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Aliases for KIAA1191 Gene

Aliases for KIAA1191 Gene

  • KIAA1191 2 3
  • Flavin Monooxygenase Motif-Containing Protein Of 33 KDa 3 4
  • Brain-Derived Rescue Factor P60MONOX 3 4
  • P33MONOX 3 4
  • Flavine Monooxygenase Motif-Containing Protein Of 33 KDa 3
  • Putative Monooxygenase P33MONOX 3
  • EC 1.-.-.- 4
  • P60MONOX 3

External Ids for KIAA1191 Gene

Previous GeneCards Identifiers for KIAA1191 Gene

  • GC05M176084
  • GC05M176591
  • GC05M175708
  • GC05M175753
  • GC05M175705
  • GC05M175773
  • GC05M170697

Summaries for KIAA1191 Gene

GeneCards Summary for KIAA1191 Gene

KIAA1191 (KIAA1191) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity.

UniProtKB/Swiss-Prot for KIAA1191 Gene

  • Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1191 Gene

Genomics for KIAA1191 Gene

Regulatory Elements for KIAA1191 Gene

Enhancers for KIAA1191 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F176340 0.5 ENCODE 22.3 +20.0 20006 2.6 PKNOX1 ESRRA ZNF146 SAP130 TAL1 ZNF644 RARA ZNF121 ZNF664 NCOR1 KIAA1191 ARL10 MIR1271 SIMC1 FAM153B ENSG00000250909 BRCC3P1
GH05F176360 0.6 ENCODE 11.1 +0.3 319 1.8 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FAF2 FAM153B KIAA1191 MXD3 HIGD2A SIMC1 PIR38474 ENSG00000251414
GH05F176410 1.2 Ensembl ENCODE 10.9 -52.9 -52949 8.8 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 FOS KLF13 ENSG00000251414 FAF2 HIGD2A ARL10 NOP16 ENSG00000250909 MIR1271 KIAA1191 CDHR2 RN7SL684P
GH05F176423 0.2 ENCODE 10.8 -64.1 -64072 5.6 ATF1 MLX ARID4B SIN3A ZNF48 YY1 MXD4 ZHX2 MIER2 PPARG FAF2 CDHR2 RN7SL684P MIR1271 ARL10 KIAA1191 GPRIN1 ENSG00000251414 HIGD2A CLTB
GH05F176364 0.4 ENCODE 10.5 -3.8 -3793 2.0 RING1 KLF1 SUZ12 SIN3A ZFHX2 GLIS2 EGR1 POLR2A ZNF143 CREM ZNF346 ZNF346-IT1 FAF2 KIAA1191 FAM153B SIMC1 ARL10 MIR1271
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KIAA1191 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA1191 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001297570 668 2601 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for KIAA1191 Gene

Chromosome:
5
Start:
176,346,061 bp from pter
End:
176,361,968 bp from pter
Size:
15,908 bases
Orientation:
Minus strand

Genomic View for KIAA1191 Gene

Genes around KIAA1191 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1191 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1191 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1191 Gene

Proteins for KIAA1191 Gene

  • Protein details for KIAA1191 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A73-P33MX_HUMAN
    Recommended name:
    Putative monooxygenase p33MONOX
    Protein Accession:
    Q96A73
    Secondary Accessions:
    • B2RD69
    • B8K1S6
    • Q6IA24
    • Q8NDU3
    • Q9BRE5
    • Q9H7D5
    • Q9ULM9

    Protein attributes for KIAA1191 Gene

    Size:
    305 amino acids
    Molecular mass:
    33247 Da
    Quaternary structure:
    • Interacts with COBRA1, NOL12 and PRNP.

    Alternative splice isoforms for KIAA1191 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA1191 Gene

Post-translational modifications for KIAA1191 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for KIAA1191

No data available for DME Specific Peptides for KIAA1191 Gene

Domains & Families for KIAA1191 Gene

Protein Domains for KIAA1191 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA1191 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A73

UniProtKB/Swiss-Prot:

P33MX_HUMAN :
  • Belongs to the P33MONOX family.
Family:
  • Belongs to the P33MONOX family.
genes like me logo Genes that share domains with KIAA1191: view

No data available for Gene Families for KIAA1191 Gene

Function for KIAA1191 Gene

Molecular function for KIAA1191 Gene

UniProtKB/Swiss-Prot Function:
Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

Enzyme Numbers (IUBMB) for KIAA1191 Gene

Gene Ontology (GO) - Molecular Function for KIAA1191 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21044950
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with KIAA1191: view
genes like me logo Genes that share phenotypes with KIAA1191: view

