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Aliases for KIAA1586 Gene

Aliases for KIAA1586 Gene

  • KIAA1586 2 3
  • EC 6.3.2.- 4

External Ids for KIAA1586 Gene

Previous GeneCards Identifiers for KIAA1586 Gene

  • GC06P056918
  • GC06P056958
  • GC06P057019
  • GC06P056745
  • GC06P056911

Summaries for KIAA1586 Gene

GeneCards Summary for KIAA1586 Gene

KIAA1586 (KIAA1586) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF862.

UniProtKB/Swiss-Prot for KIAA1586 Gene

  • E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins (PubMed:26524493).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1586 Gene

Genomics for KIAA1586 Gene

Regulatory Elements for KIAA1586 Gene

Enhancers for KIAA1586 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G056765 1.4 Ensembl ENCODE dbSUPER 29.6 -279.4 -279370 2.8 TBP PKNOX1 TBL1XR1 ZFP64 SIN3A RAD21 ZNF354C CBX5 FOS RELB KIAA1586 LOC101930010 LOC101927211 RAB23 GC06M056744 GC06P056805
GH06G056838 1.6 Ensembl ENCODE dbSUPER 23.7 -205.0 -205024 6.7 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CBX5 ZNF143 KIAA1586 LOC101930010 LOC101927211 BEND6 GC06P056805
GH06G056723 1.5 Ensembl ENCODE dbSUPER 21.5 -317.8 -317839 9.9 HNRNPUL1 PKNOX1 FOXA2 ZFP64 FEZF1 ZNF2 YY1 CBX5 ZNF143 FOS KIAA1586 LOC101927211 LOC101930010 GC06M056744 GC06P056616
GH06G056901 1.4 Ensembl ENCODE dbSUPER 21.5 -143.9 -143944 1.7 PKNOX1 ZFP64 RAD21 CBX5 ZNF143 ETV6 RELB CREM IKZF2 ZNF202 BEND6 LOC101927211 KIAA1586 DST BAG2 GC06M056915 GC06P056873
GH06G056849 1.3 ENCODE dbSUPER 21.5 -195.1 -195077 4.1 FOXA2 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 GATA2 ZNF143 FOS KIAA1586 LOC101930010 LOC101927211 RPL17P26
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIAA1586 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA1586 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000198386 469 2000 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for KIAA1586 Gene

Chromosome:
6
Start:
57,046,532 bp from pter
End:
57,059,326 bp from pter
Size:
12,795 bases
Orientation:
Plus strand

Genomic View for KIAA1586 Gene

Genes around KIAA1586 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1586 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1586 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1586 Gene

Proteins for KIAA1586 Gene

  • Protein details for KIAA1586 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCI6-K1586_HUMAN
    Recommended name:
    E3 SUMO-protein ligase KIAA1586
    Protein Accession:
    Q9HCI6
    Secondary Accessions:
    • A8K4M3
    • Q8IW25

    Protein attributes for KIAA1586 Gene

    Size:
    787 amino acids
    Molecular mass:
    89673 Da
    Quaternary structure:
    • Interacts with UBE2I/UBC9 and SUMO2.
    SequenceCaution:
    • Sequence=BAB13412.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1586 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1586 Gene

Post-translational modifications for KIAA1586 Gene

  • Ubiquitination at isoforms=2275
  • Modification sites at PhosphoSitePlus

Other Protein References for KIAA1586 Gene

No data available for DME Specific Peptides for KIAA1586 Gene

Domains & Families for KIAA1586 Gene

Protein Domains for KIAA1586 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA1586 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCI6

UniProtKB/Swiss-Prot:

K1586_HUMAN :
  • Binds UBE2I/UBC9 and two SUMO2 molecules via its N-terminus. The most N-terminal region interacts with the SUMO2 chain that is covalently bound to the UBE2I/UBC9 active site, while the second region interacts with another SUMO2 that is non-covalently associated with the same UBE2I/UBC9 chain.
Domain:
  • Binds UBE2I/UBC9 and two SUMO2 molecules via its N-terminus. The most N-terminal region interacts with the SUMO2 chain that is covalently bound to the UBE2I/UBC9 active site, while the second region interacts with another SUMO2 that is non-covalently associated with the same UBE2I/UBC9 chain.
genes like me logo Genes that share domains with KIAA1586: view

No data available for Gene Families for KIAA1586 Gene

Function for KIAA1586 Gene

Molecular function for KIAA1586 Gene

UniProtKB/Swiss-Prot Function:
E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins (PubMed:26524493).

