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Aliases for KIAA1586 Gene

Aliases for KIAA1586 Gene

  • KIAA1586 2 3

External Ids for KIAA1586 Gene

Previous GeneCards Identifiers for KIAA1586 Gene

  • GC06P056918
  • GC06P056958
  • GC06P057019
  • GC06P056745
  • GC06P056911

Summaries for KIAA1586 Gene

GeneCards Summary for KIAA1586 Gene

KIAA1586 (KIAA1586) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF862.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1586 Gene

Genomics for KIAA1586 Gene

Regulatory Elements for KIAA1586 Gene

Genomic Location for KIAA1586 Gene

Start:
57,046,532 bp from pter
End:
57,055,239 bp from pter
Size:
8,708 bases
Orientation:
Plus strand

Genomic View for KIAA1586 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIAA1586 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1586 Gene

Proteins for KIAA1586 Gene

  • Protein details for KIAA1586 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCI6-K1586_HUMAN
    Recommended name:
    Uncharacterized protein KIAA1586
    Protein Accession:
    Q9HCI6
    Secondary Accessions:
    • A8K4M3
    • Q8IW25

    Protein attributes for KIAA1586 Gene

    Size:
    787 amino acids
    Molecular mass:
    89673 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13412.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1586 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1586 Gene

Proteomics data for KIAA1586 Gene at MOPED

Post-translational modifications for KIAA1586 Gene

  • Ubiquitination at Lys275
  • Modification sites at PhosphoSitePlus

Other Protein References for KIAA1586 Gene

No data available for DME Specific Peptides for KIAA1586 Gene

Domains for KIAA1586 Gene

Protein Domains for KIAA1586 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA1586 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA1586: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KIAA1586 Gene

Function for KIAA1586 Gene

Gene Ontology (GO) - Molecular Function for KIAA1586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with KIAA1586: view

miRNA for KIAA1586 Gene

miRTarBase miRNAs that target KIAA1586

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIAA1586 Gene

Localization for KIAA1586 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA1586 Gene COMPARTMENTS Subcellular localization image for KIAA1586 gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA1586 Gene

Pathways for KIAA1586 Gene

SuperPathways for KIAA1586 Gene

No Data Available

Interacting Proteins for KIAA1586 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359768%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000359768 for KIAA1586 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for KIAA1586 Gene

None

No data available for Pathways by source for KIAA1586 Gene

Transcripts for KIAA1586 Gene

Unigene Clusters for KIAA1586 Gene

KIAA1586:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1586 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d
SP1: -
SP2: - -
SP3:
SP4: - -

Relevant External Links for KIAA1586 Gene

GeneLoc Exon Structure for
KIAA1586
ECgene alternative splicing isoforms for
KIAA1586

Expression for KIAA1586 Gene

mRNA expression in normal human tissues for KIAA1586 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIAA1586 Gene

SOURCE GeneReport for Unigene cluster for KIAA1586 Gene Hs.709521

genes like me logo Genes that share expressions with KIAA1586: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIAA1586 Gene

Orthologs for KIAA1586 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KIAA1586 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1586 35
  • 99.29 (n)
  • 98.8 (a)
KIAA1586 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA1586 36
  • 68 (a)
OneToOne
Species with no ortholog for KIAA1586:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KIAA1586 Gene

ENSEMBL:
Gene Tree for KIAA1586 (if available)
TreeFam:
Gene Tree for KIAA1586 (if available)

Paralogs for KIAA1586 Gene

Paralogs for KIAA1586 Gene

Selected SIMAP similar genes for KIAA1586 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for KIAA1586 Gene

genes like me logo Genes that share paralogs with KIAA1586: view

Variants for KIAA1586 Gene

Sequence variations from dbSNP and Humsavar for KIAA1586 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1157713 -- 57,046,086(+) TGTAG(A/G)TCAGG upstream-variant-2KB
rs6926980 - 57,052,740(+) TAAAT(A/G)TGAAG missense, reference
rs7740767 -- 57,048,655(+) TGGGT(A/C)TTTAG intron-variant
rs9382680 -- 57,046,776(+) TCGGA(A/G)GTGAG reference, synonymous-codon, utr-variant-5-prime
rs11965260 -- 57,050,884(+) TTCAG(A/T)TTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1586 Gene

Variant ID Type Subtype PubMed ID
nsv885913 CNV Loss 21882294
esv2732127 CNV Deletion 23290073
esv2669750 CNV Deletion 23128226
nsv526143 CNV Loss 19592680

Relevant External Links for KIAA1586 Gene

HapMap Linkage Disequilibrium report
KIAA1586
Human Gene Mutation Database (HGMD)
KIAA1586

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1586 Gene

Disorders for KIAA1586 Gene

No disorders were found for KIAA1586 Gene.

No data available for UniProtKB/Swiss-Prot for KIAA1586 Gene

Publications for KIAA1586 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for KIAA1586 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate KIAA1586
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for KIAA1586
  • Block miRNA regulation of KIAA1586 using miScript Target Protectors

Sources for KIAA1586 Gene

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