KIAA1324L Gene
protein-coding GIFtS: 46
GCID: GC07M086506
|
|
KIAA1324-like
| |
Aliases
for KIAA1324L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| KIAA1324-Like1 | | EIG121-Like1 | | EIG121L1 2 3 | | UPF0577 Protein KIAA1324-Like2 | | Estrogen-Induced Gene 121-Like Protein2 3 | | HEIG121L1 | | FLJ313401 | | |
| External Ids: | HGNC: 219451 | Entrez Gene: 2222232 | Ensembl: ENSG000001646597 | OMIM: 6140485 | UniProtKB: A8MWY03 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n408882 | |
Export aliases for KIAA1324L gene to outside databasesPrevious GC identifers: GC07M086154 GC07M086347 GC07M081117
Summaries
for KIAA1324L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KIAA1324L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KIAA1324L gene promoter:
FOXO3 POU6F1 (c2) CUTL1 Cdc5 C/EBPalpha Evi-1 FOXO3b Cart-1 FOXO3a
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIAA1324L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KIAA1324L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q21.12 Ensembl cytogenetic band: 7q21.12 HGNC cytogenetic band: 7q21.12KIAA1324L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M086506: view genomic region
(about GC identifiers)
Start:
|
86,506,222 bp from pter |
End:
|
86,689,015 bp from pter |
Size:
|
182,794 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 85,837,967-86,020,533 |
|
Proteins
for KIAA1324L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: K132L_HUMAN, A8MWY0 (See
protein sequence)Recommended Name: UPF0577 protein KIAA1324-like precursor Size: 1029 amino acids; 113842 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=AAI17310.1; Type=Erroneous initiation; Sequence=BAB71041.1; Type=Frameshift; Positions=719;
Secondary accessions: A4D1C9 B4DJV3 Q17RI6 Q96DP2Alternative splicing: 3 isoforms: A8MWY0-1 A8MWY0-2 A8MWY0-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KIAA1324L: NX_A8MWY0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A8MWY0
KIAA1324L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001136221.1 NP_689961.3
ENSEMBL proteins: ENSP00000413445 ENSP00000397377 ENSP00000378203 ENSP00000402390 ENSP00000406961 ENSP00000387496 ENSP00000381325 ENSP00000410045 ENSP00000297222
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
KIAA1324L for ontologies About GeneDecksing
KIAA1324L Antibody Products:
Assay Products for KIAA1324L: |
Protein
Domains /
Families
for KIAA1324L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KIAA1324L for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A8MWY0ProtoNet protein and cluster: A8MWY0 UniProtKB/Swiss-Prot: K132L_HUMAN, A8MWY0Similarity: Belongs to the UPF0577 family |
Function
for KIAA1324L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1324L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1324L (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1324L |
1 GenomeRNAi human phenotype for KIAA1324L:
|
Pathways & Interactions
for KIAA1324L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA1324L
|
Drugs & Compounds
for KIAA1324L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KIAA1324L
Search CenterWatch for drugs/clinical trials and news about KIAA1324L / K132L
|
Transcripts
for KIAA1324L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KIAA1324L gene (2 alternative transcripts): NM_001142749.2 NM_152748.3 Unigene Cluster for KIAA1324L: KIAA1324-like Hs.208093 [show with all ESTs]Unigene Representative Sequence: NM_00114274913 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000450689(uc003uie.3 uc011kgz.2 uc003uif.2 uc011kha.2)
ENST00000444627 ENST00000394714 ENST00000416314 ENST00000480216 ENST00000423294
ENST00000427812 ENST00000470853 ENST00000490995 ENST00000474609 ENST00000398276
ENST00000425689 ENST00000297222
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KIAA1324L (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Additional cDNA sequence: AK055902.1 AK296250.1 AK303619.1 BC117309.1 NR_030672.1 17 DOTS entries: DT.210695 DT.100735528 DT.100781795 DT.102843238 DT.307292 DT.40108629 DT.121051501 DT.102843244 DT.121051506 DT.121051446 DT.121051452 DT.75197377 DT.91671727 DT.92014153 DT.102843245 DT.121051382 DT.121051387 24/60 AceView cDNA sequences (see all 60): CD655511 AI797353 AA927017 NM_152748 CD676972 AK055902 AA010992 BQ182610 AW665873 BM752466 CB241751 AA305780 AI885785 BM759885 BM783507 CA448279 CA407428 BU687296 CB120618 AI830505 AA486911 BX498549 AI266484 BF740039
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1324L About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KIAA1324L
|
Expression
for KIAA1324L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KIAA1324L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAGCATATG
About this image
See KIAA1324L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KIAA1324L
SOURCE GeneReport for Unigene cluster: Hs.208093
SABiosciences Custom PCR Arrays for KIAA1324L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KIAA1324L
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1324L |
Orthologs
for KIAA1324L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KIAA1324L gene from 5/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
KIAA1324L1 |
KIAA1324-like |
77.73(n)
83.56(a) |
|
418645 XM_416843.3 XP_416843.3 |
lizard
(Anolis carolinensis) |
Reptilia |
KIAA1324L6 |
-- |
78(a) |
1 ↔ 1 |
5(89746388-89784761) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BX844402.12 |
-- |
75.53(n) |
|
BX844402.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
AI878084.12 |
-- |
72.85(n) |
|
325168 AI878084.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
CELE_Y73F8A.51 |
Protein Y73F8A.5 |
44.57(n)
33.81(a) |
|
178425 NM_070440.4 NP_502841.1 |
ENSEMBL Gene Tree for KIAA1324L (if available)
TreeFam Gene Tree for KIAA1324L (if available) |
Paralogs
for KIAA1324L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KIAA1324L gene
- KIAA13242
1 SIMAP similar gene for KIAA1324L using alignment to 7 protein entries: K132L_HUMAN (see all proteins):KIAA1324
KIAA1324L for paralogs About GeneDecksing
|
Genomic Variants
for KIAA1324L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KIAA1324L (86506222 - 86689015 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for KIAA1324L
2 CNVs: 0106 31373
1 Indel: 28702 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KIAA1324L |
|
Disorders
/ Diseases
for KIAA1324L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 KIAA1324L for disorders About MalaCards
KIAA1324L for disorders About GeneDecksing
OMIM gene information: 614048
OMIM disorders: --
Export disorders for KIAA1324L gene to outside databases
|
Publications
for KIAA1324L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KIAA1324L gene integrated from 9 sources:
(articles sorted by number of sources associating them with KIAA1324L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Expression of estrogen induced gene 121-like (EIG121L) during early Xenopus development. (PubMed id 17475571)1, 2 Araki T.... Nishida E. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- A transmembrane protein EIG121L is required for epide rmal differentiation during early embryonic development. (PubMed id 21177533)1 Araki T....Nishida E. (2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for KIAA1324L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KIAA1324L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KIAA1324L gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KIAA1324L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KIAA1324L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KIAA1324L gene:
Search GeneIP for patents involving KIAA1324L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIAA1324L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | |  |  |  |  | | | | |
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 |
 | | | KIAA1324L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KIAA1324L |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KIAA1324L |
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