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Aliases for KIAA1429 Gene

Aliases for KIAA1429 Gene

  • KIAA1429 2 3
  • Functional Spliceosome-Associated Protein 121 2 3
  • MSTP054 3
  • FSAP121 3

External Ids for KIAA1429 Gene

Previous GeneCards Identifiers for KIAA1429 Gene

  • GC08M095570
  • GC08M090709
  • GC08M095499

Summaries for KIAA1429 Gene

GeneCards Summary for KIAA1429 Gene

KIAA1429 (KIAA1429) is a Protein Coding gene. Diseases associated with KIAA1429 include oxyphilic adenoma. GO annotations related to this gene include poly(A) RNA binding and binding.

UniProtKB/Swiss-Prot for KIAA1429 Gene

  • Required for N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and processing (PubMed:24981863). Involved in mRNA splicing regulation, probably via its function in m6A methylation (Probable).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1429 Gene

Genomics for KIAA1429 Gene

Regulatory Elements for KIAA1429 Gene

Genomic Location for KIAA1429 Gene

Chromosome:
8
Start:
94,487,693 bp from pter
End:
94,553,529 bp from pter
Size:
65,837 bases
Orientation:
Minus strand

Genomic View for KIAA1429 Gene

Genes around KIAA1429 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1429 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1429 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1429 Gene

Proteins for KIAA1429 Gene

  • Protein details for KIAA1429 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q69YN4-VIR_HUMAN
    Recommended name:
    Protein virilizer homolog
    Protein Accession:
    Q69YN4
    Secondary Accessions:
    • Q2M1N0
    • Q6AHX9
    • Q6NT78
    • Q7Z6C7
    • Q8IXH4
    • Q9BTH4
    • Q9H9C9
    • Q9NWR3
    • Q9P2B8
    • Q9UFW1

    Protein attributes for KIAA1429 Gene

    Size:
    1812 amino acids
    Molecular mass:
    202025 Da
    Quaternary structure:
    • Associated component of the WMM complex, a N6-methyltransferase complex composed of WTAP, METTL3 and METTL14; possibly via its interaction with WTAP (PubMed:24981863). Interacts with WTAP (PubMed:24100041). Component of the WTAP complex composed of WTAP, ZC3H13, CBLL1, KIAA1429, RBM15, BCLAF1 and THRAP3 (PubMed:24100041).
    SequenceCaution:
    • Sequence=BAA91316.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14301.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB55922.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1429 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1429 Gene

Proteomics data for KIAA1429 Gene at MOPED

Post-translational modifications for KIAA1429 Gene

  • Ubiquitination at Lys 16 and Lys 899
  • Modification sites at PhosphoSitePlus

Other Protein References for KIAA1429 Gene

Antibody Products

No data available for DME Specific Peptides for KIAA1429 Gene

Domains & Families for KIAA1429 Gene

Protein Domains for KIAA1429 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA1429 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q69YN4

UniProtKB/Swiss-Prot:

VIR_HUMAN :
  • Belongs to the vir family.
Family:
  • Belongs to the vir family.
genes like me logo Genes that share domains with KIAA1429: view

No data available for Gene Families for KIAA1429 Gene

Function for KIAA1429 Gene

Molecular function for KIAA1429 Gene

UniProtKB/Swiss-Prot Function:
Required for N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and processing (PubMed:24981863). Involved in mRNA splicing regulation, probably via its function in m6A methylation (Probable).
genes like me logo Genes that share phenotypes with KIAA1429: view

Animal Models for KIAA1429 Gene

MGI Knock Outs for KIAA1429:

Animal Model Products

CRISPR Products

miRNA for KIAA1429 Gene

miRTarBase miRNAs that target KIAA1429

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIAA1429 Gene

Localization for KIAA1429 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA1429 Gene

Nucleus speckle. Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA1429 Gene COMPARTMENTS Subcellular localization image for KIAA1429 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KIAA1429 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA 24100041
genes like me logo Genes that share ontologies with KIAA1429: view

Pathways & Interactions for KIAA1429 Gene

SuperPathways for KIAA1429 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA1429 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008380 RNA splicing IEA --
GO:0080009 mRNA methylation IMP 24981863
genes like me logo Genes that share ontologies with KIAA1429: view

