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Aliases for KIAA1614 Gene

Aliases for KIAA1614 Gene

  • KIAA1614 2 3

External Ids for KIAA1614 Gene

Previous GeneCards Identifiers for KIAA1614 Gene

  • GC01P178406
  • GC01P176310
  • GC01P177402
  • GC01P178105
  • GC01P177613
  • GC01P179148
  • GC01P180882
  • GC01P152113

Summaries for KIAA1614 Gene

GeneCards Summary for KIAA1614 Gene

KIAA1614 (KIAA1614) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1614 Gene

Genomics for KIAA1614 Gene

Regulatory Elements for KIAA1614 Gene

Enhancers for KIAA1614 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F181040 0.2 Ensembl 18.7 +127.9 127947 1.4 PKNOX1 ZFP64 ZNF493 ZNF138 ZNF354C ZNF202 ZNF680 ZNF654 REST ZNF518A LHX4 ACBD6 KIAA1614 IER5 MR1 GC01P181059
GH01F180981 0.4 ENCODE 17.8 +69.0 69031 1.4 CTCF EBF1 TBX21 ZIC2 EP300 POLR2A IKZF1 SMC3 KIAA1614 LOC105371638 ENSG00000243155 STX6
GH01F180882 0.2 ENCODE 12.2 -30.9 -30935 0.2 ATF1 ZNF2 RAD21 ZEB1 RFX5 ZNF121 ZNF366 MIXL1 ZNF263 ZNF362 LOC105371638 KIAA1614 ENSG00000243155 IER5 MR1 GC01M180874
GH01F180881 0.2 ENCODE 12.2 -31.1 -31115 0.2 ATF1 ZNF2 RAD21 ZEB1 RFX5 ZNF366 MIXL1 ZNF263 ZNF362 ZNF654 LOC105371638 KIAA1614 ENSG00000243155 IER5 MR1 GC01M180874
GH01F181158 1.3 FANTOM5 Ensembl ENCODE 11.2 +247.2 247247 3.6 HDGF PKNOX1 ARNT ZNF493 ZNF121 GATA2 FOS ZNF548 KDM4B MCM5 LHX4 IER5 ACBD6 MR1 KIAA1614 STX6 LINC01732 GC01M181116
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KIAA1614 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA1614 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000548632 -154 2401 ZNF2 RAD21 ZNF121 ZNF366 DEK MIXL1 ZNF263 ZNF362 ZNF654 CEBPB

Genomic Location for KIAA1614 Gene

Chromosome:
1
Start:
180,913,154 bp from pter
End:
180,951,614 bp from pter
Size:
38,461 bases
Orientation:
Plus strand

Genomic View for KIAA1614 Gene

Genes around KIAA1614 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1614 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1614 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1614 Gene

Proteins for KIAA1614 Gene

  • Protein details for KIAA1614 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZ46-K1614_HUMAN
    Recommended name:
    Uncharacterized protein KIAA1614
    Protein Accession:
    Q5VZ46
    Secondary Accessions:
    • Q5VZ45
    • Q9HCF8

    Protein attributes for KIAA1614 Gene

    Size:
    1190 amino acids
    Molecular mass:
    126604 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13440.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1614 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1614 Gene

Post-translational modifications for KIAA1614 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIAA1614 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIAA1614 Gene

Domains & Families for KIAA1614 Gene

Protein Domains for KIAA1614 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA1614: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for KIAA1614 Gene

Function for KIAA1614 Gene

genes like me logo Genes that share phenotypes with KIAA1614: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1614 Gene

Localization for KIAA1614 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA1614 Gene COMPARTMENTS Subcellular localization image for KIAA1614 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA1614 Gene

Pathways & Interactions for KIAA1614 Gene

SuperPathways for KIAA1614 Gene

No Data Available

Interacting Proteins for KIAA1614 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356560%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000356560 for KIAA1614 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for KIAA1614 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA1614 Gene

Transcripts for KIAA1614 Gene

Unigene Clusters for KIAA1614 Gene

KIAA1614:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1614 Gene

No ASD Table

Relevant External Links for KIAA1614 Gene

GeneLoc Exon Structure for
KIAA1614
ECgene alternative splicing isoforms for
KIAA1614

Expression for KIAA1614 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIAA1614 Gene

Protein differential expression in normal tissues from HIPED for KIAA1614 Gene

This gene is overexpressed in CD4 Tcells (19.7), Liver, secretome (16.3), NK cells (9.9), and Tlymphocyte (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KIAA1614 Gene



NURSA nuclear receptor signaling pathways regulating expression of KIAA1614 Gene:

KIAA1614

SOURCE GeneReport for Unigene cluster for KIAA1614 Gene:

Hs.734816
genes like me logo Genes that share expression patterns with KIAA1614: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for KIAA1614 Gene

Orthologs for KIAA1614 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1614 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1614 34 35
  • 97.69 (n)
cow
(Bos Taurus)
Mammalia KIAA1614 34 35
  • 77.97 (n)
dog
(Canis familiaris)
Mammalia KIAA1614 34 35
  • 77.24 (n)
mouse
(Mus musculus)
Mammalia BC034090 34 16 35
  • 71.15 (n)
rat
(Rattus norvegicus)
Mammalia RGD1304622 34
  • 70.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1614 35
  • 35 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA1614 35
  • 34 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 54 (a)
OneToMany
-- 35
  • 41 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia KIAA1614 35
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkey-121a11.3 35
  • 26 (a)
OneToMany
si:ch211-13f8.1 35
  • 20 (a)
OneToMany
Species where no ortholog for KIAA1614 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1614 Gene

ENSEMBL:
Gene Tree for KIAA1614 (if available)
TreeFam:
Gene Tree for KIAA1614 (if available)

Paralogs for KIAA1614 Gene

No data available for Paralogs for KIAA1614 Gene

Variants for KIAA1614 Gene

Sequence variations from dbSNP and Humsavar for KIAA1614 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10157421 -- 180,945,963(+) ctggg(C/G)gtggt utr-variant-3-prime
rs10522338 -- 180,924,886(+) GATAA(-/AATAATAATAAT/AATAATAATAATAAT/AATAATAATAATAATAAT/AATAATAATAATAATAATAAT/T)AATAA intron-variant
rs10712482 -- 180,914,157(+) TTCAA(-/G)GGGGG intron-variant
rs10732273 -- 180,916,294(+) CAGCC(C/T)GATGG reference, missense
rs10753227 -- 180,921,438(+) ACTGA(C/G)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1614 Gene

Variant ID Type Subtype PubMed ID
esv3890804 CNV gain 25118596
nsv1001918 CNV loss 25217958
nsv1068340 CNV deletion 25765185

Variation tolerance for KIAA1614 Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.17; 75.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1614 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1614

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1614 Gene

Disorders for KIAA1614 Gene

Relevant External Links for KIAA1614

Genetic Association Database (GAD)
KIAA1614
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1614

No disorders were found for KIAA1614 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1614 Gene

Publications for KIAA1614 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  5. Identification of promoter regions in the human genome by using a retroviral plasmid library-based functional reporter gene assay. (PMID: 12805274) Khambata-Ford S. … Myers R.M. (Genome Res. 2003) 3 64

Products for KIAA1614 Gene

Sources for KIAA1614 Gene

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