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Aliases for KIAA1161 Gene

Aliases for KIAA1161 Gene

  • KIAA1161 2 3
  • Uncharacterized Family 31 Glucosidase KIAA1161 3
  • EC 3.2.1.- 4
  • NET37 3

External Ids for KIAA1161 Gene

Previous GeneCards Identifiers for KIAA1161 Gene

  • GC09M034679
  • GC09U900001
  • GC09M034361
  • GC09M034357

Summaries for KIAA1161 Gene

GeneCards Summary for KIAA1161 Gene

KIAA1161 (KIAA1161) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds. An important paralog of this gene is MGAM.

UniProtKB/Swiss-Prot for KIAA1161 Gene

  • Putative glucosidase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1161 Gene

Genomics for KIAA1161 Gene

Regulatory Elements for KIAA1161 Gene

Enhancers for KIAA1161 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F034331 0.8 Ensembl ENCODE 12.1 +44.6 44596 1.0 CTCF PKNOX1 SAP130 ARID4B RAD21 TEAD3 ZNF316 GATAD1 SMC3 NFE2 NUDT2 KIAA1161 C9orf24 CNTFR KIF24 UBAP1 GC09P034356
GH09F034333 0.9 Ensembl ENCODE 12.1 +42.3 42265 1.5 SOX13 SAP130 ARID4B ZNF644 ZNF652 THAP11 GATAD2A SOX5 HMG20B KLF11 NUDT2 KIAA1161 C9orf24 CNTFR UBAP1 GC09P034356
GH09F034346 1.1 ENCODE 11.9 +29.5 29468 1.2 SCRT1 ZNF384 ZNF48 NR2F2 YY1 ATF3 SCRT2 HNF4G ZBTB33 ZBTB17 KIAA1161 C9orf24 RNU2-50P DNAI1 FAM219A IMPDH1P1 DCAF12 ENSG00000230729 RPP25L KIF24
GH09F034341 0.9 Ensembl ENCODE 11.8 +33.1 33070 5.0 NFIA CEBPG ZIC2 NR2F2 YY1 OSR2 ATF3 SMAD4 RXRB NUDT2 KIAA1161 C9orf24 RNU2-50P DNAI1 FAM219A DCAF12 IMPDH1P1 ENSG00000230729 RPP25L
GH09F034257 0.6 ENCODE 10.6 +119.5 119499 0.2 ZNF341 RNU2-50P ENSG00000228352 DCAF12 IMPDH1P1 KIAA1161 C9orf24 PIR42088
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KIAA1161 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA1161 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001302590 -4 1801 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A YY1 ZNF207 ZNF143 KLF13

Genomic Location for KIAA1161 Gene

Chromosome:
9
Start:
34,366,666 bp from pter
End:
34,376,896 bp from pter
Size:
10,231 bases
Orientation:
Minus strand

Genomic View for KIAA1161 Gene

Genes around KIAA1161 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1161 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1161 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1161 Gene

Proteins for KIAA1161 Gene

  • Protein details for KIAA1161 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NSJ0-K1161_HUMAN
    Recommended name:
    Uncharacterized family 31 glucosidase KIAA1161
    Protein Accession:
    Q6NSJ0
    Secondary Accessions:
    • Q5T587
    • Q5T588
    • Q9ULQ9

    Protein attributes for KIAA1161 Gene

    Size:
    714 amino acids
    Molecular mass:
    81087 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI15965.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15966.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for KIAA1161 Gene

Post-translational modifications for KIAA1161 Gene

  • Glycosylation at Asn 240, Asn 250, and Asn 511
  • Modification sites at PhosphoSitePlus

Other Protein References for KIAA1161 Gene

No data available for DME Specific Peptides for KIAA1161 Gene

Domains & Families for KIAA1161 Gene

Protein Domains for KIAA1161 Gene

Suggested Antigen Peptide Sequences for KIAA1161 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NSJ0

UniProtKB/Swiss-Prot:

K1161_HUMAN :
  • Belongs to the glycosyl hydrolase 31 family.
Family:
  • Belongs to the glycosyl hydrolase 31 family.
genes like me logo Genes that share domains with KIAA1161: view

No data available for Gene Families for KIAA1161 Gene

Function for KIAA1161 Gene

Molecular function for KIAA1161 Gene

UniProtKB/Swiss-Prot Function:
Putative glucosidase.

