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Aliases for KIAA1549L Gene

Aliases for KIAA1549L Gene

  • KIAA1549-Like 2 3 5
  • C11orf41 3 4
  • C11orf69 3 4
  • Chromosome 11 Open Reading Frame 69 2
  • Chromosome 11 Open Reading Frame 41 2
  • Uncharacterized Protein C11orf69 3
  • UPF0606 Protein C11orf41 3
  • G2 3

External Ids for KIAA1549L Gene

Previous HGNC Symbols for KIAA1549L Gene

  • C11orf69
  • C11orf41

Previous GeneCards Identifiers for KIAA1549L Gene

  • GC11P033563

Summaries for KIAA1549L Gene

GeneCards Summary for KIAA1549L Gene

KIAA1549L (KIAA1549-Like) is a Protein Coding gene. Among its related pathways are Development VEGF signaling via VEGFR2 - generic cascades. An important paralog of this gene is KIAA1549.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1549L Gene

Genomics for KIAA1549L Gene

Regulatory Elements for KIAA1549L Gene

Enhancers for KIAA1549L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KIAA1549L on UCSC Golden Path with GeneCards custom track

Genomic Location for KIAA1549L Gene

Chromosome:
11
Start:
33,376,568 bp from pter
End:
33,674,102 bp from pter
Size:
297,535 bases
Orientation:
Plus strand

Genomic View for KIAA1549L Gene

Genes around KIAA1549L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1549L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1549L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1549L Gene

Proteins for KIAA1549L Gene

  • Protein details for KIAA1549L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVL6-K154L_HUMAN
    Recommended name:
    UPF0606 protein KIAA1549L
    Protein Accession:
    Q6ZVL6
    Secondary Accessions:
    • B0QYU0

    Protein attributes for KIAA1549L Gene

    Size:
    1849 amino acids
    Molecular mass:
    198999 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIAA1549L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1549L Gene

Proteomics data for KIAA1549L Gene at MOPED

Post-translational modifications for KIAA1549L Gene

  • Glycosylation at Ser 105, Thr 644, Ser 656, and Thr 753
  • Modification sites at PhosphoSitePlus

Other Protein References for KIAA1549L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIAA1549L Gene

Domains & Families for KIAA1549L Gene

Protein Domains for KIAA1549L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA1549L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZVL6

UniProtKB/Swiss-Prot:

K154L_HUMAN :
  • Belongs to the UPF0606 family.
Family:
  • Belongs to the UPF0606 family.
genes like me logo Genes that share domains with KIAA1549L: view

No data available for Gene Families for KIAA1549L Gene

Function for KIAA1549L Gene

genes like me logo Genes that share phenotypes with KIAA1549L: view

Animal Models for KIAA1549L Gene

MGI Knock Outs for KIAA1549L:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIAA1549L Gene

Localization for KIAA1549L Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA1549L Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA1549L Gene COMPARTMENTS Subcellular localization image for KIAA1549L gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for KIAA1549L Gene

Pathways & Interactions for KIAA1549L Gene

genes like me logo Genes that share pathways with KIAA1549L: view

Pathways by source for KIAA1549L Gene

1 R&D Systems pathway for KIAA1549L Gene

Interacting Proteins for KIAA1549L Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000315295%0d%0a9606.ENSP00000339007%0d%0a9606.ENSP00000244769%0d%0a
Selected Interacting proteins: ENSP00000315295 Q6ZVL6-K154L_HUMAN for KIAA1549L Gene via STRING I2D

Gene Ontology (GO) - Biological Process for KIAA1549L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
genes like me logo Genes that share ontologies with KIAA1549L: view

No data available for SIGNOR curated interactions for KIAA1549L Gene

Drugs & Compounds for KIAA1549L Gene

No Compound Related Data Available

Transcripts for KIAA1549L Gene

Unigene Clusters for KIAA1549L Gene

KIAA1549-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1549L Gene

No ASD Table

Relevant External Links for KIAA1549L Gene

GeneLoc Exon Structure for
KIAA1549L
ECgene alternative splicing isoforms for
KIAA1549L

Expression for KIAA1549L Gene

mRNA expression in normal human tissues for KIAA1549L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIAA1549L Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x8.9), Brain - Cortex (x8.2), and Brain - Anterior cingulate cortex (BA24) (x7.3).

Protein differential expression in normal tissues from HIPED for KIAA1549L Gene

This gene is overexpressed in Monocytes (45.0) and Frontal cortex (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIAA1549L Gene



SOURCE GeneReport for Unigene cluster for KIAA1549L Gene Hs.502266

genes like me logo Genes that share expression patterns with KIAA1549L: view

Protein tissue co-expression partners for KIAA1549L Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for KIAA1549L Gene

Orthologs for KIAA1549L Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1549L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C15H11orf41 35
  • 84.73 (n)
  • 80.66 (a)
KIAA1549L 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C18H11orf41 35
  • 85.1 (n)
  • 80.64 (a)
KIAA1549L 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D430041D05Rik 35
  • 85.91 (n)
  • 89.79 (a)
D430041D05Rik 16
D430041D05Rik 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIAA1549L 35
  • 96.74 (n)
  • 95.78 (a)
KIAA1549L 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100362814 35
  • 80.98 (n)
  • 76.41 (a)
oppossum
(Monodelphis domestica)
Mammalia KIAA1549L 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1549L 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1549L 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1549L 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1549l 35
  • 63.36 (n)
  • 62.36 (a)
Str.5692 35
zebrafish
(Danio rerio)
Actinopterygii kiaa1549la 35
  • 57.5 (n)
  • 49.44 (a)
KIAA1549L (3 of 3) 36
  • 57 (a)
OneToMany
kiaa1549la 36
  • 37 (a)
OneToMany
kiaa1549lb 36
  • 42 (a)
OneToMany
Species with no ortholog for KIAA1549L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1549L Gene

ENSEMBL:
Gene Tree for KIAA1549L (if available)
TreeFam:
Gene Tree for KIAA1549L (if available)

Paralogs for KIAA1549L Gene

Paralogs for KIAA1549L Gene

Pseudogenes.org Pseudogenes for KIAA1549L Gene

genes like me logo Genes that share paralogs with KIAA1549L: view

Variants for KIAA1549L Gene

Sequence variations from dbSNP and Humsavar for KIAA1549L Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs716125 -- 33,492,941(-) ATCAC(A/G)AATAC intron-variant
rs716844 -- 33,493,142(-) ACCCC(A/C)GCTGC intron-variant
rs723026 -- 33,621,260(-) AACTC(C/T)TGTTC intron-variant
rs730729 -- 33,535,493(-) gtttc(A/G)ccatg intron-variant
rs731737 -- 33,412,360(-) TAATT(A/C)TTTTA intron-variant

Variation tolerance for KIAA1549L Gene

Residual Variation Intolerance Score: 22.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.06; 60.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for KIAA1549L Gene

Disorders for KIAA1549L Gene

Relevant External Links for KIAA1549L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1549L

No disorders were found for KIAA1549L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1549L Gene

Publications for KIAA1549L Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. A genome-wide association study of attempted suicide. (PMID: 21423239) Willour V.L. … Potash J.B. (Mol. Psychiatry 2012) 3
  3. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A. … Levine B. (Nature 2011) 3
  4. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for KIAA1549L Gene

Sources for KIAA1549L Gene

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