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Aliases for KIAA1191 Gene

Aliases for KIAA1191 Gene

  • KIAA1191 2 3
  • Flavin Monooxygenase Motif-Containing Protein Of 33 KDa 3 4
  • P60MONOX Brain-Derived Rescue Factor 2 3
  • Brain-Derived Rescue Factor P60MONOX 3 4
  • P33MONOX 3 4
  • Flavine Monooxygenase Motif-Containing Protein Of 33 KDa 3
  • Putative Monooxygenase P33MONOX 3
  • EC 1.-.-.- 4
  • P60MONOX 3

External Ids for KIAA1191 Gene

Previous GeneCards Identifiers for KIAA1191 Gene

  • GC05M176084
  • GC05M176591
  • GC05M175708
  • GC05M175753
  • GC05M175705
  • GC05M175773
  • GC05M170697

Summaries for KIAA1191 Gene

GeneCards Summary for KIAA1191 Gene

KIAA1191 (KIAA1191) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity.

UniProtKB/Swiss-Prot for KIAA1191 Gene

  • Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

Additional gene information for KIAA1191 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1191 Gene

Genomics for KIAA1191 Gene

Regulatory Elements for KIAA1191 Gene

Enhancers for KIAA1191 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H176340 0.8 ENCODE 22.3 +20.0 20006 2 PKNOX1 FOXA2 NFIB RARA TCF12 ZNF121 GATA2 ATF7 ZEB2 NFIL3 KIAA1191 ARL10 MIR1271 SIMC1 FAM153B ENSG00000250909 BRCC3P1
GH05H176410 1.6 Ensembl ENCODE dbSUPER 10.9 -52.9 -52949 8 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 FOS SP5 ENSG00000251414 FAF2 HIGD2A ARL10 NOP16 UIMC1 ENSG00000250909 MIR1271 KIAA1191 CDHR2
GH05H176552 1.3 Ensembl ENCODE dbSUPER 10.3 -191.8 -191841 3 BCOR SIN3A ZMYM3 BMI1 BATF ZIC2 ZKSCAN1 GLIS2 POLR2A FOSL2 FAF2 ENSG00000250909 NSD1 ENSG00000251414 ARL10 MIR1271 KIAA1191 UNC5A CDHR2 GC05M176548
GH05H176360 1.1 ENCODE 11.1 +0.3 319 1 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 FAF2 FAM153B KIAA1191 MXD3 HIGD2A PRELID1 SIMC1 PIR38474 ENSG00000251414
GH05H176423 0.8 ENCODE dbSUPER 10.8 -64.1 -64072 5 GLIS1 ZSCAN29 ELF1 SETDB1 FAF2 CDHR2 RN7SL684P MIR1271 ARL10 KIAA1191 GPRIN1 ENSG00000251414 HIGD2A CLTB
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIAA1191 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA1191 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000191208 667 1800 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 SP5

Genomic Location for KIAA1191 Gene

Chromosome:
5
Start:
176,346,061 bp from pter
End:
176,361,968 bp from pter
Size:
15,908 bases
Orientation:
Minus strand

Genomic View for KIAA1191 Gene

Genes around KIAA1191 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1191 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1191 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1191 Gene

Proteins for KIAA1191 Gene

  • Protein details for KIAA1191 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A73-P33MX_HUMAN
    Recommended name:
    Putative monooxygenase p33MONOX
    Protein Accession:
    Q96A73
    Secondary Accessions:
    • B2RD69
    • B8K1S6
    • Q6IA24
    • Q8NDU3
    • Q9BRE5
    • Q9H7D5
    • Q9ULM9

    Protein attributes for KIAA1191 Gene

    Size:
    305 amino acids
    Molecular mass:
    33247 Da
    Quaternary structure:
    • Interacts with COBRA1, NOL12 and PRNP.

    Alternative splice isoforms for KIAA1191 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1191 Gene

Post-translational modifications for KIAA1191 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for KIAA1191

No data available for DME Specific Peptides for KIAA1191 Gene

Domains & Families for KIAA1191 Gene

Gene Families for KIAA1191 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KIAA1191 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA1191 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A73

UniProtKB/Swiss-Prot:

P33MX_HUMAN :
  • Belongs to the P33MONOX family.
Family:
  • Belongs to the P33MONOX family.
genes like me logo Genes that share domains with KIAA1191: view

Function for KIAA1191 Gene

Molecular function for KIAA1191 Gene

UniProtKB/Swiss-Prot Function:
Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

Enzyme Numbers (IUBMB) for KIAA1191 Gene

Gene Ontology (GO) - Molecular Function for KIAA1191 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21044950
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with KIAA1191: view
genes like me logo Genes that share phenotypes with KIAA1191: view

Animal Model Products

CRISPR Products

miRNA for KIAA1191 Gene

miRTarBase miRNAs that target KIAA1191

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1191 Gene

Localization for KIAA1191 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA1191 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA1191 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KIAA1191 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with KIAA1191: view

