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Aliases for KIAA1324L Gene

Aliases for KIAA1324L Gene

  • KIAA1324-Like 2 3 5
  • Estrogen-Induced Gene 121-Like Protein 3 4
  • EIG121-Like 2 3
  • EIG121L 3 4
  • HEIG121L 4

External Ids for KIAA1324L Gene

Previous GeneCards Identifiers for KIAA1324L Gene

  • GC07M086154
  • GC07M086347
  • GC07M086506
  • GC07M081117

Summaries for KIAA1324L Gene

GeneCards Summary for KIAA1324L Gene

KIAA1324L (KIAA1324-Like) is a Protein Coding gene. An important paralog of this gene is KIAA1324.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1324L Gene

Genomics for KIAA1324L Gene

Regulatory Elements for KIAA1324L Gene

Promoters for KIAA1324L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KIAA1324L on UCSC Golden Path with GeneCards custom track

Genomic Location for KIAA1324L Gene

Chromosome:
7
Start:
86,876,906 bp from pter
End:
87,059,699 bp from pter
Size:
182,794 bases
Orientation:
Minus strand

Genomic View for KIAA1324L Gene

Genes around KIAA1324L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1324L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1324L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1324L Gene

Proteins for KIAA1324L Gene

  • Protein details for KIAA1324L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MWY0-K132L_HUMAN
    Recommended name:
    UPF0577 protein KIAA1324-like
    Protein Accession:
    A8MWY0
    Secondary Accessions:
    • A4D1C9
    • B4DJV3
    • Q17RI6
    • Q96DP2

    Protein attributes for KIAA1324L Gene

    Size:
    1029 amino acids
    Molecular mass:
    113842 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI17310.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71041.1; Type=Frameshift; Positions=719; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1324L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1324L Gene

Proteomics data for KIAA1324L Gene at MOPED

Post-translational modifications for KIAA1324L Gene

  • Glycosylation at Asn 169, Asn 405, and Asn 691
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for KIAA1324L Gene

Domains & Families for KIAA1324L Gene

Protein Domains for KIAA1324L Gene

Suggested Antigen Peptide Sequences for KIAA1324L Gene

Graphical View of Domain Structure for InterPro Entry

A8MWY0

UniProtKB/Swiss-Prot:

K132L_HUMAN :
  • Belongs to the UPF0577 family.
Family:
  • Belongs to the UPF0577 family.
genes like me logo Genes that share domains with KIAA1324L: view

No data available for Gene Families for KIAA1324L Gene

Function for KIAA1324L Gene

genes like me logo Genes that share phenotypes with KIAA1324L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1324L Gene

Localization for KIAA1324L Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA1324L Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA1324L Gene COMPARTMENTS Subcellular localization image for KIAA1324L gene
Compartment Confidence
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
nucleus 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for KIAA1324L Gene

Pathways & Interactions for KIAA1324L Gene

SuperPathways for KIAA1324L Gene

No Data Available

Interacting Proteins for KIAA1324L Gene

Gene Ontology (GO) - Biological Process for KIAA1324L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA1324L Gene

Drugs & Compounds for KIAA1324L Gene

No Compound Related Data Available

Transcripts for KIAA1324L Gene

Unigene Clusters for KIAA1324L Gene

KIAA1324-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1324L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22
SP1: - - -
SP2: -
SP3:
SP4:
SP5: -

Relevant External Links for KIAA1324L Gene

GeneLoc Exon Structure for
KIAA1324L
ECgene alternative splicing isoforms for
KIAA1324L

Expression for KIAA1324L Gene

mRNA expression in normal human tissues for KIAA1324L Gene

mRNA differential expression in normal tissues according to GTEx for KIAA1324L Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.1).

