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KIAA1328 Gene

protein-coding   GIFtS: 42
GCID: GC18P034483

KIAA1328

  Search for KIAA1328
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
KIAA13281 2
hinderin2
Uncharacterized Protein KIAA13282

External Ids:    HGNC: 292481   Entrez Gene: 575362   Ensembl: ENSG000001504777   UniProtKB: Q86T903   

Export aliases for KIAA1328 gene to outside databases

Previous GC identifers: GC18P034232 GC18P032661 GC18P032663 GC18P031267


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KIAA1328 Gene:
KIAA1328 (KIAA1328) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KIAA1328 gene promoter:
         HSF1 (long)   Nkx5-1   Pax-3   PPAR-gamma1   CBF-A   CBF-B   HSF1short   PPAR-gamma2   Pax-4a   CBF(2)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KIAA1328

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KIAA1328


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.2   Ensembl cytogenetic band:  18q12.2   HGNC cytogenetic band: 18q12.2

KIAA1328 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA1328 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P034483:  view genomic region     (about GC identifiers)

Start:
34,409,069 bp from pter      End:
34,812,135 bp from pter
Size:
403,067 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: K1328_HUMAN, Q86T90 (See protein sequence)
Recommended Name: Uncharacterized protein KIAA1328  
Size: 577 amino acids; 65373 Da
Sequence caution: Sequence=BAA92566.2; Type=Erroneous initiation;
Secondary accessions: Q05DL0 Q49AG6 Q9P2L8
Alternative splicing: 4 isoforms:  Q86T90-1   Q86T90-2   Q86T90-3   Q86T90-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KIAA1328: NX_Q86T90

Explore proteomics data for KIAA1328 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KIAA1328 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065827.1  
    ENSEMBL proteins: 
     ENSP00000468653   ENSP00000280020   ENSP00000465036   ENSP00000467248   ENSP00000466355  
     ENSP00000465550   ENSP00000470002   ENSP00000467507   ENSP00000470371   ENSP00000441359  
     ENSP00000390515  

    KIAA1328 Human Recombinant Protein Products:

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    Novus Biologicals KIAA1328 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for KIAA1328 

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    LSBio Antibodies in human, mouse, rat for KIAA1328

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for KIAA1328 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q86T90


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for KIAA1328:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KIAA1328
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KIAA1328
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    miRNA
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    miRTarBase miRNAs that target KIAA1328:
    hsa-mir-335-5p (MIRT017652)

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    Selected qRT-PCR Assays for microRNAs that regulate KIAA1328 (see all 11):
    hsa-miR-3128 hsa-miR-576-5p hsa-miR-449c* hsa-miR-4263 hsa-miR-4306 hsa-miR-488 hsa-miR-335 hsa-miR-2355-5p
    SwitchGear 3'UTR luciferase reporter plasmidKIAA1328 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat KIAA1328

    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1328


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KIAA1328
    Interactions:

        Search GeneGlobe Interaction Network for KIAA1328

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for KIAA1328 (Q86T903 ENSP000002800204) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APCP250543, ENSP000002574304I2D: score=3 STRING: ENSP00000257430
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KIAA1328 (K1328)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KIAA1328 gene: 
    NM_020776.1  

    Unigene Cluster for KIAA1328:

    KIAA1328
    Hs.4045  [show with all ESTs]
    Unigene Representative Sequence: AB037749
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592611 ENST00000280020(uc002kzz.3 uc002lab.3 uc002lac.1)
    ENST00000592521 ENST00000590617 ENST00000587139 ENST00000591619 ENST00000591911
    ENST00000590456 ENST00000586135 ENST00000586501 ENST00000599493 ENST00000601437
    ENST00000543923 ENST00000435985(uc021uiw.1 uc002lad.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KIAA1328 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KIAA1328 (see all 11):
    hsa-miR-3128 hsa-miR-576-5p hsa-miR-449c* hsa-miR-4263 hsa-miR-4306 hsa-miR-488 hsa-miR-335 hsa-miR-2355-5p
    SwitchGear 3'UTR luciferase reporter plasmidKIAA1328 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat KIAA1328
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    OriGene ORF clones in mouse, rat for KIAA1328
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    GenScript: all cDNA clones in your preferred vector: KIAA1328 (NM_020776)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA1328
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat KIAA1328
      QuantiTect SYBR Green Assays in human, mouse, rat KIAA1328
      QuantiFast Probe-based Assays in human, mouse, rat KIAA1328

    Additional mRNA sequence: 