Enzyme Numbers (IUBMB) for KIAA1161 Gene

Gene Ontology (GO) - Molecular Function for KIAA1161 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA --
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with KIAA1161: view
genes like me logo Genes that share phenotypes with KIAA1161: view

Animal Models for KIAA1161 Gene

MGI Knock Outs for KIAA1161:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KIAA1161 Gene

Localization for KIAA1161 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA1161 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA1161 Gene COMPARTMENTS Subcellular localization image for KIAA1161 gene
Compartment Confidence
nucleus 3
golgi apparatus 2
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KIAA1161 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with KIAA1161: view

Pathways & Interactions for KIAA1161 Gene

SuperPathways for KIAA1161 Gene

No Data Available

Interacting Proteins for KIAA1161 Gene

Gene Ontology (GO) - Biological Process for KIAA1161 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0008152 metabolic process IEA --
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway IEA --
GO:0048741 skeletal muscle fiber development IEA --
GO:0051897 positive regulation of protein kinase B signaling IEA --
genes like me logo Genes that share ontologies with KIAA1161: view

No data available for Pathways by source and SIGNOR curated interactions for KIAA1161 Gene

Transcripts for KIAA1161 Gene

mRNA/cDNA for KIAA1161 Gene

Unigene Clusters for KIAA1161 Gene

KIAA1161:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1161 Gene

No ASD Table

Relevant External Links for KIAA1161 Gene

GeneLoc Exon Structure for
KIAA1161
ECgene alternative splicing isoforms for
KIAA1161

Expression for KIAA1161 Gene

mRNA expression in normal human tissues for KIAA1161 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIAA1161 Gene

This gene is overexpressed in Muscle - Skeletal (x6.1).

Protein differential expression in normal tissues from HIPED for KIAA1161 Gene

This gene is overexpressed in Liver (24.2), Placenta (18.9), and CD8 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIAA1161 Gene



Protein tissue co-expression partners for KIAA1161 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIAA1161 Gene:

KIAA1161

SOURCE GeneReport for Unigene cluster for KIAA1161 Gene:

Hs.522083
genes like me logo Genes that share expression patterns with KIAA1161: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for KIAA1161 Gene

Orthologs for KIAA1161 Gene

This gene was present in the common ancestor of animals.

Orthologs for KIAA1161 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1161 34 35
  • 99.11 (n)
cow
(Bos Taurus)
Mammalia KIAA1161 34
  • 87.8 (n)
dog
(Canis familiaris)
Mammalia KIAA1161 34 35
  • 87.19 (n)
rat
(Rattus norvegicus)
Mammalia RGD1309821 34
  • 85.09 (n)
mouse
(Mus musculus)
Mammalia AI464131 34 16 35
  • 84.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1161 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 76 (a)
OneToMany
KIAA1161 34
  • 74.84 (n)
-- 35
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 72 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1161 34
  • 66.47 (n)
Str.14314 34
zebrafish
(Danio rerio)
Actinopterygii si:dkey-228b2.5 35
  • 66 (a)
OneToMany
si:ch211-117c19.1 35
  • 64 (a)
OneToMany
LOC100537539 34
  • 63.39 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003993 34
  • 51.86 (n)
fruit fly
(Drosophila melanogaster)
Insecta tobi 35
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToMany
-- 35
  • 41 (a)
OneToMany
-- 35
  • 41 (a)
OneToMany
-- 35
  • 39 (a)
OneToMany
Species where no ortholog for KIAA1161 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1161 Gene

ENSEMBL:
Gene Tree for KIAA1161 (if available)
TreeFam:
Gene Tree for KIAA1161 (if available)

Paralogs for KIAA1161 Gene

Paralogs for KIAA1161 Gene

genes like me logo Genes that share paralogs with KIAA1161: view

Variants for KIAA1161 Gene

Sequence variations from dbSNP and Humsavar for KIAA1161 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10651045 -- 34,374,902(+) TCTCA(-/AAAA)AAAAA intron-variant
rs10758255 -- 34,370,022(+) CTCTC(A/T)CACAC utr-variant-3-prime
rs10814106 -- 34,374,509(+) GCCCA(A/G)CGCAC intron-variant
rs10814107 -- 34,374,590(+) ACTAT(A/G)TGCTA intron-variant
rs10814108 -- 34,374,629(+) GCTCA(C/T)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1161 Gene

Variant ID Type Subtype PubMed ID
esv3620335 CNV gain 21293372
nsv1015595 CNV gain 25217958
nsv1016251 CNV gain 25217958
nsv1028418 CNV gain 25217958
nsv1125318 OTHER inversion 24896259
nsv831542 CNV gain 17160897

Variation tolerance for KIAA1161 Gene

Gene Damage Index Score: 11.80; 93.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1161 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1161

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1161 Gene

Disorders for KIAA1161 Gene

Relevant External Links for KIAA1161

Genetic Association Database (GAD)
KIAA1161
Human Genome Epidemiology (HuGE) Navigator
KIAA1161
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1161

No disorders were found for KIAA1161 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1161 Gene

Publications for KIAA1161 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J. … Lambert J.C. (Mol. Psychiatry 2009) 3 46 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  5. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 3 64

Products for KIAA1161 Gene

Sources for KIAA1161 Gene

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