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Aliases for KIAA1429 Gene

Aliases for KIAA1429 Gene

  • KIAA1429 2 3
  • Functional Spliceosome-Associated Protein 121 2 3
  • Protein Virilizer Homolog 3
  • MSTP054 3
  • FSAP121 3

External Ids for KIAA1429 Gene

Previous GeneCards Identifiers for KIAA1429 Gene

  • GC08M095570
  • GC08M090709
  • GC08M095499

Summaries for KIAA1429 Gene

GeneCards Summary for KIAA1429 Gene

KIAA1429 (KIAA1429) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and binding.

UniProtKB/Swiss-Prot for KIAA1429 Gene

  • Required for N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and processing (PubMed:24981863). Involved in mRNA splicing regulation, probably via its function in m6A methylation (Probable).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1429 Gene

Genomics for KIAA1429 Gene

Regulatory Elements for KIAA1429 Gene

Enhancers for KIAA1429 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F094718 0.2 ENCODE 70.6 -166.6 -166553 2.9 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC KIAA1429 RBM12B INTS8 ENSG00000253704 ENSG00000254283 LINC01298 PSMA2P2 GEM C8orf37 PLEKHF2
GH08F095267 0.2 ENCODE 32.9 -716.0 -716019 3.4 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 INTS8 KIAA1429 C8orf37 MTERF3 TRS-AGA2-5 LINC01298
GH08F094552 0.6 ENCODE 22.4 -0.1 -79 2.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 KIAA1429 INTS8 GEM C8orf37 RPL34P18 RAD54B LOC101926977
GH08F093738 0.6 ENCODE 22.4 +813.3 813308 3.4 HDGF ATF1 ARNT CREB3L1 WRNIP1 ZNF133 ZFP64 ARID4B SIN3A DMAP1 LOC105375645 KIAA1429 RBM12B RBM12B-AS1
GH08F095024 0.5 ENCODE 20.8 -471.7 -471653 2.3 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143 INTS8 KIAA1429 TP53INP1 MIR3150B ENSG00000253878 CCNE2 RNU6-1209P ENSG00000254307 GC08P094978
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KIAA1429 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIAA1429 Gene

Chromosome:
8
Start:
94,487,693 bp from pter
End:
94,553,529 bp from pter
Size:
65,837 bases
Orientation:
Minus strand

Genomic View for KIAA1429 Gene

Genes around KIAA1429 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1429 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1429 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1429 Gene

Proteins for KIAA1429 Gene

  • Protein details for KIAA1429 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q69YN4-VIR_HUMAN
    Recommended name:
    Protein virilizer homolog
    Protein Accession:
    Q69YN4
    Secondary Accessions:
    • Q2M1N0
    • Q6AHX9
    • Q6NT78
    • Q7Z6C7
    • Q8IXH4
    • Q9BTH4
    • Q9H9C9
    • Q9NWR3
    • Q9P2B8
    • Q9UFW1

    Protein attributes for KIAA1429 Gene

    Size:
    1812 amino acids
    Molecular mass:
    202025 Da
    Quaternary structure:
    • Associated component of the WMM complex, a N6-methyltransferase complex composed of WTAP, METTL3 and METTL14; possibly via its interaction with WTAP (PubMed:24981863). Interacts with WTAP (PubMed:24100041). Component of the WTAP complex composed of WTAP, ZC3H13, CBLL1, KIAA1429, RBM15, BCLAF1 and THRAP3 (PubMed:24100041).
    SequenceCaution:
    • Sequence=BAA91316.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14301.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB55922.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1429 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1429 Gene

Post-translational modifications for KIAA1429 Gene

  • Ubiquitination at Lys 16 and Lys 899
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KIAA1429 Gene

Domains & Families for KIAA1429 Gene

Protein Domains for KIAA1429 Gene

Suggested Antigen Peptide Sequences for KIAA1429 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q69YN4

UniProtKB/Swiss-Prot:

VIR_HUMAN :
  • Belongs to the vir family.
Family:
  • Belongs to the vir family.
genes like me logo Genes that share domains with KIAA1429: view

No data available for Gene Families for KIAA1429 Gene

Function for KIAA1429 Gene

Molecular function for KIAA1429 Gene

UniProtKB/Swiss-Prot Function:
Required for N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and processing (PubMed:24981863). Involved in mRNA splicing regulation, probably via its function in m6A methylation (Probable).

