KIAA1549L Gene
protein-coding GIFtS: 39
GCID: GC11P033563
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KIAA1549-like(Previous names: chromosome 11 open reading frame 69, chromosome 11 open...)
(Previous symbols: C11orf69, C11orf41)
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Aliases
for KIAA1549L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| KIAA1549-Like1 | | Chromosome 11 Open Reading Frame 411 | | C11orf411 2 3 5 | | Chromosome 11 Open Reading Frame 691 | | C11orf691 2 3 | | Uncharacterized Protein C11orf692 | | G21 2 5 | | UPF0606 Protein C11orf412 | | MGC348301 | | UPF0606 Protein KIAA1549L2 |
Export aliases for KIAA1549L gene to outside databases |
Summaries
for KIAA1549L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KIAA1549L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for KIAA1549L
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIAA1549L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA1549L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p13 Ensembl cytogenetic band: 11p13 HGNC cytogenetic band: 11p13KIAA1549L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P033563: view genomic region
(about GC identifiers)
Start:
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33,563,618 bp from pter |
End:
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33,695,648 bp from pter |
Size:
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132,031 bases |
Orientation:
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plus strand |
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Proteins
for KIAA1549L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: K154L_HUMAN, Q6ZVL6 (See
protein sequence)Recommended Name: UPF0606 protein KIAA1549L Size: 1849 amino acids; 198999 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: B0QYU0Alternative splicing: 2 isoforms: Q6ZVL6-1 Q6ZVL6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KIAA1549L: NX_Q6ZVL6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZVL6
KIAA1549L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036326.2
ENSEMBL proteins: ENSP00000433481 ENSP00000315295 ENSP00000265654 ENSP00000374376
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
KIAA1549L for ontologies About GeneDecksing
KIAA1549L Antibody Products:
Assay Products for KIAA1549L: |
Protein
Domains /
Families
for KIAA1549L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KIAA1549L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6ZVL6ProtoNet protein and cluster: Q6ZVL6 UniProtKB/Swiss-Prot: K154L_HUMAN, Q6ZVL6Similarity: Belongs to the UPF0606 family |
Function
for KIAA1549L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1549L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1549L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1549L |
1 GenomeRNAi human phenotype for KIAA1549L:
Animal Models:
8 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for D430041D05Rik):
KIAA1549L for phenotypes About GeneDecksing
|
Pathways & Interactions
for KIAA1549L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA1549L
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for KIAA1549L (Q6ZVL63 ENSP000003743764) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for KIAA1549L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KIAA1549L
Search CenterWatch for drugs/clinical trials and news about KIAA1549L / K154L
|
Transcripts
for KIAA1549L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KIAA1549L gene: NM_012194.2 Unigene Cluster for KIAA1549L: KIAA1549-like Hs.502266 [show with all ESTs]Unigene Representative Sequence: NM_0121944 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000526400 ENST00000321505(uc021qfs.1) ENST00000265654(uc001mun.1)
ENST00000389726
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1549L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1549L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for KIAA1549L | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIAA1549L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA1549L |
Additional cDNA sequence: AK094307.1 BC025668.1 U10991.1 4 DOTS entries: DT.95363486 DT.113455 DT.40120123 DT.95158585 24/71 AceView cDNA sequences (see all 71): BQ014403 BM554951 BC025668 AK124395 AL134210 AI143560 F10635 BG680827 BU101740 H06878 AA338590 AI307115 NM_152314 CB144300 AI207921 AW204610 AK094307 F13042 BM925783 BM721556 AI092385 BM721534 CB140942 BG026182
GeneLoc Exon Structure
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Expression
for KIAA1549L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See KIAA1549L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIAA1549L
SOURCE GeneReport for Unigene cluster: Hs.502266
SABiosciences Custom PCR Arrays for KIAA1549L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIAA1549L
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat KIAA1549L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA1549L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA1549L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1549L |
Orthologs
for KIAA1549L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KIAA1549L gene from 4/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
C5H11orf411 |
chromosome 5 open reading frame, human C11orf41 |
70.39(n)
73.73(a) |
|
421598 XM_419635.3 XP_419635.3 |
lizard
(Anolis carolinensis) |
Reptilia |
C11orf416 |
-- |
71(a) |
1 ↔ 1 |
1(61816599-61907487) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.56922 |
Transcribed sequence with moderate similarity to protein more |
76.71(n) |
|
BQ524255.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5665921 |
UPF0606 protein C11orf41-like |
55.86(n)
47.2(a) |
|
566592 XM_689868.5 XP_694960.5 |
ENSEMBL Gene Tree for KIAA1549L (if available)
TreeFam Gene Tree for KIAA1549L (if available) |
Paralogs
for KIAA1549L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KIAA1549L gene
- KIAA15492
KIAA1549L for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for KIAA1549L
PGOHUM00000244707
|
Genomic Variants
for KIAA1549L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KIAA1549L (33563618 - 33695648 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KIAA1549L: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIAA1549L |
|
Disorders
/ Diseases
for KIAA1549L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KIAA1549L for disorders About GeneDecksing
OMIM gene information: 612297
OMIM disorders: --
1  disease for KIAA1549L: About MalaCardsataxia
Export disorders for KIAA1549L gene to outside databases
|
Publications
for KIAA1549L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIAA1549L gene integrated from 9 sources:
(articles sorted by number of sources associating them with KIAA1549L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A genome-wide association study of attempted suicide. (PubMed id 21423239)1 Willour V.L....Potash J.B. (2011)
- A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
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External Searches for KIAA1549L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing KIAA1549L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KIAA1549L gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KIAA1549L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KIAA1549L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KIAA1549L gene:
Search GeneIP for patents involving KIAA1549L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIAA1549L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KIAA1549L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIAA1549L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA1549L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KIAA1549L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA1549L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA1549L |
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 | | | KIAA1549L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1549L |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA1549L |
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