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Aliases for KIAA1549L Gene

Aliases for KIAA1549L Gene

  • KIAA1549-Like 2 3
  • C11orf41 3 4 6
  • C11orf69 3 4
  • G2 3 6
  • Chromosome 11 Open Reading Frame 69 2
  • Chromosome 11 Open Reading Frame 41 2
  • Uncharacterized Protein C11orf69 3
  • UPF0606 Protein KIAA1549L 3
  • UPF0606 Protein C11orf41 3

External Ids for KIAA1549L Gene

Previous HGNC Symbols for KIAA1549L Gene

  • C11orf69
  • C11orf41

Summaries for KIAA1549L Gene

GeneCards Summary for KIAA1549L Gene

KIAA1549L (KIAA1549-Like) is a Protein Coding gene. Among its related pathways are Development VEGF signaling via VEGFR2 - generic cascades. An important paralog of this gene is KIAA1549.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1549L Gene

Genomics for KIAA1549L Gene

Genomic Location for KIAA1549L Gene

Start:
33,542,072 bp from pter
End:
33,674,102 bp from pter
Size:
132,031 bases
Orientation:
Plus strand

Genomic View for KIAA1549L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIAA1549L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1549L Gene

No data available for Regulatory Elements for KIAA1549L Gene

Proteins for KIAA1549L Gene

  • Protein details for KIAA1549L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVL6-K154L_HUMAN
    Recommended name:
    UPF0606 protein KIAA1549L
    Protein Accession:
    Q6ZVL6
    Secondary Accessions:
    • B0QYU0

    Protein attributes for KIAA1549L Gene

    Size:
    1849 amino acids
    Molecular mass:
    198999 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIAA1549L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1549L Gene

Proteomics data for KIAA1549L Gene at MOPED

Post-translational modifications for KIAA1549L Gene

  • Glycosylation at Ser105, Thr638, Thr644, Ser650, Ser651, Ser656, Thr753, and Thr759
  • Modification sites at PhosphoSitePlus

Other Protein References for KIAA1549L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIAA1549L Gene

Domains for KIAA1549L Gene

Protein Domains for KIAA1549L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6ZVL6

UniProtKB/Swiss-Prot:

K154L_HUMAN :
  • Q6ZVL6
Family:
  • Belongs to the UPF0606 family.
genes like me logo Genes that share domains with KIAA1549L: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for KIAA1549L Gene

Function for KIAA1549L Gene

genes like me logo Genes that share phenotypes with KIAA1549L: view

miRNA for KIAA1549L Gene

miRTarBase miRNAs that target KIAA1549L

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate KIAA1549L
    • Block miRNA regulation of KIAA1549L using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for KIAA1549L

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIAA1549L Gene

    Localization for KIAA1549L Gene

    Subcellular locations from UniProtKB/Swiss-Prot for KIAA1549L Gene

    Membrane; Single-pass membrane protein.

    Gene Ontology (GO) - Cellular Components for KIAA1549L Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0016021 integral component of membrane IEA --
    genes like me logo Genes that share ontologies with KIAA1549L: view

    No data available for Subcellular locations from COMPARTMENTS for KIAA1549L Gene

    Pathways for KIAA1549L Gene

    genes like me logo Genes that share pathways with KIAA1549L: view

    Pathways by source for KIAA1549L Gene

    1 R&D Systems pathway for KIAA1549L Gene

    Interacting Proteins for KIAA1549L Gene

    STRING Interaction Network Preview (showing 2 interactants - click image to see details)
    http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000315295%0d%0a9606.ENSP00000339007%0d%0a9606.ENSP00000244769%0d%0a
    Selected Interacting proteins: ENSP00000315295 Q6ZVL6-K154L_HUMAN for KIAA1549L Gene via STRING I2D

    Gene Ontology (GO) - Biological Process for KIAA1549L Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0002230 positive regulation of defense response to virus by host IMP 22020285
    GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
    genes like me logo Genes that share ontologies with KIAA1549L: view

    Transcripts for KIAA1549L Gene

    mRNA/cDNA for KIAA1549L Gene

    Unigene Clusters for KIAA1549L Gene

    KIAA1549-like:
    Representative Sequences:

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate KIAA1549L
      • Block miRNA regulation of KIAA1549L using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for KIAA1549L

      Primer Products

      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1549L Gene

      No ASD Table

      Relevant External Links for KIAA1549L Gene

      GeneLoc Exon Structure for
      KIAA1549L
      ECgene alternative splicing isoforms for
      KIAA1549L

      Expression for KIAA1549L Gene

      mRNA expression in normal human tissues for KIAA1549L Gene

      mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

      mRNA differential expression in normal tissues according to GTEx for KIAA1549L Gene

      This gene is overexpressed in Brain - Frontal Cortex (BA9) (8.9), Brain - Cortex (8.2), and Brain - Anterior cingulate cortex (BA24) (7.3).

