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KIAA1644 Gene

protein-coding   GIFtS: 40
GCID: GC22M044639          (predicted)

KIAA1644

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
KIAA16441 2
Uncharacterized Protein KIAA16442

External Ids:    HGNC: 293351   Entrez Gene: 853522   Ensembl: ENSG000001389447   UniProtKB: Q3SXP73   

Export aliases for KIAA1644 gene to outside databases

Previous GC identifers: GC22M041256 GC22M042901 GC22U900118 GC22M042897 GC22M042964 GC22M027592


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KIAA1644 Gene:
KIAA1644 (KIAA1644) is a protein-coding gene. Diseases associated with KIAA1644 include uterine fibroid, and cerebritis.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIAA1644 gene promoter:
         Oct-B1   oct-B3   oct-B2   Lmo2   POU3F2   Roaz   AREB6   HEN1   Sox9   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KIAA1644

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIAA1644


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  22q13.31   HGNC cytogenetic band: 22q13

KIAA1644 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA1644 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M044639:  view genomic region     (about GC identifiers)

Start:
44,639,547 bp from pter      End:
44,708,731 bp from pter
Size:
69,185 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: K1644_HUMAN, Q3SXP7 (See protein sequence)
Recommended Name: Uncharacterized protein KIAA1644 precursor  
Size: 199 amino acids; 22573 Da
Secondary accessions: A6NHP0 A9Z1Z0 Q3SXP8 Q5JZ71 Q9BYB5

Explore the universe of human proteins at neXtProt for KIAA1644: NX_Q3SXP7

Explore proteomics data for KIAA1644 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn53, Asn95

  • See KIAA1644 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001092764.1  
    ENSEMBL proteins: 
     ENSP00000370568  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q3SXP7


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    K1644_HUMAN, Q3SXP7: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane3
    lysosome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    KIAA1644 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIAA1644
    Interactions:

        Search GeneGlobe Interaction Network for KIAA1644

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIAA1644 (K1644)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KIAA1644 gene: 
    NM_001099294.1  

    Unigene Cluster for KIAA1644:

    KIAA1644
    Hs.6829  [show with all ESTs]
    Unigene Representative Sequence: NM_001099294
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000381176(uc003bet.2)
    miRNA
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    Additional mRNA sequence: 

    AB051431.1 AK090953.1 BC068280.1 BC104183.1 BC104184.1 

    2 DOTS entries:

    DT.95157574  DT.92407473 

    Selected AceView cDNA sequences (see all 70):

    BM970429 BM662042 AI207922 AW069525 BU739788 BE910231 BQ931474 Z45383 
    BF054986 BM713334 BM718569 Z41100 BF108887 T16816 BQ958904 BF516072 
    BI668901 AA912027 AA476987 AA127895 BU959430 AI494141 BM716046 AA663744 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIAA1644 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAACTGTTC
    KIAA1644 Expression
    About this image


    KIAA1644 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
             Thalamus
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
    KIAA1644 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIAA1644 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6829
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1644

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KIAA1644 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1810041L15Rik1 , 5 RIKEN cDNA 1810041L15 gene1, 5 87.54(n)1
    94.44(a)1
      15 (39.78 cM)5
    723011  NM_001163145.11  NP_001156617.11 
     843792055 
    chicken
    (Gallus gallus)
    Aves KIAA16441 KIAA1644 73.37(n)
    77.39(a)
      100857276  XM_004938036.1  XP_004938093.1 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA16446
    KIAA1644
    64(a)
    1 ↔ 1
    5(85399532-85613240)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017330251 uncharacterized LOC101733025 72.04(n)
    70.97(a)
      101733025  XM_004920385.1  XP_004920442.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-14k9.21 si:dkey-14k9.2 65.16(n)
    61.81(a)
      560435  NM_001030141.1  NP_001025312.1 


    ENSEMBL Gene Tree for KIAA1644 (if available)
    TreeFam Gene Tree for KIAA1644 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIAA1644 (see all 2048)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1354421,2
    C--27602301(-) aaaaa-/CATGCAC 1 -- int10--------
    rs588251391,2
    C--27602302(+) TGCAT-/G/GT  
            
    TTTTT
    1 -- int11NA 2
    rs1354301,2
    C--28573601(-) CTGTT-/GTTAAGAG 1 -- int10--------
    rs130585191,2
    C,F,A--44639120(+) CCCAGT/CGTGAG 1 -- ds50019Minor allele frequency- C:0.28NA WA CSA EA 369
    rs1409644361,2
    --44639206(+) AGAGGC/TACCTG 1 -- ds50010--------
    rs558103501,2
    C--44639261(+) CCCCC-/CACCCT 1 -- ds50010--------
    rs1156193051,2
    C,F--44639261(+) TGCCCG/ACCCCC 1 -- ds50011Minor allele frequency- A:0.09WA 118
    rs601399601,2
    C--44639269(+) CCCCC-/CACCCT 1 -- ds50010--------
    rs2012521951,2
    C--44639314(+) TGCCA-/GATT  
            
    GATTC
    1 -- ds50010--------
    rs768444961,2
    C--44639408(+) GGACTC/TGTGTG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for KIAA1644 (44639547 - 44708731 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KIAA1644 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2742673CNV Deletion23290073
    esv2724351CNV Deletion23290073
    esv2554291CNV Deletion19546169
    esv2677488CNV Deletion23128226
    esv2724348CNV Deletion23290073
    esv2724346CNV Deletion23290073
    esv2657182CNV Deletion23128226
    dgv784e201CNV Deletion23290073
    esv2724353CNV Deletion23290073
    esv2724347CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for KIAA1644:    
    About MalaCards
    uterine fibroid    cerebritis


    KIAA1644 for disorders           About GeneDecksing


    Export disorders for KIAA1644 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIAA1644 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KIAA1644)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PubMed id 11258795)1, 2, 3 Hirosawa M.... Ohara O. (DNA Res. 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I.... Wright H. (Nature 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85352 HGNC: 29335 AceView: KIAA1644 Ensembl:ENSG00000138944 euGenes: HUgn85352
    ECgene: KIAA1644 H-InvDB: KIAA1644

    (According to HUGE)
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    HUGE: KIAA1644

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIAA1644 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIAA1644 gene:
    Search GeneIP for patents involving KIAA1644

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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