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Aliases for KIAA1324L Gene

Aliases for KIAA1324L Gene

  • KIAA1324 Like 2 3 5
  • Estrogen-Induced Gene 121-Like Protein 3 4
  • EIG121-Like 2 3
  • EIG121L 3 4
  • UPF0577 Protein KIAA1324-Like 3
  • HEIG121L 4

External Ids for KIAA1324L Gene

Previous GeneCards Identifiers for KIAA1324L Gene

  • GC07M086154
  • GC07M086347
  • GC07M086506
  • GC07M081117

Summaries for KIAA1324L Gene

GeneCards Summary for KIAA1324L Gene

KIAA1324L (KIAA1324 Like) is a Protein Coding gene. An important paralog of this gene is KIAA1324.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1324L Gene

Genomics for KIAA1324L Gene

Regulatory Elements for KIAA1324L Gene

Enhancers for KIAA1324L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F086647 0.4 FANTOM5 15.4 +413.7 413681 0.2 GRM3 KIAA1324L GC07P086675
GH07F087144 0.4 ENCODE 11.8 -84.7 -84712 0.8 PKNOX1 MTA2 GTF2E2 JUNB EP300 GABPA TFDP1 ZFHX2 PBX2 EED KIAA1324L TP53TG1 PIR39826 ENSG00000261462
GH07F087100 0.2 ENCODE 11.4 -41.0 -40966 1.2 ZNF692 SCRT2 IKZF1 PRDM1 KIAA1324L ENSG00000261462
GH07F086939 0.6 ENCODE 11.3 +120.3 120300 0.2 CTCF ZNF654 TRIM22 UBTF REST RAD21 JUND SMC3 HMBOX1 ZNF652 LOC101927420 DMTF1 KIAA1324L TMEM243 ENSG00000200397 GC07M086929 GC07M087044
GH07F086933 0.6 FANTOM5 11.3 +125.6 125591 0.4 ATF1 HINFP NR4A1 ZBTB11 ZNF175 PTRF ZNF644 GABPA CREB3 ZNF589 DMTF1 LOC101927420 KIAA1324L ENSG00000200397 TMEM243 GC07M086929 LOC105375382
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KIAA1324L on UCSC Golden Path with GeneCards custom track

Promoters for KIAA1324L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000311323 199 1801 HDGF ATF1 ARNT CREB3L1 SIN3A ZNF2 GATA2 REST KAT8 MEF2D

Genomic Location for KIAA1324L Gene

Chromosome:
7
Start:
86,876,906 bp from pter
End:
87,059,699 bp from pter
Size:
182,794 bases
Orientation:
Minus strand

Genomic View for KIAA1324L Gene

Genes around KIAA1324L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1324L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1324L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1324L Gene

Proteins for KIAA1324L Gene

  • Protein details for KIAA1324L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MWY0-K132L_HUMAN
    Recommended name:
    UPF0577 protein KIAA1324-like
    Protein Accession:
    A8MWY0
    Secondary Accessions:
    • A4D1C9
    • B4DJV3
    • Q17RI6
    • Q96DP2

    Protein attributes for KIAA1324L Gene

    Size:
    1029 amino acids
    Molecular mass:
    113842 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI17310.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71041.1; Type=Frameshift; Positions=719; Evidence={ECO:0000305};

    Alternative splice isoforms for KIAA1324L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1324L Gene

Post-translational modifications for KIAA1324L Gene

  • Glycosylation at Asn 169, Asn 405, and Asn 691
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KIAA1324L Gene

Domains & Families for KIAA1324L Gene

Protein Domains for KIAA1324L Gene

Suggested Antigen Peptide Sequences for KIAA1324L Gene

Graphical View of Domain Structure for InterPro Entry

A8MWY0

UniProtKB/Swiss-Prot:

K132L_HUMAN :
  • Belongs to the UPF0577 family.
Family:
  • Belongs to the UPF0577 family.
genes like me logo Genes that share domains with KIAA1324L: view

No data available for Gene Families for KIAA1324L Gene

Function for KIAA1324L Gene

genes like me logo Genes that share phenotypes with KIAA1324L: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1324L Gene

Localization for KIAA1324L Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA1324L Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA1324L Gene COMPARTMENTS Subcellular localization image for KIAA1324L gene
Compartment Confidence
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for KIAA1324L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KIAA1324L: view

Pathways & Interactions for KIAA1324L Gene

SuperPathways for KIAA1324L Gene

No Data Available

Interacting Proteins for KIAA1324L Gene

Gene Ontology (GO) - Biological Process for KIAA1324L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA1324L Gene

Transcripts for KIAA1324L Gene

Unigene Clusters for KIAA1324L Gene

KIAA1324-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1324L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22
SP1: - - -
SP2: -
SP3:
SP4:
SP5: -

Relevant External Links for KIAA1324L Gene

GeneLoc Exon Structure for
KIAA1324L
ECgene alternative splicing isoforms for
KIAA1324L

Expression for KIAA1324L Gene

mRNA expression in normal human tissues for KIAA1324L Gene

mRNA differential expression in normal tissues according to GTEx for KIAA1324L Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.1).

