nsv1117939 CNV deletion 24896259
nsv438347 CNV loss 16468122
nsv474011 CNV novel sequence insertion 20440878
nsv474076 CNV novel sequence insertion 20440878
nsv474078 CNV novel sequence insertion 20440878
nsv474543 CNV novel sequence insertion 20440878
nsv475318 CNV novel sequence insertion 20440878
nsv477880 CNV novel sequence insertion 20440878
nsv478151 CNV novel sequence insertion 20440878
nsv478728 CNV novel sequence insertion 20440878
nsv479260 CNV novel sequence insertion 20440878
nsv479469 CNV novel sequence insertion 20440878
nsv479502 CNV novel sequence insertion 20440878
nsv479666 CNV novel sequence insertion 20440878
nsv479708 CNV novel sequence insertion 20440878
nsv480150 CNV novel sequence insertion 20440878
nsv480179 CNV novel sequence insertion 20440878
nsv480881 CNV novel sequence insertion 20440878
nsv481033 CNV novel sequence insertion 20440878
nsv481543 CNV novel sequence insertion 20440878
nsv519623 CNV loss 19592680
nsv589103 CNV loss 21841781
nsv829266 CNV gain 20364138

Variation tolerance for KIAA1644 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1644 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1644

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1644 Gene

Disorders for KIAA1644 Gene

Relevant External Links for KIAA1644

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1644

No disorders were found for KIAA1644 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1644 Gene

Publications for KIAA1644 Gene

  1. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PMID: 11258795) Hirosawa M. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors. (PMID: 22120523) Pei J. … Grishin N.V. (Cell. Signal. 2012) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for KIAA1644 Gene

Sources for KIAA1644 Gene

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