Protein differential expression in normal tissues from HIPED for KIAA1324L Gene

This gene is overexpressed in Heart (25.9), Frontal cortex (15.2), Cerebral cortex (12.4), and Fetal Brain (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for KIAA1324L Gene



SOURCE GeneReport for Unigene cluster for KIAA1324L Gene Hs.208093

genes like me logo Genes that share expression patterns with KIAA1324L: view

Protein tissue co-expression partners for KIAA1324L Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KIAA1324L Gene

Orthologs for KIAA1324L Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA1324L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1324L 36
  • 100 (a)
OneToOne
KIAA1324L 35
  • 99.71 (n)
  • 99.81 (a)
cow
(Bos Taurus)
Mammalia KIAA1324L 35
  • 93.63 (n)
  • 96.31 (a)
KIAA1324L 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA1324L 36
  • 97 (a)
OneToOne
KIAA1324L 35
  • 94.03 (n)
  • 97.05 (a)
mouse
(Mus musculus)
Mammalia 9330182L06Rik 16
9330182L06Rik 36
  • 93 (a)
OneToOne
9330182L06Rik 35
  • 89.11 (n)
  • 93 (a)
oppossum
(Monodelphis domestica)
Mammalia KIAA1324L 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1324L 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1563349 35
  • 88.61 (n)
  • 93.38 (a)
chicken
(Gallus gallus)
Aves KIAA1324L 35
  • 77.73 (n)
  • 83.25 (a)
KIAA1324L 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1324L 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1324l 35
  • 72.14 (n)
  • 74.38 (a)
Str.15116 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9737 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-233h19.2 36
  • 62 (a)
OneToMany
si:dkey-153k10.9 36
  • 65 (a)
OneToMany
si:dkey-5i3.1 36
  • 57 (a)
OneToMany
-- 35
si:dkey-153k10.9 35
  • 66.29 (n)
  • 67.15 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y73F8A.5 35
  • 44.79 (n)
  • 33.92 (a)
Y73F8A.5 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for KIAA1324L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIAA1324L Gene

ENSEMBL:
Gene Tree for KIAA1324L (if available)
TreeFam:
Gene Tree for KIAA1324L (if available)

Paralogs for KIAA1324L Gene

Paralogs for KIAA1324L Gene

(1) SIMAP similar genes for KIAA1324L Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with KIAA1324L: view

Variants for KIAA1324L Gene

Sequence variations from dbSNP and Humsavar for KIAA1324L Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1029366 - 86,914,839(+) CACAT(A/T)TGTAC reference, missense
rs34412146 - 86,909,986(-) TGGCT(C/G)TCTGT reference, missense
rs34577440 - 86,909,870(-) GAAAG(G/T)AAGGG reference, missense
rs885996 -- 86,981,618(+) GAACC(C/G)CTAGT intron-variant
rs885997 -- 86,981,699(+) AAGAT(A/G)GCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1324L Gene

Variant ID Type Subtype PubMed ID
nsv888633 CNV Gain 21882294
nsv527889 CNV Gain 19592680
nsv824202 CNV Loss 20364138
esv270310 CNV Insertion 20981092
nsv5825 CNV Insertion 18451855
nsv525634 CNV Gain 19592680
esv998639 CNV Deletion 20482838
esv2734771 CNV Deletion 23290073
esv2674083 CNV Deletion 23128226
esv1677921 CNV Deletion 17803354
nsv483124 CNV Gain 15286789
nsv8171 CNV Gain 18304495

Variation tolerance for KIAA1324L Gene

Residual Variation Intolerance Score: 31.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1324L Gene

HapMap Linkage Disequilibrium report
KIAA1324L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1324L Gene

Disorders for KIAA1324L Gene

Relevant External Links for KIAA1324L

Genetic Association Database (GAD)
KIAA1324L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1324L

No disorders were found for KIAA1324L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1324L Gene

Publications for KIAA1324L Gene

  1. Expression of estrogen induced gene 121-like (EIG121L) during early Xenopus development. (PMID: 17475571) Araki T. … Nishida E. (Gene Expr. Patterns 2007) 3 4 67
  2. A transmembrane protein EIG121L is required for epidermal differentiation during early embryonic development. (PMID: 21177533) Araki T. … Nishida E. (J. Biol. Chem. 2011) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3

Products for KIAA1324L Gene

Sources for KIAA1324L Gene

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