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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KIAA1644 Gene

protein-coding GIFtS: 37
GCID: GC22M044639 (predicted)

KIAA1644

Search for KIAA1644
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
KIAA1644¹ ²
Uncharacterized Protein KIAA1644²

External Ids:	HGNC: 29335¹	Entrez Gene: 85352²	Ensembl: ENSG00000138944⁷	UniProtKB: Q3SXP7³

Export aliases for KIAA1644 gene to outside databases

Previous GC identifers: GC22M041256 GC22M042901 GC22U900118 GC22M042897 GC22M042964 GC22M027592

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KIAA1644 gene promoter:
Oct-B1 oct-B3 oct-B2 Lmo2 POU3F2 Roaz AREB6 HEN1 Sox9 RSRFC4
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA1644

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band: 22q13.31 HGNC cytogenetic band: 22q13

KIAA1644 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA1644 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M044639: view genomic region (about GC identifiers)

Start:	44,639,547 bp from pter	End:	44,708,731 bp from pter
Size:	69,185 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: K1644_HUMAN, Q3SXP7 (See protein sequence)

Recommended Name: Uncharacterized protein KIAA1644 precursor

Size: 199 amino acids; 22573 Da

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Secondary accessions: A6NHP0 A9Z1Z0 Q3SXP8 Q5JZ71 Q9BYB5

Explore the universe of human proteins at neXtProt for KIAA1644: NX_Q3SXP7

KIAA1644 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001092764.1

ENSEMBL proteins:

ENSP00000370568

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

KIAA1644 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q3SXP7

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KIAA1644

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for KIAA1644 gene:

NM_001099294.1

Unigene Cluster for KIAA1644:

KIAA1644

Hs.6829 [show with all ESTs]

Unigene Representative Sequence: NM_001099294

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000381176(uc003bet.2)

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Additional cDNA sequence:

AB051431.1 AK090953.1 BC068280.1 BC104183.1 BC104184.1

2 DOTS entries:

DT.95157574 DT.92407473

24/70 AceView cDNA sequences (see all 70):

BE910231 BF054986 AI207922 BM718569 BM970429 BU739788 AW069525 BM662042

Z45383 BM713334 Z41100 BQ931474 BF108887 BF516072 BI668901 AI147935

BU743011 AI494141 AA912027 BU959430 CA440909 BM716046 T16816 AA476987

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KIAA1644 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAACTGTTC

About this image

KIAA1644 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KIAA1644 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIAA1644

SOURCE GeneReport for Unigene cluster: Hs.6829

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1644 gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	1810041L15Rik^{1 , 5}	RIKEN cDNA 1810041L15 gene^{1, 5}	87.54(n)¹ 94.44(a)¹		15 (39.78 cM)⁵ 72301¹ NM_001163145.1¹ NP_001156617.1¹ 84379205⁵
chicken (Gallus gallus)	Aves	LOC100857276¹	uncharacterized LOC100857276	72.19(n) 75.69(a)		100857276 XM_003640423.1 XP_003640471.1
lizard (Anolis carolinensis)	Reptilia	KIAA1644⁶	--	74(a)	1 ↔ 1	5(85569165-85591121)
zebrafish (Danio rerio)	Actinopterygii	si:dkey-14k9.2¹	si:dkey-14k9.2	65.81(n) 63.59(a)		560435 NM_001030141.1 NP_001025312.1

ENSEMBL Gene Tree for KIAA1644 (if available)
TreeFam Gene Tree for KIAA1644 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs13058519^1,2	C,F,A,	--	44639120(+)	`CCCAGT/CGTGAG`	1	--	ds500¹		9		NA WA CSA EA	369
rs140964436^1,2		--	44639206(+)	`AGAGGC/TACCTG`	1	--	ds500¹		0	--	--	--	--
rs115619305^1,2	F,	--	44639261(+)	`TGCCCG/ACCCCC`	1	--	ds500¹		1		WA	118
rs200527658^1,2		--	44639261(+)	`GCCCG-/CCCCCC`	1	--	ds500¹		0	--	--	--	--
rs201252195^1,2		--	44639314(+)	`TGCCA-/GATT GATTC`	1	--	ds500¹		0	--	--	--	--
rs144821627^1,2		--	44639444(+)	`GCTGGA/GACCCC`	1	--	ds500¹		0	--	--	--	--
rs79301995^1,2		--	44639492(+)	`ATTATG/ACGGGC`	1	--	ds500¹		1		WA	118
rs113524056^1,2		--	44639542(+)	`CGTCAG/ATCTAG`	1	--	ds500¹		2		CSA	2
rs112676402^1,2	C,	--	44639856(+)	`GAGGTC/TTCCTG`	1	--	ut3¹		2		WA	120
rs139416993^1,2		--	44639883(+)	`GAGCCC/TCTCAC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KIAA1644 (44639547 - 44708731 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for KIAA1644
3 CNVs: 4130 73836 2027

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KIAA1644 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KIAA1644)

Utopia: connect your pdf to the dynamic
world of online information

Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PubMed id 11258795)^{1, 2, 3} Hirosawa M....Ohara O. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
The DNA sequence of human chromosome 22. (PubMed id 10591208)² Dunham I....O'Brien K.P. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 85352	HGNC: 29335	AceView: KIAA1644	Ensembl:ENSG00000138944	euGenes: HUgn85352
ECgene: KIAA1644	H-InvDB: KIAA1644

(According to HUGE)
About This Section

HUGE: KIAA1644

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KIAA1644	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KIAA1644 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KIAA1644 gene:
Search GeneIP for patents involving KIAA1644

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1644

	Browse SwitchGear 3'UTR luciferase reporter plasmids for KIAA1644
	Browse SwitchGear Promoter luciferase reporter plasmids for KIAA1644

ThermoFisher Antibodies for KIAA1644

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA1644

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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KIAA1644 Gene

KIAA1644

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KIAA1644 Gene

KIAA1644

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