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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KIAA1524 Gene

protein-coding   GIFtS: 47
GCID: GC03M108268

KIAA1524

 Explore 14 diseases affiliated with
KIAA1524 via our new
 Human Malady Compendium 
Biological research products
for KIAA1524
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
KIAA15241 2
Cancerous Inhibitor Of PP2A2 3
CIP2A2 3
P90 Autoantigen2 3
P901
Protein CIP2A2

External Ids:    HGNC: 293021   Entrez Gene: 576502   Ensembl: ENSG000001635077   OMIM: 6106435   UniProtKB: Q8TCG13   

Export aliases for KIAA1524 gene to outside databases

Previous GC identifers: GC03M105062 GC03M107796 GC03M109549 GC03M109589 GC03M109751 GC03M105641


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CIP2A_HUMAN, Q8TCG1
Function: Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell
growth and tumor formation

Gene Wiki entry for KIAA1524


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIAA1524 gene promoter:
         TBP   SRF   AP-1   AML1a   ATF-2   SRF (504 AA)   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   TFIID   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KIAA1524

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA1524


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.13   Ensembl cytogenetic band:  3q13.13   HGNC cytogenetic band: 3q13.13

KIAA1524 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA1524 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M108268:  view genomic region     (about GC identifiers)

Start:
108,268,716 bp from pter      End:
108,308,491 bp from pter
Size:
39,776 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CIP2A_HUMAN, Q8TCG1 (See protein sequence)
Recommended Name: Protein CIP2A  
Size: 905 amino acids; 102185 Da
Subunit: Interacts with MYC
Subcellular location: Membrane; Single-pass membrane protein (Potential). Cytoplasm. Note=Slightly concentrates in the
perinuclear region
Miscellaneous: Antibodies against KIAA1524 are present in sera from many patients with gastric or prostate cancer,
suggesting that it may act as a marker for such cancers
Sequence caution: Sequence=AAH63433.1; Type=Erroneous initiation; Sequence=BAA96048.1; Type=Erroneous initiation;
Sequence=BAB14305.1; Type=Erroneous initiation;
Secondary accessions: A1L4J7 B9EGC3 Q6P4G6 Q8WVP8 Q96PI2 Q9H9C6 Q9P204
Alternative splicing: 2 isoforms:  Q8TCG1-1   Q8TCG1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KIAA1524: NX_Q8TCG1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TCG1

  • KIAA1524 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065941.2  
    ENSEMBL proteins: 
     ENSP00000419487   ENSP00000295746   ENSP00000417297   ENSP00000419428  

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    Uscn Proteins for KIAA1524

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--
    GO:0016021integral to membrane IEA--


    KIAA1524 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    KIAA1524 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q8TCG1

    ProtoNet protein and cluster: Q8TCG1


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CIP2A_HUMAN, Q8TCG1
    Function: Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell
    growth and tumor formation

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17632056


    KIAA1524 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for KIAA1524:
     Increased gamma-H2AX phosphory 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for C330027C09Rik):
     reproductive system 

    KIAA1524 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA1524

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/10 Interacting proteins for KIAA1524 (Q8TCG11, 3 ENSP000002957464) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011061, 3, ENSP000003672074EBI-1379376,EBI-1058440 I2D: score=2 STRING: ENSP00000367207
    PPP2R1AP301531, 3, ENSP000003248044EBI-1379376,EBI-302388 I2D: score=1 STRING: ENSP00000324804
    APCP250543I2D: score=2 
    GAGE5Q130693I2D: score=2 
    DVL2O146413I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIAA1524
    Search CenterWatch for drugs/clinical trials and news about KIAA1524 / CIP2A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KIAA1524 gene: 
    NM_020890.2  

    Unigene Cluster for KIAA1524:

    KIAA1524
    Hs.591308  [show with all ESTs]
    Unigene Representative Sequence: NM_020890
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491772(uc003dxc.1) ENST00000295746(uc003dxb.4) ENST00000481530(uc010hpv.1)
    ENST00000487834(uc010hpw.1) ENST00000468953 ENST00000461666

    miRNA
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    hsa-miR-607 hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidKIAA1524 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB040957.1 AF334474.1 AK022912.1 AK056933.1 AK308315.1 AK310446.1 AL713689.1 BC017659.1 
    BC063433.1 BC082961.1 BC130564.1 BC136371.1 

    6 DOTS entries:

    DT.97836465  DT.407309  DT.120927086  DT.120927100  DT.95321882  DT.97786136 

    24/61 AceView cDNA sequences (see all 61):

    AI792786 BE550585 BX281315 AB040957 BC017659 BC063433 AF334474 BE046367 
    AL713689 AI733143 AA445987 AI364440 BF061832 AI193460 AK022912 NM_020890 
    BM788957 AK056933 N38996 BP355764 AW274500 AI743717 AA768209 BP358870 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1524 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^
    SP1:              -     -           -                                                                                                                           
    SP2:                                -                                                                                                                           
    SP3:              -                 -                                                                                                                           
    SP4:              -     -           -           -                                                                                                               
    SP5:                                                                                                                                                        -   

    ExUns: 21 ^ 22a · 22b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for KIAA1524

