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Aliases for KIAA1456 Gene

Aliases for KIAA1456 Gene

  • KIAA1456 2 3
  • TRM9L 3 4 6
  • C8orf79 3 4
  • Probable TRNA Methyltransferase 9-Like Protein 3
  • Chromosome 8 Open Reading Frame 79 2
  • EC 2.1.1.- 4

External Ids for KIAA1456 Gene

Previous Symbols for KIAA1456 Gene

  • C8orf79

Summaries for KIAA1456 Gene

GeneCards Summary for KIAA1456 Gene

KIAA1456 (KIAA1456) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is ALKBH8.

UniProtKB/Swiss-Prot for KIAA1456 Gene

  • May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1456 Gene

Genomics for KIAA1456 Gene

Genomic Location for KIAA1456 Gene

Start:
12,945,642 bp from pter
End:
13,031,503 bp from pter
Size:
85,862 bases
Orientation:
Plus strand

Genomic View for KIAA1456 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIAA1456 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1456 Gene

No data available for Regulatory Elements for KIAA1456 Gene

Proteins for KIAA1456 Gene

  • Protein details for KIAA1456 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9K7-CH079_HUMAN
    Recommended name:
    Uncharacterized protein KIAA1456 isoform
    Protein Accession:
    Q8N9K7
    Secondary Accessions:

    Protein attributes for KIAA1456 Gene

    Size:
    121 amino acids
    Molecular mass:
    13671 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIAA1456 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for KIAA1456 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P272-K1456_HUMAN
    Recommended name:
    Probable tRNA methyltransferase 9-like protein
    Protein Accession:
    Q9P272
    Secondary Accessions:
    • Q96AW6

    Protein attributes for KIAA1456 Gene

    Size:
    454 amino acids
    Molecular mass:
    51299 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA95980.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA95980.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1456 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1456 Gene

Proteomics data for KIAA1456 Gene at MOPED

Post-translational modifications for KIAA1456 Gene

Other Protein References for KIAA1456 Gene

No data available for DME Specific Peptides for KIAA1456 Gene

Domains for KIAA1456 Gene

Protein Domains for KIAA1456 Gene

UniProtKB/Swiss-Prot:

K1456_HUMAN
Family:
  • Belongs to the methyltransferase superfamily.:
    • Q9P272
genes like me logo Genes that share domains with KIAA1456: view

No data available for Gene Families for KIAA1456 Gene

Function for KIAA1456 Gene

Molecular function for KIAA1456 Gene

UniProtKB/Swiss-Prot Function: May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9.

Enzyme Numbers (IUBMB) for KIAA1456 Gene

Gene Ontology (GO) - Molecular Function for KIAA1456 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with KIAA1456: view

Phenotypes for KIAA1456 Gene

GenomeRNAi human phenotypes for KIAA1456:
genes like me logo Genes that share phenotypes with KIAA1456: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KIAA1456 Gene

Localization for KIAA1456 Gene

No data available for Gene Ontology (GO) - Cellular Components for KIAA1456 Gene

Pathways for KIAA1456 Gene

SuperPathways for KIAA1456 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA1456 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IEA --
GO:0008152 metabolic process --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with KIAA1456: view

No data available for Pathways by source for KIAA1456 Gene

Transcripts for KIAA1456 Gene

Unigene Clusters for KIAA1456 Gene

KIAA1456:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1456 Gene

No ASD Table

Relevant External Links for KIAA1456 Gene

GeneLoc Exon Structure for
KIAA1456
ECgene alternative splicing isoforms for
KIAA1456

Expression for KIAA1456 Gene

mRNA expression in normal human tissues for KIAA1456 Gene

mRNA differential expression in normal tissues according to GTEx for KIAA1456 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (13.2), Brain - Cerebellum (12.3), and Thyroid (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KIAA1456 Gene

SOURCE GeneReport for Unigene cluster for KIAA1456 Gene Hs.202521

mRNA Expression by UniProt/SwissProt for KIAA1456 Gene

Q8N9K7-CH079_HUMAN
Tissue specificity: Down-regulated in breast, bladder, colorectal, cervix and testicular carcinomas.
genes like me logo Genes that share expressions with KIAA1456: view

Orthologs for KIAA1456 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIAA1456 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1456 36
  • 98.53 (n)
  • 97.8 (a)
KIAA1456 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA1456 36
  • 82.63 (n)
  • 79.03 (a)
KIAA1456 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA1456 36
  • 86.39 (n)
  • 82.34 (a)
KIAA1456 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 6430573F11Rik 36
  • 79.34 (n)
  • 74.72 (a)
6430573F11Rik 16
6430573F11Rik 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA1456 37
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1456 37
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1304810 36
  • 78.85 (n)
  • 75.56 (a)
chicken
(Gallus gallus)
Aves KIAA1456 36
  • 66.44 (n)
  • 61.35 (a)
KIAA1456 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1456 37
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488302 36
  • 62.36 (n)
  • 54.04 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:73340 37
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42261 37
  • 9 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C35D10.12 37
  • 27 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM9 37
  • 32 (a)
OneToMany
Species with no ortholog for KIAA1456:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIAA1456 Gene

ENSEMBL:
Gene Tree for KIAA1456 (if available)
TreeFam:
Gene Tree for KIAA1456 (if available)

Paralogs for KIAA1456 Gene

Paralogs for KIAA1456 Gene

genes like me logo Genes that share paralogs with KIAA1456: view

Variants for KIAA1456 Gene

Sequence variations from dbSNP and Humsavar for KIAA1456 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs472347 -- 13,022,596(-) TCTTG(G/T)TTCTC utr-variant-3-prime
rs475181 -- 13,022,268(-) ATCTT(G/T)TATAT utr-variant-3-prime
rs476023 -- 13,022,198(-) TCAAA(A/C)ATGAA utr-variant-3-prime
rs476541 -- 13,029,240(+) GTTAT(A/T)GTGCC utr-variant-3-prime
rs480286 -- 13,029,663(+) ATCTA(A/G)GGGAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KIAA1456 Gene

Variant ID Type Subtype PubMed ID
nsv465469 CNV Loss 19166990
dgv2215e1 CNV Complex 17122850

Relevant External Links for KIAA1456 Gene

HapMap Linkage Disequilibrium report
KIAA1456

Disorders for KIAA1456 Gene

No disorders were found for KIAA1456 Gene.

No data available for UniProtKB/Swiss-Prot for KIAA1456 Gene

Publications for KIAA1456 Gene

  1. A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-I+. (PMID: 23381944) Begley U. … Begley T. (EMBO Mol Med 2013) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for KIAA1456 Gene

Sources for KIAA1456 Gene

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