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Aliases for KIAA1328 Gene

Aliases for KIAA1328 Gene

  • KIAA1328 2 3
  • Hinderin 2 3
  • Protein Hinderin 3

External Ids for KIAA1328 Gene

Previous GeneCards Identifiers for KIAA1328 Gene

  • GC18P034483
  • GC18P034232
  • GC18P032661
  • GC18P032663
  • GC18P031267

Summaries for KIAA1328 Gene

GeneCards Summary for KIAA1328 Gene

KIAA1328 (KIAA1328) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KIAA1328 Gene

  • Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1328 Gene

Genomics for KIAA1328 Gene

Regulatory Elements for KIAA1328 Gene

Enhancers for KIAA1328 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G036328 0.7 dbSUPER 5.2 -500.7 -500666 0.8 HDGF MTA2 NR2F1 JUNB GATAD2B EBF1 DPF2 ZBTB40 RELA EED FHOD3 KIAA1328 GC18P036374
GH18G036337 0.6 dbSUPER 5.1 -490.4 -490423 2.2 TFAP4 RAD51 HNF1A STAT1 BHLHE40 MIXL1 KIAA1328 GC18P036374 FHOD3
GH18G036354 0.6 ENCODE dbSUPER 5 -474.0 -474035 0.8 BHLHE40 KIAA1328 GC18P036374 FHOD3
GH18G036332 0.6 dbSUPER 4.6 -495.2 -495157 2.4 MTA2 NR2F1 HLF GATAD2B DPF2 ATF2 IKZF1 FOS IKZF2 KIAA1328 FHOD3 GC18P036374
GH18G036349 0.5 dbSUPER 5.3 -478.2 -478193 2.8 BHLHE40 CEBPA NR2F1 EBF1 KIAA1328 GC18P036374 FHOD3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIAA1328 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA1328 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000102368 -206 2201 HDGF CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207

Genomic Location for KIAA1328 Gene

Chromosome:
18
Start:
36,829,106 bp from pter
End:
37,247,316 bp from pter
Size:
418,211 bases
Orientation:
Plus strand

Genomic View for KIAA1328 Gene

Genes around KIAA1328 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1328 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1328 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1328 Gene

Proteins for KIAA1328 Gene

  • Protein details for KIAA1328 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86T90-K1328_HUMAN
    Recommended name:
    Protein hinderin
    Protein Accession:
    Q86T90
    Secondary Accessions:
    • Q05DL0
    • Q49AG6
    • Q9P2L8

    Protein attributes for KIAA1328 Gene

    Size:
    577 amino acids
    Molecular mass:
    65373 Da
    Quaternary structure:
    • Interacts (via N- and C-terminal domains) with SMC3 (via central hinge region).
    SequenceCaution:
    • Sequence=BAA92566.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1328 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1328 Gene

Post-translational modifications for KIAA1328 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIAA1328 Gene

Domains & Families for KIAA1328 Gene

Protein Domains for KIAA1328 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA1328: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for KIAA1328 Gene

Function for KIAA1328 Gene

Molecular function for KIAA1328 Gene

UniProtKB/Swiss-Prot Function:
Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes.

Gene Ontology (GO) - Molecular Function for KIAA1328 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15656913
genes like me logo Genes that share ontologies with KIAA1328: view

Phenotypes for KIAA1328 Gene

genes like me logo Genes that share phenotypes with KIAA1328: view

Animal Model Products

CRISPR Products

miRNA for KIAA1328 Gene

miRTarBase miRNAs that target KIAA1328

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1328 Gene

Localization for KIAA1328 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA1328 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA1328 Gene

Pathways & Interactions for KIAA1328 Gene

SuperPathways for KIAA1328 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA1328 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA1328 Gene

Drugs & Compounds for KIAA1328 Gene

No Compound Related Data Available

Transcripts for KIAA1328 Gene

Unigene Clusters for KIAA1328 Gene

KIAA1328:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1328 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: - - - -
SP3: -

Relevant External Links for KIAA1328 Gene

GeneLoc Exon Structure for
KIAA1328
ECgene alternative splicing isoforms for
KIAA1328

Expression for KIAA1328 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA1328 Gene

Protein differential expression in normal tissues from HIPED for KIAA1328 Gene

This gene is overexpressed in NK cells (28.6), Bone marrow mesenchymal stem cell (26.6), and Monocytes (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIAA1328 Gene



