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Aliases for KIAA1549 Gene

Aliases for KIAA1549 Gene

  • KIAA1549 2 3

External Ids for KIAA1549 Gene

Previous GeneCards Identifiers for KIAA1549 Gene

  • GC07M136862
  • GC07M137922
  • GC07M137936
  • GC07M137979
  • GC07M138172
  • GC07M138166
  • GC07M138516
  • GC07M132827

Summaries for KIAA1549 Gene

Entrez Gene Summary for KIAA1549 Gene

  • The protein encoded by this gene belongs to the UPF0606 family. This gene has been found to be fused to the BRAF oncogene in many cases of pilocytic astrocytoma. The fusion results from 2Mb tandem duplications at 7q34. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

GeneCards Summary for KIAA1549 Gene

KIAA1549 (KIAA1549) is a Protein Coding gene. Diseases associated with KIAA1549 include pilocytic astrocytoma and cerebellar astrocytoma. An important paralog of this gene is KIAA1549L.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1549 Gene

Genomics for KIAA1549 Gene

Regulatory Elements for KIAA1549 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KIAA1549 Gene

138,831,381 bp from pter
138,981,318 bp from pter
149,938 bases
Minus strand

Genomic View for KIAA1549 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIAA1549 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1549 Gene

Proteins for KIAA1549 Gene

  • Protein details for KIAA1549 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0606 protein KIAA1549
    Protein Accession:
    Secondary Accessions:
    • B6HY55
    • B6HY56
    • B6HY58
    • B6HY60
    • B6HY61
    • B6HY62
    • B6HY63
    • B6HY64
    • B6HY65
    • B6HY66
    • Q5BJD6
    • Q8IY15
    • Q9H0M3

    Protein attributes for KIAA1549 Gene

    1950 amino acids
    Molecular mass:
    210755 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH38232.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1549 Gene


neXtProt entry for KIAA1549 Gene

Proteomics data for KIAA1549 Gene at MOPED

Post-translational modifications for KIAA1549 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIAA1549 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIAA1549 Gene

Domains & Families for KIAA1549 Gene

Protein Domains for KIAA1549 Gene

Suggested Antigen Peptide Sequences for KIAA1549 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



K1549_HUMAN :
  • Belongs to the UPF0606 family.
  • Belongs to the UPF0606 family.
genes like me logo Genes that share domains with KIAA1549: view

No data available for Gene Families for KIAA1549 Gene

Function for KIAA1549 Gene

Phenotypes for KIAA1549 Gene

GenomeRNAi human phenotypes for KIAA1549:
genes like me logo Genes that share phenotypes with KIAA1549: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIAA1549

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1549 Gene

Localization for KIAA1549 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA1549 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for KIAA1549 Gene COMPARTMENTS Subcellular localization image for KIAA1549 gene
Compartment Confidence
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for KIAA1549 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KIAA1549: view

Pathways & Interactions for KIAA1549 Gene

SuperPathways for KIAA1549 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA1549 Gene


No data available for Pathways by source and SIGNOR curated interactions for KIAA1549 Gene

Drugs & Compounds for KIAA1549 Gene

No Compound Related Data Available

Transcripts for KIAA1549 Gene

mRNA/cDNA for KIAA1549 Gene

Unigene Clusters for KIAA1549 Gene

Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIAA1549

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1549 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c
SP1: -

Relevant External Links for KIAA1549 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIAA1549 Gene

mRNA expression in normal human tissues for KIAA1549 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIAA1549 Gene

This gene is overexpressed in Pancreas (x4.8).

Protein differential expression in normal tissues from HIPED for KIAA1549 Gene

This gene is overexpressed in Liver (34.4) and Liver, secretome (24.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIAA1549 Gene

SOURCE GeneReport for Unigene cluster for KIAA1549 Gene Hs.605380

genes like me logo Genes that share expression patterns with KIAA1549: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KIAA1549 Gene