No data available for Pathways by source and SIGNOR curated interactions for KIAA1429 Gene

Drugs & Compounds for KIAA1429 Gene

No Compound Related Data Available

Transcripts for KIAA1429 Gene

Unigene Clusters for KIAA1429 Gene

KIAA1429:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1429 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19
SP1: -
SP2: - - - -
SP3: -
SP4:
SP5:

Relevant External Links for KIAA1429 Gene

GeneLoc Exon Structure for
KIAA1429
ECgene alternative splicing isoforms for
KIAA1429

Expression for KIAA1429 Gene

mRNA expression in normal human tissues for KIAA1429 Gene

Protein differential expression in normal tissues from HIPED for KIAA1429 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.4), Lymph node (10.3), Pancreas (6.9), Lung (6.3), and Kidney (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIAA1429 Gene



SOURCE GeneReport for Unigene cluster for KIAA1429 Gene Hs.202238

genes like me logo Genes that share expression patterns with KIAA1429: view

Protein tissue co-expression partners for KIAA1429 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KIAA1429 Gene

Orthologs for KIAA1429 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA1429 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1429 35
  • 99.71 (n)
  • 99.67 (a)
KIAA1429 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA1429 35
  • 93.73 (n)
  • 97.74 (a)
KIAA1429 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA1429 35
  • 95.41 (n)
  • 98.27 (a)
KIAA1429 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1110037F02Rik 16
1110037F02Rik 36
  • 93 (a)
OneToOne
1110037F02Rik 35
  • 89.91 (n)
  • 95.75 (a)
oppossum
(Monodelphis domestica)
Mammalia KIAA1429 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia RGD1559904 35
  • 89.49 (n)
  • 96.13 (a)
chicken
(Gallus gallus)
Aves KIAA1429 36
  • 86 (a)
OneToOne
KIAA1429 35
  • 79.77 (n)
  • 86.31 (a)
lizard
(Anolis carolinensis)
Reptilia KIAA1429 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9561 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7330 35
kiaa1429 35
  • 70.35 (n)
  • 72.77 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-79l20.4 36
  • 57 (a)
OneToOne
si:ch211-79l20.4 35
  • 58.87 (n)
  • 57.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta vir 36
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToOne
Species with no ortholog for KIAA1429:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1429 Gene

ENSEMBL:
Gene Tree for KIAA1429 (if available)
TreeFam:
Gene Tree for KIAA1429 (if available)

Paralogs for KIAA1429 Gene

Pseudogenes.org Pseudogenes for KIAA1429 Gene

genes like me logo Genes that share paralogs with KIAA1429: view

No data available for Paralogs for KIAA1429 Gene

Variants for KIAA1429 Gene

Sequence variations from dbSNP and Humsavar for KIAA1429 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs7814840 - 94,519,241(+) ATCAA(C/T)AACAC reference, missense
rs8117 -- 94,488,696(-) CCTTT(C/T)GGGAA utr-variant-3-prime
rs1048029 -- 94,510,149(-) GTACT(C/G)TGATT intron-variant
rs1055796 -- 94,511,172(+) TTCCA(A/C/G/T)ATAAC intron-variant, reference, missense
rs1055797 -- 94,511,005(-) GGTAA(A/C)ATTTT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KIAA1429 Gene

Variant ID Type Subtype PubMed ID
esv2662586 CNV Deletion 23128226
esv21754 CNV Loss 19812545
nsv438072 CNV Loss 16468122

Variation tolerance for KIAA1429 Gene

Residual Variation Intolerance Score: 1.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.57; 56.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1429 Gene

HapMap Linkage Disequilibrium report
KIAA1429
Human Gene Mutation Database (HGMD)
KIAA1429

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1429 Gene

Disorders for KIAA1429 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KIAA1429 Gene - From: DISEASES

Disorder Aliases PubMed IDs
oxyphilic adenoma
  • follicular adenoma, oxyphilic cell
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for KIAA1429

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1429
genes like me logo Genes that share disorders with KIAA1429: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KIAA1429 Gene

Publications for KIAA1429 Gene

  1. Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. (PMID: 24981863) Schwartz S. … Regev A. (Cell Rep 2014) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for KIAA1429 Gene

Sources for KIAA1429 Gene

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