Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KIAA1161 Gene

Aliases for KIAA1161 Gene

  • KIAA1161 2 3
  • Uncharacterized Family 31 Glucosidase KIAA1161 3
  • EC 3.2.1.- 4
  • NET37 3

External Ids for KIAA1161 Gene

Previous GeneCards Identifiers for KIAA1161 Gene

  • GC09M034679
  • GC09U900001
  • GC09M034361
  • GC09M034357

Summaries for KIAA1161 Gene

GeneCards Summary for KIAA1161 Gene

KIAA1161 (KIAA1161) is a Protein Coding gene. Among its related pathways are Ectoderm Differentiation. GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds. An important paralog of this gene is MGAM.

UniProtKB/Swiss-Prot for KIAA1161 Gene

  • Putative glucosidase.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1161 Gene

Genomics for KIAA1161 Gene

Regulatory Elements for KIAA1161 Gene

Enhancers for KIAA1161 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G034341 1.2 Ensembl ENCODE dbSUPER 11.9 +33.1 33070 5.0 NFIA CEBPG ZIC2 NR2F2 YY1 OSR2 JUND ATF3 HNF4A SMAD4 NUDT2 KIAA1161 C9orf24 RNU2-50P FAM219A DNAI1 IMPDH1P1 DCAF12 ENSG00000230729 RPP25L
GH09G034333 1 ENCODE dbSUPER 12.1 +42.3 42336 1.4 SOX13 SAP130 ARID4B ZNF644 ZNF652 THAP11 SOX5 GATAD2A HMG20B KLF11 NUDT2 KIAA1161 C9orf24 CNTFR UBAP1 GC09P034356
GH09G034346 0.9 ENCODE dbSUPER 11.9 +29.5 29468 1.2 SCRT1 MAX ZNF384 ZNF48 NR2F2 YY1 JUND ATF3 SCRT2 HNF4G KIAA1161 C9orf24 RNU2-50P DNAI1 FAM219A IMPDH1P1 DCAF12 ENSG00000230729 RPP25L KIF24
GH09G034332 0.8 ENCODE 12.1 +44.3 44349 0.2 CTCF PKNOX1 SAP130 ARID4B RAD21 TEAD3 ZNF316 GATAD1 SMC3 NFE2 KIAA1161 C9orf24 CNTFR NUDT2 GC09P034356
GH09G033620 1.1 Ensembl ENCODE 4.8 +755.8 755786 2.2 ATF1 PKNOX1 ARNT CHAMP1 ZEB1 ZNF335 ZNF366 ZBTB2 CEBPB ZEB2 ENSG00000260947 TRBV24OR9-2 CYP4F26P KIAA1161 PIR37945 ANXA2P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIAA1161 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA1161 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234518 -104 1601 HDGF PKNOX1 MLX CREB3L1 AGO1 ARID4B SIN3A YY1 ZNF207 ZNF143

Genomic Location for KIAA1161 Gene

Chromosome:
9
Start:
34,366,666 bp from pter
End:
34,376,896 bp from pter
Size:
10,231 bases
Orientation:
Minus strand

Genomic View for KIAA1161 Gene

Genes around KIAA1161 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1161 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1161 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1161 Gene

Proteins for KIAA1161 Gene

  • Protein details for KIAA1161 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NSJ0-K1161_HUMAN
    Recommended name:
    Uncharacterized family 31 glucosidase KIAA1161
    Protein Accession:
    Q6NSJ0
    Secondary Accessions:
    • Q5T587
    • Q5T588
    • Q9ULQ9

    Protein attributes for KIAA1161 Gene

    Size:
    714 amino acids
    Molecular mass:
    81087 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI15965.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15966.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for KIAA1161 Gene

Post-translational modifications for KIAA1161 Gene

  • Glycosylation at isoforms=240, posLast=250250, and posLast=511511
  • Modification sites at PhosphoSitePlus

Other Protein References for KIAA1161 Gene

No data available for DME Specific Peptides for KIAA1161 Gene

Domains & Families for KIAA1161 Gene

Protein Domains for KIAA1161 Gene

Suggested Antigen Peptide Sequences for KIAA1161 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NSJ0

UniProtKB/Swiss-Prot:

K1161_HUMAN :
  • Belongs to the glycosyl hydrolase 31 family.
Family:
  • Belongs to the glycosyl hydrolase 31 family.
genes like me logo Genes that share domains with KIAA1161: view

No data available for Gene Families for KIAA1161 Gene

Function for KIAA1161 Gene

Molecular function for KIAA1161 Gene

UniProtKB/Swiss-Prot Function:
Putative glucosidase.

