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Aliases for KIAA1614 Gene

Aliases for KIAA1614 Gene

  • KIAA1614 2 3

External Ids for KIAA1614 Gene

Previous GeneCards Identifiers for KIAA1614 Gene

  • GC01P178406
  • GC01P176310
  • GC01P177402
  • GC01P178105
  • GC01P177613
  • GC01P179148
  • GC01P180882
  • GC01P152113

Summaries for KIAA1614 Gene

GeneCards Summary for KIAA1614 Gene

KIAA1614 (KIAA1614) is a Protein Coding gene.

Additional gene information for KIAA1614 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1614 Gene

Genomics for KIAA1614 Gene

Regulatory Elements for KIAA1614 Gene

Enhancers for KIAA1614 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H181126 2 FANTOM5 Ensembl ENCODE dbSUPER 21 +216.2 216183 6 HDGF PKNOX1 ARNT FEZF1 ZNF2 FOS ZNF548 ZC3H11A JUNB REST LHX4 ACBD6 KIAA1614 IER5 MR1 GC01M181116 LINC01732
GH01H181132 2 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +221.8 221762 4 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 ZNF207 FOS LHX4 IER5 ENSG00000225359 ENSG00000232309 ACBD6 KIAA1614 MR1 STX6 GC01M181116 LINC01732
GH01H180925 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10 +14.0 14015 3 ELF3 TBP MLX ARID4B NFXL1 THRB ZSCAN9 RARA TCF12 GLIS2 ENSG00000243155 KIAA1614 GC01P180946
GH01H180981 0.9 ENCODE dbSUPER 17.8 +69.0 69031 1 MAZ NR2F1 ELF1 EBF1 ZIC2 POLR2A IKZF1 SMC3 RUNX3 IKZF2 KIAA1614 LOC105371638 ENSG00000243155 STX6
GH01H180881 1.2 Ensembl ENCODE 12.2 -31.1 -31054 0 ATF1 ZNF2 RAD21 ZEB1 RFX5 TCF12 ZNF121 ZNF366 ZNF143 ATF7 LOC105371638 KIAA1614 ENSG00000243155 IER5 MR1 GC01M180874
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIAA1614 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA1614 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000016585 -254 1801 ZNF687 SUZ12 NR2F1 BACH1 DPF2 ZNF592 POLR2A IKZF1 ZBTB33 MLLT1

Genomic Location for KIAA1614 Gene

Chromosome:
1
Start:
180,913,154 bp from pter
End:
180,951,614 bp from pter
Size:
38,461 bases
Orientation:
Plus strand

Genomic View for KIAA1614 Gene

Genes around KIAA1614 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1614 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1614 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1614 Gene

Proteins for KIAA1614 Gene

  • Protein details for KIAA1614 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZ46-K1614_HUMAN
    Recommended name:
    Uncharacterized protein KIAA1614
    Protein Accession:
    Q5VZ46
    Secondary Accessions:
    • Q5VZ45
    • Q9HCF8

    Protein attributes for KIAA1614 Gene

    Size:
    1190 amino acids
    Molecular mass:
    126604 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13440.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1614 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1614 Gene

Post-translational modifications for KIAA1614 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIAA1614 Gene

No data available for DME Specific Peptides for KIAA1614 Gene

Domains & Families for KIAA1614 Gene

Gene Families for KIAA1614 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KIAA1614 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA1614: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for KIAA1614 Gene

Function for KIAA1614 Gene

genes like me logo Genes that share phenotypes with KIAA1614: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KIAA1614
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1614 Gene

Localization for KIAA1614 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA1614 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA1614 Gene

Pathways & Interactions for KIAA1614 Gene

SuperPathways for KIAA1614 Gene

No Data Available

Interacting Proteins for KIAA1614 Gene

Gene Ontology (GO) - Biological Process for KIAA1614 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA1614 Gene

Drugs & Compounds for KIAA1614 Gene

No Compound Related Data Available

Transcripts for KIAA1614 Gene

mRNA/cDNA for KIAA1614 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIAA1614 Gene

KIAA1614:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KIAA1614
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1614 Gene

No ASD Table

Relevant External Links for KIAA1614 Gene

GeneLoc Exon Structure for
KIAA1614
ECgene alternative splicing isoforms for
KIAA1614

Expression for KIAA1614 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA1614 Gene

Protein differential expression in normal tissues from HIPED for KIAA1614 Gene

This gene is overexpressed in CD4 Tcells (19.7), Liver, secretome (16.3), NK cells (9.9), and Tlymphocyte (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KIAA1614 Gene



NURSA nuclear receptor signaling pathways regulating expression of KIAA1614 Gene:

KIAA1614

SOURCE GeneReport for Unigene cluster for KIAA1614 Gene:

Hs.734816
genes like me logo Genes that share expression patterns with KIAA1614: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA1614 Gene

Orthologs for KIAA1614 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1614 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1614 33 34
  • 97.69 (n)
cow
(Bos Taurus)
Mammalia KIAA1614 33 34
  • 77.97 (n)
dog
(Canis familiaris)
Mammalia KIAA1614 33 34
  • 77.24 (n)
mouse
(Mus musculus)
Mammalia BC034090 33 16 34
  • 71.15 (n)
rat
(Rattus norvegicus)
Mammalia RGD1304622 33
  • 70.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1614 34
  • 35 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA1614 34
  • 34 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 54 (a)
OneToMany
-- 34
  • 41 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia KIAA1614 34
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkey-121a11.3 34
  • 26 (a)
OneToMany
si:ch211-13f8.1 34
  • 20 (a)
OneToMany
Species where no ortholog for KIAA1614 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1614 Gene

ENSEMBL:
Gene Tree for KIAA1614 (if available)
TreeFam:
Gene Tree for KIAA1614 (if available)

Paralogs for KIAA1614 Gene

No data available for Paralogs for KIAA1614 Gene

Variants for KIAA1614 Gene

Sequence variations from dbSNP and Humsavar for KIAA1614 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000003037 -- 180,918,232(+) AAATA(C/G)CATCT intron-variant
rs1000004522 -- 180,928,269(+) AGGCC(C/T)CCAGG intron-variant
rs1000110127 -- 180,913,423(+) AAGGG(C/T)CGTGG intron-variant
rs1000126344 -- 180,925,072(+) AGTGG(C/G)TGTCC intron-variant
rs1000141223 -- 180,913,689(+) GTGCG(A/G)TCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1614 Gene

Variant ID Type Subtype PubMed ID
esv3890804 CNV gain 25118596
nsv1001918 CNV loss 25217958
nsv1068340 CNV deletion 25765185

Variation tolerance for KIAA1614 Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.17; 75.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1614 Gene

Human Gene Mutation Database (HGMD)
KIAA1614
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1614

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1614 Gene

Disorders for KIAA1614 Gene

Relevant External Links for KIAA1614

Genetic Association Database (GAD)
KIAA1614
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1614

No disorders were found for KIAA1614 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1614 Gene

Publications for KIAA1614 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 60
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 60
  5. Identification of promoter regions in the human genome by using a retroviral plasmid library-based functional reporter gene assay. (PMID: 12805274) Khambata-Ford S … Myers RM (Genome research 2003) 3 60

Products for KIAA1614 Gene

Sources for KIAA1614 Gene

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