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Aliases for KIAA1147 Gene

Aliases for KIAA1147 Gene

  • KIAA1147 2 3
  • LCHN 3 4
  • Predicted Protein Of HQ2561 3
  • Protein LCHN 3
  • PRO2561 3

External Ids for KIAA1147 Gene

Previous GeneCards Identifiers for KIAA1147 Gene

  • GC07M141003
  • GC07M141356
  • GC07M135653

Summaries for KIAA1147 Gene

GeneCards Summary for KIAA1147 Gene

KIAA1147 (KIAA1147) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KIAA1147 Gene

  • May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1147 Gene

Genomics for KIAA1147 Gene

Regulatory Elements for KIAA1147 Gene

Enhancers for KIAA1147 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G141662 1.1 ENCODE dbSUPER 28.6 +38.4 38443 3.0 ELF3 NFIB SIN3A RAD21 YY1 GATA2 FOS ZNF217 MBD2 MTA1 KIAA1147 WEE2 TAS2R5 ENSG00000270157 ENSG00000244701 WEE2-AS1 PIR48863
GH07G141673 1.3 Ensembl ENCODE dbSUPER 12.1 +26.8 26767 3.8 ZNF493 ZFP64 RAD21 ZNF354C FOS EGR2 ZNF202 ZNF680 ZNF654 ZBTB11 TAS2R6P TAS2R5 WEE2-AS1 PRSS37 ENSG00000270157 KIAA1147 WEE2 TAS2R4 SSBP1 TMEM178B
GH07G141649 1.3 Ensembl ENCODE dbSUPER 11.5 +52.1 52124 1.7 PKNOX1 WRNIP1 SIN3A BMI1 RAD21 RFX5 ZNF366 ZNF143 CREM ZNF654 KIAA1147 WEE2 AGK ENSG00000244701 ENSG00000261570
GH07G141671 0.9 FANTOM5 ENCODE 16.4 +29.9 29940 1.0 NRF1 CEBPB TRIM24 CEBPG CLEC5A KIAA1147 WEE2 ENSG00000270157 PIR58736 GC07M141687
GH07G141736 1.2 ENCODE 11.7 -36.2 -36173 3.1 MLX CREB3L1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 WEE2-AS1 PRSS37 TAS2R6P WEE2 KIAA1147 TAS2R5 TAS2R4 SSBP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KIAA1147 on UCSC Golden Path with GeneCards custom track

Promoters for KIAA1147 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000219187 269 1801 TBL1XR1 RB1 SIN3A GLIS2 RELB CEBPB ZEB2 ZNF398 GATAD2B GLIS1

Genomic Location for KIAA1147 Gene

Chromosome:
7
Start:
141,656,728 bp from pter
End:
141,702,169 bp from pter
Size:
45,442 bases
Orientation:
Minus strand

Genomic View for KIAA1147 Gene

Genes around KIAA1147 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1147 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1147 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1147 Gene

Proteins for KIAA1147 Gene

  • Protein details for KIAA1147 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D1U4-LCHN_HUMAN
    Recommended name:
    Protein LCHN
    Protein Accession:
    A4D1U4
    Secondary Accessions:
    • Q9ULS3

    Protein attributes for KIAA1147 Gene

    Size:
    455 amino acids
    Molecular mass:
    51446 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KIAA1147 Gene

Post-translational modifications for KIAA1147 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIAA1147 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIAA1147 Gene

Domains & Families for KIAA1147 Gene

Protein Domains for KIAA1147 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA1147 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A4D1U4

UniProtKB/Swiss-Prot:

LCHN_HUMAN :
  • Belongs to the LCHN family.
Family:
  • Belongs to the LCHN family.
genes like me logo Genes that share domains with KIAA1147: view

No data available for Gene Families for KIAA1147 Gene

Function for KIAA1147 Gene

Molecular function for KIAA1147 Gene

UniProtKB/Swiss-Prot Function:
May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia.
genes like me logo Genes that share phenotypes with KIAA1147: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1147 Gene

Localization for KIAA1147 Gene

Gene Ontology (GO) - Cellular Components for KIAA1147 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with KIAA1147: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for KIAA1147 Gene

Pathways & Interactions for KIAA1147 Gene

SuperPathways for KIAA1147 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA1147 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051179 localization IBA --
genes like me logo Genes that share ontologies with KIAA1147: view

No data available for Pathways by source and SIGNOR curated interactions for KIAA1147 Gene

Transcripts for KIAA1147 Gene

mRNA/cDNA for KIAA1147 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIAA1147 Gene

KIAA1147:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1147 Gene

No ASD Table

Relevant External Links for KIAA1147 Gene

GeneLoc Exon Structure for
KIAA1147
ECgene alternative splicing isoforms for
KIAA1147

Expression for KIAA1147 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA1147 Gene

Protein differential expression in normal tissues from HIPED for KIAA1147 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.5), Bone (12.7), Fetal Brain (11.9), Frontal cortex (11.5), and Blymphocyte (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIAA1147 Gene



NURSA nuclear receptor signaling pathways regulating expression of KIAA1147 Gene:

KIAA1147

SOURCE GeneReport for Unigene cluster for KIAA1147 Gene:

Hs.521240

Evidence on tissue expression from TISSUES for KIAA1147 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with KIAA1147: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA1147 Gene

Orthologs for KIAA1147 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1147 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1147 35 34
  • 99.85 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA1147 34 35
  • 92.12 (n)
cow
(Bos Taurus)
Mammalia KIAA1147 34 35
  • 91.53 (n)
mouse
(Mus musculus)
Mammalia E330009J07Rik 34 16 35
  • 89.94 (n)
rat
(Rattus norvegicus)
Mammalia RGD1563986 34
  • 89.89 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1147 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1147 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1147 34 35
  • 80.33 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA1147 35
  • 84 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-238n5.4 34 35
  • 65 (a)
Species where no ortholog for KIAA1147 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1147 Gene

ENSEMBL:
Gene Tree for KIAA1147 (if available)
TreeFam:
Gene Tree for KIAA1147 (if available)

Paralogs for KIAA1147 Gene

(1) SIMAP similar genes for KIAA1147 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIAA1147: view

No data available for Paralogs for KIAA1147 Gene

Variants for KIAA1147 Gene

Sequence variations from dbSNP and Humsavar for KIAA1147 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs150720419 -- 141,703,542(+) GGCAC(-/TGTG/TGTGTGTGTGTGTG)TGTGT upstream-variant-2KB
rs201443252 -- 141,677,401(+) AAAAA(-/AAAT)ATATA intron-variant
rs201716585 -- 141,700,478(+) GTCTG(-/A)AAAAA intron-variant
rs374308623 -- 141,699,916(+) TCACT(-/CA/CTCA)CACAC intron-variant
rs57034632 -- 141,677,402(+) AAAAA(-/AA)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1147 Gene

Variant ID Type Subtype PubMed ID
esv34135 CNV loss 18971310
nsv475452 CNV novel sequence insertion 20440878
nsv5973 CNV insertion 18451855

Variation tolerance for KIAA1147 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 25.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KIAA1147 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1147

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1147 Gene

Disorders for KIAA1147 Gene

Relevant External Links for KIAA1147

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KIAA1147

No disorders were found for KIAA1147 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1147 Gene

Publications for KIAA1147 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. (PMID: 24129315) Guo A. … Comb M.J. (Mol. Cell. Proteomics 2014) 4 64
  5. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3 64

Products for KIAA1147 Gene

Sources for KIAA1147 Gene

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