Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KIAA1549L Gene

Aliases for KIAA1549L Gene

  • KIAA1549 Like 2 3 5
  • C11orf41 3 4
  • C11orf69 3 4
  • Chromosome 11 Open Reading Frame 69 2
  • Chromosome 11 Open Reading Frame 41 2
  • Uncharacterized Protein C11orf69 3
  • UPF0606 Protein KIAA1549L 3
  • UPF0606 Protein C11orf41 3
  • G2 3

External Ids for KIAA1549L Gene

Previous HGNC Symbols for KIAA1549L Gene

  • C11orf69
  • C11orf41

Previous GeneCards Identifiers for KIAA1549L Gene

  • GC11P033563

Summaries for KIAA1549L Gene

GeneCards Summary for KIAA1549L Gene

KIAA1549L (KIAA1549 Like) is a Protein Coding gene. Among its related pathways are Development VEGF signaling via VEGFR2 - generic cascades. An important paralog of this gene is KIAA1549.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1549L Gene

Genomics for KIAA1549L Gene

Regulatory Elements for KIAA1549L Gene

Enhancers for KIAA1549L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G033687 2 FANTOM5 Ensembl ENCODE dbSUPER 16.2 +316.4 316444 11.3 PKNOX1 FOXA2 SIN3A FEZF1 ZNF2 YY1 ZNF766 FOS REST ZNF592 CD59 KIAA1549L LOC105376617 FBXO3 FBXO3-AS1 PIR36412
GH11G033370 1 FANTOM5 ENCODE 16.7 -4.5 -4523 2.2 ELF3 CTCF TAL1 JUN ZNF48 FOSL1 TCF12 GATA2 SCRT2 ZSCAN29 KIAA1549L CD59 LOC105376617 HIPK3
GH11G033718 1.5 Ensembl ENCODE dbSUPER 9.7 +345.7 345706 7.3 PKNOX1 FOXA2 ATF1 ARNT SIN3A BRCA1 GATA2 FOS DEK JUNB FBXO3 FBXO3-AS1 CD59 LOC105376617 ENSG00000255272 NAT10 KIAA1549L C11orf91 TCP11L1 GC11P033706
GH11G033731 1.3 ENCODE dbSUPER 10.9 +358.5 358549 7.7 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 YY1 ZNF766 ZNF143 CD59 LOC105376617 FBXO3-AS1 KIAA1549L FBXO3 ENSG00000255272 ENSG00000254619 GC11P033706
GH11G033375 1.1 Ensembl ENCODE 11.8 +0.1 133 2.6 CTCF MXI1 SUZ12 SIN3A BACH1 FEZF1 RBBP5 ZKSCAN1 E2F1 ZFHX2 KIAA1549L CD59 LOC105376617 ENSG00000254537
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIAA1549L on UCSC Golden Path with GeneCards custom track

Genomic Location for KIAA1549L Gene

Chromosome:
11
Start:
33,376,568 bp from pter
End:
33,674,102 bp from pter
Size:
297,535 bases
Orientation:
Plus strand

Genomic View for KIAA1549L Gene

Genes around KIAA1549L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1549L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1549L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1549L Gene

Proteins for KIAA1549L Gene

  • Protein details for KIAA1549L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVL6-K154L_HUMAN
    Recommended name:
    UPF0606 protein KIAA1549L
    Protein Accession:
    Q6ZVL6
    Secondary Accessions:
    • B0QYU0

    Protein attributes for KIAA1549L Gene

    Size:
    1849 amino acids
    Molecular mass:
    198999 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIAA1549L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1549L Gene

Post-translational modifications for KIAA1549L Gene

  • Glycosylation at posLast=105105, posLast=644644, posLast=656656, and posLast=753753
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KIAA1549L Gene

Domains & Families for KIAA1549L Gene

Protein Domains for KIAA1549L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA1549L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZVL6

UniProtKB/Swiss-Prot:

K154L_HUMAN :
  • Belongs to the UPF0606 family.
Family:
  • Belongs to the UPF0606 family.
genes like me logo Genes that share domains with KIAA1549L: view

No data available for Gene Families for KIAA1549L Gene

Function for KIAA1549L Gene

genes like me logo Genes that share phenotypes with KIAA1549L: view

Animal Models for KIAA1549L Gene

MGI Knock Outs for KIAA1549L:

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIAA1549L Gene

Localization for KIAA1549L Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA1549L Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA1549L gene
Compartment Confidence
plasma membrane 3
nucleus 2
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for KIAA1549L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KIAA1549L: view

Pathways & Interactions for KIAA1549L Gene

genes like me logo Genes that share pathways with KIAA1549L: view

Pathways by source for KIAA1549L Gene

1 R&D Systems pathway for KIAA1549L Gene

Interacting Proteins for KIAA1549L Gene

Selected Interacting proteins: Q6ZVL6-K154L_HUMAN for KIAA1549L Gene via IID

Symbol External ID(s) Details
ATXN1
GRB2

Gene Ontology (GO) - Biological Process for KIAA1549L Gene

None

No data available for SIGNOR curated interactions for KIAA1549L Gene

Drugs & Compounds for KIAA1549L Gene

No Compound Related Data Available

Transcripts for KIAA1549L Gene

Unigene Clusters for KIAA1549L Gene

KIAA1549-like:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1549L Gene

No ASD Table

Relevant External Links for KIAA1549L Gene

GeneLoc Exon Structure for
KIAA1549L
ECgene alternative splicing isoforms for
KIAA1549L

Expression for KIAA1549L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA1549L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIAA1549L Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x8.9), Brain - Cortex (x8.2), and Brain - Anterior cingulate cortex (BA24) (x7.3).