Gene Ontology (GO) - Molecular Function for KIAA1429 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with KIAA1429: view
genes like me logo Genes that share phenotypes with KIAA1429: view

Animal Models for KIAA1429 Gene

MGI Knock Outs for KIAA1429:

Animal Model Products

miRNA for KIAA1429 Gene

miRTarBase miRNAs that target KIAA1429

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIAA1429 Gene

Localization for KIAA1429 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA1429 Gene

Nucleus speckle. Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA1429 Gene COMPARTMENTS Subcellular localization image for KIAA1429 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KIAA1429 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IEA,IDA 24100041
GO:0016607 nuclear speck IEA,IDA 24100041
GO:0036396 colocalizes_with MIS complex IDA 24981863
genes like me logo Genes that share ontologies with KIAA1429: view

Pathways & Interactions for KIAA1429 Gene

SuperPathways for KIAA1429 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA1429 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0080009 mRNA methylation IMP 24981863
genes like me logo Genes that share ontologies with KIAA1429: view

No data available for Pathways by source and SIGNOR curated interactions for KIAA1429 Gene

Transcripts for KIAA1429 Gene

Unigene Clusters for KIAA1429 Gene

KIAA1429:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1429 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19
SP1: -
SP2: - - - -
SP3: -
SP4:
SP5:

Relevant External Links for KIAA1429 Gene

GeneLoc Exon Structure for
KIAA1429
ECgene alternative splicing isoforms for
KIAA1429

Expression for KIAA1429 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIAA1429 Gene

Protein differential expression in normal tissues from HIPED for KIAA1429 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.4), Lymph node (10.3), Pancreas (6.9), Lung (6.3), and Kidney (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIAA1429 Gene



Protein tissue co-expression partners for KIAA1429 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KIAA1429 Gene:

KIAA1429

SOURCE GeneReport for Unigene cluster for KIAA1429 Gene:

Hs.202238
genes like me logo Genes that share expression patterns with KIAA1429: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIAA1429 Gene

Orthologs for KIAA1429 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA1429 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1429 34 35
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia KIAA1429 34 35
  • 95.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 95 (a)
OneToMany
-- 35
  • 92 (a)
OneToMany
cow
(Bos Taurus)
Mammalia KIAA1429 34 35
  • 93.73 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1429 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1110037F02Rik 34 16 35
  • 89.91 (n)
rat
(Rattus norvegicus)
Mammalia RGD1559904 34
  • 89.49 (n)
chicken
(Gallus gallus)
Aves KIAA1429 34 35
  • 79.77 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA1429 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1429 34
  • 70.35 (n)
Str.7330 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.9561 34
zebrafish
(Danio rerio)
Actinopterygii si:ch211-79l20.4 34 35
  • 58.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta vir 35
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
OneToOne
Species where no ortholog for KIAA1429 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1429 Gene

ENSEMBL:
Gene Tree for KIAA1429 (if available)
TreeFam:
Gene Tree for KIAA1429 (if available)

Paralogs for KIAA1429 Gene

Pseudogenes.org Pseudogenes for KIAA1429 Gene

genes like me logo Genes that share paralogs with KIAA1429: view

No data available for Paralogs for KIAA1429 Gene

Variants for KIAA1429 Gene

Sequence variations from dbSNP and Humsavar for KIAA1429 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10086311 -- 94,520,085(+) GCATG(C/T)CTGTA intron-variant
rs10087221 -- 94,514,850(+) AGCAC(G/T)TTTAA intron-variant
rs10089982 -- 94,537,704(+) CTTTA(A/G)TTTTT intron-variant
rs10090029 -- 94,534,238(+) AAAAA(A/C)AAATG intron-variant
rs10094477 -- 94,522,181(+) ataca(C/T)gtatc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1429 Gene

Variant ID Type Subtype PubMed ID
dgv7271n100 CNV gain 25217958
dgv7272n100 CNV gain 25217958
dgv7273n100 CNV gain 25217958
esv21754 CNV loss 19812545
esv2662586 CNV deletion 23128226
esv3584580 CNV gain 24956385
esv3618078 CNV loss 21293372
nsv438072 CNV loss 16468122
nsv611750 CNV loss 21841781

Variation tolerance for KIAA1429 Gene

Residual Variation Intolerance Score: 1.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.57; 56.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1429 Gene

Human Gene Mutation Database (HGMD)
KIAA1429
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1429

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1429 Gene

Disorders for KIAA1429 Gene

Relevant External Links for KIAA1429

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1429

No disorders were found for KIAA1429 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1429 Gene

Publications for KIAA1429 Gene

  1. Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. (PMID: 24981863) Schwartz S. … Regev A. (Cell Rep 2014) 2 3 4 64
  2. Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle. (PMID: 24100041) Horiuchi K. … Hamakubo T. (J. Biol. Chem. 2013) 2 3 4 64
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for KIAA1429 Gene

Sources for KIAA1429 Gene

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