    AB037749.2 AK292288.1 AK304230.1 AL832625.2 BC008670.1 BC037903.1 BC045585.1 BC127204.1 
    BX648875.1 

    10 DOTS entries:

    DT.99954251  DT.212377  DT.95359245  DT.40106499  DT.95113083  DT.95316013  DT.95359246  DT.100651785 
    DT.91841765  DT.121104318 

    Selected AceView cDNA sequences (see all 40):

    BC008670 BI860191 AA456093 BQ181150 AB037749 BF058927 AA774587 BU608573 
    AW466880 BC045585 BM799992 AK130479 D59640 BX648875 AW084689 BE784176 
    D59747 AA889675 BI459488 AL832625 BC037903 D59639 BM927293 AI015609 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1328    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                          -     -                 -                 -               
    SP2:              -           -     -                                   -               
    SP3:                                      -                                             


    ECgene alternative splicing isoforms for KIAA1328

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KIAA1328 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAACATTTT
    KIAA1328 Expression
    About this image

    KIAA1328 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KIAA1328 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.4045
        Custom PCR Arrays for KIAA1328
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1328

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KIAA1328 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia AW5549181 , 5 expressed sequence AW5549181, 5 81.18(n)1
    73.08(a)1
      18 (13.74 cM)5
    2252891  NM_001033532.31  NP_001028704.21 
     251689995 
    chicken
    (Gallus gallus)
    Aves KIAA13281 KIAA1328 59.79(n)
    49.4(a)
      426890  NM_001031404.1  NP_001026575.1 
    lizard
    (Anolis carolinensis)
    Reptilia KIAA13286
    KIAA1328
    68(a)
    1 ↔ 1
    GL343372.1(226807-385730)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia kiaa13281 KIAA1328 59.03(n)
    54.96(a)
      100145612  XM_002940565.2  XP_002940611.2 
    zebrafish
    (Danio rerio)
    Actinopterygii 570652832   -- 73.16(n)   334126  57065283 


    ENSEMBL Gene Tree for KIAA1328 (if available)
    TreeFam Gene Tree for KIAA1328 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KIAA1328 gene

    Find genes that share paralogs with KIAA1328           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for KIAA1328
    PGOHUM00000237824


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KIAA1328 (see all 6323)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1876237191,2
    --34411261(+) TCAATA/GGCACC 1 -- int10--------
    rs1419005101,2
    --34411278(+) TTTTA-/TTGTTGTT 1 -- int10--------
    rs1446945231,2
    --34411345(+) AGGAAC/TGTTTT 1 -- int10--------
    rs1912436571,2
    --34411456(+) ATTACA/GGTTCC 1 -- int10--------
    rs11477651,2
    C,F,A,H--34411602(-) TTATAC/TTGCAA 1 -- int129Minor allele frequency- T:0.37NS EA NA WA CSA 2941
    rs1848555871,2
    C--34411698(+) ATAATA/GATTAC 1 -- int10--------
    rs728852351,2
    C,F--34411769(+) ATTTCC/TTTCAA 1 -- int12Minor allele frequency- T:0.12NA EA 240
    rs1485047431,2
    --34411811(+) CCTCTC/TTACCA 1 -- int10--------
    rs118755231,2
    C,F,H--34412056(+) TCCCCG/ATAAAA 1 -- int12Minor allele frequency- A:0.50NA CSA 6
    rs1892306231,2
    --34412278(+) CTTGCA/GGTGGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for KIAA1328 (34409069 - 34659069 bp, first 250kb of KIAA1328)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KIAA1328 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716965CNV Deletion23290073
    esv2140858CNV Deletion18987734
    esv2671487CNV Deletion23128226
    esv2672898CNV Deletion23128226
    esv2716963CNV Deletion23290073
    esv2659277CNV Deletion23128226
    esv2658205CNV Deletion23128226
    esv2716964CNV Deletion23290073
    nsv2257CNV Insertion18451855
    nsv2258CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KIAA1328
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with KIAA1328           About GenesLikeMe

    Genetic Association Database (GAD): KIAA1328

    Export disorders for KIAA1328 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KIAA1328 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with KIAA1328)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)
    3. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    4. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    5. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    8. Hinderin, a five-domains protein including coiled-coil motifs that binds to SMC3. (PubMed id 15656913)1 Patel C.A. and Ghiselli G. (BMC Cell Biol. 2005)
    9. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (Nature 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57536 HGNC: 29248 AceView: KIAA1328 Ensembl:ENSG00000150477 euGenes: HUgn57536
    ECgene: KIAA1328 H-InvDB: KIAA1328

    (According to HUGE)
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    HUGE: KIAA1328

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KIAA1328 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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