Protein differential expression in normal tissues from HIPED for KIAA1549L Gene

This gene is overexpressed in Monocytes (45.0) and Frontal cortex (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KIAA1549L Gene



Protein tissue co-expression partners for KIAA1549L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KIAA1549L Gene:

KIAA1549L

SOURCE GeneReport for Unigene cluster for KIAA1549L Gene:

Hs.502266

Evidence on tissue expression from TISSUES for KIAA1549L Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with KIAA1549L: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA1549L Gene

Orthologs for KIAA1549L Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1549L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1549L 34 35
  • 96.74 (n)
mouse
(Mus musculus)
Mammalia D430041D05Rik 34 16 35
  • 85.91 (n)
dog
(Canis familiaris)
Mammalia C18H11orf41 34
  • 85.1 (n)
KIAA1549L 35
  • 80 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C15H11orf41 34
  • 84.73 (n)
KIAA1549L 35
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100362814 34
  • 80.98 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1549L 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1549L 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1549L 35
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1549L 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1549l 34
  • 63.36 (n)
Str.5692 34
zebrafish
(Danio rerio)
Actinopterygii kiaa1549la 34 35
  • 57.5 (n)
KIAA1549L (3 of 3) 35
  • 57 (a)
OneToMany
kiaa1549lb 35
  • 42 (a)
OneToMany
Species where no ortholog for KIAA1549L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1549L Gene

ENSEMBL:
Gene Tree for KIAA1549L (if available)
TreeFam:
Gene Tree for KIAA1549L (if available)

Paralogs for KIAA1549L Gene

Paralogs for KIAA1549L Gene

Pseudogenes.org Pseudogenes for KIAA1549L Gene

genes like me logo Genes that share paralogs with KIAA1549L: view

Variants for KIAA1549L Gene

Sequence variations from dbSNP and Humsavar for KIAA1549L Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000013915 -- 33,639,186(+) CTACA(A/G)TTTTC intron-variant
rs1000026368 -- 33,534,985(+) AATTT(C/T)CATGA intron-variant
rs1000030637 -- 33,456,473(+) TGGCG(C/T)GATCA intron-variant
rs1000047291 -- 33,449,882(+) CTCAC(C/T)GATTT intron-variant
rs1000048341 -- 33,402,744(+) CTGGA(A/G)CAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1549L Gene

Variant ID Type Subtype PubMed ID
esv1006984 CNV insertion 20482838
esv1275018 CNV insertion 17803354
esv1598603 CNV insertion 17803354
esv2312289 CNV deletion 18987734
esv2339040 CNV deletion 18987734
esv2744324 CNV deletion 23290073
esv2744325 CNV deletion 23290073
esv2744326 CNV deletion 23290073
esv2744327 CNV deletion 23290073
esv2762904 CNV gain 21179565
esv3547565 CNV deletion 23714750
esv3547569 CNV deletion 23714750
esv3625883 CNV gain 21293372
esv3625890 CNV gain 21293372
nsv1113376 CNV deletion 24896259
nsv1116672 CNV tandem duplication 24896259
nsv1141191 CNV duplication 24896259
nsv1142107 CNV tandem duplication 24896259
nsv475943 CNV novel sequence insertion 20440878
nsv513310 CNV insertion 21212237
nsv521130 CNV gain 19592680
nsv825821 CNV loss 20364138
nsv832112 CNV gain 17160897
nsv832113 CNV gain 17160897

Variation tolerance for KIAA1549L Gene

Residual Variation Intolerance Score: 22.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.06; 60.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1549L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1549L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1549L Gene

Disorders for KIAA1549L Gene

Relevant External Links for KIAA1549L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1549L

No disorders were found for KIAA1549L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1549L Gene

Publications for KIAA1549L Gene

  1. PAX5-KIAA1549L: a novel fusion gene in a case of pediatric B-cell precursor acute lymphoblastic leukemia. (PMID: 26157485) Anderl S. … Strehl S. (Mol Cytogenet 2015) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A genome-wide association study of attempted suicide. (PMID: 21423239) Willour V.L. … Potash J.B. (Mol. Psychiatry 2012) 3 64
  4. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A. … Levine B. (Nature 2011) 3 64
  5. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3 64

Products for KIAA1549L Gene

Sources for KIAA1549L Gene

Content
Loading form....