Enzyme Numbers (IUBMB) for KIAA1161 Gene

Gene Ontology (GO) - Molecular Function for KIAA1161 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA --
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with KIAA1161: view
genes like me logo Genes that share phenotypes with KIAA1161: view

Animal Models for KIAA1161 Gene

MGI Knock Outs for KIAA1161:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIAA1161 Gene

Localization for KIAA1161 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA1161 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA1161 gene
Compartment Confidence
nucleus 3
plasma membrane 2
golgi apparatus 2
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KIAA1161 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with KIAA1161: view

Pathways & Interactions for KIAA1161 Gene

SuperPathways for KIAA1161 Gene

SuperPathway Contained pathways
1 Ectoderm Differentiation
genes like me logo Genes that share pathways with KIAA1161: view

Pathways by source for KIAA1161 Gene

1 BioSystems pathway for KIAA1161 Gene

Interacting Proteins for KIAA1161 Gene

Gene Ontology (GO) - Biological Process for KIAA1161 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0008152 metabolic process IEA --
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway IEA --
GO:0048741 skeletal muscle fiber development IEA --
GO:0051897 positive regulation of protein kinase B signaling IEA --
genes like me logo Genes that share ontologies with KIAA1161: view

No data available for SIGNOR curated interactions for KIAA1161 Gene

Drugs & Compounds for KIAA1161 Gene

No Compound Related Data Available

Transcripts for KIAA1161 Gene

mRNA/cDNA for KIAA1161 Gene

Unigene Clusters for KIAA1161 Gene

KIAA1161:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1161 Gene

No ASD Table

Relevant External Links for KIAA1161 Gene

GeneLoc Exon Structure for
KIAA1161
ECgene alternative splicing isoforms for
KIAA1161

Expression for KIAA1161 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA1161 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIAA1161 Gene

This gene is overexpressed in Muscle - Skeletal (x6.1).

Protein differential expression in normal tissues from HIPED for KIAA1161 Gene

This gene is overexpressed in Liver (24.2), Placenta (18.9), and CD8 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIAA1161 Gene



Protein tissue co-expression partners for KIAA1161 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIAA1161 Gene:

KIAA1161

SOURCE GeneReport for Unigene cluster for KIAA1161 Gene:

Hs.522083

Evidence on tissue expression from TISSUES for KIAA1161 Gene

  • Liver(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with KIAA1161: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA1161 Gene

Orthologs for KIAA1161 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA1161 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1161 34 35
  • 99.11 (n)
cow
(Bos Taurus)
Mammalia KIAA1161 34
  • 87.8 (n)
dog
(Canis familiaris)
Mammalia KIAA1161 34 35
  • 87.19 (n)
rat
(Rattus norvegicus)
Mammalia RGD1309821 34
  • 85.09 (n)
mouse
(Mus musculus)
Mammalia AI464131 16 35 34
  • 84.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1161 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 76 (a)
OneToMany
KIAA1161 34
  • 74.84 (n)
-- 35
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 72 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1161 34
  • 66.47 (n)
Str.14314 34
zebrafish
(Danio rerio)
Actinopterygii si:dkey-228b2.5 35
  • 66 (a)
OneToMany
si:ch211-117c19.1 35
  • 64 (a)
OneToMany
LOC100537539 34
  • 63.39 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003993 34
  • 51.86 (n)
fruit fly
(Drosophila melanogaster)
Insecta tobi 35
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToMany
-- 35
  • 41 (a)
OneToMany
-- 35
  • 41 (a)
OneToMany
-- 35
  • 39 (a)
OneToMany
Species where no ortholog for KIAA1161 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1161 Gene

ENSEMBL:
Gene Tree for KIAA1161 (if available)
TreeFam:
Gene Tree for KIAA1161 (if available)

Paralogs for KIAA1161 Gene

Paralogs for KIAA1161 Gene

genes like me logo Genes that share paralogs with KIAA1161: view

Variants for KIAA1161 Gene

Sequence variations from dbSNP and Humsavar for KIAA1161 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000035147 -- 34,373,318(+) GATCA(C/G)AGGAT intron-variant
rs1000107597 -- 34,374,785(+) TAGTC(C/T)CAGCT intron-variant
rs1000234117 -- 34,377,286(+) GATGA(C/G)AGGGA upstream-variant-2KB
rs1000457136 -- 34,377,032(+) GGCGG(A/C)TCTGT upstream-variant-2KB
rs1000661143 -- 34,378,749(+) CGTGG(A/G)GTGGA downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KIAA1161 Gene

Variant ID Type Subtype PubMed ID
esv3620335 CNV gain 21293372
nsv1015595 CNV gain 25217958
nsv1016251 CNV gain 25217958
nsv1028418 CNV gain 25217958
nsv1125318 OTHER inversion 24896259
nsv831542 CNV gain 17160897

Variation tolerance for KIAA1161 Gene

Gene Damage Index Score: 11.80; 93.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1161 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1161

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1161 Gene

Disorders for KIAA1161 Gene

Relevant External Links for KIAA1161

Genetic Association Database (GAD)
KIAA1161
Human Genome Epidemiology (HuGE) Navigator
KIAA1161
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1161

No disorders were found for KIAA1161 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1161 Gene

Publications for KIAA1161 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J. … Lambert J.C. (Mol. Psychiatry 2009) 3 46 64
  3. NET37, a nuclear envelope transmembrane protein with glycosidase homology, is involved in myoblast differentiation. (PMID: 19706595) Datta K. … Gerace L. (J. Biol. Chem. 2009) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for KIAA1161 Gene

Sources for KIAA1161 Gene

Content
Loading form....