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Aliases for KIAA1456 Gene

Aliases for KIAA1456 Gene

  • KIAA1456 2 3
  • C8orf79 3 4
  • TRM9L 3 4
  • Probable TRNA Methyltransferase 9-Like Protein 3
  • Chromosome 8 Open Reading Frame 79 2
  • EC 2.1.1.- 4

External Ids for KIAA1456 Gene

Previous HGNC Symbols for KIAA1456 Gene

  • C8orf79

Previous GeneCards Identifiers for KIAA1456 Gene

  • GC08P012644
  • GC08P012830
  • GC08U900355
  • GC08P012806
  • GC08P012809
  • GC08P012810
  • GC08P012811
  • GC08P012812

Summaries for KIAA1456 Gene

GeneCards Summary for KIAA1456 Gene

KIAA1456 (KIAA1456) is a Protein Coding gene. Among its related pathways are tRNA processing and Gene Expression. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is ALKBH8.

UniProtKB/Swiss-Prot for KIAA1456 Gene

  • May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1456 Gene

Genomics for KIAA1456 Gene

Regulatory Elements for KIAA1456 Gene

Enhancers for KIAA1456 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around KIAA1456 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIAA1456 Gene

Chromosome:
8
Start:
12,945,642 bp from pter
End:
13,031,503 bp from pter
Size:
85,862 bases
Orientation:
Plus strand

Genomic View for KIAA1456 Gene

Genes around KIAA1456 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1456 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1456 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1456 Gene

Proteins for KIAA1456 Gene

  • Protein details for KIAA1456 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9K7-CH079_HUMAN
    Recommended name:
    Uncharacterized protein KIAA1456 isoform
    Protein Accession:
    Q8N9K7

    Protein attributes for KIAA1456 Gene

    Size:
    121 amino acids
    Molecular mass:
    13671 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIAA1456 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for KIAA1456 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P272-K1456_HUMAN
    Recommended name:
    Probable tRNA methyltransferase 9-like protein
    Protein Accession:
    Q9P272
    Secondary Accessions:
    • Q96AW6

    Protein attributes for KIAA1456 Gene

    Size:
    454 amino acids
    Molecular mass:
    51299 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA95980.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA95980.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1456 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1456 Gene

Post-translational modifications for KIAA1456 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIAA1456 Gene

No data available for DME Specific Peptides for KIAA1456 Gene

Domains & Families for KIAA1456 Gene

Protein Domains for KIAA1456 Gene

Suggested Antigen Peptide Sequences for KIAA1456 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P272

UniProtKB/Swiss-Prot:

K1456_HUMAN :
  • Belongs to the methyltransferase superfamily.
Family:
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with KIAA1456: view

No data available for Gene Families for KIAA1456 Gene

Function for KIAA1456 Gene

Molecular function for KIAA1456 Gene

UniProtKB/Swiss-Prot Function:
May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9.

Enzyme Numbers (IUBMB) for KIAA1456 Gene

Gene Ontology (GO) - Molecular Function for KIAA1456 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IBA --
GO:0008175 tRNA methyltransferase activity EXP 23381944
GO:0008198 ferrous iron binding IBA --
GO:0016300 tRNA (uracil) methyltransferase activity IBA --
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IBA --
genes like me logo Genes that share ontologies with KIAA1456: view
genes like me logo Genes that share phenotypes with KIAA1456: view

Animal Model Products

CRISPR Products

miRNA for KIAA1456 Gene

miRTarBase miRNAs that target KIAA1456

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1456 Gene

Localization for KIAA1456 Gene

Gene Ontology (GO) - Cellular Components for KIAA1456 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm TAS --
genes like me logo Genes that share ontologies with KIAA1456: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for KIAA1456 Gene

Pathways & Interactions for KIAA1456 Gene

genes like me logo Genes that share pathways with KIAA1456: view

Pathways by source for KIAA1456 Gene

Interacting Proteins for KIAA1456 Gene

Gene Ontology (GO) - Biological Process for KIAA1456 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002098 tRNA wobble uridine modification IBA --
GO:0006400 tRNA modification TAS --
GO:0030488 tRNA methylation IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with KIAA1456: view

