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Aliases for KIAA1462 Gene

Aliases for KIAA1462 Gene

  • KIAA1462 2 3
  • JCAD 3 4 6
  • Junctional Protein Associated With Coronary Artery Disease 2 3

External Ids for KIAA1462 Gene

Summaries for KIAA1462 Gene

GeneCards Summary for KIAA1462 Gene

KIAA1462 (KIAA1462) is a Protein Coding gene. Diseases associated with KIAA1462 include artery disease and coronary artery disease.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1462 Gene

Genomics for KIAA1462 Gene

Genomic Location for KIAA1462 Gene

Start:
30,012,800 bp from pter
End:
30,115,494 bp from pter
Size:
102,695 bases
Orientation:
Minus strand

Genomic View for KIAA1462 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIAA1462 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1462 Gene

Regulatory Elements for KIAA1462 Gene

Proteins for KIAA1462 Gene

  • Protein details for KIAA1462 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P266-JCAD_HUMAN
    Recommended name:
    Junctional protein associated with coronary artery disease
    Protein Accession:
    Q9P266
    Secondary Accessions:
    • Q5HYA7
    • Q5T992
    • Q86WZ9
    • Q9BYJ2

    Protein attributes for KIAA1462 Gene

    Size:
    1359 amino acids
    Molecular mass:
    148351 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA95986.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI46027.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KIAA1462 Gene

Proteomics data for KIAA1462 Gene at MOPED

Post-translational modifications for KIAA1462 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIAA1462 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIAA1462 Gene

Domains for KIAA1462 Gene

Protein Domains for KIAA1462 Gene

genes like me logo Genes that share domains with KIAA1462: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KIAA1462 Gene

Function for KIAA1462 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIAA1462 Gene

Localization for KIAA1462 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA1462 Gene

Cell junction, adherens junction. Note=Colocalizes with VE-Cadherin, in endothelial cells but not in epithelial cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA1462 Gene COMPARTMENTS Subcellular localization image for KIAA1462 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KIAA1462 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005911 cell-cell junction IEA --
GO:0005912 adherens junction IEA --
GO:0030054 cell junction --
genes like me logo Genes that share ontologies with KIAA1462: view

Pathways for KIAA1462 Gene

SuperPathways for KIAA1462 Gene

No Data Available

Interacting Proteins for KIAA1462 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364526%0d%0a9606.ENSP00000356480%0d%0a9606.ENSP00000372035%0d%0a
Selected Interacting proteins: ENSP00000364526 for KIAA1462 Gene via STRING

Gene Ontology (GO) - Biological Process for KIAA1462 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with KIAA1462: view

No data available for Pathways by source for KIAA1462 Gene

Transcripts for KIAA1462 Gene

Unigene Clusters for KIAA1462 Gene

KIAA1462:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1462 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - -
SP2: - - - - -
SP3: - -
SP4:
SP5:

Relevant External Links for KIAA1462 Gene

GeneLoc Exon Structure for
KIAA1462
ECgene alternative splicing isoforms for
KIAA1462

Expression for KIAA1462 Gene

mRNA expression in normal human tissues for KIAA1462 Gene

mRNA differential expression in normal tissues according to GTEx for KIAA1462 Gene

This gene is overexpressed in Colon - Sigmoid (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for KIAA1462 Gene

SOURCE GeneReport for Unigene cluster for KIAA1462 Gene Hs.533953

genes like me logo Genes that share expressions with KIAA1462: view

Orthologs for KIAA1462 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1462 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1462 36
  • 99.04 (n)
  • 98.82 (a)
KIAA1462 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia JCAD 37
  • 59 (a)
OneToOne
KIAA1462 36
  • 69.64 (n)
  • 60.03 (a)
dog
(Canis familiaris)
Mammalia KIAA1462 36
  • 74.36 (n)
  • 65.36 (a)
KIAA1462 37
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 9430020K01Rik 36
  • 68.23 (n)
  • 56.19 (a)
9430020K01Rik 16
9430020K01Rik 37
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA1462 37
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1462 37
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1562037 36
  • 67.51 (n)
  • 55.07 (a)
chicken
(Gallus gallus)
Aves KIAA1462 36
  • 56.96 (n)
  • 46.99 (a)
KIAA1462 37
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1462 37
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1462 36
  • 48.67 (n)
  • 36.75 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-203c7.2 37
  • 19 (a)
OneToMany
svilb 37
  • 14 (a)
OneToMany
Species with no ortholog for KIAA1462:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1462 Gene

ENSEMBL:
Gene Tree for KIAA1462 (if available)
TreeFam:
Gene Tree for KIAA1462 (if available)

Paralogs for KIAA1462 Gene

Pseudogenes.org Pseudogenes for KIAA1462 Gene

genes like me logo Genes that share paralogs with KIAA1462: view

No data available for Paralogs for KIAA1462 Gene

Variants for KIAA1462 Gene

Sequence variations from dbSNP and Humsavar for KIAA1462 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs15579 -- 30,014,633(+) GTAGT(A/C/T)GTTTC utr-variant-3-prime
rs755753 -- 30,020,885(+) TGTTA(C/T)TAAGA intron-variant
rs765906 -- 30,044,694(+) TTTTT(A/T)AATTT intron-variant
rs765907 -- 30,044,698(+) ttaat(A/T)taaGC intron-variant
rs943438 -- 30,038,806(-) TCCAC(A/G)TGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1462 Gene

Variant ID Type Subtype PubMed ID
esv2672894 CNV Deletion 23128226

Relevant External Links for KIAA1462 Gene

HapMap Linkage Disequilibrium report
KIAA1462
Human Gene Mutation Database (HGMD)
KIAA1462

Disorders for KIAA1462 Gene

Relevant External Links for KIAA1462

Genetic Association Database (GAD)
KIAA1462
Human Genome Epidemiology (HuGE) Navigator
KIAA1462
genes like me logo Genes that share disorders with KIAA1462: view

No data available for UniProtKB/Swiss-Prot for KIAA1462 Gene

Publications for KIAA1462 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J. … Lambert J.C. (Mol. Psychiatry 2009) 3 49
  3. Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23. (PMID: 21088011) Erdmann J. … Schunkert H. (Eur. Heart J. 2011) 3 49
  4. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. (PMID: 21378988) (Nat. Genet. 2011) 3 49
  5. A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions. (PMID: 21884682) Akashi M. … Furuse M. (Biochem. Biophys. Res. Commun. 2011) 2 3

Products for KIAA1462 Gene

Sources for KIAA1462 Gene

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