      Protein differential expression in normal tissues for KIAA1549L Gene

      This gene is overexpressed in Monocytes (45.0) and Frontal cortex (14.2).

      Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KIAA1549L Gene

      SOURCE GeneReport for Unigene cluster for KIAA1549L Gene Hs.502266

      genes like me logo Genes that share expressions with KIAA1549L: view

      Expression partners for KIAA1549L Gene

      In Situ Assay Products

      No data available for mRNA Expression by UniProt/SwissProt for KIAA1549L Gene

      Orthologs for KIAA1549L Gene

      This gene was present in the common ancestor of chordates.

      Orthologs for KIAA1549L Gene

      Organism Taxonomy Gene Similarity Type Details
      cow
      (Bos Taurus)
      Mammalia C15H11orf41 35
      • 84.73 (n)
      • 80.66 (a)
      KIAA1549L 36
      • 80 (a)
      OneToOne
      dog
      (Canis familiaris)
      Mammalia C18H11orf41 35
      • 85.1 (n)
      • 80.64 (a)
      KIAA1549L 36
      • 80 (a)
      OneToOne
      mouse
      (Mus musculus)
      Mammalia D430041D05Rik 35
      • 85.91 (n)
      • 89.79 (a)
      D430041D05Rik 16
      D430041D05Rik 36
      • 78 (a)
      OneToOne
      chimpanzee
      (Pan troglodytes)
      Mammalia KIAA1549L 35
      • 96.74 (n)
      • 95.78 (a)
      KIAA1549L 36
      • 98 (a)
      OneToOne
      rat
      (Rattus norvegicus)
      Mammalia LOC100362814 35
      • 80.98 (n)
      • 76.41 (a)
      oppossum
      (Monodelphis domestica)
      Mammalia KIAA1549L 36
      • 68 (a)
      OneToOne
      platypus
      (Ornithorhynchus anatinus)
      Mammalia KIAA1549L 36
      • 55 (a)
      OneToOne
      chicken
      (Gallus gallus)
      Aves KIAA1549L 36
      • 69 (a)
      OneToOne
      lizard
      (Anolis carolinensis)
      Reptilia KIAA1549L 36
      • 69 (a)
      OneToOne
      tropical clawed frog
      (Silurana tropicalis)
      Amphibia kiaa1549l 35
      • 63.36 (n)
      • 62.36 (a)
      Str.5692 35
      zebrafish
      (Danio rerio)
      Actinopterygii kiaa1549la 35
      • 57.5 (n)
      • 49.44 (a)
      KIAA1549L (3 of 3) 36
      • 57 (a)
      OneToMany
      kiaa1549la 36
      • 37 (a)
      OneToMany
      kiaa1549lb 36
      • 42 (a)
      OneToMany
      Species with no ortholog for KIAA1549L:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • baker's yeast (Saccharomyces cerevisiae)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • fruit fly (Drosophila melanogaster)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • rainbow trout (Oncorhynchus mykiss)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • wheat (Triticum aestivum)
      • worm (Caenorhabditis elegans)

      Evolution for KIAA1549L Gene

      ENSEMBL:
      Gene Tree for KIAA1549L (if available)
      TreeFam:
      Gene Tree for KIAA1549L (if available)

      Paralogs for KIAA1549L Gene

      Paralogs for KIAA1549L Gene

      Pseudogenes.org Pseudogenes for KIAA1549L Gene

      genes like me logo Genes that share paralogs with KIAA1549L: view

      Variants for KIAA1549L Gene

      Sequence variations from dbSNP and Humsavar for KIAA1549L Gene

      SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
      rs20450 -- 33,550,923(+) TGAAC(A/G)AGAAC intron-variant
      rs723026 -- 33,621,260(-) AACTC(C/T)TGTTC intron-variant
      rs735327 -- 33,579,035(-) TGCTA(C/T)GGTGT intron-variant
      rs761433 -- 33,598,229(-) CTCTG(A/T)CACAC intron-variant
      rs761434 -- 33,598,226(-) TGACA(C/G)ACACA intron-variant

      Relevant External Links for KIAA1549L Gene

      HapMap Linkage Disequilibrium report
      KIAA1549L

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KIAA1549L Gene

      Disorders for KIAA1549L Gene

      No disorders were found for KIAA1549L Gene.

      No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for KIAA1549L Gene

      Publications for KIAA1549L Gene

      1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
      2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
      3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
      4. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3
      5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

      Products for KIAA1549L Gene

      Sources for KIAA1549L Gene

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