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Aliases for KIAA1586 Gene

Aliases for KIAA1586 Gene

  • KIAA1586 2 3

External Ids for KIAA1586 Gene

Previous GeneCards Identifiers for KIAA1586 Gene

  • GC06P056918
  • GC06P056958
  • GC06P057019
  • GC06P056745
  • GC06P056911

Summaries for KIAA1586 Gene

GeneCards Summary for KIAA1586 Gene

KIAA1586 (KIAA1586) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF862.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1586 Gene

Genomics for KIAA1586 Gene

Regulatory Elements for KIAA1586 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIAA1586 Gene

Chromosome:
6
Start:
57,046,532 bp from pter
End:
57,059,326 bp from pter
Size:
12,795 bases
Orientation:
Plus strand

Genomic View for KIAA1586 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIAA1586 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1586 Gene

Proteins for KIAA1586 Gene

  • Protein details for KIAA1586 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCI6-K1586_HUMAN
    Recommended name:
    Uncharacterized protein KIAA1586
    Protein Accession:
    Q9HCI6
    Secondary Accessions:
    • A8K4M3
    • Q8IW25

    Protein attributes for KIAA1586 Gene

    Size:
    787 amino acids
    Molecular mass:
    89673 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13412.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1586 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1586 Gene

Proteomics data for KIAA1586 Gene at MOPED

Post-translational modifications for KIAA1586 Gene

  • Ubiquitination at Lys 275
  • Modification sites at PhosphoSitePlus

Other Protein References for KIAA1586 Gene

No data available for DME Specific Peptides for KIAA1586 Gene

Domains & Families for KIAA1586 Gene

Protein Domains for KIAA1586 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA1586 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA1586: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KIAA1586 Gene

Function for KIAA1586 Gene

Gene Ontology (GO) - Molecular Function for KIAA1586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with KIAA1586: view

Phenotypes for KIAA1586 Gene

GenomeRNAi human phenotypes for KIAA1586:
genes like me logo Genes that share phenotypes with KIAA1586: view

Animal Model Products

CRISPR Products

miRNA for KIAA1586 Gene

miRTarBase miRNAs that target KIAA1586

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIAA1586

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1586 Gene

Localization for KIAA1586 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA1586 Gene COMPARTMENTS Subcellular localization image for KIAA1586 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA1586 Gene

Pathways & Interactions for KIAA1586 Gene

SuperPathways for KIAA1586 Gene

No Data Available

Interacting Proteins for KIAA1586 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359768%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000359768 for KIAA1586 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for KIAA1586 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA1586 Gene

Drugs & Compounds for KIAA1586 Gene

No Compound Related Data Available

Transcripts for KIAA1586 Gene

Unigene Clusters for KIAA1586 Gene

KIAA1586:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIAA1586

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1586 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d
SP1: -
SP2: - -
SP3:
SP4: - -

Relevant External Links for KIAA1586 Gene

GeneLoc Exon Structure for
KIAA1586
ECgene alternative splicing isoforms for
KIAA1586

Expression for KIAA1586 Gene

mRNA expression in normal human tissues for KIAA1586 Gene

Protein differential expression in normal tissues from HIPED for KIAA1586 Gene

This gene is overexpressed in Fetal heart (20.1), Fetal Brain (12.0), Urinary Bladder (6.9), CD4 Tcells (6.5), and Monocytes (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIAA1586 Gene



SOURCE GeneReport for Unigene cluster for KIAA1586 Gene Hs.709521

genes like me logo Genes that share expression patterns with KIAA1586: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KIAA1586 Gene

Orthologs for KIAA1586 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KIAA1586 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1586 35
  • 99.29 (n)
  • 98.8 (a)
KIAA1586 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA1586 36
  • 68 (a)
OneToOne
Species with no ortholog for KIAA1586:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KIAA1586 Gene

ENSEMBL:
Gene Tree for KIAA1586 (if available)
TreeFam:
Gene Tree for KIAA1586 (if available)

Paralogs for KIAA1586 Gene

Paralogs for KIAA1586 Gene

(1) SIMAP similar genes for KIAA1586 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for KIAA1586 Gene

genes like me logo Genes that share paralogs with KIAA1586: view

Variants for KIAA1586 Gene

Sequence variations from dbSNP and Humsavar for KIAA1586 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1047394 -- 57,058,879(+) ACAGT(A/C)CTGAG intron-variant
rs1157713 -- 57,046,086(+) TGTAG(A/G)TCAGG upstream-variant-2KB
rs6926980 - 57,052,740(+) TAAAT(A/G)TGAAG missense, reference, nc-transcript-variant
rs6929783 -- 57,056,141(+) cttcc(C/T)gggtt downstream-variant-500B, intron-variant
rs7740767 -- 57,048,655(+) TGGGT(A/C)TTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1586 Gene

Variant ID Type Subtype PubMed ID
nsv885913 CNV Loss 21882294
esv2732127 CNV Deletion 23290073
esv2669750 CNV Deletion 23128226
nsv526143 CNV Loss 19592680

Variation tolerance for KIAA1586 Gene

Residual Variation Intolerance Score: 56.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.28; 85.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1586 Gene

HapMap Linkage Disequilibrium report
KIAA1586
Human Gene Mutation Database (HGMD)
KIAA1586

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1586 Gene

Disorders for KIAA1586 Gene

Relevant External Links for KIAA1586

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1586
genes like me logo Genes that share disorders with KIAA1586: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1586 Gene

Publications for KIAA1586 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for KIAA1586 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate KIAA1586
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for KIAA1586
  • Block miRNA regulation of KIAA1586 using miScript Target Protectors

Sources for KIAA1586 Gene

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