Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KIAA1524 Gene

Aliases for KIAA1524 Gene

  • KIAA1524 2 3
  • Cancerous Inhibitor Of Protein Phosphatase 2A 2 3
  • Cancerous Inhibitor Of PP2A 3 4
  • P90 Autoantigen 3 4
  • CIP2A 3 4
  • P90 3

External Ids for KIAA1524 Gene

Previous GeneCards Identifiers for KIAA1524 Gene

  • GC03M105062
  • GC03M107796
  • GC03M109549
  • GC03M109589
  • GC03M109751
  • GC03M108268
  • GC03M105641

Summaries for KIAA1524 Gene

GeneCards Summary for KIAA1524 Gene

KIAA1524 (KIAA1524) is a Protein Coding gene. Among its related pathways are DNA Damage. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for KIAA1524 Gene

  • Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation.

Gene Wiki entry for KIAA1524 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1524 Gene

Genomics for KIAA1524 Gene

Regulatory Elements for KIAA1524 Gene

Genomic Location for KIAA1524 Gene

Chromosome:
3
Start:
108,545,752 bp from pter
End:
108,589,644 bp from pter
Size:
43,893 bases
Orientation:
Minus strand

Genomic View for KIAA1524 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIAA1524 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1524 Gene

Proteins for KIAA1524 Gene

  • Protein details for KIAA1524 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCG1-CIP2A_HUMAN
    Recommended name:
    Protein CIP2A
    Protein Accession:
    Q8TCG1
    Secondary Accessions:
    • A1L4J7
    • B9EGC3
    • Q6P4G6
    • Q8WVP8
    • Q96PI2
    • Q9H9C6
    • Q9P204

    Protein attributes for KIAA1524 Gene

    Size:
    905 amino acids
    Molecular mass:
    102185 Da
    Quaternary structure:
    • Interacts with MYC.
    Miscellaneous:
    • Antibodies against KIAA1524 are present in sera from many patients with gastric or prostate cancer, suggesting that it may act as a marker for such cancers
    SequenceCaution:
    • Sequence=AAH63433.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA96048.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14305.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1524 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1524 Gene

Proteomics data for KIAA1524 Gene at MOPED

Post-translational modifications for KIAA1524 Gene

  • Ubiquitination at Lys 629 and Lys 647
  • Modification sites at PhosphoSitePlus

Other Protein References for KIAA1524 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KIAA1524 (CIP2A)

No data available for DME Specific Peptides for KIAA1524 Gene

Domains & Families for KIAA1524 Gene

Protein Domains for KIAA1524 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA1524 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA1524: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KIAA1524 Gene

Function for KIAA1524 Gene

Molecular function for KIAA1524 Gene

UniProtKB/Swiss-Prot Function:
Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation.

Gene Ontology (GO) - Molecular Function for KIAA1524 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 17632056
genes like me logo Genes that share ontologies with KIAA1524: view
genes like me logo Genes that share phenotypes with KIAA1524: view

Animal Model Products

CRISPR Products

miRNA for KIAA1524 Gene

miRTarBase miRNAs that target KIAA1524

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIAA1524

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1524 Gene

Localization for KIAA1524 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA1524 Gene

Membrane; Single-pass membrane protein. Cytoplasm. Note=Slightly concentrates in the perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA1524 Gene COMPARTMENTS Subcellular localization image for KIAA1524 gene
Compartment Confidence
plasma membrane 4
cytosol 2

Gene Ontology (GO) - Cellular Components for KIAA1524 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KIAA1524: view

Pathways & Interactions for KIAA1524 Gene

SuperPathways for KIAA1524 Gene

Superpath Contained pathways
1 DNA Damage
genes like me logo Genes that share pathways with KIAA1524: view

Pathways by source for KIAA1524 Gene

1 Cell Signaling Technology pathway for KIAA1524 Gene

Gene Ontology (GO) - Biological Process for KIAA1524 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEA --
GO:2000179 positive regulation of neural precursor cell proliferation IEA --
genes like me logo Genes that share ontologies with KIAA1524: view