Enzyme Numbers (IUBMB) for KIAA1586 Gene

Gene Ontology (GO) - Molecular Function for KIAA1586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0016874 ligase activity IEA --
GO:0061665 SUMO ligase activity IDA 26524493
genes like me logo Genes that share ontologies with KIAA1586: view

Phenotypes for KIAA1586 Gene

genes like me logo Genes that share phenotypes with KIAA1586: view

Animal Model Products

CRISPR Products

miRNA for KIAA1586 Gene

miRTarBase miRNAs that target KIAA1586

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1586 Gene

Localization for KIAA1586 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA1586 gene
Compartment Confidence
nucleus 3
plasma membrane 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA1586 Gene

Pathways & Interactions for KIAA1586 Gene

SuperPathways for KIAA1586 Gene

No Data Available

UniProtKB/Swiss-Prot Q9HCI6-K1586_HUMAN

  • Pathway: Protein modification; protein sumoylation.

Interacting Proteins for KIAA1586 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359768%0d%0a9606.ENSP00000237201%0d%0a
Selected Interacting proteins: Q9HCI6-K1586_HUMAN ENSP00000359768 for KIAA1586 Gene via IID STRING

Gene Ontology (GO) - Biological Process for KIAA1586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016925 protein sumoylation IEA --
genes like me logo Genes that share ontologies with KIAA1586: view

No data available for Pathways by source and SIGNOR curated interactions for KIAA1586 Gene

Drugs & Compounds for KIAA1586 Gene

No Compound Related Data Available

Transcripts for KIAA1586 Gene

Unigene Clusters for KIAA1586 Gene

KIAA1586:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1586 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d
SP1: -
SP2: - -
SP3:
SP4: - -

Relevant External Links for KIAA1586 Gene

GeneLoc Exon Structure for
KIAA1586
ECgene alternative splicing isoforms for
KIAA1586

Expression for KIAA1586 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA1586 Gene

Protein differential expression in normal tissues from HIPED for KIAA1586 Gene

This gene is overexpressed in Fetal heart (20.1), Fetal Brain (12.0), Urinary Bladder (6.9), CD4 Tcells (6.5), and Monocytes (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIAA1586 Gene



NURSA nuclear receptor signaling pathways regulating expression of KIAA1586 Gene:

KIAA1586

SOURCE GeneReport for Unigene cluster for KIAA1586 Gene:

Hs.709521

Evidence on tissue expression from TISSUES for KIAA1586 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with KIAA1586: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA1586 Gene

Orthologs for KIAA1586 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KIAA1586 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1586 34 35
  • 99.29 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1586 35
  • 68 (a)
OneToOne
Species where no ortholog for KIAA1586 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KIAA1586 Gene

ENSEMBL:
Gene Tree for KIAA1586 (if available)
TreeFam:
Gene Tree for KIAA1586 (if available)

Paralogs for KIAA1586 Gene

Paralogs for KIAA1586 Gene

(1) SIMAP similar genes for KIAA1586 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for KIAA1586 Gene

genes like me logo Genes that share paralogs with KIAA1586: view

Variants for KIAA1586 Gene

Sequence variations from dbSNP and Humsavar for KIAA1586 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000117532 -- 57,052,024(+) TTGAT(A/G)TCATT intron-variant
rs1000326687 -- 57,046,464(+) CGCGG(A/G)GCAGT upstream-variant-2KB
rs1000614937 -- 57,048,551(+) CTGAC(C/T)CTGCC intron-variant
rs1001108755 -- 57,047,039(+) GATTG(C/T)CCTTC intron-variant
rs1002185308 -- 57,046,531(+) CGGGG(A/T)AGGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KIAA1586 Gene

Variant ID Type Subtype PubMed ID
dgv1780e212 CNV loss 25503493
dgv1781e212 CNV gain 25503493
esv2669750 CNV deletion 23128226
esv2732127 CNV deletion 23290073
esv2763988 CNV loss 21179565
esv3609110 CNV loss 21293372
esv3609111 CNV gain 21293372
esv3609112 CNV loss 21293372
esv3890849 CNV loss 25118596
nsv526143 CNV loss 19592680
nsv603189 CNV loss 21841781
nsv970717 CNV duplication 23825009

Variation tolerance for KIAA1586 Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.28; 85.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1586 Gene

Human Gene Mutation Database (HGMD)
KIAA1586
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1586

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1586 Gene

Disorders for KIAA1586 Gene

Relevant External Links for KIAA1586

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1586

No disorders were found for KIAA1586 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1586 Gene

Publications for KIAA1586 Gene

  1. A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly. (PMID: 26524493) Eisenhardt N. … Pichler A. (Nat. Struct. Mol. Biol. 2015) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 4 64
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 64

Products for KIAA1586 Gene

Sources for KIAA1586 Gene

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