KIAA1429 Gene
protein-coding GIFtS: 46
GCID: GC08M095570
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KIAA1429
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Aliases
for KIAA1429 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| KIAA14291 2 | | FSAP1211 | | DKFZP434I1161 | | Functional Spliceosome-Associated Protein 1212 | | Protein Virilizer Homolog2 |
Export aliases for KIAA1429 gene to outside databasesPrevious GC identifer: GC08M090709 |
Summaries
for KIAA1429 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: VIR_HUMAN, Q69YN4Function: May be involved in mRNA splicing regulation (By similarity)
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Genomic Views
for KIAA1429 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KIAA1429 gene promoter:
AML1a AP-2gamma C/EBPalpha FOXL1 FAC1 STAT3 Meis-1a ATF Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIAA1429
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA1429 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q22.1 Ensembl cytogenetic band: 8q22.1 HGNC cytogenetic band: 8q22.1KIAA1429 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M095570: view genomic region
(about GC identifiers)
Start:
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95,499,921 bp from pter |
End:
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95,565,757 bp from pter |
Size:
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65,837 bases |
Orientation:
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minus strand |
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Proteins
for KIAA1429 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VIR_HUMAN, Q69YN4 (See
protein sequence)Recommended Name: Protein virilizer homolog Size: 1812 amino acids; 202025 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAA91316.1; Type=Erroneous initiation; Sequence=BAB14301.1; Type=Erroneous initiation;Sequence=CAB55922.1; Type=Erroneous initiation;
Secondary accessions: Q2M1N0 Q6AHX9 Q6NT78 Q7Z6C7 Q8IXH4 Q9BTH4 Q9H9C9 Q9NWR3 Q9P2B8 Q9UFW1Alternative splicing: 4 isoforms: Q69YN4-1 Q69YN4-2 Q69YN4-3 Q69YN4-4 Explore the universe of human proteins at neXtProt for KIAA1429: NX_Q69YN4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q69YN4
KIAA1429 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_056311.2 NP_892121.1
ENSEMBL proteins: ENSP00000297591 ENSP00000429909 ENSP00000430857 ENSP00000428784 ENSP00000398390 ENSP00000395600
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
KIAA1429 for ontologies About GeneDecksing
KIAA1429 Antibody Products:
Assay Products for KIAA1429: |
Protein
Domains /
Families
for KIAA1429 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KIAA1429 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q69YN4ProtoNet protein and cluster: Q69YN4 UniProtKB/Swiss-Prot: VIR_HUMAN, Q69YN4Similarity: Belongs to the vir family |
Function
for KIAA1429 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: VIR_HUMAN, Q69YN4Function: May be involved in mRNA splicing regulation (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1429 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1429 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1429 |
1 GenomeRNAi human phenotype for KIAA1429:
|
Pathways & Interactions
for KIAA1429 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA1429
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/17 Interacting proteins for KIAA1429 (Q69YN43 ENSP000002975914) via UniProtKB, MINT, STRING, and/or I2D (see all 17)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
KIAA1429 for ontologies About GeneDecksing
|
Drugs & Compounds
for KIAA1429 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KIAA1429
Search CenterWatch for drugs/clinical trials and news about KIAA1429 / VIR
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Transcripts
for KIAA1429 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KIAA1429 gene (2 alternative transcripts): NM_015496.4 NM_183009.2 Unigene Cluster for KIAA1429: KIAA1429 Hs.202238 [show with all ESTs]Unigene Representative Sequence: CR62745410 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000297591(uc010maz.2 uc003ygo.2) ENST00000521080 ENST00000522263
ENST00000522196 ENST00000517624 ENST00000523263 ENST00000523405 ENST00000421249(uc003ygp.3)
ENST00000519001 ENST00000437199
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1429 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1429 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): KIAA1429 (NM_015496) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KIAA1429 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA1429 |
Additional cDNA sequence: AB037850.1 AF116724.1 AK000668.1 AK022906.1 AL117434.1 AL832487.1 BC003701.1 BC053875.1 BC069239.1 BC112288.1 BC113380.1 CR627454.1 11 DOTS entries: DT.215218 DT.97762759 DT.100791871 DT.86847512 DT.405259 DT.105540 DT.100791873 DT.121477046 DT.95166092 DT.95166094 DT.95166096 24/250 AceView cDNA sequences (see all 250): CB157805 CB110204 CB109933 AI351181 AI624792 AA465319 BU190994 CB109234 BX331522 AK022906 AI652842 AA424182 CR620832 BC053875 CD108987 AA203689 CB109272 AI338824 CB109182 AA912095 CB109207 Z45498 BF035302 AI371073
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1429 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KIAA1429
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Expression
for KIAA1429 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIAA1429 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACGCTCCTT
About this image
See KIAA1429 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIAA1429
SOURCE GeneReport for Unigene cluster: Hs.202238
SABiosciences Custom PCR Arrays for KIAA1429
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIAA1429
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KIAA1429 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KIAA1429 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KIAA1429 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1429 |
Orthologs
for KIAA1429 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KIAA1429 gene from 6/20 species (see all 20) About this table
ENSEMBL Gene Tree for KIAA1429 (if available)
TreeFam Gene Tree for KIAA1429 (if available) |
Paralogs
for KIAA1429 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KIAA1429 gene
KIAA1429 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for KIAA1429
PGOHUM00000244688
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Genomic Variants
for KIAA1429 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KIAA1429 (95499921 - 95565757 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for KIAA1429
3 CNVs: 1798 95570 65197 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIAA1429 |
|
Disorders
/ Diseases
for KIAA1429 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KIAA1429 for disorders About GeneDecksing
3  diseases for KIAA1429: About MalaCardsvirilization oxyphilic adenoma adenoma
1 disease from the University of Copenhagen DISEASES database for KIAA1429:Oxyphilic adenoma Export disorders for KIAA1429 gene to outside databases
|
Publications
for KIAA1429 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIAA1429 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with KIAA1429) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for KIAA1429 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KIAA1429 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KIAA1429 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KIAA1429 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KIAA1429 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KIAA1429 gene:
Search GeneIP for patents involving KIAA1429
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIAA1429 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | KIAA1429 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1429 |
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