Orthologs for KIAA1549 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1549 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia KIAA1549 35
  • 77.01 (n)
  • 72.18 (a)
KIAA1549 36
  • 72 (a)
(Mus musculus)
Mammalia D630045J12Rik 35
  • 78.24 (n)
  • 73.29 (a)
D630045J12Rik 16
D630045J12Rik 36
  • 72 (a)
(Pan troglodytes)
Mammalia KIAA1549 35
  • 98.88 (n)
  • 98.29 (a)
KIAA1549 36
  • 98 (a)
(Rattus norvegicus)
Mammalia RGD1306271 35
  • 78.08 (n)
  • 72.83 (a)
(Bos Taurus)
Mammalia KIAA1549 36
  • 76 (a)
(Monodelphis domestica)
Mammalia KIAA1549 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia KIAA1549 36
  • 48 (a)
(Gallus gallus)
Aves KIAA1549 35
  • 61.69 (n)
  • 55.11 (a)
KIAA1549 36
  • 48 (a)
(Anolis carolinensis)
Reptilia KIAA1549 36
  • 46 (a)
(Danio rerio)
Actinopterygii si:dkeyp-27e10.3 35
  • 57.97 (n)
  • 53.35 (a)
si:ch211-1e14.1 36
  • 34 (a)
si:dkeyp-27e10.3 36
  • 38 (a)
Species with no ortholog for KIAA1549:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1549 Gene

Gene Tree for KIAA1549 (if available)
Gene Tree for KIAA1549 (if available)

Paralogs for KIAA1549 Gene

Paralogs for KIAA1549 Gene

genes like me logo Genes that share paralogs with KIAA1549: view

Variants for KIAA1549 Gene

Sequence variations from dbSNP and Humsavar for KIAA1549 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs34003116 -- 138,969,216(+) TTGTC(-/A)GTGCA intron-variant
rs34025564 -- 138,877,692(+) CTACA(-/C)ACATG intron-variant
rs28713442 -- 138,888,928(+) TAAAA(A/G)TCCTA intron-variant
rs28706894 -- 138,888,895(+) TGATA(C/T)TGGAT intron-variant
rs28587775 -- 138,973,014(+) GCGGG(G/T)TTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1549 Gene

Variant ID Type Subtype PubMed ID
esv2735212 CNV Deletion 23290073
nsv831154 CNV Gain 17160897
esv2735227 CNV Deletion 23290073
esv2665390 CNV Deletion 23128226
esv2611670 CNV Insertion 19546169
esv259637 OTHER Complex 20981092
esv259833 OTHER Complex 20981092
esv1717918 CNV Insertion 17803354
nsv5969 CNV Loss 18451855
nsv831155 CNV Loss 17160897

Variation tolerance for KIAA1549 Gene

Residual Variation Intolerance Score: 98.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.56; 99.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1549 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1549 Gene

Disorders for KIAA1549 Gene

MalaCards: The human disease database

(8) MalaCards diseases for KIAA1549 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pilocytic astrocytoma
  • juvenile pilocytic astrocytoma
cerebellar astrocytoma
  • astrocytoma of cerebellum
pilocytic astrocytoma of cerebellum
  • cerebellar pilocytic astrocytoma
pilomyxoid astrocytoma
fibrillary astrocytoma
  • gemistocytic astrocytoma
- elite association


  • Note=A chromosomal aberration involving KIAA1549 is found in pilocytic astrocytoma. A tandem duplication of 2 Mb at 7q34 leads to the expression of a KIAA1549-BRAF fusion protein with a constitutive kinase activity and inducing cell transformation. {ECO:0000269 PubMed:18974108}.

Relevant External Links for KIAA1549

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KIAA1549: view

No data available for Genatlas for KIAA1549 Gene

Publications for KIAA1549 Gene

  1. KIAA1549: BRAF Gene Fusion and FGFR1 Hotspot Mutations Are Prognostic Factors in Pilocytic Astrocytomas. (PMID: 26083571) Becker A.P. … Reis R.M. (J. Neuropathol. Exp. Neurol. 2015) 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Oncogenic KIAA1549-BRAF fusion with activation of the MAPK/ERK pathway in pediatric oligodendrogliomas. (PMID: 25794445) Kumar A. … Sarkar C. (Cancer Genet 2015) 67
  4. Posterior fossa and spinal gangliogliomas form two distinct clinicopathologic and molecular subgroups. (PMID: 24529209) Gupta K. … Ellison D.W. (Acta Neuropathol Commun 2014) 67
  5. Analysis of KIAA1549-BRAF fusion gene expression and IDH1/IDH2 mutations in low grade pediatric astrocytomas. (PMID: 24532263) Cruz G.R. … Toledo S.R. (J. Neurooncol. 2014) 67

Products for KIAA1549 Gene

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