Protein tissue co-expression partners for KIAA1328 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KIAA1328 Gene:

KIAA1328

SOURCE GeneReport for Unigene cluster for KIAA1328 Gene:

Hs.4045

mRNA Expression by UniProt/SwissProt for KIAA1328 Gene:

Q86T90-K1328_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with KIAA1328: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA1328 Gene

Orthologs for KIAA1328 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1328 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1328 34 35
  • 99.31 (n)
dog
(Canis familiaris)
Mammalia KIAA1328 34 35
  • 85.47 (n)
cow
(Bos Taurus)
Mammalia KIAA1328 34 35
  • 85.04 (n)
mouse
(Mus musculus)
Mammalia AW554918 34 16 35
  • 81.18 (n)
rat
(Rattus norvegicus)
Mammalia RGD1562608 34
  • 80.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 57 (a)
OneToMany
-- 35
  • 44 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia KIAA1328 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1328 34 35
  • 59.79 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA1328 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1328 34
  • 59.03 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:162344 34 35
  • 48.27 (n)
-- 34
Species where no ortholog for KIAA1328 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1328 Gene

ENSEMBL:
Gene Tree for KIAA1328 (if available)
TreeFam:
Gene Tree for KIAA1328 (if available)

Paralogs for KIAA1328 Gene

Pseudogenes.org Pseudogenes for KIAA1328 Gene

genes like me logo Genes that share paralogs with KIAA1328: view

No data available for Paralogs for KIAA1328 Gene

Variants for KIAA1328 Gene

Sequence variations from dbSNP and Humsavar for KIAA1328 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000008585 -- 36,837,009(+) ATCAG(C/T)CAATG intron-variant
rs1000025108 -- 37,143,544(+) TTTTT(G/T)CTTAT intron-variant
rs1000028780 -- 36,927,482(+) TGGCT(C/T)ACGCC intron-variant
rs1000038458 -- 37,126,105(+) GTGCA(C/T)AAATT intron-variant
rs1000041015 -- 37,011,979(+) CCGCA(G/T)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1328 Gene

Variant ID Type Subtype PubMed ID
dgv3334n100 CNV loss 25217958
dgv3335n100 CNV loss 25217958
esv2140858 CNV deletion 18987734
esv2658205 CNV deletion 23128226
esv2659277 CNV deletion 23128226
esv2671487 CNV deletion 23128226
esv2672898 CNV deletion 23128226
esv2716963 CNV deletion 23290073
esv2716964 CNV deletion 23290073
esv2716965 CNV deletion 23290073
esv27487 CNV loss 19812545
esv2758722 CNV gain 17122850
esv34228 CNV gain 17911159
esv3583013 CNV loss 25503493
esv3583016 CNV loss 25503493
esv3642236 CNV loss 21293372
esv3642237 CNV gain 21293372
esv3642239 CNV loss 21293372
esv3642240 CNV loss 21293372
esv3642243 CNV loss 21293372
esv3642244 CNV loss 21293372
esv3642245 CNV gain 21293372
nsv1059177 CNV gain 25217958
nsv1059592 CNV loss 25217958
nsv1060521 CNV loss 25217958
nsv1062166 CNV loss 25217958
nsv1071455 CNV deletion 25765185
nsv2257 CNV insertion 18451855
nsv2258 CNV deletion 18451855
nsv438283 CNV loss 16468122
nsv478167 CNV novel sequence insertion 20440878
nsv576651 CNV loss 21841781
nsv576653 CNV loss 21841781
nsv817789 CNV gain 17921354
nsv833621 CNV loss 17160897

Variation tolerance for KIAA1328 Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1328 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1328

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1328 Gene

Disorders for KIAA1328 Gene

Relevant External Links for KIAA1328

Genetic Association Database (GAD)
KIAA1328
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1328

No disorders were found for KIAA1328 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1328 Gene

Publications for KIAA1328 Gene

  1. Hinderin, a five-domains protein including coiled-coil motifs that binds to SMC3. (PMID: 15656913) Patel C.A. … Ghiselli G. (BMC Cell Biol. 2005) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  5. Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years. (PMID: 24347629) Shaffer J.R. … Marazita M.L. (G3 (Bethesda) 2014) 3 64

Products for KIAA1328 Gene

Sources for KIAA1328 Gene

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