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KIAA1524 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTTTATTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See KIAA1524 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KIAA1524

    SOURCE GeneReport for Unigene cluster: Hs.591308

    UniProtKB/Swiss-Prot: CIP2A_HUMAN, Q8TCG1
    Tissue specificity: Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell
    carcinomas (HNSCC). Present in liver cancer cells (at protein level)

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KIAA1524 gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia C330027C09Rik1 , 5 RIKEN cDNA C330027C09 gene1, 5 87.13(n)1
    87.61(a)1
      16 (30.75 cM)5
    2241711  NM_172616.21  NP_766204.21 
     489941855 
    chicken
    (Gallus gallus)
    Aves KIAA15241 KIAA1524 71.84(n)
    70.73(a)
      418410  NM_001030785.1  NP_001025956.1 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA15246
    --
    69(a)
    1 ↔ 1
    3(169146330-169175769)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.102822 Transcribed sequences 76.87(n)    BX738099.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1741601 zgc:174160 56.62(n)
    52.08(a)
      560948  NM_001114421.1  NP_001107893.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG127026
    --
    15(a)
    1 ↔ 1
    X(19653201-19656356)
    worm
    (Caenorhabditis elegans)
    Secernentea B0432.71 Protein B0432.7 41.63(n)
    28.5(a)
      181989  NM_061289.2  NP_493690.2 


    ENSEMBL Gene Tree for KIAA1524 (if available)
    TreeFam Gene Tree for KIAA1524 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/664 NCBI SNPs in KIAA1524 are shown (see all 664    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1493109181,2
    --108268278(+) AGTACA/GGACTT 1 -- int10--------
    rs26031411,2
    C,F,H,--108268286(-) AAAGAG/AGAAAG 1 -- int118Minor allele frequency- A:0.01NS EA NA WA CSA 1228
    rs1844176701,2
    --108268340(+) AAAGGA/GCTACT 1 -- int10--------
    rs1897725851,2
    --108268474(+) AAATTG/TAATAA 1 -- int10--------
    rs1810935761,2
    --108268495(+) TTAGTC/TTTTTC 1 -- int10--------
    rs1129922051,2
    --108268638(+) TCTAAA/TTTGGA 1 -- int12Minor allele frequency- T:0.05CSA WA 120
    rs1170909561,2
    F,--108268700(+) TTTAAC/TGTTTT 1 -- int11Minor allele frequency- T:0.03EA 120
    rs799369861,2
    C,F,--108268721(+) TTTTAT/CAGACC 1 -- ut311Minor allele frequency- C:0.16WA 118
    rs1446046731,2
    --108268766(+) TTTTTC/TATATT 1 -- ut310--------
    rs777417621,2
    C,--108268861(+) GCATAA/GTATTT 1 -- ut312Minor allele frequency- G:0.20WA 120

    HapMap Linkage Disequilibrium report for KIAA1524 (108268716 - 108308491 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KIAA1524: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIAA1524
    DNA2.0 Custom Variant and Variant Library Synthesis for KIAA1524

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KIAA1524 for disorders           About GeneDecksing

    OMIM gene information: 610643    OMIM disorders: --

    14 diseases for KIAA1524:    About MalaCards
    renal cell carcinoma    squamous cell carcinoma    myeloid leukemia    liver cancer
    cervical cancer    cervicitis    ovarian cancer    gastric cancer
    lung cancer    prostate cancer    breast cancer    carcinoma
    leukemia    prostatitis


    Export disorders for KIAA1524 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KIAA1524 gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with KIAA1524)
        Utopia: connect your pdf to the dynamic
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    1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. CIP2A inhibits PP2A in human malignancies. (PubMed id 17632056)1, 2 Junttila M.R.... Westermarck J. (2007)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Cloning and characterization of a novel 90 kDa 'companion' auto- antigen of p62 overexpressed in cancer. (PubMed id 12118381)1, 2 Soo Hoo L.... Chan E.K.L. (2002)
    5. CIP2A is overexpressed in esophageal squamous cell car cinoma. (PubMed id 21140243)1 Qu W....Yu J. (2012)
    6. CIP2A is highly expressed in hepatocellular carcinoma and predicts poor prognosis. (PubMed id 22847158)1 He H....Liu Y. (2012)
    7. Expression and prognostic significance of CIP2A mRNA i n hepatocellular carcinoma and nontumoral liver tissues. (PubMed id 22537152)1 Huang P....Zou R. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. CIP2A overexpression is associated with c-Myc expressi on in colorectal cancer. (PubMed id 22310977)1 Bockelman C....Haglund C. (2012)
    10. CIP2A is overexpressed in human ovarian cancer and reg ulates cell proliferation and apoptosis. (PubMed id 22923389)1 Fang Y....Zhang S. (2012)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57650 HGNC: 29302 AceView: KIAA1524 Ensembl:ENSG00000163507 euGenes: HUgn57650
    ECgene: KIAA1524 H-InvDB: KIAA1524

    (According to HUGE)
    About This Section
    HUGE: KIAA1524

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KIAA1524 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KIAA1524 gene:
    Search GeneIP for patents involving KIAA1524

    GeneCards and IP:
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