No data available for SIGNOR curated interactions for KIAA1524 Gene

Drugs & Compounds for KIAA1524 Gene

No Compound Related Data Available

Transcripts for KIAA1524 Gene

Unigene Clusters for KIAA1524 Gene

KIAA1524:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KIAA1524

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1524 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^
SP1: - - -
SP2: -
SP3: - -
SP4: - - - -
SP5: -
SP6: - -

ExUns: 21 ^ 22a · 22b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for KIAA1524 Gene

GeneLoc Exon Structure for
KIAA1524
ECgene alternative splicing isoforms for
KIAA1524

Expression for KIAA1524 Gene

mRNA expression in normal human tissues for KIAA1524 Gene

Protein differential expression in normal tissues from HIPED for KIAA1524 Gene

This gene is overexpressed in Bone (63.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIAA1524 Gene



SOURCE GeneReport for Unigene cluster for KIAA1524 Gene Hs.591308

mRNA Expression by UniProt/SwissProt for KIAA1524 Gene

Q8TCG1-CIP2A_HUMAN
Tissue specificity: Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level).
genes like me logo Genes that share expression patterns with KIAA1524: view

Protein tissue co-expression partners for KIAA1524 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KIAA1524 Gene

Orthologs for KIAA1524 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA1524 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIAA1524 35
  • 91.2 (n)
  • 91.28 (a)
KIAA1524 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA1524 35
  • 91.05 (n)
  • 91.27 (a)
KIAA1524 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C330027C09Rik 35
  • 87.17 (n)
  • 87.61 (a)
C330027C09Rik 16
C330027C09Rik 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIAA1524 35
  • 99.67 (n)
  • 99.56 (a)
KIAA1524 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1310335 35
  • 86.48 (n)
  • 87.73 (a)
oppossum
(Monodelphis domestica)
Mammalia KIAA1524 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1524 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1524 35
  • 71.81 (n)
  • 70.81 (a)
KIAA1524 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1524 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1524 35
  • 67.78 (n)
  • 66.82 (a)
Str.10282 35
zebrafish
(Danio rerio)
Actinopterygii zgc:174160 35
  • 56.87 (n)
  • 52.32 (a)
zgc:174160 36
  • 51 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4843 35
worm
(Caenorhabditis elegans)
Secernentea B0432.7 36
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToOne
Species with no ortholog for KIAA1524:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIAA1524 Gene

ENSEMBL:
Gene Tree for KIAA1524 (if available)
TreeFam:
Gene Tree for KIAA1524 (if available)

Paralogs for KIAA1524 Gene

No data available for Paralogs for KIAA1524 Gene

Variants for KIAA1524 Gene

Sequence variations from dbSNP and Humsavar for KIAA1524 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1026336 -- 108,584,590(+) ctcca(C/T)gtggc intron-variant
rs1454194 -- 108,565,143(-) TCATG(A/G)CACTA intron-variant
rs1947430 -- 108,566,925(-) AAATA(C/T)TTATT intron-variant
rs2045095 -- 108,554,594(-) AGCAT(A/G)TGCAA intron-variant
rs2278909 -- 108,578,961(+) CTCTT(G/T)CAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1524 Gene

Variant ID Type Subtype PubMed ID
nsv829658 CNV Gain 17160897
dgv5229n71 CNV Loss 21882294
nsv524016 CNV Loss 19592680

Variation tolerance for KIAA1524 Gene

Residual Variation Intolerance Score: 67.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.03; 87.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1524 Gene

HapMap Linkage Disequilibrium report
KIAA1524

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1524 Gene

Disorders for KIAA1524 Gene

Relevant External Links for KIAA1524

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1524
genes like me logo Genes that share disorders with KIAA1524: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1524 Gene

Publications for KIAA1524 Gene

  1. Cancerous inhibitor of protein phosphatase 2A (CIP2A) protein is involved in centrosome separation through the regulation of NIMA (never in mitosis gene A)-related kinase 2 (NEK2) protein activity. (PMID: 24214971) Jeong A.L. … Yang Y. (J. Biol. Chem. 2014) 2 67
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  5. CIP2A cooperates with H-Ras to promote epithelial-mesenchymal transition in cervical-cancer progression. (PMID: 25458953) Wu Y. … Zheng P.S. (Cancer Lett. 2015) 67

Products for KIAA1524 Gene

Sources for KIAA1524 Gene

Back to Top

Content