Protein differential expression in normal tissues from HIPED for KIAA1324L Gene

This gene is overexpressed in Heart (25.9), Frontal cortex (15.2), Cerebral cortex (12.4), and Fetal Brain (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIAA1324L Gene



Protein tissue co-expression partners for KIAA1324L Gene

NURSA nuclear receptor signaling pathways regulating expression of KIAA1324L Gene:

KIAA1324L

SOURCE GeneReport for Unigene cluster for KIAA1324L Gene:

Hs.208093
genes like me logo Genes that share expression patterns with KIAA1324L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KIAA1324L Gene

Orthologs for KIAA1324L Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA1324L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1324L 34 35
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia KIAA1324L 34 35
  • 94.03 (n)
cow
(Bos Taurus)
Mammalia KIAA1324L 34 35
  • 93.63 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1324L 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 9330182L06Rik 34 16 35
  • 89.11 (n)
rat
(Rattus norvegicus)
Mammalia RGD1563349 34
  • 88.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1324L 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1324L 34 35
  • 77.73 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA1324L 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1324l 34
  • 72.14 (n)
Str.15116 34
zebrafish
(Danio rerio)
Actinopterygii si:dkey-153k10.9 34 35
  • 66.29 (n)
si:ch211-233h19.2 35
  • 62 (a)
OneToMany
si:dkey-5i3.1 35
  • 57 (a)
OneToMany
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9737 34
worm
(Caenorhabditis elegans)
Secernentea CELE_Y73F8A.5 34
  • 44.79 (n)
Y73F8A.5 35
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
Species where no ortholog for KIAA1324L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIAA1324L Gene

ENSEMBL:
Gene Tree for KIAA1324L (if available)
TreeFam:
Gene Tree for KIAA1324L (if available)

Paralogs for KIAA1324L Gene

Paralogs for KIAA1324L Gene

(1) SIMAP similar genes for KIAA1324L Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with KIAA1324L: view

Variants for KIAA1324L Gene

Sequence variations from dbSNP and Humsavar for KIAA1324L Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1006247 -- 86,979,449(+) TTCAC(A/G)GTAGG intron-variant
rs1006248 -- 86,979,470(+) TTAAA(A/G)CCTAA intron-variant
rs1012834 -- 86,998,840(+) CCATA(A/C)ATAGT intron-variant
rs1012835 -- 86,999,054(+) TCCAC(C/T)CCATC intron-variant
rs1014634 -- 86,945,884(+) acaaa(C/T)tggga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1324L Gene

Variant ID Type Subtype PubMed ID
esv1677921 CNV deletion 17803354
esv2674083 CNV deletion 23128226
esv2734771 CNV deletion 23290073
esv3306033 CNV mobile element insertion 20981092
esv3349167 CNV insertion 20981092
esv3542038 CNV deletion 23714750
esv3614027 CNV loss 21293372
esv3614029 CNV gain 21293372
esv998639 CNV deletion 20482838
nsv1028503 CNV gain 25217958
nsv1122166 CNV deletion 24896259
nsv1144191 CNV deletion 24896259
nsv1145931 CNV duplication 26484159
nsv483124 CNV gain 15286789
nsv525634 CNV gain 19592680
nsv527889 CNV gain 19592680
nsv5825 CNV insertion 18451855
nsv8171 CNV gain 18304495
nsv824202 CNV loss 20364138

Variation tolerance for KIAA1324L Gene

Residual Variation Intolerance Score: 31.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1324L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1324L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1324L Gene

Disorders for KIAA1324L Gene

Relevant External Links for KIAA1324L

Genetic Association Database (GAD)
KIAA1324L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1324L

No disorders were found for KIAA1324L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1324L Gene

Publications for KIAA1324L Gene

  1. Expression of estrogen induced gene 121-like (EIG121L) during early Xenopus development. (PMID: 17475571) Araki T. … Nishida E. (Gene Expr. Patterns 2007) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts. (PMID: 22479309) Boraska V. … Zeggini E. (PLoS ONE 2012) 46 64

Products for KIAA1324L Gene

Sources for KIAA1324L Gene

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