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KIAA1407 Gene

protein-coding   GIFtS: 41
GCID: GC03M113682          (predicted)

KIAA1407

  Search for KIAA1407
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
KIAA14071 2
Coiled-Coil Domain-Containing Protein KIAA14072

External Ids:    HGNC: 292721   Entrez Gene: 575772   Ensembl: ENSG000001636177   UniProtKB: Q8NCU43   

Export aliases for KIAA1407 gene to outside databases

Previous GC identifers: GC03M110504 GC03M113253 GC03M114964 GC03M115003 GC03M115165 GC03M111057


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KIAA1407 Gene:
KIAA1407 (KIAA1407) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIAA1407 gene promoter:
         Tal-1   POU6F1 (c2)   Ik-3   E47   NF-AT   NF-AT4   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KIAA1407

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIAA1407


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.31   Ensembl cytogenetic band:  3q13.31   HGNC cytogenetic band: 3q13.31

KIAA1407 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA1407 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M113682:  view genomic region     (about GC identifiers)

Start:
113,682,984 bp from pter      End:
113,775,460 bp from pter
Size:
92,477 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: K1407_HUMAN, Q8NCU4 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein KIAA1407  
Size: 936 amino acids; 110568 Da
Secondary accessions: Q9P2E0

Explore the universe of human proteins at neXtProt for KIAA1407: NX_Q8NCU4

Explore proteomics data for KIAA1407 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KIAA1407 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065868.1  
    ENSEMBL proteins: 
     ENSP00000295878   ENSP00000418382   ENSP00000418099   ENSP00000418991   ENSP00000419159  
     ENSP00000446381  

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    Search eBioscience for ELISAs for KIAA1407 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026174 SFI1/KIAA1407

    Graphical View of Domain Structure for InterPro Entry Q8NCU4

    ProtoNet protein and cluster: Q8NCU4


    Find genes that share domains with KIAA1407           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         3 GenomeRNAi human phenotypes for KIAA1407:
     Decreased viability with pacli  Increased S DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIAA1407
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    SwitchGear 3'UTR luciferase reporter plasmidKIAA1407 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIAA1407
    Interactions:

        Search GeneGlobe Interaction Network for KIAA1407

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for KIAA1407 (Q8NCU43 ENSP000002958784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALCOCO2Q131373, ENSP000002589474I2D: score=1 STRING: ENSP00000258947
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIAA1407 (K1407)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KIAA1407 gene: 
    NM_020817.1  

    Unigene Cluster for KIAA1407:

    KIAA1407
    Hs.477159  [show with all ESTs]
    Unigene Representative Sequence: AF509494
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295878(uc003eax.3 uc011bip.1) ENST00000460813 ENST00000527855
    ENST00000481358(uc011bio.1) ENST00000491000 ENST00000483766 ENST00000463695
    ENST00000480588 ENST00000545063(uc011bin.1)
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate KIAA1407:
    hsa-miR-146a* hsa-miR-561 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidKIAA1407 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat KIAA1407
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat KIAA1407
      QuantiFast Probe-based Assays in human, mouse, rat KIAA1407

    Additional mRNA sequence: 

    AB037828.1 AF509494.1 AK125304.1 AK295855.1 AK302488.1 BC150592.1 

    7 DOTS entries:

    DT.312379  DT.408927  DT.120867160  DT.95093833  DT.100022122  DT.40131294  DT.91806999 

    Selected AceView cDNA sequences (see all 77):

    AI056457 AA743318 AB037828 AA400761 AA398917 AI689804 BM713081 AF509494 
    AK125304 AW614521 BX436915 AA435645 CA314296 AI950183 AI985341 AI979103 
    NM_020817 AW193515 AA953707 BM353150 BI829144 CF147004 BE219240 BU619867 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIAA1407 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCCACCTG
    KIAA1407 Expression
    About this image


    KIAA1407 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Mature B-Cells Peripheral Blood
     
     Testis (Reproductive System)
    KIAA1407 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIAA1407 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.477159
        Custom PCR Arrays for KIAA1407
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    QuantiFast Probe-based Assays in human, mouse, rat KIAA1407
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1407

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KIAA1407 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2610015P09Rik1 , 5 RIKEN cDNA 2610015P09 gene1, 5 79.44(n)1
    71.38(a)1
      16 (28.44 cM)5
    2121531  NM_027801.11  NP_082077.11 
     438898005 
    chicken
    (Gallus gallus)
    Aves KIAA14071 KIAA1407 58.98(n)
    45.33(a)
      418352  XM_416572.4  XP_416572.3 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA14076
    KIAA1407
    46(a)
    1 ↔ 1
    3(176496609-176517308)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kiaa14071 KIAA1407 ortholog 55.23(n)
    45.98(a)
      100493616  XM_004912276.1  XP_004912333.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:922181 zgc:92218 48.32(n)
    37.4(a)
      494495  NM_001009986.1  NP_001009986.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG172586
    --
    15(a)
    1 ↔ 1
    2L(3032210-3035348)


    ENSEMBL Gene Tree for KIAA1407 (if available)
    TreeFam Gene Tree for KIAA1407 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIAA1407 (see all 1570)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1478841391,2
    --113650477(+) TCTGAA/GAGGTC 1 -- int10--------
    rs1457857171,2
    C--113650561(+) AAAAC-/AAAAAA 1 -- int10--------
    rs68093471,2
    C,F,A,H--113650711(+) AGTTAC/TATTTT 1 -- int120Minor allele frequency- T:0.36NS EA NA WA CSA 2342
    rs130606191,2
    C--113650762(+) TTTTTA/TAAATG 1 -- int12Minor allele frequency- T:0.25NA 4
    rs747317431,2
    C--113650763(+) TTTTT-/A/TA  
            
    AATGA
    1 -- int10--------
    rs792323791,2
    --113650763(+) TTTTTA/TAATGA 1 -- int10--------
    rs1415285911,2
    C--113650814(+) AGCCAC/TGTCGT 1 -- int10--------
    rs119183211,2
    C,H--113650817(+) CATGTC/TGTAGA 1 -- int10--------
    rs1843014751,2
    --113650833(+) TAAAGA/TTCAAT 1 -- int10--------
    rs1890826381,2
    --113650842(+) ATTCAA/GGGTGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for KIAA1407 (113682984 - 113775460 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KIAA1407:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv822222CNV Loss20364138
    nsv877352CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIAA1407
    DNA2.0 Custom Variant and Variant Library Synthesis for KIAA1407

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIAA1407 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KIAA1407)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57577 HGNC: 29272 AceView: KIAA1407 Ensembl:ENSG00000163617 euGenes: HUgn57577
    ECgene: KIAA1407 H-InvDB: KIAA1407

    (According to HUGE)
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    HUGE: KIAA1407

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIAA1407 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KIAA1407 gene:
    Search GeneIP for patents involving KIAA1407

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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