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Aliases for KIAA1328 Gene

Aliases for KIAA1328 Gene

  • KIAA1328 2 3
  • Hinderin 2 3

External Ids for KIAA1328 Gene

Previous GeneCards Identifiers for KIAA1328 Gene

  • GC18P034483
  • GC18P034232
  • GC18P032661
  • GC18P032663
  • GC18P031267

Summaries for KIAA1328 Gene

GeneCards Summary for KIAA1328 Gene

KIAA1328 (KIAA1328) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KIAA1328 Gene

  • Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1328 Gene

Genomics for KIAA1328 Gene

Regulatory Elements for KIAA1328 Gene

Enhancers for KIAA1328 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KIAA1328 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA1328 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIAA1328 on UCSC Golden Path with GeneCards custom track

Genomic Location for KIAA1328 Gene

36,829,106 bp from pter
37,247,316 bp from pter
418,211 bases
Plus strand

Genomic View for KIAA1328 Gene

Genes around KIAA1328 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1328 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1328 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1328 Gene

Proteins for KIAA1328 Gene

  • Protein details for KIAA1328 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein hinderin
    Protein Accession:
    Secondary Accessions:
    • Q05DL0
    • Q49AG6
    • Q9P2L8

    Protein attributes for KIAA1328 Gene

    577 amino acids
    Molecular mass:
    65373 Da
    Quaternary structure:
    • Interacts (via N- and C-terminal domains) with SMC3 (via central hinge region).
    • Sequence=BAA92566.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1328 Gene


neXtProt entry for KIAA1328 Gene

Proteomics data for KIAA1328 Gene at MOPED

Post-translational modifications for KIAA1328 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIAA1328 Gene

Domains & Families for KIAA1328 Gene

Protein Domains for KIAA1328 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA1328: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for KIAA1328 Gene

Function for KIAA1328 Gene

Molecular function for KIAA1328 Gene

UniProtKB/Swiss-Prot Function:
Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes.

Phenotypes for KIAA1328 Gene

genes like me logo Genes that share phenotypes with KIAA1328: view

Animal Model Products

CRISPR Products

miRNA for KIAA1328 Gene

miRTarBase miRNAs that target KIAA1328

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1328 Gene

Localization for KIAA1328 Gene

Subcellular locations from

Jensen Localization Image for KIAA1328 Gene COMPARTMENTS Subcellular localization image for KIAA1328 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA1328 Gene

Pathways & Interactions for KIAA1328 Gene

SuperPathways for KIAA1328 Gene

No Data Available

Interacting Proteins for KIAA1328 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q86T90-K1328_HUMAN ENSP00000280020 for KIAA1328 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for KIAA1328 Gene


No data available for Pathways by source and SIGNOR curated interactions for KIAA1328 Gene

Drugs & Compounds for KIAA1328 Gene

No Compound Related Data Available

Transcripts for KIAA1328 Gene

Unigene Clusters for KIAA1328 Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1328 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: - - - -
SP3: -

Relevant External Links for KIAA1328 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIAA1328 Gene

mRNA expression in normal human tissues for KIAA1328 Gene

Protein differential expression in normal tissues from HIPED for KIAA1328 Gene

This gene is overexpressed in NK cells (28.6), Bone marrow mesenchymal stem cell (26.6), and Monocytes (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIAA1328 Gene

SOURCE GeneReport for Unigene cluster for KIAA1328 Gene Hs.4045

mRNA Expression by UniProt/SwissProt for KIAA1328 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with KIAA1328: view

Protein tissue co-expression partners for KIAA1328 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for KIAA1328 Gene

Orthologs for KIAA1328 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1328 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KIAA1328 35
  • 85.04 (n)
  • 77.82 (a)
KIAA1328 36
  • 62 (a)
(Canis familiaris)
Mammalia KIAA1328 35
  • 85.47 (n)
  • 78.12 (a)
KIAA1328 36
  • 77 (a)
(Mus musculus)
Mammalia AW554918 35
  • 81.18 (n)
  • 73.08 (a)
AW554918 16
AW554918 36
  • 68 (a)
(Pan troglodytes)
Mammalia KIAA1328 35
  • 99.31 (n)
  • 98.61 (a)
KIAA1328 36
  • 98 (a)
(Rattus norvegicus)
Mammalia RGD1562608 35
  • 80.09 (n)
  • 73.08 (a)
(Monodelphis domestica)
Mammalia KIAA1328 36
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
-- 36
  • 44 (a)
(Gallus gallus)
Aves KIAA1328 35
  • 59.79 (n)
  • 49.4 (a)
KIAA1328 36
  • 42 (a)
(Anolis carolinensis)
Reptilia KIAA1328 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1328 35
  • 59.03 (n)
  • 54.96 (a)
(Danio rerio)
Actinopterygii -- 35
zgc:162344 35
  • 48.27 (n)
  • 39.62 (a)
zgc:162344 36
  • 28 (a)
Species with no ortholog for KIAA1328:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1328 Gene

Gene Tree for KIAA1328 (if available)
Gene Tree for KIAA1328 (if available)

Paralogs for KIAA1328 Gene Pseudogenes for KIAA1328 Gene

genes like me logo Genes that share paralogs with KIAA1328: view

No data available for Paralogs for KIAA1328 Gene

Variants for KIAA1328 Gene

Sequence variations from dbSNP and Humsavar for KIAA1328 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs12326301 - 37,067,460(+) AGGAG(C/G/T)GCCTT nc-transcript-variant, reference, missense
rs167729 -- 37,006,666(+) CTCCC(C/T)GCTCC intron-variant
rs167730 -- 37,016,186(+) tagtt(A/T)cttta intron-variant
rs170452 -- 37,118,768(-) cctgc(G/T)agcaa intron-variant
rs172822 -- 37,040,658(+) gactt(A/G)aatct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1328 Gene

Variant ID Type Subtype PubMed ID
dgv1024e1 CNV Complex 17122850
esv34228 CNV Gain 17911159
nsv817789 CNV Gain 17921354
nsv438283 CNV Loss 16468122
nsv909545 CNV Loss 21882294
esv2671487 CNV Deletion 23128226
nsv909546 CNV Gain 21882294
esv27487 CNV Loss 19812545
esv2672898 CNV Deletion 23128226
esv2716963 CNV Deletion 23290073
esv2659277 CNV Deletion 23128226
esv2716964 CNV Deletion 23290073
esv2140858 CNV Deletion 18987734
esv2716965 CNV Deletion 23290073
nsv2257 CNV Insertion 18451855
nsv909547 CNV Gain 21882294
nsv833621 CNV Loss 17160897
nsv2258 CNV Loss 18451855
esv2658205 CNV Deletion 23128226

Variation tolerance for KIAA1328 Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1328 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1328 Gene

Disorders for KIAA1328 Gene

Relevant External Links for KIAA1328

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KIAA1328 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1328 Gene

Publications for KIAA1328 Gene

  1. Hinderin, a five-domains protein including coiled-coil motifs that binds to SMC3. (PMID: 15656913) Patel C.A. … Ghiselli G. (BMC Cell Biol. 2005) 2 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  4. Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years. (PMID: 24347629) Shaffer J.R. … Marazita M.L. (G3 (Bethesda) 2014) 3
  5. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3

Products for KIAA1328 Gene

Sources for KIAA1328 Gene