KIAA1432 Gene
protein-coding GIFtS: 44
GCID: GC09P005629
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KIAA1432
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Aliases
for KIAA1432 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| KIAA14321 2 | | BA207C16.11 | | Connexin-43-Interacting Protein Of 150 KDa2 3 | | CIP1502 3 | | Connexin 43-Interacting Protein 150 KDa2 | | Protein RIC1 Homolog2 |
Export aliases for KIAA1432 gene to outside databasesPrevious GC identifers: GC09P005783 GC09P005610 GC09P005619 GC09P005577 |
Summaries
for KIAA1432 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RIC1_HUMAN, Q4ADV7Function: Required for phosphorylation and localization of GJA1
|
Genomic Views
for KIAA1432 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KIAA1432 gene promoter:
AP-4 AP-2gamma Tal-1beta AP-2beta ITF-2 AP-2alpha Pax-4a AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIAA1432
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA1432 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p24.1 Ensembl cytogenetic band: 9p24.1 HGNC cytogenetic band: 9p24.1KIAA1432 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P005629: view genomic region
(about GC identifiers)
Start:
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5,629,025 bp from pter |
End:
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5,776,557 bp from pter |
Size:
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147,533 bases |
Orientation:
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plus strand |
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Proteins
for KIAA1432 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RIC1_HUMAN, Q4ADV7 (See
protein sequence)Recommended Name: Protein RIC1 homolog Size: 1423 amino acids; 159301 Da
Subunit: Interacts with GJA1
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAI36617.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAI44297.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14150.1;Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAE16982.1; Type=Erroneous initiation;Note=Translation N-terminally extended; Sequence=CAB66809.1; Type=Erroneous initiation; Note=Translation N-terminallyextended; Sequence=CAI95003.1; Type=Erroneous gene model prediction; Sequence=CAI95004.1; Type=Erroneous gene modelprediction;
Secondary accessions: B2RN24 B7ZM67 G5E932 Q4VXJ8 Q4VXJ9 Q76MT5 Q8N6E0 Q8TEH4 Q9H0A5 Q9H9S1Alternative splicing: 3 isoforms: Q4ADV7-1 Q4ADV7-2 Q4ADV7-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KIAA1432: NX_Q4ADV7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q4ADV7
KIAA1432 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001129392.2 NP_001193486.1 NP_065880.2
ENSEMBL proteins: ENSP00000251879 ENSP00000416696 ENSP00000439488 ENSP00000442632 ENSP00000438005 ENSP00000402240 ENSP00000398823 ENSP00000370943
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
KIAA1432 for ontologies About GeneDecksing
KIAA1432 Antibody Products:
Assay Products for KIAA1432: |
Protein
Domains /
Families
for KIAA1432 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KIAA1432 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q4ADV7ProtoNet protein and cluster: Q4ADV7 UniProtKB/Swiss-Prot: RIC1_HUMAN, Q4ADV7Similarity: Belongs to the RIC1 familySimilarity: Contains 2 WD repeats |
Function
for KIAA1432 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RIC1_HUMAN, Q4ADV7Function: Required for phosphorylation and localization of GJA1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1432 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1432 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for KIAA1432 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA1432 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1432 |
Animal Models:
6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for C030046E11Rik):
KIAA1432 for phenotypes About GeneDecksing
|
Pathways & Interactions
for KIAA1432 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KIAA1432
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
4 Interacting proteins for KIAA1432 (Q4ADV73 ENSP000004022404) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for KIAA1432 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KIAA1432
Search CenterWatch for drugs/clinical trials and news about KIAA1432 / RIC1
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Transcripts
for KIAA1432 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KIAA1432 gene (3 alternative transcripts): NM_001135920.2 NM_001206557.1 NM_020829.3 Unigene Cluster for KIAA1432: KIAA1432 Hs.211520 [show with all ESTs]Unigene Representative Sequence: NM_0208299 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000251879(uc003zjh.3) ENST00000414202(uc003zji.3 uc003zjl.4)
ENST00000545641 ENST00000276898(uc003zjj.1) ENST00000545243 ENST00000490816
ENST00000418622 ENST00000449720 ENST00000381532
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1432 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1432 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): KIAA1432 (NM_020829) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIAA1432 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA1432 |
Additional cDNA sequence: AB037853.2 AB205401.1 AK022642.1 AK074150.1 AK124394.1 AL136875.1 BC023535.2 BC030576.1 BC041044.1 BC136616.1 BC144296.1 10 DOTS entries: DT.314576 DT.95149177 DT.86846937 DT.100781802 DT.86852249 DT.101971733 DT.95157248 DT.91912214 DT.40299465 DT.75154682 24/112 AceView cDNA sequences (see all 112): AI016962 CK429853 CF265040 AW966938 BQ008932 C03605 AK074150 T08140 AA250979 AW445127 AA432319 AA630125 BX097642 BM467828 AK124394 AI143412 BF198075 AK022642 BE048232 AL136875 AA250978 AL138104 CB152016 BU623083
GeneLoc Exon Structure
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Expression
for KIAA1432 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIAA1432 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGCCCAGCA
About this image
See KIAA1432 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIAA1432
SOURCE GeneReport for Unigene cluster: Hs.211520
UniProtKB/Swiss-Prot: RIC1_HUMAN, Q4ADV7Tissue specificity: Present in kidney and various cell lines (at protein level). Widely expressed at low level
SABiosciences Custom PCR Arrays for KIAA1432
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIAA1432
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIAA1432 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA1432 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA1432 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1432 |
Orthologs
for KIAA1432 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KIAA1432 gene from 9/28 species (see all 28) About this table
ENSEMBL Gene Tree for KIAA1432 (if available)
TreeFam Gene Tree for KIAA1432 (if available) |
Paralogs
for KIAA1432 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for KIAA1432 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KIAA1432 (5629025 - 5776557 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for KIAA1432
5 CNVs: 65320 100569 44391 95821 65319
1 Indel: 95822
Human Gene Mutation Database (HGMD): KIAA1432
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIAA1432 |
|
Disorders
/ Diseases
for KIAA1432 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 KIAA1432 for disorders About MalaCards
KIAA1432 for disorders About GeneDecksing
OMIM gene information: 610354
OMIM disorders: --
Export disorders for KIAA1432 gene to outside databases
|
Publications
for KIAA1432 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIAA1432 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with KIAA1432) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
- Molecular cloning and functional analysis of a novel Cx43 partner protein CIP150. (PubMed id 16112082)1, 2, 9 Akiyama M.... Takeya T. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for KIAA1432 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing KIAA1432 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KIAA1432 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KIAA1432 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KIAA1432 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KIAA1432 gene:
Search GeneIP for patents involving KIAA1432
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIAA1432 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | KIAA1432 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1432 |
|  |  |  | | | | Search ThermoFisher Antibodies for KIAA1432 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA1432 |
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