Animal Model Products

miRNA for KIAA1191 Gene

miRTarBase miRNAs that target KIAA1191

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1191 Gene

Localization for KIAA1191 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA1191 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA1191 Gene COMPARTMENTS Subcellular localization image for KIAA1191 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for KIAA1191 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with KIAA1191: view

Pathways & Interactions for KIAA1191 Gene

SuperPathways for KIAA1191 Gene

No Data Available

Interacting Proteins for KIAA1191 Gene

Gene Ontology (GO) - Biological Process for KIAA1191 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with KIAA1191: view

No data available for Pathways by source and SIGNOR curated interactions for KIAA1191 Gene

Transcripts for KIAA1191 Gene

Unigene Clusters for KIAA1191 Gene

KIAA1191:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1191 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e
SP1: - - - - -
SP2: - - -
SP3: -
SP4: - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - -
SP8: - - - -
SP9: - - - - - - - - - - -
SP10: - - - -
SP11: - - - - - - - -
SP12: - - - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - - - - -
SP15: - - -
SP16: - - - - - -
SP17: -
SP18: - - - - - - - - - - - -

Relevant External Links for KIAA1191 Gene

GeneLoc Exon Structure for
KIAA1191
ECgene alternative splicing isoforms for
KIAA1191

Expression for KIAA1191 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIAA1191 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KIAA1191 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.4), Placenta (8.1), Prostate (7.1), and Lymph node (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIAA1191 Gene



Protein tissue co-expression partners for KIAA1191 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIAA1191 Gene:

KIAA1191

SOURCE GeneReport for Unigene cluster for KIAA1191 Gene:

Hs.743257

mRNA Expression by UniProt/SwissProt for KIAA1191 Gene:

Q96A73-P33MX_HUMAN
Tissue specificity: Down-regulated in the occipital lobe of an early stage Alzheimer disease patients.
genes like me logo Genes that share expression patterns with KIAA1191: view

Primer Products

No data available for mRNA differential expression in normal tissues for KIAA1191 Gene

Orthologs for KIAA1191 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1191 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1191 34 35
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia KIAA1191 34 35
  • 90.6 (n)
cow
(Bos Taurus)
Mammalia P33MONOX 34 35
  • 86.56 (n)
rat
(Rattus norvegicus)
Mammalia LOC306766 34
  • 85.26 (n)
mouse
(Mus musculus)
Mammalia 4833439L19Rik 34 16 35
  • 84.71 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 74 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1191 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1191 34 35
  • 72.56 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA1191 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1191 34
  • 68.94 (n)
Str.245 34
zebrafish
(Danio rerio)
Actinopterygii zgc:123105 34 35
  • 63.96 (n)
Species where no ortholog for KIAA1191 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1191 Gene

ENSEMBL:
Gene Tree for KIAA1191 (if available)
TreeFam:
Gene Tree for KIAA1191 (if available)

Paralogs for KIAA1191 Gene

genes like me logo Genes that share paralogs with KIAA1191: view

No data available for Paralogs for KIAA1191 Gene

Variants for KIAA1191 Gene

Sequence variations from dbSNP and Humsavar for KIAA1191 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10063877 -- 176,357,917(+) ATGCA(C/T)TCTGG intron-variant
rs10516135 -- 176,349,050(+) TCAAA(C/T)GCTCA intron-variant
rs11124 -- 176,346,159(+) GCCTC(C/T)CTATG intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs11134974 -- 176,354,956(+) TCAGG(C/T)AAATG intron-variant
rs111468056 -- 176,357,307(+) AAAAA(A/G)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1191 Gene

Variant ID Type Subtype PubMed ID
esv2648102 CNV deletion 19546169
nsv1023853 CNV gain 25217958
nsv462549 CNV gain 19166990
nsv600341 CNV gain 21841781
nsv980762 CNV duplication 23825009

Variation tolerance for KIAA1191 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1191 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1191

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1191 Gene

Disorders for KIAA1191 Gene

Relevant External Links for KIAA1191

Genetic Association Database (GAD)
KIAA1191
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1191

No disorders were found for KIAA1191 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1191 Gene

Publications for KIAA1191 Gene

  1. Characterizing the novel protein p33MONOX. (PMID: 21153684) Mishra M. … Heese K. (Mol. Cell. Biochem. 2011) 2 3 4 64
  2. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4 64
  3. Brain site-specific gene expression analysis in Alzheimer's disease patients. (PMID: 17032350) Yokota T. … Heese K. (Eur. J. Clin. Invest. 2006) 3 4 64
  4. Isolation and characterization of novel CAG repeat containing genes expressed in human brain. (PMID: 10565538) Zuehlke C. … Schwinger E. (DNA Seq. 1999) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for KIAA1191 Gene

Sources for KIAA1191 Gene

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