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Aliases for KIAA1147 Gene

Aliases for KIAA1147 Gene

  • KIAA1147 2 3
  • LCHN 3 4
  • Predicted Protein Of HQ2561 3
  • Protein LCHN 3
  • PRO2561 3

External Ids for KIAA1147 Gene

Previous GeneCards Identifiers for KIAA1147 Gene

  • GC07M141003
  • GC07M141356
  • GC07M135653

Summaries for KIAA1147 Gene

GeneCards Summary for KIAA1147 Gene

KIAA1147 (KIAA1147) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KIAA1147 Gene

  • May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia.

Additional gene information for KIAA1147 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA1147 Gene

Genomics for KIAA1147 Gene

GeneHancer (GH) Regulatory Elements for KIAA1147 Gene

Promoters and enhancers for KIAA1147 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I141700 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.2 222 2.6 RB1 SIN3A ZNF335 GLIS2 RUNX3 ZNF362 CEBPB ZNF398 ZEB2 NFIL3 KIAA1147 TAS2R5 GC07M141687 PIR58736
GH07I141662 Enhancer 1 ENCODE dbSUPER 28.6 +38.4 38442 3 ELF3 FOXA2 CLOCK NFIB SIN3A RAD21 YY1 FOS RXRA GATAD2B ENSG00000270157 PIR48863 KIAA1147 WEE2 TAS2R5 ENSG00000244701 WEE2-AS1
GH07I141736 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 11.8 -36.2 -36173 3.1 MLX ZFP64 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 WEE2-AS1 SSBP1 TAS2R6P TAS2R5 PRSS37 WEE2 KIAA1147 TAS2R4
GH07I141671 Enhancer 0.8 FANTOM5 ENCODE 16.4 +29.9 29940 1 ATF4 NRF1 CEBPB TRIM24 CEBPG CLEC5A KIAA1147 WEE2 ENSG00000270157 GC07M141687 PIR58736
GH07I141649 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.5 +52.1 52124 1.7 CTCF MXI1 PKNOX1 ZBTB6 MAX SIN3A PAX8 BMI1 RAD21 RFX5 KIAA1147 WEE2 AGK ENSG00000244701 ENSG00000261570
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KIAA1147 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KIAA1147 gene promoter:

Genomic Locations for KIAA1147 Gene

Genomic Locations for KIAA1147 Gene
chr7:141,656,728-141,702,169
(GRCh38/hg38)
Size:
45,442 bases
Orientation:
Minus strand
chr7:141,356,528-141,401,953
(GRCh37/hg19)

Genomic View for KIAA1147 Gene

Genes around KIAA1147 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA1147 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA1147 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA1147 Gene

Proteins for KIAA1147 Gene

  • Protein details for KIAA1147 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D1U4-LCHN_HUMAN
    Recommended name:
    Protein LCHN
    Protein Accession:
    A4D1U4
    Secondary Accessions:
    • Q9ULS3

    Protein attributes for KIAA1147 Gene

    Size:
    455 amino acids
    Molecular mass:
    51446 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KIAA1147 Gene

Post-translational modifications for KIAA1147 Gene

No Post-translational modifications

Other Protein References for KIAA1147 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KIAA1147 Gene

Domains & Families for KIAA1147 Gene

Gene Families for KIAA1147 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KIAA1147 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA1147 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A4D1U4

UniProtKB/Swiss-Prot:

LCHN_HUMAN :
  • Belongs to the LCHN family.
Family:
  • Belongs to the LCHN family.
genes like me logo Genes that share domains with KIAA1147: view

Function for KIAA1147 Gene

Molecular function for KIAA1147 Gene

UniProtKB/Swiss-Prot Function:
May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia.
genes like me logo Genes that share phenotypes with KIAA1147: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA1147 Gene

Localization for KIAA1147 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KIAA1147 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with KIAA1147: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for KIAA1147 Gene

Pathways & Interactions for KIAA1147 Gene

SuperPathways for KIAA1147 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA1147 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051179 localization IBA --
genes like me logo Genes that share ontologies with KIAA1147: view

No data available for Pathways by source and SIGNOR curated interactions for KIAA1147 Gene

Drugs & Compounds for KIAA1147 Gene

No Compound Related Data Available

Transcripts for KIAA1147 Gene

mRNA/cDNA for KIAA1147 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KIAA1147 Gene

KIAA1147:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA1147 Gene

No ASD Table

Relevant External Links for KIAA1147 Gene

GeneLoc Exon Structure for
KIAA1147
ECgene alternative splicing isoforms for
KIAA1147

Expression for KIAA1147 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA1147 Gene

Protein differential expression in normal tissues from HIPED for KIAA1147 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.5), Bone (12.7), Fetal Brain (11.9), Frontal cortex (11.5), and Blymphocyte (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KIAA1147 Gene



NURSA nuclear receptor signaling pathways regulating expression of KIAA1147 Gene:

KIAA1147

SOURCE GeneReport for Unigene cluster for KIAA1147 Gene:

Hs.521240

Evidence on tissue expression from TISSUES for KIAA1147 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with KIAA1147: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA1147 Gene

Orthologs for KIAA1147 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA1147 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1147 33 34
  • 99.85 (n)
dog
(Canis familiaris)
Mammalia KIAA1147 33 34
  • 92.12 (n)
cow
(Bos Taurus)
Mammalia KIAA1147 33 34
  • 91.53 (n)
mouse
(Mus musculus)
Mammalia E330009J07Rik 33 16 34
  • 89.94 (n)
rat
(Rattus norvegicus)
Mammalia RGD1563986 33
  • 89.89 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1147 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1147 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1147 33 34
  • 80.33 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA1147 34
  • 84 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-238n5.4 33 34
  • 65 (a)
Species where no ortholog for KIAA1147 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA1147 Gene

ENSEMBL:
Gene Tree for KIAA1147 (if available)
TreeFam:
Gene Tree for KIAA1147 (if available)

Paralogs for KIAA1147 Gene

(1) SIMAP similar genes for KIAA1147 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KIAA1147: view

No data available for Paralogs for KIAA1147 Gene

Variants for KIAA1147 Gene

Sequence variations from dbSNP and Humsavar for KIAA1147 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs142235678 uncertain-significance, Congenital cataract, Cataract and cardiomyopathy 141,653,243(-) C/ genic_downstream_transcript_variant, intron_variant
rs143849281 likely-benign, Cataract and cardiomyopathy, Congenital cataract 141,653,386(-) TGTTT/TGTTTGTTT genic_downstream_transcript_variant, intron_variant
rs184938991 uncertain-significance, Cataract and cardiomyopathy, Congenital cataract 141,654,134(-) A/T genic_downstream_transcript_variant, intron_variant
rs191308473 uncertain-significance, Cataract and cardiomyopathy, Congenital cataract 141,653,916(-) G/A genic_downstream_transcript_variant, intron_variant
rs202211411 uncertain-significance, Congenital cataract, Cataract and cardiomyopathy 141,654,161(-) G/A/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA1147 Gene

Variant ID Type Subtype PubMed ID
esv34135 CNV loss 18971310
nsv475452 CNV novel sequence insertion 20440878
nsv5973 CNV insertion 18451855

Variation tolerance for KIAA1147 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 25.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIAA1147 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA1147

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA1147 Gene

Disorders for KIAA1147 Gene

Additional Disease Information for KIAA1147

No disorders were found for KIAA1147 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA1147 Gene

Publications for KIAA1147 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects. (PMID: 25489052) Myklebust LM … Arnesen T (Human molecular genetics 2015) 4 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for KIAA1147 Gene

Sources for KIAA1147 Gene

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