Pathways & Interactions for KIAA1191 Gene

SuperPathways for KIAA1191 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA1191 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with KIAA1191: view

No data available for Pathways by source and SIGNOR curated interactions for KIAA1191 Gene

Drugs & Compounds for KIAA1191 Gene

No Compound Related Data Available

Transcripts for KIAA1191 Gene

Unigene Clusters for KIAA1191 Gene

KIAA1191:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1191 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e
SP1: - - - - -
SP2: - - -
SP3: -
SP4: - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - -
SP8: - - - -
SP9: - - - - - - - - - - -
SP10: - - - -
SP11: - - - - - - - -
SP12: - - - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - - - - -
SP15: - - -
SP16: - - - - - -
SP17: -
SP18: - - - - - - - - - - - -

Relevant External Links for KIAA1191 Gene

GeneLoc Exon Structure for
KIAA1191
ECgene alternative splicing isoforms for
KIAA1191

Expression for KIAA1191 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA1191 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIAA1191 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.4), Placenta (8.1), Prostate (7.1), and Lymph node (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIAA1191 Gene



Protein tissue co-expression partners for KIAA1191 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIAA1191 Gene:

KIAA1191

SOURCE GeneReport for Unigene cluster for KIAA1191 Gene:

Hs.743257

mRNA Expression by UniProt/SwissProt for KIAA1191 Gene:

Q96A73-P33MX_HUMAN
Tissue specificity: Down-regulated in the occipital lobe of an early stage Alzheimer disease patients.

Evidence on tissue expression from TISSUES for KIAA1191 Gene

  • Nervous system(4.8)
  • Intestine(4.3)
  • Liver(4.3)
  • Muscle(4.3)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with KIAA1191: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA1191 Gene

Orthologs for KIAA1191 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1191 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1191 33 34
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia KIAA1191 33 34
  • 90.6 (n)
cow
(Bos Taurus)
Mammalia P33MONOX 33 34
  • 86.56 (n)
rat
(Rattus norvegicus)
Mammalia LOC306766 33
  • 85.26 (n)
mouse
(Mus musculus)
Mammalia 4833439L19Rik 16 34 33
  • 84.71 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
OneToMany
-- 34
  • 70 (a)
OneToMany
-- 34
  • 70 (a)
OneToMany
-- 34
  • 68 (a)
OneToMany
-- 34
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1191 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1191 33 34
  • 72.56 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA1191 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1191 33
  • 68.94 (n)
Str.245 33
zebrafish
(Danio rerio)
Actinopterygii zgc:123105 33 34
  • 63.96 (n)
Species where no ortholog for KIAA1191 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1191 Gene

ENSEMBL:
Gene Tree for KIAA1191 (if available)
TreeFam:
Gene Tree for KIAA1191 (if available)

Paralogs for KIAA1191 Gene

genes like me logo Genes that share paralogs with KIAA1191: view

No data available for Paralogs for KIAA1191 Gene

Variants for KIAA1191 Gene

Sequence variations from dbSNP and Humsavar for KIAA1191 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000022065 -- 176,360,314(+) ACCAC(G/T)CCTGG intron-variant, upstream-variant-2KB
rs1000054837 -- 176,360,529(+) GGTGC(C/G)GTGGC intron-variant, upstream-variant-2KB
rs1000087492 -- 176,353,000(+) GTCTA(C/G)TACCT intron-variant
rs1000498433 -- 176,345,906(+) TGAAT(-/A)GGGGG intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1000524989 -- 176,353,304(+) CTGCT(A/C/T)CCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1191 Gene

Variant ID Type Subtype PubMed ID
esv2648102 CNV deletion 19546169
nsv1023853 CNV gain 25217958
nsv462549 CNV gain 19166990
nsv600341 CNV gain 21841781
nsv980762 CNV duplication 23825009

Variation tolerance for KIAA1191 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1191 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1191

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1191 Gene

Disorders for KIAA1191 Gene

Relevant External Links for KIAA1191

Genetic Association Database (GAD)
KIAA1191
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1191

No disorders were found for KIAA1191 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1191 Gene

Publications for KIAA1191 Gene

  1. Characterizing the novel protein p33MONOX. (PMID: 21153684) Mishra M … Heese K (Molecular and cellular biochemistry 2011) 2 3 4 60
  2. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 60
  3. Brain site-specific gene expression analysis in Alzheimer's disease patients. (PMID: 17032350) Yokota T … Heese K (European journal of clinical investigation 2006) 3 4 60
  4. Isolation and characterization of novel CAG repeat containing genes expressed in human brain. (PMID: 10565538) Zühlke C … Schwinger E (DNA sequence : the journal of DNA sequencing and mapping 1999) 2 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for KIAA1191 Gene

Sources for KIAA1191 Gene

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