No data available for SIGNOR curated interactions for KIAA1456 Gene

Drugs & Compounds for KIAA1456 Gene

No Compound Related Data Available

Transcripts for KIAA1456 Gene

Unigene Clusters for KIAA1456 Gene

KIAA1456:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1456 Gene

No ASD Table

Relevant External Links for KIAA1456 Gene

GeneLoc Exon Structure for
KIAA1456
ECgene alternative splicing isoforms for
KIAA1456

Expression for KIAA1456 Gene

mRNA expression in normal human tissues for KIAA1456 Gene

mRNA differential expression in normal tissues according to GTEx for KIAA1456 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x13.2), Brain - Cerebellum (x12.3), and Thyroid (x6.5).

Protein differential expression in normal tissues from HIPED for KIAA1456 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIAA1456 Gene



Protein tissue co-expression partners for KIAA1456 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIAA1456 Gene:

KIAA1456

SOURCE GeneReport for Unigene cluster for KIAA1456 Gene:

Hs.202521

mRNA Expression by UniProt/SwissProt for KIAA1456 Gene:

Q8N9K7-CH079_HUMAN
Tissue specificity: Down-regulated in breast, bladder, colorectal, cervix and testicular carcinomas.
genes like me logo Genes that share expression patterns with KIAA1456: view

Primer Products

Orthologs for KIAA1456 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KIAA1456 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIAA1456 34
  • 82.63 (n)
  • 79.03 (a)
KIAA1456 35
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA1456 34
  • 86.39 (n)
  • 82.34 (a)
KIAA1456 35
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 6430573F11Rik 34
  • 79.34 (n)
  • 74.72 (a)
6430573F11Rik 16
6430573F11Rik 35
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIAA1456 34
  • 98.53 (n)
  • 97.8 (a)
KIAA1456 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1304810 34
  • 78.85 (n)
  • 75.56 (a)
oppossum
(Monodelphis domestica)
Mammalia KIAA1456 35
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1456 35
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1456 34
  • 66.44 (n)
  • 61.35 (a)
KIAA1456 35
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1456 35
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488302 34
  • 62.36 (n)
  • 54.04 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:73340 35
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42261 35
  • 9 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C35D10.12 35
  • 27 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM9 35
  • 32 (a)
OneToMany
Species where no ortholog for KIAA1456 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIAA1456 Gene

ENSEMBL:
Gene Tree for KIAA1456 (if available)
TreeFam:
Gene Tree for KIAA1456 (if available)

Paralogs for KIAA1456 Gene

Paralogs for KIAA1456 Gene

genes like me logo Genes that share paralogs with KIAA1456: view

Variants for KIAA1456 Gene

Sequence variations from dbSNP and Humsavar for KIAA1456 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2272624 - 12,952,158(-) TCCCG(A/T)TGCGA intron-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
VAR_029821 -
VAR_056243 -
VAR_056244 -
VAR_056245 -

Structural Variations from Database of Genomic Variants (DGV) for KIAA1456 Gene

Variant ID Type Subtype PubMed ID
dgv7083n100 CNV loss 25217958
dgv7084n100 CNV gain 25217958
esv2759594 CNV loss 17122850
esv3576525 CNV gain 25503493
esv3616295 CNV gain 21293372
nsv1017762 CNV loss 25217958
nsv1026381 CNV loss 25217958
nsv1030002 CNV loss 25217958
nsv1033244 CNV loss 25217958
nsv465469 CNV loss 19166990
nsv610406 CNV gain 21841781
nsv610409 CNV loss 21841781

Variation tolerance for KIAA1456 Gene

Residual Variation Intolerance Score: 92.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.86; 58.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1456 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1456

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1456 Gene

Disorders for KIAA1456 Gene

Relevant External Links for KIAA1456

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1456

No disorders were found for KIAA1456 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1456 Gene

Publications for KIAA1456 Gene

  1. A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-I+. (PMID: 23381944) Begley U. … Begley T. (EMBO Mol Med 2013) 2 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. Genome-wide diet-gene interaction analyses for risk of colorectal cancer. (PMID: 24743840) Figueiredo J.C. … . (PLoS Genet. 2014) 3 65

Products for KIAA1456 Gene

Sources for KIAA1456 Gene

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